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PYN Phynova

1.375
0.00 (0.00%)
13 May 2024 - Closed
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Phynova LSE:PYN London Ordinary Share GB00B0YBCM49 ORD 1P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.00 0.00% 1.375 0.00 01:00:00
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
0 0 N/A 0

Interim Results

27/06/2008 7:01am

UK Regulatory


    RNS Number : 6691X
  Phynova Group PLC
  27 June 2008
   
    27th June 2008


    Phynova Group PLC

    ("Phynova" or the "Company")


    PHYNOVA ANNOUNCES HALF-YEARLY RESULTS FOR PERIOD ENDED 31 MARCH 2008

    Phynova (AIM: PYN), the developer of prescription pharmaceuticals derived from plants used in Chinese medicines, today announces its
half-yearly results for the six month period ended 31 March 2008. 

    These results are prepared in accordance with International Reporting Standards ("IFRS") and key highlights are as follows:

    Financial highlights
    *     Operating loss in line with expectations at £1.46 million (2007: £1.3 million).
    *     Cash as of 31 March 2008 was £501,000 (2007: £2.75 million).  In April 2008, Phynova raised £1.2 million before expenses by means
of a placing with existing investors.
    *     Research and operational costs remain low for a drug development company, demonstrating prudent financial management.

    Research / pipeline highlights
    *     PYN 17 for the treatment of the symptoms of chronic hepatitis C: preliminary data demonstrates safety and tolerability in Phase
I/II trials. Currently planning next stage of clinical development, with results anticipated in 2009. 
    *     PYN 6 laboratory research indicates a higher degree of efficiency against MRSA, with further potential for the treatment of acne.
A patent has been filed and commercial discussions are underway. 
    *     PYN 18 activities against hepatitis C virus and dengue fever virus confirmed at Rega Institute in Belgium, a world-leading anti
viral screening laboratory. New patents filed on both anti viral activities.
    *     PYN 7 range of cell-based assays confirms potential anti-cancer activity and justify progression to next stage of preclinical
development.
    *     Ongoing discussions with potential partners regarding several of Phynova's drug candidates.

    Post-period updates
    *     In April 2008, Phynova created and listed its American Depositary Receipts ("ADRs") on the OTCQX (www.OTCQX.com) trading platform
in New York.  This listing gives a presence in the US Capital markets and access to the largest pool of biotech and life science investors
in the world.
    *     £1.2 million fund raising from existing investors, part of which is intended to be used to fund clinical development of PYN 17,
Phynova's treatment of the symptoms of chronic hepatitis C.
    *     The Company continues to seek suitable acquisition opportunities. 
    Robert Miller, Chief Executive Officer of Phynova said:

    "We have had a very busy first half to the year and these results demonstrate our ongoing progress in developing high quality drug
candidates. With several compounds ready to go into clinical trials and a strong supporting pipeline, we believe our approach to drug
development continues to offer significant opportunities for treating infectious diseases."

    - ENDS-

    For further information, please contact: 

 Phynova Group PLC                    Tel: 01993 880700
 Tony Mills

 John East & Partners Limited        Tel: 020 7628 2200
 John East/Simon Clements

 Evolution Securities China Limited  Tel: 020 7220 4850
 Barry Saint/Esther Lee

 Capital MS&L                        Tel: 020 7307 5330
 Mary Clark/Anna Mitchell



    Notes to editors:


    About Phynova

    Phynova (AIM: PYN) is a UK company developing new prescription pharmaceuticals derived from plants used in Chinese medicines. The
Company is focused on viral and bacterial diseases, metabolic diseases and cancer. Phynova's lead product for hepatitis C has now completed
a Phase I/II trial in the US and the next stage of clinical development is anticipated to start in the second half of 2008. Two further
products, for fatty liver disease and post-operative ileus, are targeted for entry to the clinic and there are a further four products in
preclinical development.
    
For further information please visit www.phynova.com.

    
    
    Chairman's Statement

    I am pleased to report Phynova's progress during the first half of this financial year.

    Strong clinical results and significant potential for development in our pipeline reaffirms the Board's belief that the Company's
business model offers an attractive route for drug development. 

    Our research and development programme, which includes work with our colleagues at Botanic Century (Beijing) Co. Ltd ("Botanic
Century"), has yielded strong results, both in clinical trials and in early-stage drug development. As a result, we are in discussions with
a number of potential partners regarding the commercialisation of Phynova's portfolio. While these discussions are at a relatively early
stage, we believe this interest demonstrates the significant opportunity and market appetite for safe, effective drugs.

    As announced by the Company in April 2008, Phynova secured in excess of £1.2 million funding from existing shareholders. Part of the new
funds will be used to progress the clinical development of PYN17 and other drugs in our pipeline.

    As we continue to develop our drug candidates and identify new opportunities we will keep our shareholders updated and look forward to
sharing our successes with you in the future.

