C4x Discovery Share Discussion Threads

[alloa2003] 01/7/2020 14:21

Oh yes there is a relevance there but no need to flood the board with the same news.

Starting to stink of ramping :) Again

Now run along with Stig like the little sheep you so obviously are lol

[golden prospect] 01/7/2020 07:24

O/T

Indivior annoucement 1st July 2020


"The plea agreement between Mr. Thaxter and the DOJ is in his personal capacity and not on behalf of the Group"

[the stigologist] 01/7/2020 01:52

Announced overnight

Indivior Ex-CEO pleads guilty

Obviously his position untenable

Hopefully draws a line under things

$600k fine is nothing

[amaretto1] 30/6/2020 18:24

Large late reported trades

[alloa2003] 30/6/2020 12:05

Amaretto1 - another Stig alias :)

[toffeeman] 30/6/2020 11:31

That gap is a long way from closing

[amaretto1] 30/6/2020 10:53

Brain dead !

[alloa2003] 30/6/2020 10:04

So anyone asks a question and they get sarky comments?

[t0pgrader] 30/6/2020 07:52

You don't deserve an answer you half wit but here you go...https://www.c4xdiscovery.com/partnered-programmes.html

[t0pgrader] 29/6/2020 22:59

Sudden change of CEO at INDV is troubling given their Chairman is only interim. What's the story?

[amaretto1] 29/6/2020 21:16

Please rise :-)

[the stigologist] 29/6/2020 20:05

As it happens following those Results the Company did an 'virtual' Institutional Roadshow and raised £1m+ from decent name Institutions so I'm guessing that is a hint at how much cash runway they think they have before they will be able to get more inflows

[the stigologist] 29/6/2020 20:03

The Company updated on both NRF2 and IL17 programmes in results statement

From my layman takes extra data studies sounded like i'd guess 3-6 month delay? on NRF2

On IL17 strong interest it seems to be just a case of opting for the best partner presumably they have to make a choice between negotiating when they look desperate or when they look strong (they may be stronger following any INDV / C4X3256 Phase I start and milestone payment)

Anyway I expect news from INDV 'imminently' given their CEO change today a Clinical Trial start may be something positive for them to release at last.


Oral NRF-2 Activator Programme

C4XD is progressing a series of novel potent activators of the NRF-2 pathway for the treatment of Sickle Cell Disease and Pulmonary Arterial Hypertension. In C4XD studies, multiple lead compounds show >12hr duration of action following low oral dosing on activation of NRF-2 in key tissues such as lung and liver, as well as blood. Candidate nomination studies continue and C4XD now has a shortlist of three lead compounds to enable selection of the candidate. Following commercial discussions, the Company is enhancing the data package with additional studies to further support our commercial proposition.

Oral IL-17 Inhibitor Programme

Interleukin-17 ("IL-17") is a high-value, clinically validated target for inflammation and autoimmune diseases such as psoriasis (estimated to be worth c.$24 billion per annum by 2027 1 ). Current treatments are based on injectable monoclonal antibodies and an oral option would be highly desirable to increase the number of patients able to access IL-17 targeted drugs. Recent data of C4XD ' s prototype lead oral compound demonstrates activity for the first time in IL-17 driven pre-clinical inflammation disease models following oral dosing. C4XD continues to receive strong interest from potential partners for this oral IL-17 inhibitor approach.

[t0pgrader] 29/6/2020 14:10

> DaveMac3 Fair enough. Thanks for pointing that out. In the recent interview in April '20 CD conceded that a deal wasnt imminent because they wouldn't be able to extract the right deal terms until the selection of the chosen molecule had been finalised.

Putting that to one side, presumably good news is not far away re the Oral IL-17 Inhibitor programme which CD described as almost a feeding frenzy amongst potential partners/licencees?

[alloa2003] 29/6/2020 12:37

Prior to the fundraising there was a feeling that the company was being held to ransom by some potential third parties - looking to drag out negotiations. Could this possibly have delayed the 12 month timescale together with the Covid-19 pandemic?

[davemac3] 29/6/2020 11:22

t0pgrader,
1632 was Covid related, 1629 did allude to something negative. That video was more than a year ago and if you listened to you it you would have heard Clive say they were very close to a deal on NRF-2 and he would be disappointed if a deal hadn't been done within a year. Looks like things have been delayed, either they haven't found a candidate yet or potential partners are holding back due to Covid, although the year was almost up when Covid took off.

[t0pgrader] 28/6/2020 21:20

Yes that's possible. Yr post 1629 seemed to allude to something negative.

[davemac3] 28/6/2020 19:09

My point is that C4X have NRF-2 activators that Clive Dix reckons are the best out there. So they could develop a potential treatment for Covid-19 but would take a couple of years even in the current climate. So probably not useful for this pandemic but could potentially be useful for future SARS type diseases.

[t0pgrader] 28/6/2020 18:24

> Davemac c4xd not involved in Covid discovery so what's yr point?

[amaretto1] 27/6/2020 12:07

Wake me up when it over 100 pence Zzzzzz