Futura Medical Share Discussion Threads

[lbo] 02/7/2022 14:39

https://www.asa.org.uk/rulings/pro-bono-bio-entrepreneur-ltd-a17-400871.htmlJust like in the failed IDEA-033 studies in which Flexiseq was the placebo which were then relied on to get it also approved as a class 2b medical device gel. Med3000 had been used as the placebo treatment in the FM57 study on Med2005 and therefore the researcher had initially believed Med3000 had no therapeutic effect. The trial did not set out to measure the efficacy of Med3000. therefore, considered that its reported effectiveness by the advertiser was a post-hoc findingalso concerned that there was not an adequate placebo control for Med3000 in the trial. therefore, considered that the study did not provide adequate evidence for the claim clinically provenhttps://www.nice.org.uk/advice/mib80One specialist commentator felt that the clinical effectiveness has not been demonstrated. The absence of an adequate placebo (an inactive topical gel) for highlighted as a limitation by 3 commentators. One commentator said that without it, the clinical effectiveness could be attributed to the placebo effect of rubbing a gelhttps://www.ftc.gov/business-guidance/blog/2021/04/look-back-post-hoc-analysisWhat happened next gets to the FTCs allegation that the respondents, in effect, deceptively sliced and diced the data in search of a positive marketing message. According to the complaint, the respondents subjected the data to post hoc analyses of different subgroups of test subjects. (The complaint describes a post hoc analysis as statistical analysis conducted after the data have been collected in hopes of discovering statistical relationships that suggest cause and effect.) The FTC concern is that unplanned, post hoc subgroup analyses pose a high risk of generating spurious findings.

[lbo] 02/7/2022 14:36

How ironic Futura references articles from 2016 on their website to try support the supposed ‘commercial potential’. Yet those references actually say side effects are not the main reason for men discontinuing PDE5 inhibitors like Viagra



Corona G., First-generation phosphodiesterase type 5 inhibitors dropout: a comprehensive review and meta- analysis, Andrology, 2016,



It was actually because of lack of efficacy. So MED3000 with its even more questionable efficacy will have even higher dropout rates.

[petroc] 02/7/2022 14:36

Conclusions from FM57:
MED3000 consistently showed statistical improvements against before treatment (baseline) with clinically important differences across all ED severities.
MED3000 also showed statistical improvements on both GAQ (Global Assessment Questionnaire) and SEAR (Self-Esteem And Relationship Questionnaire) secondary endpoints.
MED3000 also showed meaningful clinical differences across all ED patient groups, mild, moderate and severe, which is a key evaluation criteria for regulators.
MED3000 begins to work immediately in some patients, with 60% of patients seeing onset of their erection within 10 minutes of application.
MED3000 had an excellent safety profile with very low incidence of adverse events in males and female partners.
Results demonstrated that MED3000 has the potential to be an effective, clinically proven, topical treatment for erectile dysfunction.
Results enabled Futura to receive approval for MED3000 in the EU as a medical device and will enable Futura to pursue the medical device regulatory pathway for MED3000 in the US.

[lbo] 02/7/2022 14:24

After Phase III Failure, UK Firm Pushes Placebo to Treat Erectile Dysfunction






Does it work?

MED3000 was recently granted a CE mark as an approved medical device in the EU. Does this mean it works? No. Unlike drugs, medical devices don't need to be proven efficacious to be sold; they only need to show conformity with safety regulations, which the CE mark indicates.

So how effective is MED3000 really?

The first thing to note is that MED3000 has never been shown to be more effective than any control treatment - because it was the control treatment.

A placebo or not?

Something else has changed since the old version of Futura's FAQ. In the previous version, Futura seemed to accept that MED3000 was acting as a placebo. Describing the results of the second trial, they said that "the placebo effect was far greater than first indicated and presents an exciting opportunity in its own right."

But in the current FAQ, and across the current site, Futura seem reluctant to describe MED3000 as a placebo.

But if you look back before Med2005 failed its phase 3 study. Its on the record that Med3000 was just the placebo gel in FM57.



