Share Name Share Symbol Market Type Share ISIN Share Description
Destiny Pharma Plc LSE:DEST London Ordinary Share GB00BDHSP575 ORD GBP0.01
  Price Change % Change Share Price Shares Traded Last Trade
  -4.00 -2.33% 167.50 37,921 13:47:29
Bid Price Offer Price High Price Low Price Open Price
165.00 170.00 171.50 167.50 171.50
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Pharmaceuticals & Biotechnology -6.48 -12.00 100
Last Trade Time Trade Type Trade Size Trade Price Currency
16:28:09 O 17,769 170.00 GBX

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Date Time Title Posts
15/4/202109:05Destiny Pharma plc530

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Destiny Pharma Daily Update: Destiny Pharma Plc is listed in the Pharmaceuticals & Biotechnology sector of the London Stock Exchange with ticker DEST. The last closing price for Destiny Pharma was 171.50p.
Destiny Pharma Plc has a 4 week average price of 141.50p and a 12 week average price of 100p.
The 1 year high share price is 246p while the 1 year low share price is currently 30p.
There are currently 59,861,921 shares in issue and the average daily traded volume is 107,196 shares. The market capitalisation of Destiny Pharma Plc is £100,268,717.68.
edmonda: The FY results update shows how Destiny has transformed its portfolio and share price in the last year. With DEST now owning two Phase 3-ready assets, Equity Dev has a fair value of £214m or 358p / share. Read their new research note here:
sev22: This latest dip in the share price is a great opportunity for new investors to get on board as well as PIs like myself to top up my current holding. An extract from the latest House broker's note suggests there is still massive potential upside. 'Whilst the shares have more than doubled year-to-date, we see further substantial upside. As a consequence of this data, we raise our risk-adjusted NPV target price to 370p, on account of increasing the probability of XF-73 reaching the market from 53% to 67%. This excludes any value for other XF platform drugs or SPOR-COV, which may enter the clinic in 2022.'
gb904150: Nice update from ED: hTTtps:// Our fair value of Destiny Pharma has increased to £213.6m (357p per share) from £156.9m (262p per share) as a result of Destiny becoming a company with two Phase 3-ready programs. NB The Management of Destiny will host an Investor Webinar on the trial results TOMORROW , Tuesday 30th at 3.30pm.
mach100: Or Malcolm how about posting on DEST threads about Destiny and perhaps about Open Orphan on ORPH thread? Just a thought of mine instead of hawking DEST elsewhere. I come here to read about DEST and don't need information about other companies here. Revolutionary?
supracat: I had the pleasure and was fortunate enough too to be introduced to Destiny back in 2005 and invested a small amount. When they IPOd I scaled back my holding to just a few thousand shares and sold out at 130p ish. But I always liked the company and where they were headed and couldn't believe when that price dropped to low 30s and therefore built my holding each day by snapping up shares in the low to high 30s over a period of months. Probably sustained the share price in the 30s at the time with these purchases as others bailed out. Who knows where the journey will end up but for me personally I like the story, I like destiny's patient approach and their gutsy motive to acquire another product at phase 3 to complement thier pipeline. Xf73 P2b trial will clearly be a key driver to ultimate value so let's see where this ride goes. I'm a believer and certainly hope another Novacyt here.
neo2725: Some calculations for us all, I have been working out the free float before and after the recent placing, before is easy to work out via the destiny website under the capital structure tab or just type destiny pharma major stakeholders into google and it’s the first link. It was 66.6% of all shares held by major investors so a free float of shares for us PIs of 33.4% of remaining shares. Now after the recent placing we need to dilute these down by the additional 15.9million new shares which hit the market on Monday giving 59,816,921 shares currently in issue, about a 26% dilution by my maths, factor in the two RNS from Sir Nigel Rudd and Unicorn assets management who have taken a 3% and 5% stake this gives a current free float of about 43% shares in private hands. This is 25,700,000 shares give or take, I imagine as we approach results in q1 2021 this pool of shares will reduce and we may see increase in share price. I cannot see people who have taken part in the placing selling for sub 65p. With broker targets of £2.60 and £3 on a successful trial this share has much upside and little down IMO but do your own research.