    Financial review

    This is the first report by the Company presented under EU endorsed IFRS.

    The interim financial information has been prepared on the basis of the accounting policies which will be adopted in the annual report
for the year ending 30 September 2008 in accordance with IFRS. The comparative figures have also been restated to reflect this. There has
been no significant impact on either the current period results or the restated historic results. An explanation, including the impact of
transition to IFRS, is included in the notes to the interim financial information. In the six months ended 31 March 2008, Phynova recorded a
pre-tax loss of £1.46 million, which was in line with management's expectations. 

    The Company's cash position, as at 31 March 2008, was £501,000. In April 2008, Phynova raised £1.2 million before expenses by means of a
placing with existing investors. These funds were raised through a placing of new ordinary shares at 40 pence per share with existing
investors and private investors who predominantly benefited from the tax relief offered by the UK Government's Enterprise Investment Scheme
("EIS"). This funding is being used to progress the clinical development of PYN17 and to further advance the drug pipeline. 

    The management continues to exercise prudent cash management demonstrated by relatively low administrative and operational costs. 

    In November 2007 Phynova announced that its ordinary shares had been admitted to trading on PLUS Traded (unlisted), which is a PLUS
Markets secondary market for companies already admitted to trading on AIM. At the end of March, Phynova announced its intention to create
and list American Depositary Receipts ("ADRs") on the OTCQX platform in New York. The ADRs were listed for trading in April 2008, while
retaining the Company's main AIM listing. Both of these listings were undertaken to improve liquidity and increase access for international
investors.

    Pipeline

    PYN 17 
    In November 2007, Phynova announced successful Phase I/II preliminary results for its lead candidate, PYN 17, for the treatment of the
symptoms of chronic hepatitis C. The results confirmed that the trial met its primary endpoint, demonstrating safety and tolerability. 

    Hepatitis C affects over 170 million people worldwide, including over four million people in the US. PYN 17 is the only drug currently
in development specifically for the treatment of the debilitating symptoms, impaired health related quality of life ("HRQoL") and liver
inflammation associated with the disease. Currently available antiviral treatments with pegylated interferon and ribavirin are only
effective in approximately 50 per cent of patients treated, often with significant associated toxicity and side effects. As a result, it is
estimated that the market for treatments for hepatitis C will grow to around US$9 billion by 2010, and the Directors believe that the
Company is well placed to participate in this market growth. 


    PYN 22 
    Phynova is developing PYN 22 for the treatment of non alcoholic fatty liver disease. 

    Obesity is a huge medical problem globally, particularly in developed countries. One of the increasingly recognised complications of
obesity is non-alcoholic fatty liver disease ("NAFLD"), which can lead to liver cirrhosis and hepatocellular carcinoma. Currently there is
no specific treatment for NAFLD and there remains a high unmet medical need. 

    Preclinical data generated by Phynova's Chinese collaborators shows that PYN22 reduces blood lipids, the percentage of body fat and
liver fat. This preclinical data has been confirmed and extended by a leading academic group in the UK who have shown that PYN22 reduces
body fat, as well as having some effect on insulin resistance. 

    A dossier has now been completed and a preliminary regulatory meeting with the MHRA is scheduled to discuss the design of a first human
study. Licensing discussions are ongoing with several companies.

    PYN 9 
    PYN 9 is in development for post-operative ileus, a form of bowel obstruction/hypomotility associated with surgery and/or the use of
opiate pain killers that is widely seen after abdominal surgery. It is a key cause of delayed hospital discharge and, in some cases,
post-operative morbidity.

    PYN 9 has shown promising efficacy in preclinical studies targeting increased bowel movement in conditions where the bowel motility has
been impaired.

    An Investigational New Drug application has been filed by Phynova“s Chinese associate, Botanic Century, and a Phase I clinical study in
China is expected to begin during 2008. Phynova is preparing a preclinical development plan for Europe and continuing commercial
discussions.


    PYN 6 
    PYN 6, the antibacterial drug candidate, has shown great promise against MRSA and the Company has initiated studies aimed at formulating
the drug for topical application.  

    An estimated 100,000 patients in the UK contract an antibiotic resistant infection while in hospital each year. The reported cost to the
NHS of treating these infections is in excess of £1 billion. With the sharp increase of so-called "super-bugs" such as MRSA in hospitals,
there is a major need for new anti-bacterial treatments.
    
Pre-clinical work was conducted by Phynova in collaboration with the University of East London. Inhibition was demonstrated against all of
the strains of MRSA that were tested, at levels equivalent to (mupirocin-susceptible MRSA) or some tenfold better than (mupirocin-resistant
MRSA) mupirocin, the topical antibiotic currently routinely used for treatment of skin infections involving MRSA. Methicillin and mupirocon
resistance commonly occurs together in Staphylococcus aureus, with a growing incidence worldwide. Resistance to PYN 6 has not been observed
even after prolonged culture of numerous MRSA strains with PYN 6. 