PLO = Placebo (identical gel to MED2005 but without the active pharmaceutical ingredient glyceryl trinitrate)

[mikethebike4] 02/7/2022 09:49

LBO

Welcome to the future

LOL
LOL
LOL

You have said all this and more repeated literally hundreds of times

It does not make it true by virtue? of your repetition

Fortunately nobody takes any notice of you

For those new to this thread bear in mind that LBO is out for revenge having lost all his money years and years ago

and currently large pharma are more than happy for him to try and discredit any product that is in competition with theirs

Bear in mind the following :-

Viagra (Sildenafil) taken orally or by injection into a vein

has side effects which may include (official):

sensitivity to light
muscle aches
heartburn
nose bleeding
flushed skin
problems falling asleep
tingling in the arms, feet, legs, or hands
numbness in the arms, feet, legs, or hands
headache
diarrhea
heartburn
trouble differentiating between colors like blue and green
seeing a blue tinge on things

Viagra may also cause serious side effects that require immediate medical attention. Symptoms may include:

chest pain
fainting
blurred vision
severe, sudden loss of vision
ringing in ears
sudden loss of or decrease in hearing
dizziness
rash
burning during urination
itching during urination
shortness of breath that worsens
an erection that lasts longer than 4 hours

No side effects with Med3000 !!!!

Viagra/Sildenafil has all those mentioned above - no wonder because it is internal and not applied externally as is MED3000

This is what MED competitors don't want people to realise

[lbo] 01/7/2022 18:35

Falsehttps://www.discovermagazine.com/health/the-erection-of-a-placeboDoes it work?MED3000 was recently granted a CE mark as an approved medical device in the EU. Does this mean it works? No. Unlike drugs, medical devices don't need to be proven efficacious to be sold; they only need to show conformity with safety regulations, which the CE mark indicates.So how effective is MED3000 really?The first thing to note is that MED3000 has never been shown to be more effective than any control treatment - because it was the control treatment.A placebo or not?Something else has changed since the old version of Futura's FAQ. In the previous version, Futura seemed to accept that MED3000 was acting as a placebo. Describing the results of the second trial, they said that "the placebo effect was far greater than first indicated and presents an exciting opportunity in its own right."But in the current FAQ, and across the current site, Futura seem reluctant to describe MED3000 as a placebo.But if you look back before Med2005 failed its phase 3 study. Its on the record that Med3000 was just the placebo gel in FM57.https://www.futuramedical.com/media/2204/interim-results-presentation-six-months-to-30-june-2019.pdfPLO = Placebo (identical gel to MED2005 but without the active pharmaceutical ingredient glyceryl trinitrate)

[lbo] 01/7/2022 17:31

Even placebos like Med3000 can have side effects. In FM57 the men and women reported headaches and burning pain! Ouch!!https://www.washingtonpost.com/archive/lifestyle/wellness/2002/04/30/the-nocebo-effect-placebos-evil-twin/6945da76-fb8e-401e-a4f2-0439d36f4c6a/A Viagra study also showed using a placebo was also just as likely to harm you. It compared some 4,500 patients taking the drug to about 3,100 on placebo. So based on that study Med3000 even as a placebo is just as likely to harm you as viagra.https://www.ox.ac.uk/news/science-blog/harmful-placebosA new review of data from 250,726 trial participants has found that 1 in 20 people who took placebos in trials dropped out because of serious adverse events (side effects). Almost half of the participants reported less serious adverse events. The adverse events ranged from abdominal pain and anorexia to burning, chest pain, fatigue, and even death.

[mikethebike4] 01/7/2022 16:44

LBO

Welcome to the future

LOL
LOL
LOL

You have said all this and more repeated literally hundreds of times

It does not make it true by virtue? of your repetition

Fortunately nobody takes any notice of you

For those new to this thread bear in mind that LBO is out for revenge having lost all his money years and years ago

and currently large pharma are more than happy for him to try and discredit any product that is in competition with theirs

Bear in mind the following :-

Viagra (Sildenafil) taken orally or by injection into a vein

has side effects which may include (official):

sensitivity to light
muscle aches
heartburn
nose bleeding
flushed skin
problems falling asleep
tingling in the arms, feet, legs, or hands
numbness in the arms, feet, legs, or hands
headache
diarrhea
heartburn
trouble differentiating between colors like blue and green
seeing a blue tinge on things

Viagra may also cause serious side effects that require immediate medical attention. Symptoms may include:

chest pain
fainting
blurred vision
severe, sudden loss of vision
ringing in ears
sudden loss of or decrease in hearing
dizziness
rash
burning during urination
itching during urination
shortness of breath that worsens
an erection that lasts longer than 4 hours

No side effects with Med3000 !!!!

