Ip Share Discussion Threads

[bottomfisher] 14/1/2021 14:16

Does anyone know what has happened to the 7% of IPO that Invesco has sold?. Invesco was IPO's second biggest shareholder, and there is no sign that any of IPO's other major shareholders have used the disposal to increase their stakes. It would have been a real sign of confidence in the company if the shares had been placed with another long-term strategic shareholder, such as the Railways Pension Fund or Baillie Gifford. Surely it would have been in IPO's interests to make sure that the shares were placed safely with long-term investors rather than just dumped on the market.

[bamboo2] 13/1/2021 22:01

Wet, The article you posted is now getting reported more widely. There has been a gradual improvement in accuracy over the past few years, but this looks like a major step forward.



Researchers have found a simple way to eliminate almost all sequencing errors produced by a widely used portable DNA sequencer, potentially enabling scientists working outside the lab to study and track microorganisms like the SARS-CoV-2 virus more efficiently.

Using special molecular tags, the team was able to reduce the five-to-15 percent error rate of Oxford Nanopore Technologies' MinION device to less than 0.005 percent—even when sequencing many long stretches of DNA at a time.

"The MinION has revolutionized the field of genomics by freeing DNA sequencing from the confines of large laboratories," says Ryan Ziels, an assistant professor of civil engineering at the University of British Columbia and the co-lead author of the study, which was published this week in Nature Methods. "But until now, researchers haven't been able to rely on the device in many settings because of its fairly high out-of-the-box error rate."

Genome sequences can reveal a great deal about an organism, including its identity, its ancestry and its strengths and vulnerabilities. Scientists use this information to better understand the microbes living in a particular environment, as well as to develop diagnostic tools and treatments. But without accurate portable DNA sequencers, crucial genetic details could be missed when research is conducted out in the field or in smaller laboratories.

So Ziels and his collaborators at Aalborg University created a unique barcoding system that can make long-read DNA sequencing platforms like the MinION over 1000 times more accurate. After tagging the target molecules with these barcodes, researchers proceed as they usually would—amplifying, or making multiple copies of, the tagged molecules using the standard PCR technique and sequencing the resulting DNA.

The researchers can then use the barcodes to easily identify and group relevant DNA fragments in the sequencing data, ultimately producing near-perfect sequences from fragments that are up to 10 times longer than conventional technologies can process. Longer stretches of DNA allow the detection of even slight genetic variations and the assembly of genomes in high resolution.

"A beautiful thing about this method is that it is applicable to any gene of interest that can be amplified," says Ziels, whose team has made the code and protocol for processing the sequencing data available through open-source repositories. "This means that it can be very useful in any field where the combination of high-accuracy and long-range genomic information is valuable, such as cancer research, plant research, human genetics and microbiome science."

Ziels is currently collaborating with Metro Vancouver to develop an expanded version of the method that permits the near-real-time detection of microorganisms in water and wastewater. With an accurate picture of the microorganisms present in their water systems, says Ziels, communities may be able to improve their public health strategies and treatment technologies—and better control the spread of harmful microorganisms like SARS-CoV-2.

[bamboo2] 13/1/2021 13:36

Interesting to try some comparisons with other manufacturers.

Oxford Nanopore [ONT] Value $2.3B order value $125m [Figs from 06/2020]
[note, excludes the £115m order in Autumn from UK Govt]

Illumina [ILMN] mcap $52.7B t/o $3,546m


Pacbio [PACB] mcap $6.22B t/o $90m


Let me know if there are more up to date figures, or a better way to compare ONT, ILMN, and PACB

[wetpantz] 13/1/2021 08:53

More positive developments for ONT sequencing technology:

hxxps://www.sciencedaily.com/releases/2021/01/210112144811.htm

Researchers have found a simple way to eliminate almost all sequencing errors produced by a widely used portable DNA sequencer, potentially enabling scientists working outside the lab to study and track microorganisms like the SARS-CoV-2 virus more efficiently.

[bamboo2] 12/1/2021 11:05

Oxford Nanopore and Nvidia collaborate to partner the DGX AI compute system with ultra-high throughput PromethION sequencer

Tue 12th January 2021

PromethION
Oxford Nanopore Technologies and Nvidia are collaborating this year to integrate the NVIDIA DGX Station A100 into Oxford Nanopore’s ultra-high throughput sequencing system, PromethION. Partnering the NVIDIA A100 Tensor Core GPU technology with the PromethION device aims to deliver the world’s most powerful sequencer that supports real-time analyses at scale, and can also analyse any length fragment of DNA/RNA.