    PYN 6 has also shown significant activity against the Propionibacterium acnes organism which causes acne.

    Phynova is now preparing a preclinical package; a new patent application has been filed; and commercial discussions are underway with
several acne treatment companies. 

    PYN 18 
    PYN 18, the novel antiviral agent, has been confirmed in studies carried out at the Rega Institute in Belgium (one of the world's
leading virology centres) to have activity against hepatitis C virus and against dengue virus, with early data indicating a novel mechanism
of action in dengue virus over other acute viral infection treatments. New patent applications have been filed and PYN18 has attracted
interest from several companies in the antiviral field.

    PYN 7 
    PYN 7, the cancer drug candidate, has shown promising activity against a range of cancer cells. Work is continuing with collaborators in
Birmingham (UK) and Hong Kong to explore the mechanisms of action and activity.

    PYN 5
    Phynova's candidate for RSV and the SARS virus was granted UK patents.

    
Outlook 

    The positive progress made in the Phynova pipeline during the first half of our financial year has been reflected in the Company's
business development activities. 

    While Phynova's research and development programme continues to strengthen its pipeline, the Company is currently in early stage
discussions with a number of potential partners regarding the potential commercialisation of drug candidates in its pipeline. Due to the
nature of these discussions, Phynova is unable to disclose further details and more information will be disclosed to the market as
appropriate. While it must be stressed that there are no guarantees that these discussions will come to fruition, the Directors believe that
these discussions are yet another encouraging sign that Phynova's approach to drug development is an increasingly attractive proposition to
major pharmaceutical companies.


    K Watkin
    Chairman
    27th June 2008  
    CONSOLIDATED INCOME STATEMENT
    For the six months ended 31 March 2008 

                                            Six months      Six months          12 months
                                                 Ended           Ended              Ended
                                             31 March        31 March       30 September 
                                                  2008           2007               2007 
                                             Unaudited       Unaudited          Unaudited
                                 Notes           £'000           £'000              £'000

 Revenue                                             -               -                  -

 Research and development costs                  (513)           (341)            (1,028)
 Administrative costs                            (946)           (997)            (1,948)

 Operating loss                                (1,459)         (1,338)            (2,976)

 Finance income                                     19              42                 84
 Share of losses of associates                    (10)             (8)               (43)

 Loss before tax                               (1,450)         (1,304)            (2,935)
 Taxation                                          231               -                 93
 Loss for the period
 attributable to                               (1,219)         (1,304)            (2,842)
 equity holders of the company

 Basic and diluted loss per        3            (6.2)p          (7.2)p            (15.1)p
 share (pence)

      
    CONSOLIDATED STATEMENT OF CHANGES IN EQUITY
    For the six months ended 31 March 2008

                                         Share            Merger  Foreign
                                 Share   premiu  Warrant  Differ  Exchang  Retained  Total equity
                                 capita      m   reserve    ence        e    losses
                                     l   reserv           reserv  reserve
                                              e                e
                                  £'000   £'000    £'000   £'000    £'000     £'000         £'000

 At 1 October 2006                  148   3,498      369     643        -   (3,001)         1,657
 Loss for the period                  -       -        -       -        -   (1,304)       (1,304)
 Exchange difference arising on
 translation of foreign
 operations
                                      -       -        -       -      (2)         -           (2)
 Shares issued during the
 period                              40   2,738        -       -        -         -         2,778
 Cost of share issues                 -   (213)        -       -        -         -         (213)
 At 31 March 2007                   188   6,023      369     643      (2)   (4,305)         2,916

 Loss for the period                  -       -        -       -        -   (1,538)       (1,538)
 Share-based payment                  -       -        -       -        -        47            47
 Shares issued during the year
                                      7     249        -       -        -         -           256
 Cost of share issues                 -       -        -       -        -         -             -
  At 30 September 2007              195   6,272      369     643      (2)   (5,796)         1,681

 Loss for the period                  -       -        -       -        -   (1,219)       (1,219)
 Exchange difference arising on
 translation of foreign
 operations
                                      -       -        -       -       22         -            22

 At 31 March 2008                   195   6,272      369     643       20   (7,015)           484


      
    CONSOLIDATED SUMMARISED BALANCE SHEET AS AT 31 MARCH 2008

                                                    At         At           At
                                             31 March   31 March            30
                                                  2008      2007    September 
                                                                         2007 
                                             Unaudited  Unaudited    Unaudited
                                                 £'000      £'000        £'000
 Assets

 Non-current assets
 Plant and equipment                                16         19           16
 Investment in associated undertaking              559        575          547

 Total non-current assets                          575        594          563

 Current assets
 Trade and other receivables                       515        266          419
 Cash and cash equivalents                         501      2,748        1,427

