Oxford Biomedica Share Discussion Threads

[pharmaboy3] 27/10/2020 17:59

Interesting partnership Merck signed deal with small British company 4D.Apparently keytruda far more effective with tailored mictobiomed gut bacteria .Bacteria act as a channel for keytruda .HTTps://www.4dpharmaplc.com/en/newsroom/press-releases/4d-pharma-collaborates-msd-live-biotherapeutics-vaccinesMight be interesting pathway for us ?

[marcusl2] 27/10/2020 15:07

Axovant Gene Therapies Ltd is due to present at its virtual Parkinson's disease R&D day individual patient-level data from Cohort 2 of the Phase 2 SUNRISE-PD study that is evaluating its AXO-Lenti-PD gene therapy for the treatment of Parkinson's disease (Friday)

[marcusl2] 27/10/2020 14:48

Sanofi Gene therapy research in hemophilia A type of retrovirus called a lentivirus are being investigated as a DNA delivery service. Sanofi scientists are pursuing lentiviruses as delivery vehicles because24: They are large and can carry a lot of information: They are big enough to hold both the corrected DNA sequence of factor VIII, biochemical switches to turn them on or off, and biological information that would prevent white blood cells from attacking the retrovirus. They can integrate into the genome in the liver cells, so that when the cells divide the corrected DNA is reproduced consistently. This is one of many experimental approaches to gene therapy at Sanofi. HTTps://www.sanofi.com/en/science-and-innovation/stories/science-behind-sanofis-hemophilia-pipeline

[marcusl2] 27/10/2020 14:34

"Our work is hypothesis generating, hinting at a potential synergism between radiation and CART-BCMA therapy, which has been reported by others in the literature," Manjunath said. "Future prospective trials that combine radiation with CART-BCMA may further optimize safety and long-term efficacy of this novel cell therapy." This study, which is a retrospective analysis of a collaboration project with Novartis HTTps://www.news-medical.net/news/20201027/Radiation-therapy-before-CART-BCMA-appears-to-be-a-safe-option-for-multiple-myeloma-patients.aspx

[marcusl2] 27/10/2020 11:54

BELINDA (CCTL019H2301) Indication 2nd line Diffuse large B-cell lymphoma (DLBCL) Read-out Milestone(s) H2-2021

[marcusl2] 27/10/2020 11:49

Novartis submission schedule 2021 Kymriah tisagenlecleucel, CTL019 r/r DLBCL 1st relapse LCM Kymriah tisagenlecleucel, CTL019 r/r Follicular lymphoma 2024 Kymriah tisagenlecleucel, CTL019 r/r DLBCL (+ pembro Kymriah LCM tisagenlecleucel, CTL019 1L high risk ALL, pediatrics & young adults

[marcusl2] 27/10/2020 11:47

CTL019 Kymriah® CD19 CART Lymphoma r/r DLBCL (+ pembro) JEZ567 JEZ567 CD123 CART AML LXF821 LXF821 EGFR CART Glioblastoma multiforme MCM998 MCM998, LXG250 BCMA CART, CD19 CART Multiple myeloma PHE885 PHE885 BCMA Cell therapy Multiple Myeloma YTB323 YTB323  ibrutinib CD19 CART Haematological malignancy Phase III CTL019 Kymriah® CD19 CART r/r Follicular lymablphoma 1L high risk ALL, pediatrics and young adults r/r DLBCL 1st relapse

[marcusl2] 27/10/2020 11:23

Exact Sciences $EXAS to Acquire Thrive Earlier Detection for Cash and Stock up to $2.15 Billion

[dominiccummings] 27/10/2020 09:27

Latest available ONS stats (to 9th October). Odd that a fortnight ago there is little sign of a surge in deaths. Weekly provisional figures on deaths registered in England and Wales1,2,3,4,5,6,7,8 Note that up-to-date counts of the total numbers of deaths involving coronavirus (COVID-19) are published by Department of Health and Social Care (DHSC) on the GOV.UK website. ONS figures differ from the DHSC counts as the latter include deaths which have not yet been registered. Week number 41 Week ended 09-Oct-20 Total deaths, all ages 9,954 Total deaths: average of corresponding week over the previous 5 years 1 (England and Wales) 9,811 Total deaths: average of corresponding Note: Deaths could possibly be counted in both causes presented. If a death had an underlying respiratory cause and a mention of COVID-19 then it would appear in both counts. Deaths by cause 2,3,4,5 Deaths where the underlying cause was respiratory disease (ICD-10 J00-J99) 976 Deaths where COVID-19 was mentioned on the death certificate (ICD-10 U07.1 and U07.2) 438

[jasierock] 27/10/2020 09:21

I dont think it will be too long before we are 'approached'

[marcusl2] 27/10/2020 08:39

ANTHONY FAUCI: And I think it'll be a positive answer by the end of this year, the end of November, the beginning of December so that we can start distributing vaccine to those who are most in need, particularly health care workers and the vulnerable among us in the population. HTTps://finance.yahoo.com/video/dr-anthony-fauci-getting-covid-185147111.html

[marcusl2] 27/10/2020 08:06

If the AZ vaccine needs to be given annually then profits from; 1- Vaccine 2- Kymriah 3- 2nd Car T soon hopefully ( probably Multiple Myeloma ) 4- Money from Axovant 5- Progress on the rest of the pipeline. Should soon start to look good in 2021.

