 It would be lovely to get a Christmas present from OXB in the form of a positive update before year end but I think its much more realistic to expect an update via RNS on 2024 results and 2025 guidance somewhere between the third week of January and the second week of February. Whilst its true that Lucy will already have a fairly solid idea of 2024 revenues it will take a bit more time to be able to give a reliable ebitda figure (which we know will be negative). I also think Frank and Lucy will want to interrogate Seb robustly on the 2025 sales pipeline and have as much time as possible before they have to pin their colours to a mast with a revenue number for 2025.
I think we can all be fairly confident that the company has made its revenue guidance numbers for 2024 and probably at the higher end of the guidance range. It has missed Stuart's April forecast of more or less break even as cash burn has been higher than anticipated - but hopefully ebitda will be negative by no more than single digit millions.
I also think we can be confident that we are going to have a great 2025 and I believe revenue guidance will be at least GBP170-180m and with a return to profitability. So by this time next year revenues should have doubled in 24 months.
Finally I think we can expect that the 3 year rolling forward guidance will be re-based on the 2024 numbers and so forward 3 year CAGR will fall from 35% to 25-30% but with early forecasts for 2026 revenues of ca GBP225m.
So many potential OXB investors are waiting in the wings to see Frank hit the first year of his recovery guidance and once that is in the bag (and profitability close by) I would think this news should be worth at least 100-150p on the share price taking us to the mid to high 500s by February and hopefully drifting into the 600s by the time of the annual results presentation in April. And so back into the FTSE250 maybe in Q2 but definitely in Q3.
For the many of us here who have hoped the company would develop a much better PR/IR/Comms strategy with a steady flow of news to keep investors engaged and excited - I think that we are going to have to accept that won't happen and in the words of someone in this community our Comms people are going to continue to be noticeable by their resounding silence.
As such we are going to have to depend on the quarterly updates - which hopefully will be formalised into a transparent and regular reporting calendar which follow the quarters: end of Jan/end of April/end of July/end of October - and which will be essential as the company looks more to the US investment commnunity. And we are going to have to depend on continuing to play Cluedo sleuthing around (as Harry does so brilliantly) the tidbits of information we are given but always guessing and never sure of exactly what game is afoot.
As such we should maximise opportunities to interrogate and question the management team whenever we have the opportunity to do so. And otherwise practice what for me is always difficult - patience.
In the meantime as the year draws to a close may I thank all of you in this OXB community who have helped to educate and entertain me this year and wish you all a fabulous festive season.
Happy holidays. |
Good question Sean.
I would have thought that OXB know the revenue figure for this year to the penny now (unless there are some invoices out there which are due in the next fortnight and still to be banked).
But would they say anything other than "on track to close the year in line with previous guidance" (or similar)?
If we get a news RNS then I would have thought they will tag a trading update on there, but then we're into the odds of news in the last week before Christmas.
I appreciate that it seems a bit contradictory, but long before OXB give us the 2024 preliminary results at the end of Q1, what the market is really interested in is the guidance for 2025. We saw that first hand when the price dropped before the record 2021 results and all through 2022 on the end of the vaccine contract.
Happily we are basically looking at the reverse of that this time (loss for 2024 / record revenue for 2025). |
Are we not due a promised quarterly business update? Wouldnt that be a good time to release news? |
Appreciate that we've already done the shepherds having the chat with the angel of the EU competitions regulator. Surely this today is the star in the east for OXB? (Copenhagen being east for those of us in Blighty at least).
www.catalent.com/catalent-news/catalent-and-novo-holdings-fulfill-all-regulatory-closing-conditions-for-pending-transaction/
Not long now imho until the wise men (and female men, before someone starts a petition) begin loading the gold onto the Camels. |
Mr 230p let us down this evening then...... |
Incredible, trading this afternoon. 10p drop in price, over 200K shares traded in 420 deals. Will it finish at 430 at 4.30? |
There are some real Shenanigans going on today between the market makers in OXB .
Unusual price action . I suggest it's possibly going to break meaningfully one way or another but my sense tells me it will be "higher ".