Viagra/Sildenafil has all those mentioned above - no wonder because it is internal and not applied externally as is MED3000

This is what MED competitors don't want people to realise

[petroc] 01/7/2022 15:36

LiarBO clearly has no filter on the totally unconnected rubbish he will post to keep his stock bashing posts at the top of the board. Totally shameless behaviour. I wouldn't mind so much if he actually came up with something new instead of rubbish that he's copy/pasted many, many, times before. There again, there's nothing new for him to say, is there? All the news that comes out about MED3000 shows it in a positive light.

[lbo] 01/7/2022 15:12

Zeeboeffect gel on the way! LOL



treatment of ED with oral placebo capsules demonstrates clinical effects, improving erectile function and quality of erection.





Arousal Gel: Is It Worth Trying, Or Just A Scam?

[lbo] 01/7/2022 15:05

For many, whether or not placebo use is ethical depends partly on whether patients are being deceived and whether there is a known better treatment.
A clinician who doesnt deceive a patient, and who provides a placebo for something for which there is no known treatment, such as irritable bowel syndrome, might be ethically OK, says Jeremy Howick, of the Department of Primary Health Care Sciences, at the University of Oxford, and lead author of the Plos One study. But there is no evidence that this company is enhancing care. What they’ve been doing is completely unethical



What standards are applied to evidence? The position taken by the ASA is a tried and tested one which has developed over the course of many years. It reflects the opinion of the wider scientific and academic community, rather than judgements made solely by the ASA. There are many aspects that are taken into consideration when evidence is reviewed and each claim is judged on its merits alongside the evidence presented to support it. Evidence submitted for health claims should normally include at least one adequately controlled experimental human

[petroc] 01/7/2022 14:35

You can tell when LiarBO is rattled, he starts bringing in what he thinks are his 'big guns'! Hahaha! It's very amusing that he's using people's comments from years ago to try to prove his case, which is impossible anyway because he hasn't got a case. Nope, not one slight hint of a whiff of a story. All he's got is 'it might not work because of blah blah blah..(insert any old unconnected rubbish)'. Compare that to the tests that MED has undergone and proved its efficacy time and time again, no wonder LiarBO, the board's stock basher, is rattled!

[mikethebike4] 01/7/2022 14:32

LBO

Welcome to the future

LOL
LOL
LOL

You have said all this and more repeated literally hundreds of times

It does not make it true by virtue? of your repetition

Fortunately nobody takes any notice of you

For those new to this thread bear in mind that LBO is out for revenge having lost all his money years and years ago

and currently large pharma are more than happy for him to try and discredit any product that is in competition with theirs

Bear in mind the following :-

Viagra (Sildenafil) taken orally or by injection into a vein

has side effects which may include (official):

sensitivity to light
muscle aches
heartburn
nose bleeding
flushed skin
problems falling asleep
tingling in the arms, feet, legs, or hands
numbness in the arms, feet, legs, or hands
headache
diarrhea
heartburn
trouble differentiating between colors like blue and green
seeing a blue tinge on things

Viagra may also cause serious side effects that require immediate medical attention. Symptoms may include:

chest pain
fainting
blurred vision
severe, sudden loss of vision
ringing in ears
sudden loss of or decrease in hearing
dizziness
rash
burning during urination
itching during urination
shortness of breath that worsens
an erection that lasts longer than 4 hours

No side effects with Med3000 !!!!

