 It's very hard to compare SJ, as until quite recently the US basically had 2 conservative parties. I'm sure you know but early days Ronald Reagan was a card carrying democrat and when asked why he changed, he replied that he hadn't changed it was the democrats who had. Go back even further and the republicans are the abolitionists and hold power in what are now the democratic strongholds of the north east.
As for contesting the election then it depends on if the migrants being rushed through swing it (some states now having half a million more voters than previously registered) but I have a feeling that DT will win by such a margin that it can't be swung that way. Regardless of policies or personalities people look at what is in their pockets vs what is being spent on their behalf, and apart some very specific groups that is the biggest single issue.
Al Gore contested Bush's win
Hillary contested Trump's win
Trump contested Biden's win
That just happens. Bush Senior and John McCain both had the good grace to just accept the vote.
I share your worries about the UK. Starmer is an extreme left follower of Michel Pablo. Look at his history if you doubt that and why he followed Pablo and not the society of Labour lawyers. Corbyn would never have picked him as an underling if he didn't have extreme views and of course he is in No 10. I just worry a lot about his judgement - the fact that he thought Lammy the best in the Labour party to represent us on the world stage and of course it's very likely that our chancellor has also been picked for ideology over ability. The only thing we know for sure is that the public sector and the big unionised lobbies will be ok. Everybody else is likely to be paying for it. |
It's far from certain that the US election result will be a smooth uncontested affair and there could well be 10 days of uncertainty hanging over markets following bonfire night on 5th November.The polls are nudging in Trump's favour and discussions i've had with American tourists in various European localities over the last year have on balance pointed in that direction.Kamala Harris's policies are pretty radical.For example,she suggests reforming capital gains tax to be taxed as income,some of her policies are right out of the muted Rachel Reeves handbook.(What a farce waiting for this UK budget has become).I'm not surprised Labour party members are hanging round Democratic conventions,they could be bedfellows. |
Or one of them maybe? (we have 4 in P3).
I think that disease is fortunately tiny numbers of kids - so it will be very hard to recruit. It does seem to be a candidate platform for many other things though.
With current OXB of course, we get paid for CDMO services but are insulated from the trial costs. Good possibilities for our LV there though imho. |
Harry, good find.
I assume Castle Creek Biosciences are our "undisclosed US-based late-stage cell and gene therapy company".
Primary Completion: 2023-01-17
Results First Submitted: 2024-01-17
Results First Posted: 2024-04-01
There does not appear to be urgency to advance the product. |
Sean,
Personal anecdote here for what it's worth:-
I used to work for an American multinational company and still have friends from that time. Most Americans tell you their politics (that just seems to be a thing for them) but you have to remember that regardless of their allegiance, the Donald is a known quantity for all Americans and they know that last time he was president he did the job for 1 dollar and during his term there were no US wars (I believe the first time since Carter but haven't checked that).
The most controversial thing he did was withdraw the US from the Paris accord where Obama had signed up to cripple America with climate regulations which nations like China and India would be exempt from.
Now whether the average American believes that a very expensive climate policy can control the weather or not, they do remember their heating / fuel bills (the latter hitting everything else) under Trump vs what they became when Biden re-shackled them to crippling net zero commitments on day 1 of his presidency.
Those are huge costs as we know in the UK now with Ed's budget to change the weather on behalf of HMG. Someone has to pay and guess who that will be.
I read a book years ago (Freakonomics) and then its sequel and the story on US guns is very interesting. There are a few places - mostly limited to certain blocks in some well known cities where virtually all the gun crime takes place. In the other 99% of America then guns live in drawers and cupboards and mostly never see the light of day. I can't remember the exact passage now and I'm not going to look it up, but if you are a product of a functional family with at least one working adult (the vast majority of them are that and churchgoing) then bees and swimming pools are a far bigger risk to you than any gun. |
I am a little concerned at the potential for damage to markets if events on the other side of the pond reach their full potential for madness in a couple of weeks time. There are more guns than people remember. |
Are you employing a professional research assistant to find this stuff ? !!! |
takeiteasy,
It's fine, your guess is as good as mine or anybody else's - and unless OXB tell us (see below) a lot of what we type here is to some varying extent just a guess.
