Genflow Biosciences Share Discussion Threads

[steg] 23/4/2024 18:30

Jigsaw coming together very nicely 👍

[northeast14] 23/4/2024 18:00

All very interesting!

[moneymunch] 23/4/2024 06:16

Acknowledgements

We thank Dr. Lin Gan from the Institutional Mouse Transgenic Core Facility at the University of Rochester for generating the Sirt6 transgenic mice.

[moneymunch] 23/4/2024 05:52

Most certainly Northeast. Gl -)



Published: 22 April 2024

Hepatic Sirt6 activation abrogates acute liver failure


Discussion

In this work, we revealed a crucial role of Sirt6 in protecting against both APAP-induced and BDL-induced ALF. Our investigation has begun from an interesting observation that hepatic Sirt6 expression significantly downregulated in the livers of human and mice with acute liver failure. The rescue and maintenance of Sirt6 expression in the Sirt6-Tg mice after APAP administration protected against the pathological changes during APAP-induced liver toxicity by limiting oxidative stress and inflammation. The protective effect of hepatic Sirt6 was further validated in Sirt6-HepTg mice and in the mice treated with the specific Sirt6 activator MDL-800. Hepatic-specific Sirt6 knockout in mice exacerbated, but hepatic overexpression of Sirt6 ameliorated, acute liver damages-induced by both APAP and BDL. Furthermore, the Sirt6 activator MDL-800 presented better therapeutic potential to alleviate liver injury in mice than NAC, which is the only proved antidote for APAP overdose up to now. Taken together, these results demonstrate that Sirt6 could be an important therapeutic target for the treatment of ALF.

..............

In conclusion, our results revealed a crucial role of hepatic Sirt6 in the protection of acute hepatotoxicity. Genetic overexpression of Sirt6 and the pharmacological activation of Sirt6 ameliorated oxidative stress, inflammation, and liver injury. The potential mechanisms whereby Sirt6 protects against hepatotoxicity include that Sirt6 inhibits JNK and caspase 3/9 activation, enhanced Nrf2/HO-1 pathway and attenuates PARP1 expression and activity. Therefore, Sirt6 orchestrates the safeguard against hepatotoxicity and may serve as a new therapeutic target for the ALF.

[northeast14] 22/4/2024 18:59

One day it will be our turn. There’s no way genflow aren’t going un noticed

[moneymunch] 22/4/2024 17:47

UK biotech signs $1bn deal to develop liver disease drugs

Ochre Bio partnering with Germany’s Boehringer Ingelheim on treatments that will harness the organ’s capacity to regenerate


Ian Johnston 14 HOURS AGO



German pharma group Boehringer Ingelheim has struck an up to $1bn partnership with a UK biotech to develop treatments for chronic liver disease that aim to harness the organ’s capacity to regenerate.

Under the drug discovery partnership, Ochre Bio will receive $35mn in upfront and near-term payments, rising to more than $1bn in payments and royalties if treatments are successfully brought through clinical trials. It is a similar milestone-based structure to many partnerships in the pharmaceutical industry.


The liver is the only organ that can regrow and repair itself and Ochre Bio will seek to develop drugs that restore this ability in diseased livers.

The company’s work to date has involved analysing thousands of donated human livers to develop an understanding of the causes of disease, and studying whether making changes to RNA — a vital molecule for translating genetic information into proteins — can extend the lifespan of transplanted livers.

“What we’re trying to do is give the liver a little nudge in the right direction to support it to regenerate,” said Quin Wills, chief scientific officer and co-founder of Ochre Bio. “What happens in a cirrhotic liver is [cells] don’t have that decision-making process any more to start dividing and restoring capacity. By changing certain ‘switches’, using these RNA therapies, we help them make those decisions again.”

There have been a series of recent developments in the treatment of liver disease, which is the third-largest cause of early death in the UK and other high-income countries. It is also the largest killer of 35- to 49-year-olds in the UK, according to the UK Health Security Agency.

The US Food and Drug Administration recently approved the first-ever drug designed specifically for the most common liver disease, metabolic dysfunction-associated steatohepatitis or mash, developed by Madrigal Pharmaceuticals.

People with mash have a build-up of fat deposits in the liver and it is estimated to affect 115mn people worldwide. The approval of Madrigal’s drug should help other treatments to pass regulatory hurdles, according to analysts at investment bank William Blair.

The disease is often linked with weight gain and has become more common as obesity levels have risen.

Pharma groups are optimistic about the potential for new weight loss and diabetes drugs known as GLP-1s to treat liver diseases.

A weight-loss drug licensed by Boehringer Ingelheim from Danish biotech Zealand Pharma has had positive results in liver disease trials, while Novo Nordisk is looking at the effect of its weight-loss drug Wegovy on mash.