 Total current assets                            1,016      3,014        1,846

 Total assets                                    1,591      3,608        2,409

 Liabilities

 Current liabilities
 Trade and other payables                        (764)      (339)        (385)
 Provisions                                      (343)      (353)        (343)

 Total liabilities                             (1,107)      (692)        (728)

 Total net assets                                  484      2,916        1,681

 Capital and reserves attributable to
 equity holders of the company
 Share capital                                     195        188          195
 Share premium reserve                           6,272      6,023        6,272
 Warrant Reserve                                   369        369          369
 Merger difference reserve                         643        643          643
 Foreign Exchange reserve                           20        (2)          (2)
 Retained earnings                             (7,015)    (4,305)      (5,796)

 Total equity                                      484      2,916        1,681

      
    CONSOLIDATED SUMMARISED CASH FLOW STATEMENT
    For the six months ended 31 March 2008

                                    Six months      Six months               12months
                                         Ended           Ended                  Ended
                                      31 March       31 March      30 September 2007 
                                          2008            2007
                                     Unaudited       Unaudited              Unaudited
                                         £'000           £'000                  £'000
 Cash flows from operating
 activities
 Loss before tax                       (1,450)         (1,304)                (2,935)
 Adjustments for:
 Depreciation                                6               3                      7
 Finance Income                           (19)            (42)                   (84)
 Share of losses of associates              10               8                     43
 Share-based payment charge                  -               -                     47

 Operating loss before changes         (1,453)         (1,335)                (2,922)
 in working capital

 Decrease/(Increase) in trade               42            (12)                   (71)
 and other receivables
 Increase in trade and other               379             134                    173
 payables
 Increase/(Decrease) in                      -            (18)                   (28)
 provisions

 Cash used in operations               (1,032)         (1,231)                (2,848)

 Income tax received                        93               -                      -

 Net cash used in operating              (939)         (1,231)                (2,848)
 activities

 Cash flows from investing
 activities
 Purchase of plant and                     (6)            (14)                   (16)
 equipment
 Investment in Associated                    -           (592)                  (592)
 Undertakings
 Interest received                          19              42                     84

 Cash used in investing                    13            (564)                  (524)
 activities

 Cash flows from financing
 activities
 Issue of ordinary shares                    -           2,778                  3,033
 Share issue costs                                       (213)                  (212)

 Cash generated by financing                 -           2,565                  2,821
 activities

 (Decrease)/Increase in cash             (926)             770                  (551)
 and cash equivalents
 Cash and cash equivalents at            1,427           1,978                  1,978
 beginning of period

 Cash and cash equivalents at              501           2,748                  1,427
 end of period



    
  
    NOTES TO THE HALF-YEARLY FINANCIAL INFORMATION
    For the six months ended 31 March 2008

1.              BASIS OF PREPARATION

    The unaudited Interim Report was approved by the Board of Directors on 26 June 2008.

    The financial information for the six months ended 31 March 2008 and for the six months ended 31 March 2007 is unaudited.

    The financial information presented for the Group does not constitute "statutory accounts" within the meaning of Section 240 of the
Companies Act 1985.

    The information for the year ended 30 September 2007 has been extracted from the financial statements of the statutory accounts of
Phynova Group PLC which were prepared under UK Generally Accepted Accounting Principles ("UK GAAP") and have been delivered to the Registrar
of Companies. The auditors have reported on those financial statements; their report was unqualified, did not include any references to
which the auditors drew attention by way of emphasis without qualifying their report and did not contain any statements under either Section
237(2) or Section 237(3) of the Companies Act 1985. This audited information has been restated, as necessary, for the adoption of IFRS. The
restatements have not been audited.

2.             BASIS OF ACCOUNTING

    The financial information presented in this report has been prepared using accounting policies that will be used in the preparation of
the financial statements for the year ending 30 September 2008. The policies are set out below. These policies are in accordance with
International Financial Reporting Standards (IFRS) as endorsed for use in the European Union and International Financial Reporting
Interpretations Committee (IFRIC) interpretations that are expected to be applicable for the year ending 30 September 2008. The disclosures
required by IFRS 1 'First-time Adoption of International Financial Reporting Standards' concerning the transition from UK GAAP to IFRS are
given in note 6.

    The Group has elected to make use of the exemptions available in IFRS 1 as follows:

    *     IFRS 2 'Share-based Payments' has been applied to all grants of equity instruments after 7 November 2002 that were unvested at 1
October 2006.

    *     IFRS 3 'Business Combinations' has not been applied retrospectively to business combinations that occurred before 1 October 2006.

    The interim financial information has been prepared on the historical cost basis or fair value as appropriate.


    2.1 Basis of consolidation

    Where the Company has the power, either directly or indirectly, to govern the financial and operating policies of another entity or
business so as to obtain benefits from its activities, it is classified as a subsidiary. The consolidated financial information presents the
results of the Company and its subsidiaries Phynova Limited and Phynova China Limited as if they formed a single entity ("the Group"). Inter
company transactions and balances between the Group companies are therefore eliminated in full.