[marcusl2] 27/10/2020 08:01

Kymriah (USD 122 million, +51% cc) grew strongly in Europe, US and Japan. Coverage continues to expand, with more than 260 qualified treatment centers and 26 countries having coverage for at least one indication. Kymriah Phase II ELARA trial met its primary endpoint (complete response rate) at the interim analysis, demonstrating clinically meaningful benefit in patients with relapsed or refractory follicular lymphoma. No new safety signals were observed.

[marcusl2] 27/10/2020 07:56

Oxford Covid vaccine works in all ages, trials suggest Vaccine being trialled by Oxford University and AstraZeneca offers hope for all age groups HTTps://www.theguardian.com/world/2020/oct/27/covid-vaccine-uk-oxford-university-astrazeneca-works-in-all-ages-trials-suggest?utm_term=Autofeed&CMP=twt_gu&utm_medium&utm_source=Twitter#Echobox=1603784632

[marcusl2] 26/10/2020 21:38

HTTps://www.bbc.co.uk/news/health-54690374

[marcusl2] 26/10/2020 21:15

I`ll be jealous if you win Jasie HTTps://www.pharmiweb.jobs/job/1066196/senior-scientist-computer-aided-biology/?TrackID=6740

[pharmaboy3] 26/10/2020 19:18

T-cells from recovered COVID-19 patients show promise to protect vulnerable patients from infection: Immunotherapy experts apply proven model to grow SARS-CoV-2-fighting T-cells from convalescent donorsHTTps://www.sciencedaily.com/releases/2020/10/201026114218.htm

[harry s truman] 26/10/2020 18:34

I hope you are Jasie, but I'm feeling that the Halloween sweep needs something of a miracle for anybody above you to win it. Martin buying says nothing imminent to me and as for the AZ vaccine, there only seems to be about 2 people outside of OXB, AZ and this BB who actually know we are in on the manufacturing side. So even on great AZ news this week, it might tale a while for that to filter through. I think best to look upon this as a warmup for the Christmas spectacular, which (if all the planets line up) will have multiple RNS releases from JD factored into that year end price.

[jasierock] 26/10/2020 18:22

I rekon I'm bang in the Sweet Spot at 8.65 Harry! Margot Robbie sent me a 'fingers crossed' message today so I guess she's hoping for the best!

[harry s truman] 26/10/2020 18:09

Well chaps, it's the final countdown... 4 trading days left, but at today's 827 close it's currently looking pretty good for KymriahKardashian. Is there news this week to change that? Oh, the suspense ;) 750 robs12 833 KymriahKardashian 840 timax 848 digger 850 antreg 861 avc0nway 865 jasie 869 mr_mike 880 catch007 888 pb3 889 hopeSprings 890 trovax 899 elsol 902 boadicea 911 ewads 916 northstand 920 effham 925 fhasson 941 marcus 975 2upthespurs 987 icejelly 999 riskblue 1010 swans 1031 dmorford 1066 bunlop 1200 sturichardson 1250 gh 1299 sharelog 1313 hst 1380 flc 1400 don corleone 1428 gareth 1959 Abd009

[dominiccummings] 26/10/2020 17:12

#10302 Well you don't have much breadth in you view of life do you little Corvid?

[small crow] 26/10/2020 16:51

Dom, whether you understand numbers... or whether you just pretend to read them. ;-)

[marcusl2] 26/10/2020 16:15

HTTps://www.youtube.com/watch?v=fc4eK09tnIU

[marcusl2] 26/10/2020 14:07

Juno success. HTTps://www.youtube.com/watch?v=01e0tWhKsMU "We got in the room and he said – it’s the best news, no detectable disease. Not a single cell found. I started crying. we won’t know for years but I’m so optimistic that my incurable cancer has just been cured, that the CAR-T has got to every last cell, that there isn’t one rogue mutant thing ready to start replicating itself and get the better of me, that I will be here to see my children grow up. It changes everything." HTTps://abtandme.com/2020/10/23/sword-of-damocles/

[trovax] 26/10/2020 13:41

A bit of news out on the Astra Zeneca front :-)