hedgehog 100: Interesting to compare DEST to recent trebler SCLP at the moment: DEST: 57p, market cap. £25M. SCLP: 15.875p, market cap. £99.87M. 07/09/2020 07:00 UK Regulatory (RNS & others) Destiny Pharma PLC Collaboration to co-develop treatment for COVID-19 "... Destiny Pharma and SporeGen are also very pleased to announce that IUK has awarded a grant of GBP800,000 to fund the majority of the GBP1 million cost of the initial SPOR-COV programme. ..." 27/08/2020 07:00 UK Regulatory (RNS & others) Scancell Holdings Plc Funds awarded by Innovate UK for COVID-19 vaccine "... With Scancell set to receive approximately GBP2m of the consortium awarded funding, the Company expects it to cover the majority of the development and Phase 1 trial costs. ..."
hedgehog 100: 27/07/2020 07:00 UKREG Destiny Pharma PLC Update on Phase 2b clinical study of XF-73 Update on Phase 2b clinical study of lead asset XF-73 in the prevention of post-surgical bacterial infections Protocol amendment agreed with FDA to reduce Phase 2b study size without compromising its statistical power or clinical value Study two thirds enrolled. Recruitment now expected to complete by year end Planned study interim safety review to be announced in August 2020 Brighton, United Kingdom - 27 July 2020 - Destiny Pharma plc (AIM: DEST), a clinical stage biotechnology company focused on the development of novel treatments for hospital infections that address the global challenge of antimicrobial resistance (AMR), is pleased to announce a clinical protocol amendment has been agreed with FDA for its ongoing phase 2b study of lead asset XF-73. The study is evaluating XF-73, as a nasal gel, for the prevention of post-surgical hospital infections caused by Staphylococcus aureus bacteria, such as MRSA. The agreed amendment recognizes the impact COVID-19 has had in slowing patient recruitment in clinical studies since March and the FDA's willingness to support certain protocol amendments that help to accelerate the completion of ongoing clinical trials but do not compromise a study's integrity and clinical objectives. The amendment to the protocol incorporates a change to the primary patient population where the primary endpoint for the study will be measured. The primary microbiological endpoint post-surgery will now be measured in those patients who had a positive load of nasal Staphylococcus aureus before receiving the study treatment. This contrasts to the original primary population, which included all randomised patients regardless of their baseline nasal load of Staphylococcus aureus. Very importantly, this change enables a reduction in the prospectively defined study size from 200 patients to 125 while maintaining the statistical power of the study and its clinical value. This preserves the potential of the trial results to be a key step towards the Phase 3 clinical trial programme of XF-73. Destiny Pharma has informed all appropriate regulatory bodies and ethics committees involved. Other protocol modifications agreed with the FDA regarding study procedures will also make it easier for hospitals to recruit and retain hospital patients. Destiny Pharma expects that as the incidence of COVID-19 continues to decline in European hospitals they will begin recruiting patients into the study again and that recruitment into US study sites is likely to lag, given the higher infection incidence. That said, the study has already enrolled 77 patients out of the new target of 125 and the Company expects to have over 20 sites open in three countries actively recruiting the remaining patients in the next few months with the majority of these being FDA-compliant sites in Europe. The study remains on track to complete recruitment by the end of 2020. The result of a planned interim safety review by the study's Independent Safety Monitoring Board is expected to be announced in August 2020. Neil Clark, Chief Executive Officer of Destiny Pharma, commented: "We are very pleased to have agreed the protocol amendment with the FDA. The changes will help us complete recruitment later in 2020 and still be well placed to move towards Phase 3 clinical studies if the Phase 2b results are positive. Destiny Pharma is funded through to the last quarter of 2021 and remains confident in the clinical need and significant commercial opportunity for its lead clinical asset XF-73 as a novel preventive treatment of serious hospital infections".