I think we will have a few happy days now at least, as the Motley Fool disciples who fancy a spot of OXB either buy in immediately or decide what they are selling a little of to fund the tickets. As per yesterday, after a long time of being the statue it's beginning to look like OXB is going to get another turn at being the pigeon.
To my mind now the FTSE250 at the review 4 weeks tomorrow is very achievable. I'll not say certain as nothing is until its done, but I think the planets are lining up and even if Rachel crashes the market on Wednesday then the threshold to get in will be lower for any company which can buck that trend.
Back to things which OXB don't tell us because they can't, and has this young man just told us what one of our secret Phase 3 trials is?
If so then I'd imagine OXB will be thrilled (and in his place I certainly wouldn't be accepting the offer of a weekend break at Castle Doliveux), but for us a little free glimpse?
So, he worked in QA/QC on the vaccine, the myeloma CAR-T and also FCX-007
That's another one on my list as of today. |
Lots of little shakes now between 4.15 and 4.35 and let's hope the sellers have been shaken out to move beyond 4.40 :) |
True Sean, but I've seen so many of these over the years and that article falls into the better half of them. As I say I'll take the publicity.
A lot of people follow Motley Fool and if that + the Morgan Stanley Index + any kind of news from OXB gets OXB to 325th place or higher by close of play 4 weeks on Friday then I will be very happy indeed with this year.
I think we closed today at 356th place. |
Quite a few misses Harry. They have one job and easy access to all the facts but still well off the mark, |
There's a few misses in that from someone who is a shareholder, but I'll take any publicity we can get in the runup to Nov 22nd. |
This skyrocketing growth stock is up 100% this year! Is it too late to buy?
Mark David Hartley
Wed 23 October 2024 at 4:33 pm BST 3 min read
Move aside Rolls-Royce and Fresnillo — this small-cap biotech share is skyrocketing past some of the UK’s leading growth stocks. Up 100% this year, OXB (LSE: OXB) is taking no prisoners as it fights to recover its losses from 2022.
Between November 2021 and October 2022, the share price crashed 78%, falling from a high of £16.78 to almost £3 per share. The price continued to fall through 2023 but has now recovered to £4.18 — the highest it’s been in over a year.
So what’s next for the stock?
Cutting-edge biotechnology
Previously known as Oxford Biomedica, OXB is a relatively small £442m stock listed on the FTSE All-Share index. The Oxford-based biopharmaceutical company focuses on cell and gene therapy, specialising in viral vector manufacturing. It has over 25 years of experience working with some of the leading pharmaceutical and biotech firms globally.
Recently it shifted to a pure-play contract development and manufacturing organisation (CDMO), aiming to position itself as a leader in viral vector services, helping other firms develop and commercialise gene therapies.
Over the past year, its portfolio grew to include 37 clients and 48 programmes, focusing on viral vector types like lentivirus and adeno-associated virus (AAV). The value of these contracts is approximately £94m as of 31 August.
Shaky financials
Last year was not kind to OXB, with the share price falling 50%. In the first half of 2023, it reported a 33% drop in revenues compared to the same period in 2022. The decline was primarily due to the non-recurrence of AstraZeneca Covid vaccine manufacturing. It also posted an operating EBITDA loss of £33.7m, higher than the £5.8m loss in the previous year. This was attributed to inflation combined with higher expenses related to its new Oxford Biomedica Solutions division.
Things seem to be improving in 2024, although first-half earnings were still somewhat disappointing. Both revenue and earnings per share (EPS) missed analyst expectations, by 4.7% and 110%, respectively. Although it posted a net loss of £32.5m, this was a 32% improvement on H1 2023.
The balance sheet looks okay for now, with a debt-to-equity ratio of 55.8%. However, it’s burning through cash and piling on debt, possibly due to increased operational expenses and rising bioprocessing costs.
Cash and liquidity are key areas to watch as the company expects to break even in EBITDA by the end of 2024. In an announcement made in September during the rebranding to OXB, new CEO Dr. Frank Mathias said it aims to improve its financial standing by focusing on its role as a CDMO.
It’s unclear how well the change to a CDMO will pay off, but the price is already reacting positively. However, the loss of a large client like Novartis could easily turn things around. It already faces tough competition in the CDMO market — any drop in performance could result in lost contracts.