Viagra/Sildenafil has all those mentioned above - no wonder because it is internal and not applied externally as is MED3000

This is what MED competitors don't want people to realise

[lbo] 01/7/2022 14:10

Mike like all the rampers is just desperate to try get the naive to buy in so they can sell out before the ‘swindle’; is fully exposed! ROFLMAO

mikethebike4 - 11 Apr 2018 - 14:35:10 - 4072 of 11141

Having had similar waffling, 'smoke-screen' answers from Mr Barder over the years which have turned out to end in exactly nothing I am loathe to give any credence to virtually everything he says

mikethebike4 - 11 Apr 2018 - 15:58:28 - 4091 of 11141

Company is massively over valued if you go by 'concrete' results !


mikethebike4 - 11 Apr 2018 - 15:14:56 - 4082 of 11141

I only try and bring some sort of balance into the equation to help the gullible not get carried away with fanciful future projections.

I would like nothing better than to be proved wrong about Mr Barder (our CEO since 2001) and to sale away into the sunset grasping 5 times as many £s in my fist as I paid for the shares

Unfortunately for people like J7J, Mr Barder has been through this advisors process before - with CSD500 - and look where we've got in 17 years - sales of the product did not even equal the money we paid him to be our CEO for 2017 !


mikethebike4 - 06 Dec 2017 - 10:32:27 - 3468 of 10591

"A couple of decent deals and will be back off to the races."

Do you have any idea of how long shareholders have been using these words


mikethebike4 - 23 Mar 2017 - 09:52:33 - 2560 of 10591

As someone who has been invested for many years and who attended an AGM years ago and complained to Barder about the very slow progress, I am very frustrated.
All the time the Board are drawing good salaries off the backs of shareholders money they have very little incentive to get off their backsides and get 'selling' - thats what running a company is all about at the end of the day!

mikethebike4 - 24 Feb 2020 - 09:11:58 - 7290 of 9713

why should it be any different this time when you've still got the same useless lot running the show


mikethebike4 - 07 Jan 2019 - 11:22:52 - 4692 of 9641

I repeat I very much hope you are right - no one would be happier than me if you are - however I stupidly (in hindsight) bought in when everything looked really rosy - we were told there were loads of 'distributors' all 'champing at the bit to get selling a wonderful industry disruptive product (which it still is incidentally) once the 2 year shelf-life problem was fixed. This was despite the fact that the Holland/Belgium distributor was quite happy and successful selling them with the original 18 months shelf-life
And where are we now years later - one tiny distributor from which Futura receives a total sales income only just about covering Mr Barders employment remuneration

I just hope this MED/TPR situation is not just a repeat of CSD.

As to why I don't just sell up, well my shareholding is worth such a tiny proportion of what I paid for it I might just as well hang on in the hope that new shareholders getting in now are luckier than I was and I can get some of my money back - I think what we need is Mr Barders retirement - that should give the share price a kick

[mikethebike4] 01/7/2022 13:50

LBO

LOL
LOL
LOL

You have said all this and more repeated literally hundreds of times

It does not make it true by virtue? of your repetition

Fortunately nobody takes any notice of you

For those new to this thread bear in mind that LBO is out for revenge having lost all his money years and years ago

and currently large pharma are more than happy for him to try and discredit any product that is in competition with theirs

Bear in mind the following :-

Viagra (Sildenafil) taken orally or by injection into a vein

has side effects which may include (official):

sensitivity to light
muscle aches
heartburn
nose bleeding
flushed skin
problems falling asleep
tingling in the arms, feet, legs, or hands
numbness in the arms, feet, legs, or hands
headache
diarrhea
heartburn
trouble differentiating between colors like blue and green
seeing a blue tinge on things

Viagra may also cause serious side effects that require immediate medical attention. Symptoms may include:

chest pain
fainting
blurred vision
severe, sudden loss of vision
ringing in ears
sudden loss of or decrease in hearing
dizziness
rash
burning during urination
itching during urination
shortness of breath that worsens
an erection that lasts longer than 4 hours

No side effects with Med3000 !!!!

Viagra/Sildenafil has all those mentioned above - no wonder because it is internal and not applied externally as is MED3000

This is what MED competitors don't want people to realise