      2.2 Leased assets

    Operating lease rentals are charged to the income statement on a straight line basis over the lease term.

    2.3 Research and development

    Expenditure on pure and applied research and development is charged to profit and loss in the year which it occurs.
     Internally generated intangible assets (research and development costs)
    Expenditure on internally developed products is capitalised if it can be demonstrated that:
    *     it is technically feasible to develop the product for it to be sold; 
    *     adequate resources are available to complete the development; 
    *     there is an intention to complete and sell the product; 
    *     the group is able to sell the product; 
    *     sale of the product will generate future economic benefits; and 
    *     expenditure on the project can be measured reliably.
    Capitalised development costs are amortised over the periods the group expects to benefit from selling the products developed. The
amortisation expense would be included within the cost of administrative expenses, in the consolidated income statement.
    
Development expenditure not satisfying the above criteria and expenditure on the research phase of internal projects are recognised in the
consolidated income statement as incurred.

    2.4 Plant and equipment

    Plant and equipment are stated at cost less accumulated depreciation and any accumulated impairment losses. Cost includes expenditure
that is directly attributable to the acquisition of the items. Depreciation is charged to the income statement on all plant and equipment at
rates calculated to write off the cost or valuation, less estimated residual value, of each asset on a straight line basis over the
estimated useful lives, which is 3 years for plant and equipment and 3 years for furniture and fittings.

    The assets' residual values and useful lives are determined by the Directors and reviewed and adjusted if appropriate at each balance
sheet date in accordance with Group policy for impairment of assets (note 2.6).

    2.5 Impairment of assets

    Assets that have a finite useful life and are not yet in use and are not subject to amortisation are tested annually for impairment.

    Assets that are subject to amortisation are reviewed for impairment annually and when events or circumstances suggest that the carrying
amount may not be recoverable. An impairment loss is recognised for the amount by which the assets carrying amount exceeds its recoverable
amount.

    Recoverable amount is the higher of fair value costs to sell and value in use. In assessing value in use, the estimated future cash
flows are discounted to their present value using a pre-tax discount rate that reflects current market assessments of the time value of
money and the risks specific to the asset.

    For the purpose of assessing impairment, assets are grouped at the lowest levels for which there are separately identifiable cash flows
(cash generating units).

    If the recoverable amount of an asset is estimated to be less than its carrying amount, the carrying amount of the asset is reduced to
its recoverable amount. An impairment loss is recognised immediately in the income statement, unless the relevant asset is carried at a
revalued amount, in which case the impairment loss is treated as a revaluation decrease.

    When an impairment loss subsequently reverses, the carrying amount of the asset is increased to the revised estimate of its recoverable
amount, but so that the increased carrying amount does not exceed the carrying amount that would have been determined had no impairment loss
been recognised for the asset in prior periods. A reversal of an impairment loss is recognised immediately in the income statement, unless
the relevant asset is carried at a revalued amount, in which case the reversal of the impairment loss is treated as a revaluation increase.

    2.6 Taxation 

    Deferred tax assets and liabilities are recognised where the carrying amount of an asset or liability in the balance sheet differs to
its base, except for differences arising on:

    *     The initial recognition of goodwill;
    *     Goodwill for which amortisation is not tax deductible;
    *     The initial recognition of an asset or liability in a transaction which is not a business combination and at the time of the
transaction affects neither accounting or taxable profit; and
    *     Investments in subsidiaries and jointly controlled entities where the Group is able to control the timing of the reversal of the
difference and it is probable that the difference will not reverse in the foreseeable future.

    Recognition of deferred tax assets is restricted to those instances where it is probable that taxable profit will be available against
which the difference can be utilised.

    The amount of the asset or liability is determined using tax rates that have been enacted or substantially enacted by the balance sheet
date and are expected to apply when the deferred tax liabilities / (assets) are settled / (recovered). Deferred tax balances are not
discounted.

    Deferred tax assets and liabilities are offset when the Group has a legally enforceable right to offset current tax assets and
liabilities and the deferred tax assets and liabilities relate to taxes levied by the same tax authority on either:

    *     The same taxable group company; or
    *     Different group entities which intend to settle current tax assets and liabilities on a net basis, or to realise the assets and
settle the liabilities simultaneously, on each future period in which significant amounts of deferred tax assets or liabilities are expected
to be settled or recovered.

    Current tax is provided at amounts expected to be recovered or to be paid using the tax rates and tax laws that have been enacted or
substantially enacted at the balance sheet date. When research and development tax credits are claimed they are recognised on an accrual
basis and are included as a taxation credit.

    2.7 Foreign currency translation

    The financial statements for each of the Group's entities are measured using the currency of the primary economic environment in which
the entity operates (the functional currency). The consolidated financial information is presented in sterling, which is the Group's
functional currency and presentation currency. 