Tuco. |
Or two 'people' (banks) working for the same client? |
Maybe they are one and the same person. |
Last few trades continue to illustrate we have a buyer who seems to only want to buy at exactly 4.30 max and a seller who will not sell below exactly 4.30 min....quite strange form of headlock for the share still... |
Let's not. I'd far rather see OXB grow it's revenues to close to £300m over the next 4-5 years, building a growing portfolio of royalties on multi- billions of third party sales based on it's technologies, and being rated in the markets accordingly. |
Let’s get a bidding war going! |
Aside from internal overhauls, Lonza will also seek to “elevate the importance of bolt-on M&A,” while adopting an “impartial view on organic and inorganic opportunities for future growth,” the CDMO said. |
Well there we are. 4.30 at 4.30pm! I just can't wait until tomorrow!! |
A few words today from Frank. |
Indeed. My comment on wealth referred specifically to related investments in the CGT market! With the current rediscovery of socialism as a means of economic (mis) management there will be previous little wealth creation elsewhere! |
Plutonian,
I know you know, but just for everybody else - clinical supply for Arcellx under the Licence and Supply Agreement (LSA) means trial material which will likely be low single digit millions to supply a batch for each trial. Basically a one off for each trial stage at best.
Commercial supply announced back in March (likely for J&J) will be continuous to meet demand when it starts and should be double digit millions yearly once they get established and that will continue for the commercial life of the drug. |
in vivo CAR-T cell engineering. |
CARVYKTI®▼ (ciltacabtagene autoleucel; cilta-cel) demonstrated significantly higher rates of minimal residual disease negativity compared to standard therapies in the phase III CARTITUDE-4 study.
We MAY be contracted to manufacture vector for J&J/Legend which is already approved, but there are safety issues.
Gilead/Arcellx’s Anito-Cel’s Differentiated Safety Profile Challenges J&J/Legend’s Carvykti
We ARE contracted to manufacture vector for Gilead/Arcellx which has just started phase III iMMagine-3 study. |
Red,
I agree with you about the feelgood side of this, particularly with j-ALL (our original Novartis lead indication) and CF, which both overwhelmingly affect kids.
However, and I realise I'm risking smallcrow holding a rally about this view, your last point there goes hand in hand with the discoveries. If you look at the managed economies then everything is done by committee and although they have very occasionally dropped on something good, mostly the only people who gain are those who sit on the committees and their families.
In the market economies then entrepreneurs see a market opportunity and take a risk which is usually funded by people like us who take part in the funding rounds in hopes of a good return. That system provides many companies chasing the same targets and although most fail it is a system which has delivered us almost everything we take for granted.
In my humble view it's far superior to the state approved hairstyles and the same suits all made in state factories. Unfortunately though there are an increasing number of youngsters around these days who are keen to give that system another try. |
Excellent news commercially: and also, let's all pause and consider, for the people and families who are being given new life because of these technical achievements. There is so much potential for gene therapies emerging now, across a huge range of previously unaddressable conditions, after many years of hard work and vast levels of investment. The next decade will see extraordinary benefits to health. (And, selfishly, to wealth!) |
Just a quick one for this morning:-
We're all familiar with the 20th March RNS
"Recently, the Company signed a contract with a new undisclosed US-based biotechnology company for the manufacture of lentiviral vectors as the client prepares for the commercial launch of its CAR-T programme targeting multiple myeloma. Manufacturing will take place in OxBox, the Company's Oxford-based manufacturing facility.".
As was noted at the time there were only 2 newly approved CAR-T drugs for multiple myeloma with only one of those being "new" to OXB (i.e. not BMS) so the overwhelming probability being the RNS referred to J&J.
J&J news out last night
To get on the trials a patient needs to have been failed by all previous treatments and therefore by default is in a very poorly state. 90% of those evaluable (i.e. stayed in the trial) having undetectable disease this long post-treatment with that statistical power number is an astonishing result.
Almost certainly now it will be rolled out in earlier stage patients who are pre-tested as likely to be refractory to standard treatment and will also by default be much less poorly when they get this (currently last resort) treatment.
MM is one of the more common soft cancers and J&J will sell a lot of this. QED the people who make the programming vector will need to make a lot of that too. |
It will definitely finish at 4.30, LSE rules. |
Got it in one DC :) |
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