Immupharma Share Discussion Threads

[eva_1989] 12/8/2021 11:20

PK will take min 6 months as recruitment will eat mow time.

Only positive note from the RNS is this otherwise a negative RNS

Preparations will be made to commence the Phase 3 study, following completion of the PK study. For the continued late-stage program development, ImmuPharma and Avion Pharmaceuticals LLC ("Avion"), as part of a joint steering committee, agreed on a collaborative group consisting of a Board of Key Opinion Leaders ("KOLs") and a leading medical patient advocacy group. Collectively, this network, due to its in-depth knowledge of the lupus disease and their access to lupus patient groups, will be invaluable to the successful outcome of the Phase 3 trial.

[on target] 12/8/2021 10:34

Maybe the scientists were sacked for getting the dose wrong?

[colsmith] 12/8/2021 10:34

super agree re 37265 - its precise but vague, for example ---"will move into an optimized international Phase 3 trial following the successful completion of the pharmacokinetic study." A nice 3 month delay.

How is success defined, it could be its just been completed, or its completed with some metric. Surely the key point is that either there is a reason for the tests, albeit waiting 6 months to agree, or there isn't and its just a convenient reason to delay again. Maybe the worst of it is that if the stuff works based on a statistical evaluation, which is what the industry seems to work on, then people with the malady are denied the option of another treatment. Practically the sooner its known it works or not the better - continual delay is not in the interests of anyone - or is it? So some sort of corporate deal or another approval path would seem practically worthwhile because on Fluti experience it may never get approved in that jurisdiction.

One suggestion to expedite would be to carry out the PK test in parallel with P3, or is that too obvious?

Vectura's Flutiform is an interesting case; approved widely years ago but not in the US and still seems not approved, if Skypharma, as was then, hadn't taken or had a parallel approval it would still be on the shelf. Never saw a reason for why the US didn't like!

[nobbygnome] 12/8/2021 10:24

I have no idea if the recent resignations are linked to this development but I guess it's not an unreasonable theory.

[halfbutt] 12/8/2021 10:24

Ref scientists designations..I've missed this... mmmmm

[harleydocman] 12/8/2021 10:22

Nobby,

Many LT respect your views on IMM , only the traders hate debate..

Taking today’s RNS into perspective, what are your views on the recent resignations of the scientists from the IMM board ?

Thanks

[nobbygnome] 12/8/2021 10:15

>> llol

Today is a news day so hardly surprising I have posted more. Rather going on and on about any motives for me posting instead look at the quality of what I post and debate it. Do you disagree with anything I have posted this morning? If so, I am more than happy to debate it.

Last I looked free speech is still allowed in this country (just) so I will continue to post whether you like it or not. From PMs I get I know my contribution is appreciated by a number of people here.

[lord loads of lolly] 12/8/2021 10:09

nobbygnome - before hanging on your every word, here's what you said on 10 August when challenged about your obsessive interest in IMM. This despite - allegedly - being totally uninvested in the company: "10/8/2021 13:12 Hmmm over the last couple of months, I would guess I've averaged less than 5 posts a week. As a professional investor who watches the market all day most days that is actually showing only marginal interest. But hey, don't let the truth get in the way of a good story!" Admittedly there's more news than usual to talk about this morning, but today alone you've posted NINE TIMES in the past two hours or so at 07.21, 07.23, 07.31, 07.34, 07.35, 07.50, 08.40, 09.18 & 09.44. Hardly the likely actions of someone with zero financial interest, now is it?

[supernumerary] 12/8/2021 10:01

Will this trial go on clinicaltrials.gov? I'd like to know what they're looking for - the RNS is completely non-specific.

[nobbygnome] 12/8/2021 09:44

>> on target

Well I don't think they could change the dose now as they have very little phase II data with any other dose. There were a few patients who were given 1mg monthly but my understanding is there were a few problems with that dose. My guess it's yes or no depending on how the FDA assess the results.

The drug is a peptide and there is no doubt the half-life will be very short. The company's latest theory is that the site of action is where it's injected. However, I don't buy that and it seems neither do the FDA.

[the stinger] 12/8/2021 09:29

Glad people finally realise!!

[colsmith] 12/8/2021 09:28

So the FDA take months to get to this - sure is a policy of slowdown; and for other notably drugs they work at F1 speed. Still think the company needs a non US path because there seems to be continual delay for some stranger reason; after all approving a P3 trial doesn't mean much its the results that count; so what are the FDA concerned about to delay; it passes or fails on that! The only obvious thing would seem to be the structure of the P3 trial the number of participants etc. Any how as they want this extra test why take 6 months to agree it - OK maybe it took 6 months to get 24 people on the test!

[on target] 12/8/2021 09:23

Although if the drug disappears from the blood within minutes as you keep saying, how come it had such a noticeable effect in the last phase 3 trial? That would suggest it is an incredibly potent drug wouldn't it?
Maybe by increasing the dose by a small amount that noticeable effect could easily become a very significant one?

[on target] 12/8/2021 09:21

Could the purpose of this PK study be to resolve the potential dosing issues you keep mentioning Nobbygnome? Hence 'optimised' phase 3 study?

[nobbygnome] 12/8/2021 09:18

It seems the market agrees with the realists on this board. I hope not too many got spiked this morning. Obviously if the phase I results are fine and the phase III proceeds, then the price will rise. However, it will be well into the Autumn before we find that out...

[eva_1989] 12/8/2021 08:45

Stinger - you’re clogging the board.

It’s a waste of time and others.

We get Your message..

[the stinger] 12/8/2021 08:40

1ultimate..... LOSER!

[nobbygnome] 12/8/2021 08:40

This will finish flat or down today IMHO once the implications sink in. I hate to mention it but my concerns about the PK and half-life which I bought up over 3 years ago have come home to roost. I have already received one PM this morning commending me for being right!

[the stinger] 12/8/2021 08:25

1ultimate,,,, loser!

[eva_1989] 12/8/2021 08:20

Nobby,

I agree with you.

Overall it’s a delay to start P3.

Sigh but happy with some actions and positive share prices

[the stinger] 12/8/2021 08:18

No buyers... all sellers !.. tells a story

[the stinger] 12/8/2021 08:12

Selling on mass....

[the stinger] 12/8/2021 08:09

Timberrrrrr