hedgehog 100: "finnCap Research Company Notes - 3 March 2020" "Destiny Pharma (DEST) : Corp" "Share price (p) 35.5 Target price (p) 250.0 Market cap (£m) 15.5 Enterprise value (£m) 6.4" HTTP:// Tole 13 May '20 - 12:45 - 96 of 110 0 2 0 "Surprised by the retrace here. Believe these have plenty potential going forward especially with the covid19 element. Finncap highlighted these opportunities in their most recent note. “On a more positive note, Destiny is looking at several new grant-funded projects or government-funded initiatives that could test the utility of XF-73 as a new COVID-19- related treatment. As evidenced by retrospective studies of COVID-19 patients in Wuhan, China, it is becoming established that secondary bacterial respiratory infections take advantage of immune-compromised COVID-19 intensive care patients and are a significant cause of mortality in the SARS-CoV-2 pandemic. Destiny believes that XF-73 has the potential to be part of new treatment regimens that could help reduce the incidence of such bacterial infections by reducing the bacterial carriage quickly in COVID- 19-infected patients in the ICU. Equally relevant is an increased interest in the anti-infective sector, driven by the coronavirus but also with a crossover into treatment of bacterial infections and issue of antimicrobial resistance (AMR). Lessons learned or to be learned from nations’ pandemic preparedness, or in some cases lack thereof, will hopefully drive governments to ensure that the pharmaceutical industry and innovators are sufficiently incentivised to develop new anti-bacterials that address the superbugs and AMR. If large pharma is unwilling to invest in this area, it will ultimately fall to governments to do so. The panic caused by the SARS-CoV-2 pandemic will pale into insignificance if there are microbes that became resistant to all current antibiotics! Destiny offers the possibility with its XF platform of generating novel antibiotics that have an alternative mechanism of action to existing antibiotics and where there is no evidence to date of resistance developing against the XF platform.” "
hedgehog 100: 15/07/2020 07:00 RNSNON Destiny Pharma PLC Destiny Pharma notes launch of AMR Action Fund Destiny Pharma notes launch of $1 billion pharma-backed fund to develop new anti-infectives Fund underlines the market urgency for the development of novel safe and effective antimicrobials such as Destiny Pharma's lead asset, XF-73 XF-73 is currently in a phase 2b clinical study investigating its use in the prevention of post-surgical bacterial infections Brighton, United Kingdom - 15 July 2020 - Destiny Pharma plc (AIM: DEST), a clinical stage biotechnology company focused on the development of novel, hospital infection prevention treatments that address the global challenge of antimicrobial resistance (AMR), notes the launch of the AMR Action Fund to provide financial resources and technical support to help biotechnology companies bring novel anti-infective drugs to patients. These are needed urgently to fight the worldwide rise in antimicrobial-resistant superbugs. Over 20 leading pharmaceutical companies have pledged to invest a total of $1 billion in a fund to help bridge innovative candidates in the pipeline through the later stages of drug development and to work with governments to ensure there is a sustainable pipeline of new antibiotics that address AMR. The pharmaceutical industry, in collaboration with the World Health Organization, the European Investment Bank, and the Wellcome Trust, have joined forces to design the fund, which aims to bring between two and four new antibiotics to market by 2030. For more information visit hxxps:// . This new pharma-backed fund underlines the urgency for the development of novel safe and effective antimicrobials such as Destiny Pharma's lead asset, XF-73. XF-73 is currently in a phase 2b clinical study investigating its use in the prevention of post-surgical bacterial infections, including the superbug MRSA. Neil Clark, Chief Executive Officer of Destiny Pharma, commented: "We welcome this significant new fund supporting novel drug development addressing AMR. The world needs new anti-infective drugs and Destiny Pharma is one of the leading biotechnology companies dedicated to addressing this global clinical need. The new pharma backed fund is the latest in a series of new initiatives from regulators, governments and healthcare investors to support innovation that addresses AMR."
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