But while these drugs could be used to treat early-stage disease, the industry thinks they will be less helpful against more advanced mash, which can involve extensive scarring or cirrhosis of the liver. New ways of tackling late-stage liver disease could delay the need for transplants, currently the only effective treatment.

Jack O’Meara, chief executive of Ochre Bio, told the Financial Times: “There still remains a huge unmet need there and we hope this partnership with Boehringer will be able to develop medicines that solve or offer solutions for patients at a later stage.”

Søren Tullin, head of cardiometabolic disease research at Boehringer Ingelheim, said Ochre Bio’s genomics experience and technology “holds the potential to uncover novel regenerative pathways that will make a meaningful difference in the lives of those affected by chronic liver disease”.

[moneymunch] 16/4/2024 19:56

Regeneron launches five-year $500m biotech fund

1 HOUR AGO



Biopharma giant commits $100m annually to Regeneron Ventures as it seeks to ‘fuel promising biotech innovation.’
Yesterday, as we revealed 2023 was another tough year for longevity investment, biotech heavyweight Regeneron quietly announced the formation of Regeneron Ventures, a new $500 million venture capital fund. As the fund’s exclusive limited partner, Regeneron has pledged $100 million annually over the next five years to invest in promising life sciences companies.

While the new fund’s investment mandate is broadly health focused, Regeneron Ventures says its interest is “skewed towards biotechnology, devices, tools, and enabling technologies.” The fund says that investment decisions will be guided by the quality of the science, people, and data, prioritizing “breakthrough innovation” despite the inherent risks and uncertainties. All of which should resonate well with founders in the longevity sector, offering a potential new source of funding for biotech startups targeting aging and age-related diseases.

[moneymunch] 16/4/2024 19:16

SIRT6 is an enzyme that plays an essential role in human health and contributes to epigenetic regulation of gene expression, mitochondrial health, and DNA repair. A review of literature suggests that SIRT6 could potentially help address diseases of aging, neurodegeneration, diabetes and obesity, in addition to depression. Arrivo is exploring the potential of SP-624 in multiple therapeutic areas beyond depression.

[moneymunch] 16/4/2024 18:05

Arrivo Bio Initiates Large Phase 2b Clinical Trial in Major Depressive Disorder with Novel SIRT6 Activator

Epigenetic mechanism of action offers a promising new approach to tackling MDD

April 16, 2024 08:00 AM Eastern Daylight Time
MORRISVILLE, N.C.--(BUSINESS WIRE)--

Arrivo Bio announced today a significant step forward in the fight against major depressive disorder (MDD) with the dosing of the first patient in the SP-624-202 clinical trial.

“The initiation of this study is an exciting milestone for Arrivo and the SP-624 program. Despite existing treatments, people with Major Depression often do not achieve remission and suffer unwanted side effects”


This registration-quality Phase 2b study will enroll 450 subjects with MDD and evaluate the effectiveness of SP-624, a SIRT6 activator and novel mechanism of action, compared to placebo in treating adults with Major Depressive Disorder. The SP-624-202 study will assess the change from baseline on the Montgomery-Åsberg Depression Rating Scale (MADRS) as its primary endpoint. The MADRS is a 10-item depression rating scale commonly used to assess the severity of depression in clinical trials. The large number of subjects will enable the study to explore several other investigator and patient-rated endpoints and exploratory biomarkers.

SIRT6 is an enzyme that plays an essential role in human health and contributes to epigenetic regulation of gene expression, mitochondrial health, and DNA repair. A review of literature suggests that SIRT6 could potentially help address diseases of aging, neurodegeneration, diabetes and obesity, in addition to depression. Arrivo is exploring the potential of SP-624 in multiple therapeutic areas beyond depression.

“The initiation of this study is an exciting milestone for Arrivo and the SP-624 program. Despite existing treatments, people with Major Depression often do not achieve remission and suffer unwanted side effects,” said Dr. Joel Raskin, Chief Medical Advisor at Arrivo. “This large study will significantly augment our current data on SP-624, which has the potential to be a truly transformative treatment for patients suffering from depression.”

Arrivo remains committed to advancing groundbreaking research in MDD and looks forward to sharing further developments from the SP-624-202 study. For more information on Arrivo or the SP-624-202 study, please visit www.arrivobio.com

[moneymunch] 13/4/2024 07:35

10th - 11th June 2024 - Organised by Longevity Technology who hold 3%. Gla ;-)


New international event program launches to bring longevity entrepreneurs and investors together.

Founders Forum and Longevity.Technology today announced the launch of the Founders Longevity Forum, a premier event series designed to educate and connect investors with the vast potential within the longevity market.