The use of accelerated computing and artificial intelligence to quickly and accurately sequence DNA or RNA supports the increasing availability of nanopore sequencing data, at scale, to a variety of high-throughput users. Oxford Nanopore’s technology is increasingly being used by scientific researchers analysing many thousands of genomes to better understand genetic diversity and discover new variants. Sequencing is also being increasingly adopted to generate rapid insights in healthcare settings, food safety, or environmental analysis.

NVIDIA DGS Station A100, announced in November, is a data-center-grade, GPU-powered, multi-user workgroup appliance that can tackle the most complex AI workloads. It plugs directly into an outlet in an office or laboratory, and is very quiet thanks to its refrigerant-based cooling system. It contains four NVIDIA A100 80GB GPUs, fully connected via NVIDIA NVLink, to offer a total of 320GB of GPU memory.

Unprecedented analytical power for ultra-high throughput sequencing

The 2.5 petaFLOP AI compute system from Nvidia offers unprecedented compute density, performance and flexibility in a benchtop format. Oxford Nanopore’s PromethION P48 sequencing device continues to challenge even the most powerful devices with its ability to generate as much as 10 Terabases of DNA information per 72-hour run (sufficient to analyse 96 human genomes at 30X coverage).

Breaking through the 10 Terabase run barrier was announced by Oxford Nanopore at the Community meeting in December 2020 and represents a 25% increase in data output compared to its previous best earlier in the same year. This increase has been driven by continual improvements in flow cell chemistry, many of which were included in new shipments from mid-November 2020. These developments have been reflected in customer data, with increasing yields reported across a range of sequencing applications.

Supplied in a P24 and a P48 format, PromethION is increasingly being deployed into high-throughput projects, where the rich sequencing data provided by Oxford Nanopore can be delivered at very high throughput. As with all Oxford Nanopore devices, the technology enables academic groups, core facilities and service providers to realise the value of sequencing any length fragments, from short fragments to those that are over 100,000 bases long, and to characterise base modifications, coupled with high accuracy single nucleotide or structural variant calling and phasing.

NVIDIA GPUs are already used in other Oxford Nanopore sequencing systems, driving real-time sequencing analysis at any scale. The desktop GridION includes NVIDIA V100 technology and the handheld MinION Mk1C sequencer is powered by the NVIDIA Jetson Edge AI platform.

AI, training and algorithm development as a driver of high accuracy sequence data

The use of powerful AI systems is also driving substantial improvements in the accuracy of Oxford Nanopore’s sequencing data; updated analysis algorithms can result in higher accuracy of the same sequence data.

Oxford Nanopore recently released a new machine-learning driven analysis algorithm, Bonito CRF, with which users have reported >98% single read basecalling accuracy. Basecalling is the process of identifying the sequence of bases on an individual molecule of DNA. This latest update to Bonito builds on previous work to deliver improved performance, and is trained with a larger, more diverse data set.

High single read accuracy supports very high consensus accuracy (sequencing multiple times for higher accuracy); optimised analysis tools including Guppy/Bonito basecalling, assembly with Canu/Flye and polishing with Medaka, can now enable Q45 with R9.4.1 flow cells and Q50 with R10.3 flow cells.

Variant calling performance is also improving with the latest releases. Using the latest tools, structural variation (SV) accuracy has reached gold standard of 96% with 30X rather than 60X coverage. Oxford Nanopore has now seen SNV at 99.92%, which is comparable to traditional SBS accuracy.

In addition, in late 2020 Oxford Nanopore generated modal single-read accuracy of 99.1% (99%=Q20) using a new chemistry with Bonito, delivered on internal validation sets, with a substantial proportion of these raw reads above Q20.

Oxford Nanopore and Nvidia are working closely to deploy the latest advancements in AI, with the goal of making biological analysis available to anyone, anywhere.

Further info:

Over the coming weeks, Oxford Nanopore will be providing its user base with updates on how the integration work is proceeding on PromethION compute as well as other potential device enhancements. As with other programmes, we plan to provide seamless upgrade paths to Oxford Nanopore users.