    Foreign currency transactions are translated into the functional currency using the exchange rate prevailing at the dates of the
transactions. Foreign exchange gains and losses resulting from the settlement of such transactions and from the translation at period end
exchange rates of monetary assets and liabilities denominated in foreign currencies are recognised in the income statement.

    On consolidation, the results of overseas operations are translated into sterling at rates approximating to those ruling when the
transactions took place. All assets and liabilities of overseas operations, including goodwill arising on the acquisition of those
operations, are translated at the rate ruling at the balance sheet date. Exchange differences arising on translating the opening net assets
at opening rate and the results of overseas operations at actual rate are recognised directly in equity (the "foreign exchange reserve").  

    On disposal of a foreign operation, the cumulative exchange differences recognised in the foreign exchange reserve relating to that
operation up to the date of disposal are transferred to the consolidated income statement as part of the profit or loss on disposal.

    2.8 Share-based payments

    Where share options are awarded to employees, the fair value of the options at the date of grant is charged to the income statement over
the vesting period. Non-market vesting conditions are taken into account by adjusting the number of equity instruments expected to vest at
each balance sheet date so that, ultimately, the cumulative amount recognised over the vesting period is based on the number of options that
eventually vest. Market vesting conditions are factored into the fair value of the options granted. As long as all other vesting conditions
are satisfied, a charge is made irrespective of whether the market vesting conditions are satisfied. The cumulative expense is not adjusted
for failure to achieve a market vesting condition.

    Where the terms and conditions of options are modified before they vest, the increase in fair value of the options, measured immediately
before and after the modification, is also charged to the income statement over the remaining vesting period.

    Where equity instruments are granted to persons other than employees, the income statement is charged with the fair value of goods and
services received.

    2.9 National Insurance on share options

    To the extent that the share price at the balance sheet date is greater than the exercise price on options granted under unapproved
schemes, provision for any National Insurance contributions has been made based on the prevailing rate of National Insurance. The provision
is accrued over the performance period attaching to the award.

    2.10 Segment reporting

    The group is organised and operates as one business unit being pharmaceutical drug development. The principal activity of the Group is
the research and development of drugs and their commercial out licence. The main area of research and development continues to be the
development of prescription pharmaceuticals derived from plants used in Chinese medicines.

    The Group operates in and manages any overseas research and development from the UK The associated undertakings is based in China, all
other operations are based in the UK. Since there is currently only one primary segment and one geographical segment, no separate segment
reporting has been prepared.

    2.11 Interest income

    Interest income is recognised on a time-proportion basis using the effective interest rate method.

    2.12 Associates

Where the group has the power to participate in (but not control) the financial and operating policy decisions of another entity, it is
classified as an associate. Associates are initially recognised in the consolidated balance sheet at cost. The group's share of
post-acquisition profits and losses is recognised in the consolidated income statement, except that losses in excess of the group's
investment in the associate are not recognised unless there is an obligation to make good those losses.

Profits and losses arising on transactions between the group and its associates are recognised only to the extent of unrelated investors'
interests in the associate. The investor's share in the associate's profits and losses resulting from these transactions is eliminated
against the carrying value of the associate.

Any premium paid for an associate above the fair value of the group's share of the identifiable assets, liabilities and contingent
liabilities acquired is capitalised and included in the carrying amount of the associate. The carrying amount of investment in associate is
subject to impairment in the same way as goodwill arising on a business combination described in note 2.6.

    2.13 Financial assets

The group classifies its financial assets into one of the categories discussed below, depending on the purpose for which the asset was
acquired. 

    Loans and receivables: These assets are non-derivative financial assets with fixed or determinable payments that are not quoted in an
active market. They arise principally through the provision of goods and services to customers (e.g. trade receivables), but also
incorporate other types of contractual monetary asset. They are initially recognised at fair value plus transaction costs that are directly
attributable to their acquisition or issue, and are subsequently carried at amortised cost using the effective interest rate method, less
provision for impairment. 

    Impairment provisions are recognised when there is objective evidence (such as significant financial difficulties on the part of the
counterparty or default or significant delay in payment) that the group will be unable to collect all of the amounts due under the terms
receivable, the amount of such a provision being the difference between the net carrying amount and the present value of the future expected
cash flows associated with the impaired receivable. For trade receivables, which are reported net, such provisions are recorded in a
separate allowance account with the loss being recognised within administrative expenses in the income statement. On confirmation that the
trade receivable will not be collectable, the gross carrying value of the asset is written off against the associated provision. 

    The Group's loans and receivables comprise trade and other receivables and cash and cash equivalents in the balance sheet. 

Cash and cash equivalents includes cash in hand, deposits held at call with banks, other short term highly liquid investments with original
maturities of three months or less and bank overdrafts. Bank overdrafts are shown within loans and borrowings in current liabilities on the
balance sheet.
    

