Immupharma Share Discussion Threads

[lord loads of lolly] 11/8/2021 16:25

How come you're nobbygnome if you're not short?

[nobbygnome] 11/8/2021 15:14

Sorry to disappoint you Eva but I am just Nobby and I am not short!

[eva_1989] 11/8/2021 15:09

Stinger aka Nolupus aka Nobby,

Could you please short as much as you could please ?

I've now £25500 placed with HL at sharp at 8P.

I appreciate your help...

[eva_1989] 11/8/2021 14:57

Stinger - If you don't mind could you please add more shorts ?

I want to buy around 8P -

Thanks for your help...

[eva_1989] 11/8/2021 14:56

8.85 for just £1K

ridiculous


Investment name
Immupharma Plc
Investment code
IMM.LN
Last known market price
8.85p
Value
£999.00

[the stinger] 11/8/2021 10:27

Looks like no P3 ?? Still no news !!

[supernumerary] 10/8/2021 15:05

On T - that's for Tulip-2 only, as Tulip-1 failed to meet its primary endpoint, so the figures aren't directly comparable.

However, in the numbers you highlight, ani achieved 52% improvement over placebo, while lupuzor made only 30% improvement (and their patients were retrospectively selected for anti-dsDNA marker).

From the patient point of view it means an awful lot would depend on the side-effect profile of the two drugs.

[on target] 10/8/2021 14:28

Some nasty adverse reactions there as well.

[on target] 10/8/2021 14:25

"47.8% of patients receiving anifrolumab-fnia 300mg responding compared with 31.5% of patients on placebo"

Shows how badly we need Lupus treatments.

Interesting to compare the Lupuzor results, especially on the patients with the anti-dsDNA biomarker:
"Lupuzor™ demonstrated a superior response rate over placebo (61.5% vs 47.3%)"

Bit odd that Lupuzor's placebo patients responded pretty much the same as the patients in that trial on the now approved drug?!

[waterloo01] 10/8/2021 14:19

oh...

August 9, 2021
FDA Approves Anifrolumab-Fnia for Systemic Lupus Erythematosus


In the TULIP-1 trial, 457 patients were randomly assigned 1:2:2 to receive anifrolumab-fnia 150mg, 300mg, or placebo via IV infusion every 4 weeks. In the TULIP-2 trial, 362 patients were randomly assigned 1:1 to receive anifrolumab-fnia 300mg or placebo via IV infusion every 4 weeks. The primary endpoint for both trials was the improvement in disease activity at 52 weeks, measured by SRI-4 in TULIP-1 and the British Isles Lupus Assessment Group based Composite Lupus Assessment (BICLA) in TULIP-2.

In the TULIP-1 trial, treatment with anifrolumab-fnia did not meet the primary endpoint on the SRI4 composite measure. However, results suggested a clinical benefit for anifrolumab-fnia compared with placebo based on key secondary endpoints including the reduction in OCS dose, Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) responses and BICLA responses.

Findings from the TULIP-2 trial showed a statistically significant and clinically meaningful reduction in disease activity at week 52, with 47.8% of patients receiving anifrolumab-fnia 300mg responding compared with 31.5% of patients on placebo (difference in response rates, 16.3%; 95% CI, 6.3-26.3; P =.001). Treatment with anifrolumab-fnia was also associated with a statistically significant reduction in OCS use and improvement in skin manifestations.

With regard to safety, the most common adverse reactions reported were nasopharyngitis, upper respiratory tract infection, bronchitis, infusion related reactions, herpes zoster and cough.

Saphnelo is supplied as a 2mL single-dose vial containing 300mg of anifrolumab-fnia and is expected to be available at the end of August 2021.

The use of Saphnelo is not recommended in patients with severe active lupus nephritis or severe active central nervous system lupus.

[nobbygnome] 10/8/2021 13:12

Hmmm over the last couple of months, I would guess I've averaged less than 5 posts a week. As a professional investor who watches the market all day most days that is actually showing only marginal interest. But hey, don't let the truth get in the way of a good story!

[lord loads of lolly] 10/8/2021 12:57

brad44 - remember nobby's not invested here. That's why he spends so much time on a company in which he has zero financial interest. Makes perfect sense, no?!

[brad44] 10/8/2021 11:49

Why would it worry you nobby, you are a naysayer on this stock a hater of this company and always picking negatives so I can't see why you would be worried? You are up to your old arbitrage tricks again aren't you..

[sicilian_kan] 10/8/2021 08:38

Nobby, had there been a no, there would have been an rns. So clearly any such inference would be unfounded. Much more likely to be a yes in the coming days given the information in the public domain.

[nobbygnome] 10/8/2021 07:55

The paragraph below is from the RNS on 26th June

'Immupharma PLC (LSE:IMM) (Euronext Growth Brussels: ALIMM), the specialist drug discovery and development company, announces that its US Lupuzor(TM) partner, Avion Pharmaceuticals ("Avion") has received a positive response from the US Food & Drug Administration ("FDA") for a "Type C" meeting. The FDA has advised that they do not require a formal face to face meeting and will provide their written response to Avion approximately by the end of July 2021.'

So here we are comfortably into the second week of August and still no news. Yes I know it says 'approximately' but it always worries me when you don't hear an update concerning the FDA.

[the stinger] 09/8/2021 17:35

Still no magic, mind blowing RNS I see.... the deluded still wait !! 5p soon.

[eva_1989] 09/8/2021 15:01

ultimate -

I still don't understand why someone would just put so many negative comments having no investment at all. This kind of behaviour won't earn them a penny.

I mean it's simply waste of time for them and others.

If you invest then comment. Some members are really strange... maybe they have lots of time to spend here...

Anyway, our wait seems go on here. Friday's share price movement was exciting but no RNS and punters now exiting.

I'll be ready to add more £10K should we see 8p this week... Even though i strongly believe we won't see 8P for a long time!

[1ultimate] 09/8/2021 10:12

Eva he can’t as they are imaginary haha 😂

[the stinger] 09/8/2021 10:04

Back to 7.5 p soon

[eva_1989] 09/8/2021 08:47

Show us your shorts liar haha

[the stinger] 09/8/2021 08:28

Shorts incoming..

[the stinger] 09/8/2021 07:20

5p incoming...

[nobbygnome] 09/8/2021 07:13

Sadly not an expert on RNS timings. I wish I was!

[eva_1989] 09/8/2021 07:06

Hi halfbutt,

Just double checked, I’ve just under £240K in total.

Sorry.

When I asked my HL broker, he said last time I hold over 1% of total IMM. Since then I’ve added more and my calculation shows around 1.2% but I shall ask him again today.

Alright NO RNS then!

Our expert Nobby allegations of leaky ship proved to be wrong

Oh one day!