Motif Bio Share Discussion Threads

[bountyhunter] 14/2/2019 09:50

Should be published by the FDA at some point but not available yet.

[nick rubens] 14/2/2019 09:48

Is there anywhere we can read the full FDA response?

I'd rather hear from them why they rejected it and not the brief two lines in the RNS.

[mike1608] 14/2/2019 09:46

Silly billy

[mike1608] 14/2/2019 09:45

Hahahahhaahha

[bountyhunter] 14/2/2019 09:42

lionheart, first you stated that you 'sincerely doubt' an FDA rejection would occur then after the FDA rejection did occur you accused posters here of 'silly optimism', that was my point!

lionheart69uk1 - 13 Feb 2019 - 22:15:38 - 2752 of 2824
No idea why you are all getting so excited. The market has already factored the probability of success into the current share prices. I am not expecting any sudden movement unless a FDA rejection occurs, which I sincerely doubt.

lionheart69uk114 Feb '19 - 08:47 - 2823 of 2850
0 1 2
Thank goodness I wasn't tempted by all the silly optimism on here.

[herb clark] 14/2/2019 09:42

Must be worth a punt at this price?

[davidpines] 14/2/2019 09:41

Please do not believe a word from kik6 a serial ramper who will say anything to make people buy this

[robizm] 14/2/2019 09:34

Amp are finished if mtfb do not get approval as they have huge debt.

[bookbroker] 14/2/2019 09:32

Why BIG firms kicking themselves, most relieved that this drug development programme that has been passed from pillar to post many times tell one something, except it was the losing post!

[lionheart69uk1] 14/2/2019 09:29

bountyhunter, the sudden movement occurred because FDA approval was not forthcoming. My point was that, even if had occurred, the price would not have risen by very much. My prediction was 52.5p if yes and 7.5p if no. As some over-selling appears to have occurred this morning I might jump in at 5.25p if it reaches that point or buy AMP at 0.45p which offers wider coverage I guess.

[spmc] 14/2/2019 09:28

Only 100k available on level 2 sub 9p reckon we will see 15p by lunch time

[kirk 6] 14/2/2019 09:27

5m buy orders vs 3m sell orders

[herb clark] 14/2/2019 09:26

Level 2 anyone

[kirk 6] 14/2/2019 09:23

Order book looking much better now

[mike1608] 14/2/2019 09:23

BIG firms be kicking themselves today

[pre] 14/2/2019 09:22

Tomboyb - looks like if they can satisfy FDA, then its still a goer?...that's my take on it

[bountyhunter] 14/2/2019 09:22

This is rather odd given the reason given by the FDA for non-approval...

"Importantly though, it looks to be safer"

[mr woodentop] 14/2/2019 09:19

Davidpines - its a bet based on markets typical over reaction, may be wrong but i don;t put in more than i can afford to loose

[spmc] 14/2/2019 09:18

Liver tests are done as standard in any phase 3 trial, it’s standard procedure so they musn’t have included enough of it in the nda!

[mike1608] 14/2/2019 09:16

will be 30-45 days later thou

[pre] 14/2/2019 09:15

thanks for confirming tomboyb.

[tomboyb] 14/2/2019 09:13

pre14 Feb '19 - 09:11 - 2833 of 2834
0 0 0
so outside chance FDA could still approve after the meeting if MTFB make necessary amendments?

That is the speculation -

[jack1236] 14/2/2019 09:11

Iclaprim achieves high concentrations in skin and skin structure and lung compartments. Icalprim also rapidly concentrates in the gastrointestinal tract, adrenal glands, kidneys, and liver, with a high volume of distribution exceeding 4–5 times the total body water volume. Iclaprim has 93% plasma protein binding. Iclaprim and its metabolites are rapidly and extensively excreted in the bile and urinary route. Iclaprim is metabolized by both phase 1 (CYP3A4 and CYP23C19) and phase 2 (CYP2C9 and CYP2D6) enzymes. Most of the phase 1 metabolites are subsequently conjugated to glucuronide metabolites. Less than 2% of unchanged iclaprim was found in urine and feces, confirming extensive metabolism.

[pre] 14/2/2019 09:11

so outside chance FDA could still approve after the meeting if MTFB make necessary amendments?