2.14 Financial liabilities

The group classifies its financial liabilities into one of two categories, depending on the purpose for which the liability was acquired. 

    Other financial liabilities include the Trade payables and other short-term monetary liabilities, which are initially recognised at fair
value and subsequently carried at amortised cost using the effective interest method. 

    2.15 Share capital 
    Financial instruments issued by the Group are treated as equity only to the extent that they do not meet the definition of a financial
liability. The Group's perpetual preference shares include a contractual obligation on the company to deliver cash in the form of the annual
preference dividend and, in the absence of any other terms that would indicate an equity element, have been classified wholly as a financial
liability. The Groups ordinary shares are classified as equity instruments. 
    


    2.16 Provisions

    Provisions are recognised for liabilities of uncertain timing or amount that have arisen as a result of past transactions and are
discounted at a pre-tax rate reflecting current market assessments of the time value of money and the risks specific to the liability.



3.              LOSS PER SHARE

    The calculation of the basic and diluted loss per share is based on the loss on ordinary activities after tax and on the weighted
average number of ordinary shares in issue during the period. The loss and weighted average number of shares used in the calculations are
set out below:

 Basic and diluted loss per        Loss  Weighted average number of shares  Loss per share pence
 share                            £'000
 Six months ended 31 March 2008  (1219)                         19,536,258                 (6.2)
 Six months ended 31 March 2007  (1304)                         18,083,525                 (7.2)
 12 months ended 30 September    (2842)                         18,855,303                (15.1)
 2007

    At 31 March 2008, the Company had 5,203,991 (31 March 2007: 6,954,520) share options and warrants outstanding, equivalent to 21 per
cent. of the Company's enlarged share capital, on the basis of all the share options being exercised before expiration. The share options
have not been included in the calculation of the diluted loss per share as they would dilute a loss.

    4.              Post balance sheet events


    In April 2008, the Company raised a further £1,213,370 of additional capital through the issue of 3,033,426 ordinary shares at 40 pence
per share.

    On the 16 of April 2008 the Company announced that its ADRs are now trading on the US International OTCQX platform under the symbol
PHNVY. Phynova is retaining its primary listing on the UK AIM Market. Phynova can issue ADRs in respect of up to 25 per cent. of its issued
share capital. Each ADR represents ten of Phynova“s ordinary shares.

 
5.              DIVIDENDS

    The Directors do not recommend the payment of an interim dividend.

 
6.              Explanation of transition to IFRS

    This is the first year that the Group will present its full financial information under IFRS. The last financial statements under UK
GAAP were for the year ended 30 September 2007 and the date of full transition to IFRS was therefore 1 October 2006. The following
disclosures are required in the year of transition.

    Reconciliation of Group equity at 1 October 2006 (date of transition to IFRS)

                                             Effect of          Unaudited
                                    Audited        IFRS              IFRS
                                         UK  Restatemen       As restated
                                       GAAP          t              £'000
                                      £'000       £'000
                              Note
 Plant and equipment                      8           -                 8
 Trade and other receivables            254           -               254
 Cash and cash equivalents            1,978           -             1,978

 Total assets                         2,240           -             2,240
 Trade and other payables     (i)     (207)         (5)             (212)
 Provisions                           (371)           -             (371)

 Total net assets                     1,662         (5)             1,657

 Share capital                          148           -               148
 Share premium reserve                3,498           -             3,498
 Warrant reserve                        369           -               369
 Merger difference reserve              643           -               643
 Retained earnings            (ii)  (2,996)         (5)           (3,001)

 Total equity                         1,662         (5)             1,657

    Note (i): Holiday pay provision
    IAS 19 'Employee Benefits' requires the creation of an accrued holiday pay provision. This was not required under UK GAAP.

    Note (ii): Retained earnings
    The impact of (i) is a charge to retained earnings of £4,875 at the date of transition. 

    Reconciliation of Group equity at 31 March 2007 

                                                  Effect of          Unaudited
                                         Audited        IFRS              IFRS
                                              UK  Restatemen       As restated
                                            GAAP          t              £'000
                                           £'000       £'000
                                  Note
 Plant and equipment                          19           -                19
 Investment in associated         (ii)       568           7               575
 undertaking
 Trade and other receivables                 266           -               266
 Cash and cash equivalents                 2,748           -             2,748

 Total assets                              3,601           7             3,608
 Trade and other payables          (i)     (333)         (6)             (339)
 Provisions                                (353)           -             (353)

 Total net assets                          2,915           1             2,916

 Share capital                               188           -               188
 Share premium reserve                     6,023           -             6,023
 Warrant reserve                             369           -               369
 Merger difference reserve                   643           -               643
 Retained earnings                (iii)  (4,308)           1           (4,307)

 Total equity                              2,915           1             2,916

    Note (i): Holiday pay provision
    IAS 19 'Employee Benefits' requires the creation of an accrued holiday pay provision. This was not required under UK GAAP.  