If things go well, the transition should provide more stable, long-term revenue as opposed to the volatile revenues from internal R&D. I expect it will continue to do well so if I weren’t already a shareholder, I’d happily buy the stock today.
The post This skyrocketing growth stock is up 100% this year! Is it too late to buy? appeared first on The Motley Fool UK.
Mark Hartley has positions in OXB. The Motley Fool UK has recommended AstraZeneca Plc. Views expressed on the companies mentioned in this article are those of the writer and therefore may differ from the official recommendations we make in our subscription services such as Share Advisor, Hidden Winners and Pro. Here at The Motley Fool we believe that considering a diverse range of insights makes us better investors.
Motley Fool UK 2024 |
I'm sure you are correct jez, with the odds on favourite for that being detail of the multiple myeloma CAR-T deal first mentioned in March. It's just this quantification of the word soon which has been problematic. |
Throw the charts in the bin,its obvious to me now, OXB are solely NEWS DRIVEN, I can feel it in my water though, news is coming soon. |
With the usual caveat here that I'm a lth and so will inevitably have confirmation bias, I don't understand why anyone would currently short OXB.
I understand why they did it last year when it became obvious to some that there were large holders who had to sell either to meet redemptions or because of their own fund holding rules for constituent minimum market cap values, then when we were booted from the Morgan Stanley index last November, but of late there seems to be nobody mad enough to do it.
See
Regardless of all the things I regularly bang on about, the simple fact remains that in 2 months we are in the holidays which end this year and about to go into 2025 where OXB have repeatedly reaffirmed guidance of c£130m in sales and breakeven or better EBITDA.
That's a £10 share which you can buy today for £4 so why would anyone short it?
I think the economy simply remains bad in the UK, with the large possibility that Labour will set fire to what is left of it a week today, which leaves a lot of people - especially smaller investors - very cautious.
Countering that, I'm optimistic that we have not dropped back below £4 after the high volume day which carried us here and we currently sit about 357 in market cap on the London exchange. We need 325 or better by the 22nd and if it happens then that would definitely help change things for the better. |
Imvho they could try when they did as the "drop" was timed right after the large option plan RNS for senior execs so you would figure a valuable RNS would be very unlikely to be within 10-15 days of this just for the poor optics it would leave...my humble 2 pennies worth... |
The apparent attempt to push us back to ~350p last week was a failure as, I assume, too many of us topped up in the 360's. Will they (whoever 'they' are) try again - and why? |
certainly won't be dull here atm now we are outside of the rangebound period - the buying could be simply linked to II presentations from the management following recent results :) |
I share your cautious optimism Phil. Normally timing goes against OXB (because we are just lucky like that), but anticipation of inclusion back into the MSCI would seem to be ideally timed to help with the FTSE250 goal.
A couple of cautions:-
I've read the MSCI inclusion policy doc just now and it's as clear as mud to me, unlike the FTSE250 quarterly review which is simply market cap of 325th place or higher on the review date close.
Anecdotally we do know that in the MSCI August '23 review (roughly our current share price but remember we have more shares now so a higher market cap on the same share price) we were not deleted from the MSCI index, but by November '23 our market cap saw us booted.
Assuming (always dangerous I know) that there isn't a large gap between the addition market cap and the deletion market cap, then I'm quietly hopeful that OXB will be back in the MSCI this coming review.
It would also explain quite well our recent share price movement on apparently no news. |
Feels like a game of snakes and ladders! Well if repricing over next week gets us into the 500s, that might be enough for the 250, here’s hoping. |
On the subject of MSCI rebalancing I was sent this by a market professional in relation to another stock- I assume it applies here as well.
“The pricing period will be any of the last 10 days of October (18-31 October), with a very heavy bias to the first few days. The announcement of changes will be made on 07 November with rebalance on close 26 November.” |
2 thread merit marks to chillpill for remembering that one.
For those wondering, see this link (page 6)
Which was notification of us being removed from that index back in Nov 2023 because our market cap had dropped too low.
Definitely something to keep an eye on / bear in mind to help explain today as if we were booted out c200p last year, then every chance of the reverse manoeuvre this year at c400p.
Could easily have been some anticipation of that today. |
Hopefully back in the MSCI this time and FTSE 250 next quarter. |
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