The inaugural Founders Longevity Forum will take place at Olympia London during the renowned London Tech Week, focusing on a sector that is projected to exceed $600 billion by 2025. This partnership aims to foster meaningful connections between startups, venture capitalists (VCs), corporate venture capitalists (CVCs), family offices and CEOs leading the charge in longevity.

Brent Hoberman, Co-Founder and Executive Chair of Founders Forum Group, said: “Longevity is becoming a mega trend as science makes increased healthspans more realistic, converging with a wider shift towards preventative healthcare.

“We’ve noticed a need to connect top scientists and innovative startups with funds to help them turn their dreams into reality. By bringing together the best and brightest minds working on longevity today, we can galvanize progress in this area and transform the demographic landscape.”

Taking place on New international event program launches to bring longevity entrepreneurs and investors together.4, the Founders Longevity Forum will address the investment opportunities across the longevity space, from established longevity business models such as diagnostics, longevity clinics and supplements, through to cutting-edge longevity biotech companies poised to revolutionize the biotech industry and transform society.

The event will also benefit from an advisory panel that has decades of longevity and geroscience expertise between them; the panel includes Eric Verdin, Andrea Maier, Jim Mellon and Aubrey de Grey, with further members to be announced.

“Multiple longevity events are happening and they’re all great, but few are specifically focused on bringing more investors into this rapidly accelerating field,” said Phil Newman, Founder and CEO, Longevity.Technology.

“We plan to stage events in London, Abu Dhabi and San Francisco initially to accelerate longevity investment globally, and catalyze a wave of innovation and collaboration that will redefine the future of human health.”

“We’re keen to educate investors on the vast opportunities in longevity whilst fostering meaningful connections for startups and scaleups in this niche,” said Carolyn Dawson, CEO, Founders Forum Group.

“Helping create these connections is central to our mission at Founders Forum Group as we seek to empower entrepreneurs at every stage of their journeys; with Longevity.Technology as our partner, we can forge formative alliances that propel longevity innovation.”

Key highlights of the Founders Longevity Forum:

Exclusive event – The Founders Longevity Forum will host a minimum of 120 approved guests, including high-caliber investors, family offices, longevity founders and VIPs.

Comprehensive program – guests will enjoy a half-day of content, a welcome reception, a full-day program and automatic registration for London Tech Week.

Global reach – following the London event, the Founders Longevity Forum will travel to Abu Dhabi and San Francisco.

Longevity takes center stage – The Longevity Village at London Tech Week will elevate this dynamic industry, showcasing the companies applying new technologies to extend human healthspan.

[moneymunch] 13/4/2024 07:28

Major Shareholders


ERIC LEIRE 124,000,000 35.5%
PREMIER MITON 32,000,000 9.2%
ARIAN BEESTON 17,475,000 5.0%
JONATHAN MARK SWANN 16,874,000 4.8%
SAMANTHA BAUER 14,500,000 4.1%
LONGEVITY TECH FUND 10,499,998 3.0%
SARAH BEESTON 10,000,000 2.9%

[moneymunch] 10/4/2024 20:01

Excellent, not long before this bounces Big!!! Gla :-)

[steg] 10/4/2024 19:57

As a wise man once said, follow the 💰 💰

[northeast14] 10/4/2024 18:51

£400k buy from Premier Miton! Very good show of confidence by them in Genflow

[northeast14] 09/4/2024 18:08

Still waiting for premier miton to TR1… are they still buying on open market?

[moneymunch] 09/4/2024 14:57

Eric's £50k share subscription declared along with another 1.8% for Jonathan Swann who declared his 3% back in March. The smart Money is accumulating. Gla :-)

[moneymunch] 08/4/2024 14:12

Yes indeed Northeast, the only way is UP!!! More good news coming soon. Gl :-)

[northeast14] 08/4/2024 11:05

There is only one place this cashed up company is going and that’s far North of 1.7p

[northeast14] 08/4/2024 11:04

None of the placing shares can be sold. And all of the people in the raise are serious investors or BOD or institutions. There will be no dumping

[davealders] 08/4/2024 08:45

Spot on Moneymunch.

[moneymunch] 08/4/2024 08:39

Lol...you'll regret not buying in because of your blinkered view, the £755k raise was to facilitate the arrival of institutional investors, all the directors subscribed including £50k by Genflow's CEO....much more to come with US investors in the pipeline...this is going to big, the current bargain low and miniscule market cap offers tremendous UPside opportunity. Gl :-)

[lookinggood] 08/4/2024 08:27

1.25p placing imNot buying so placees can dump out

[moneymunch] 08/4/2024 08:13

Lol...Good luck with APH, but Genflow's upside this year is potentially going to be stellar...watch this space. :-)

[blackhorse23] 08/4/2024 08:07

Money moving to APH , dividends announcement in 10 days

[blackhorse23] 08/4/2024 08:07

Safer to get out now lol