    Note (ii): Goodwill amortisation
    Under FRS 9 goodwill arising on associates was subject to amortisation but under IFRS goodwill arising on the associates is not
amortised, but instead is subject to annual impairment reviews.

    Note (iii): Retained earnings
    The impact of (i) is a charge to retained earnings of £5,910 and (ii) is a credit to retained earnings of £7,182 at the 31 March 2007.
This gives a net credit of £1,272.

    Reconciliation of Group equity at 30 September 2007 

                                                  Effect of          Unaudited
                                         Audited        IFRS              IFRS
                                              UK  Restatemen       As restated
                                            GAAP          t              £'000
                                           £'000       £'000
                                  Note
 Plant and equipment                          16           -                16
 Investment in associated         (ii)       531          16               547
 undertaking
 Trade and other receivables                 419           -               419
 Cash and cash equivalents                 1,427           -             1,427

 Total assets                              2,393          16             2,409
 Trade and other payables          (i)     (375)        (10)             (385)
 Provisions                                (343)           -             (343)

 Total net assets                          1,675           6             1,681

 Share capital                               195           -               195
 Share premium reserve                     6,272           -             6,272
 Warrant reserve                             369           -               369
 Merger difference reserve                   643           -               643
 Retained earnings                (iii)  (5,804)           6           (5,798)

 Total equity                              1,675           6             1,681

    Note (i): Holiday pay provision
    IAS 19 'Employee Benefits' requires the creation of an accrued holiday pay provision. This was not required under UK GAAP.  

    Note (ii): Goodwill amortisation
    Under FRS 9 goodwill arising on associates was subject to amortisation but under IFRS goodwill arising on the associates is not
amortised, but instead is subject to annual impairment reviews.

    Note (iii): Retained earnings
    The impact of (i) is a charge to retained earnings of £10110 and (ii) is a credit to retained earnings of £15,802 at the 30 September
2007. This gives a net credit of £5,692.

    Reconciliation of consolidated income statement for six months ended 31 March 2007

                                                        Effect of   Unaudited IFRS 
                                            Unaudited         IFRS     As restated 
                                              UK GAAP   Restatemen            £'000
                                                 £'000          t 
                                                             £'000
                                   Note
 Revenue                                             -           -                -
 Research and development costs     (i)          (341)           -            (341)
 Administrative costs            (i), (ii)       (996)         (1)            (997)
 Group operating loss                          (1,337)         (1)          (1,338)
 Share of operating loss in
 Associated undertaking                           (15)           7              (8)
 Finance income                                     42           -               42
 Loss before tax                               (1,310)           6          (1,304)
 Taxation                                            -           -                -
 Loss for the period
 attributable to equity holders                (1,310)           6          (1,304)
 of the Company

    Note (i): Holiday pay provision
    IAS 19 'Employee Benefits' requires the creation of an accrued holiday pay provision. This was not required under UK GAAP.  

    Note (ii): Goodwill amortisation
    Under FRS 9 goodwill arising on associates was subject to amortisation but under IFRS goodwill arising on the associates is not
amortised, but instead is subject to annual impairment reviews.

    Reconciliation of consolidated income statement for year ended 30 September 2007

                                                        Effect of   Unaudited IFRS 
                                            Unaudited         IFRS     As restated 
                                              UK GAAP   Restatemen            £'000
                                                 £'000          t 
                                                             £'000
                                   Note
 Revenue                                             -           -                -
 Research and development costs     (i)        (1,028)           -          (1,028)
 Administrative costs            (i), (ii)     (1,943)         (5)          (1,948)
 Group operating loss                          (2,971)         (5)          (2,976)
 Share of operating loss in
 Associated undertaking                           (59)          16             (43)
 Finance income                                     84           -               84
 Loss before tax                               (2,946)          11          (2,935)
 Taxation                                           93           -               93
 Loss for the period
 attributable to equity holders                (2,853)          11          (2,842)
 of the Company

    Note (i): Holiday pay provision
    IAS 19 'Employee Benefits' requires the creation of an accrued holiday pay provision. This was not required under UK GAAP.  

    Note (ii): Goodwill amortisation
    Under FRS 9 goodwill arising on associates was subject to amortisation but under IFRS goodwill arising on the associates is not
amortised, but instead is subject to annual impairment reviews.

    7.    TAX NOTE

    The company has a corporation tax credit in relation to research and development claims of £231,000 in the six month period to 31 March
2008 (six month to March 2007:Nil, year to 31 September 2007 £93,000). 

    8.    COPIES OF INTERIM ACCOUNTS

    Copies of the Interim Results will be available from our website www.phynova.com or by written request to the Company's registered
office. A copy of the interims will be posted to all shareholders on the 30th of June 2008

This information is provided by RNS
The company news service from the London Stock Exchange
 
  END 
 
IR FKAKPABKDOAB

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