Just been watching the cinema film about Trump's early days..quite some life he has led.
We powered through 4.40 ...this is starting to really motor again here... |
Worth keeping an eye on Milei/Argentina. It may be the start of something broader, particularly if Musk, sorry, Trump, gets in. |
We’re all singing from pretty much the same song sheet here.
The real conundrum is the quality of the candidates that are being presented to democracies worldwide.With the rigours of social media,personal safety etc,who the hell wishes to be a politician other than self-opinionated narcissists and ideologues. |
How many "workers" in the UK receive a cheque each month or if they have an emergency write out a cheque? Not many I suggest. |
I hate my phone keyboard |
March, notatch. |
Read the thread to get an idea. You'll need to go back to Match to get the full story. |
is this a good share |
FT250 inclusion now feels like a probability rather than a possibility. |
So the auction trade to end there was both 12 month highest intraday and closing price and on good volume.
I think that one is up there with seeing a star in the east wrt the MS index and then the FT250 readmissions. |
Apparently you need to be paid by cheque once a month to be a working person. |
Without going into politics, it appears Sir Starmer's very prestigious previous life is now causing problems in his current role as Prime Minister. |
“Speaking to broadcasters in Samoa, Keir Starmer said he would not use the term-‘working people’-for people who had income from assets such as shares or property. “They wouldn’t come within my definition,” he said. Downing Street hastily clarified that the prime minister did not mean people who owned small amounts of, for example, stocks or shares.”
What with supermarkets expecting one to check out your purchases (and in due course maybe stack the shelves)it seems inevitable that unworthy folk like me will be dragooned into sweeping the roads.I deserve no better.I seem to remember from my university politics course that similar sentiments were expressed by the Bolsheviks and during the period of the Third Reich. |
 Unknown unknowns Dom.
I would guess that Boston / Bedford has been Seb's highest priority as losing that late stage work (with Homology shutting up shop) would be so difficult to make up for - even with a lot of very early stage AAV work.
They seem to have done very well to react, with the impairment charge now addressed and that site becoming a LentiVector hub this year, but it can't have been easy.
I think we can all guess the likely reason why the Oxford and Boston business units are combined in the figures, and that's because one has been carrying the other with OXB not wanting to admit by how much, but my upside view on that would be to note that once the US site begins to contribute significantly then happy days - and that is simply a matter of time.
I'm pretty confident that France will contribute this year as they seem to be doing very well with Geovax and other work, but I think OXB have mentioned a few times now that whilst their LentiVector presence in the market is mature and very well known within the industry, their AAV services are not. I'm sure they have been working very hard to sort that out - as noted by 42% of our new work being AAV in the recent presentation. |
More effort needed to promote Boston part? Big pharma 'feel safer' buying in the good ole US of A. |
Reading my newsfeed this morning I was distracted by this:-
So Roche deepening their existing tie-up with Dyno.
What are Dyno? basically a bespoke AAV company which tailors vectors for specific applications using AI.
It made me ponder what Dyno can do for Roche with their AAV and AI which OXB couldn't do for a different partner with our AAV and our AI
I suspect the answer is not a lot, but I don't know for sure.
Obviously it's natural / logical for Roche to stay with the vector they selected in 2020 when OXB didn't have an AAV to offer, but surely potential here now for OXB to offer similar tie-ups to others?
Appreciate that we are pure CDMO these days, but the D there is of course development.
From all we have been told the Homology AAV was a very good one (hence the amount of cash we were willing to spend) and it is now improved further by OXB tech.
It's something we would never know about until it happened, but we are intimately involved with Novartis and BMS linked to our LV, so surely a similar AAV tie-up with a major is on the cards at some point. |
Back to OXB and earlier in the year we were all curious about why Frank had become chairman of ArcticZymes and if there was something brewing there.
This to me suggests that we are working together
(or at the very least using their technology) |
Yes i agree with all that Harry.It seems inevitable that Labour will repeat some,if not many,of the mistakes witnessed in the 70s.The road to economic ruin is invariably littered with apparently good socialist intentions.Thereagain,cynically,envy plays its part. |
It's very hard to compare SJ, as until quite recently the US basically had 2 conservative parties. I'm sure you know but early days Ronald Reagan was a card carrying democrat and when asked why he changed, he replied that he hadn't changed it was the democrats who had. Go back even further and the republicans are the abolitionists and hold power in what are now the democratic strongholds of the north east.
As for contesting the election then it depends on if the migrants being rushed through swing it (some states now having half a million more voters than previously registered) but I have a feeling that DT will win by such a margin that it can't be swung that way. Regardless of policies or personalities people look at what is in their pockets vs what is being spent on their behalf, and apart some very specific groups that is the biggest single issue.
Al Gore contested Bush's win
Hillary contested Trump's win
Trump contested Biden's win
That just happens. Bush Senior and John McCain both had the good grace to just accept the vote.
I share your worries about the UK. Starmer is an extreme left follower of Michel Pablo. Look at his history if you doubt that and why he followed Pablo and not the society of Labour lawyers. Corbyn would never have picked him as an underling if he didn't have extreme views and of course he is in No 10. I just worry a lot about his judgement - the fact that he thought Lammy the best in the Labour party to represent us on the world stage and of course it's very likely that our chancellor has also been picked for ideology over ability. The only thing we know for sure is that the public sector and the big unionised lobbies will be ok. Everybody else is likely to be paying for it. |
It's far from certain that the US election result will be a smooth uncontested affair and there could well be 10 days of uncertainty hanging over markets following bonfire night on 5th November.The polls are nudging in Trump's favour and discussions i've had with American tourists in various European localities over the last year have on balance pointed in that direction.Kamala Harris's policies are pretty radical.For example,she suggests reforming capital gains tax to be taxed as income,some of her policies are right out of the muted Rachel Reeves handbook.(What a farce waiting for this UK budget has become).I'm not surprised Labour party members are hanging round Democratic conventions,they could be bedfellows. |
Or one of them maybe? (we have 4 in P3).
I think that disease is fortunately tiny numbers of kids - so it will be very hard to recruit. It does seem to be a candidate platform for many other things though.
With current OXB of course, we get paid for CDMO services but are insulated from the trial costs. Good possibilities for our LV there though imho. |
Harry, good find.
I assume Castle Creek Biosciences are our "undisclosed US-based late-stage cell and gene therapy company".
Primary Completion: 2023-01-17
Results First Submitted: 2024-01-17
Results First Posted: 2024-04-01
There does not appear to be urgency to advance the product. |
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