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Share Name | Share Symbol | Market | Type | Share ISIN | Share Description |
---|---|---|---|---|---|
Phynova | LSE:PYN | London | Ordinary Share | GB00B0YBCM49 | ORD 1P |
Price Change | % Change | Share Price | Bid Price | Offer Price | High Price | Low Price | Open Price | Shares Traded | Last Trade | |
---|---|---|---|---|---|---|---|---|---|---|
0.00 | 0.00% | 1.375 | 0.00 | 01:00:00 |
Industry Sector | Turnover | Profit | EPS - Basic | PE Ratio | Market Cap |
---|---|---|---|---|---|
0 | 0 | N/A | 0 |
RNS Number:4616T Phynova Group PLC 30 April 2008 Press Release 30 April 2008 Phynova Group plc ("Phynova") Annual General Meeting 2008 Phynova Group plc (AIM: PYN, OTCQX: PHNVY), the developer of prescription pharmaceuticals derived from plants used in Chinese medicines, held its Annual General Meeting at Phynova's offices in Long Hanborough today. All resolutions were passed. In the temporary absence of Chairman Karl Watkin MBE, who was unavoidably detained on business in China, Non-Executive Director Michael Martin took the chair. Mr Martin said: "Phynova has made excellent progress on several fronts during the year. For our lead pipeline candidate, PYN17, we reported in November the successful completion of its Phase I/II clinical trial. This was designed to evaluate the safety and tolerability of PYN17 in chronic hepatitis C and we were delighted to report that PYN17 was well tolerated and safe, with a toxicity profile that was indistinguishable from that of the placebo, with no recorded serious adverse events. "We see great potential for PYN17, the only drug currently in clinical development for the relief of the symptoms of hepatitis C and improvement in the Health Related Quality of Life (HRQoL) of hepatitis C patients. Over 170 million people world wide are infected with hepatitis C. Four million Americans are currently believed to be infected with the virus and three quarters of these will develop chronic liver disease in which the liver injury persists for a prolonged period, if not for life. PYN17 uniquely provides symptomatic relief for patients with liver inflammation, an area of significant unmet need because of the low efficacy and recognised toxicity of current antiviral treatments. The need to address ways of improving HRQoL in chronic hepatitis C was emphasised several times in papers given at last week's meeting in Milan of the European Association for Study of the Liver, clearly demonstrating the potential for a drug like PYN17, which Phynova anticipates could one day find wide usage alongside conventional antiviral therapies for the disease. "After detailed discussions with the US Food & Drug Administration, we expect to initiate the PYN17 Phase IIb clinical study, the next stage of clinical trials, in America during the second quarter of 2008. This will provide the first proof of concept data for PYN17. We eagerly anticipate receiving the results of this trial which should be available in the second half of 2009. "For our plant-derived antibacterial PYN6, pre-clinical studies have demonstrated a high degree of bacterial inhibition against methicillin-resistant Staphylococcus aureus (MRSA) and against the acne bacterium, Propionobacterium acnes. We are now conducting formulation studies and we are in active discussions with potential partners for this product. "Encouraging results continue to emerge from our research to evaluate the effectiveness of PYN18, our novel anti-viral drug candidate against hepatitis C and dengue fever. "PYN22, our candidate for the potential treatment of fatty liver, is also moving forward successfully in pre-clinical development, having produced very encouraging initial screening data during the year. PYN22 is another drug candidate that is attracting commercial attention. "PYN9 for the treatment of post-operative ileus (or temporary bowel stasis) is being developed by our Chinese partner, Botanic Century, and has made excellent progress in pre-clinical development. Pending approval from the Chinese FDA, Botanic Century expects to begin a first clinical study before the end of 2008. We are also exploring ways in which to capitalize on our existing position in the Chinese market and our extensive contacts in the Chinese pharmaceutical business and academic communities. "Within the next twelve months, we expect to have no less than three drug candidates (PYN17, PYN22 and PYN9) in clinical trials, with other candidates progressing closer to clinical development. This is a remarkable achievement for a company of our size. At the same time, our broad pipeline means that we are not over-reliant on any one single project. We will also be continuing discussions with the potential partners who have expressed a significant level of interest in our products, either as marketing licensees or as development partners who would share the burden of clinical development costs with us. "Turning to financial matters, in November 2007 our ordinary shares commenced trading on the PLUS Markets trading platform, a quote-driven trading system that currently trades over 1,000 small and mid-cap company shares representing a combined market capitalisation of around #200 billion. Our American Depositary Receipts ("ADRs") also started trading recently on the US International OTCQX platform. This new exchange promises cost-effective access to the US pool of investment capital without the prohibitive regulatory burden of compliance with SEC regulations and the Sarbanes-Oxley Act. The OTCQX platform now trades on average over US$1 million per listed company per day, three times the liquidity of the AIM market. Our ordinary shares continue to be quoted and traded on the AIM market. Trading through PLUS and on the OTCQX is intended to enhance investor choice, improving liquidity for shareholders and providing greater access to investors. Now that we have a process by which US investors can easily invest in Phynova, we will be raising our profile in that market where we are confident that our unique business strategy and focus is likely to find a receptive audience. "In April 2008, Phynova successfully raised in excess of #1.2 million from new and existing shareholders. With the Company's proven approach to minimising corporate overheads, this financing allows us to continue to develop our scientific programme and also demonstrates investor confidence in our business. "Finally I would like to welcome all new shareholders who have invested in Phynova over the past year and thank existing stakeholders for their continued support." - Ends - For further information, please contact: Phynova Group PLC +44 (0) 1993 880700 Robert Miller, Chief Executive Officer www.phynova.com Nominated Adviser: Nabarro Wells & Co. Limited +44 (0) 20 7634 4705 Marc Cramsie Broker: Evolution Securities China Limited +44 (0) 20 7220 4850 Barry Saint Media enquiries: Abchurch Communications +44 (0) 20 7398 7700 Peter Laing/Stephanie Cuthbert stephanie.cuthbert@abchurch-group.com www.abchurch-group.com Notes to Editors: About Phynova Phynova is a UK company developing prescription pharmaceuticals derived from plants used in Chinese medicines. Phynova is focused on viral and bacterial diseases, metabolic diseases and cancer. Phynova's lead product for hepatitis C has now completed a Phase I/II trial in the US and the Phase IIb trial is scheduled to commence in the first half of 2008. Two further products, for fatty liver disease and post-operative ileus, are targeted for entry to the clinic over the next six months and there are a further four products in preclinical development. For further information please visit www.phynova.com. This information is provided by RNS The company news service from the London Stock Exchange END RAGIMMTTMMAJBTP
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