[masurenguy] 12/1/2021 07:55

Cheers bamboo2 - rambutan has already covered Invesco !

[bamboo2] 12/1/2021 07:51

rambutan2, thanks.

11/1/2021 Invesco UK Equity High Income Fund [ex Mark Barnett] announce down to 0%
2.12% remainder in other Invesco funds [not subject to redemptions].

[rambutan2] 11/1/2021 22:42

Not quite out:

[bamboo2] 11/1/2021 11:29

Mas, the days of this trading at NAV or even a premium are long gone, however, the discount still looks far too wide. I guess around 10% would be more realistic.

Essentially we now just have to wait to see what the Lansdowne lot plant to do with the remainder of their holding [under 5%], until we see the end of the forced sellers.

It's evident from the news at the weekend, that it does appear that Invesco are out. Do you know if we should be expecting a last holdings rns from them to confirm?

[masurenguy] 10/1/2021 16:53

Interesting - if you are right bamboo2 then the current shareprice upside could be circa 37% - 50% on a par NAV value !

[bamboo2] 10/1/2021 16:37

I have done a few basic calcs allowing for disposals [eg CWR] and improvements in constituents individual valuations [eg ONT] and think we could see IPGroup NAV increase from from £1.2bn to around 1.35-1.4bn.

Add in the cash at approx £300m and we can see there is still a sizeable discount on offer here.

[bamboo2] 09/1/2021 10:54

Many of the listed former flatliners showing signs of life.


1
21.4%
4
29.59% as of 17/7/2020 23/9/2020 Springer shares issued dilution to 28.22%
5
36.25% [6/3/2020]
9
11.2% [31/12/2019]
10
25.26% [06/01/2021] IPO&Parkwalk holdings added together
12
13.1% [13.72% 5/4/2020] 13.69% [22/5/2020]
13
13.5%
14
14.9%
15
25.8%
[formerly MED]

[bamboo2] 08/1/2021 08:13

Three main shareholders, WIM, Invesco and Lansdowne used to hold over 45% of the total shares. We know where approx 20% of these are now held.

Anyone know where the other 25% has gone?

[edwardt] 07/1/2021 14:16

JPM manipulate the price so they can get some commission, how scandalous to suggest such a thing happens?!

[p1nkfish] 07/1/2021 11:44

JPMORGAN bookrunner.
Says it all.
Less by chance, more deliberate imho.
Run it up, place at discount, then get out of the way. Just mho.

[bamboo2] 07/1/2021 11:36

p1nk, yes could be.

They have obviously been supplying the market with shares since the advent of problems with Woodford and subsequent redemptions. As you know this all started with WIM which then fed into valuations at Invesco and Lansdowne.

I would guess its possible that the supply of Invesco shares would have become unavailable to the market for a few days while the placing was put together, and the usual level of buying created a squeeze. Either by design or by chance!

[p1nkfish] 07/1/2021 10:17

May parr explain the run up yesterday to get the job done at what looked like a discount for the buyer vs market price???

[bamboo2] 07/1/2021 09:59

Mas, Sharecast reporting this...

"IP Group slid on Thursday after Invesco sold 61.9m shares in the company in a placing. The shares were sold at 100.5p each, according to traders, which was the lower end of the initial guidance of between 100.5p and 103p and a discount of around 9.5% to the closing share price on Wednesday.

JPMorgan was the bookrunner."

Guess the buyer/s knew they had Invesco over a barrel!

[masurenguy] 07/1/2021 09:56

Cheers Rogue Trader - be interesting to see who picked them up.
You could be right bamboo about their reasons for what appears to be selling in a hurry at at a 10% discount !

[bamboo2] 07/1/2021 09:30

Thanks Rogue Trader.

[bamboo2] 07/1/2021 09:24

Mas, Thanks. If Invesco has dumped the last of them, that has to be a good thing.

The fact that they didn't have time to sell them in a more orderly way means they might have a more desperate situation with redemptions than we know.

Assume a large trade would be delayed in publication.

[masurenguy] 07/1/2021 09:17

Re #786 - bamboo, I can't see what 62m shares he is referring to since my monitor shows a total of circa 3.2m shares traded so far today and just under 4m traded yesterday.

[bamboo2] 07/1/2021 08:55

Wet, posts crossed. Do you have a link?