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BIOG Biotech Growth Trust (the) Plc

937.00
11.00 (1.19%)
26 Apr 2024 - Closed
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Biotech Growth Trust (the) Plc LSE:BIOG London Ordinary Share GB0000385517 ORD 25P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  11.00 1.19% 937.00 937.00 945.00 941.00 927.00 937.00 32,552 16:07:00
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
Unit Inv Tr, Closed-end Mgmt -32.42M -41.3M -1.0034 -9.34 385.66M

Biotech Grw Tst PLC Annual Financial Report

25/05/2017 1:24pm

UK Regulatory


 
TIDMBIOG 
 
LONDON STOCK EXCHANGE ANNOUNCEMENT 
 
                 Legal Entity Identifier 549300Z41EP32MI2DN29 
 
 
                         The Biotech Growth Trust PLC 
 
               Audited Results for the Year Ended 31 March 2017 
 
The Company's Annual Report will be posted to shareholders on 7 June 2017. 
Members of the public may obtain copies from Frostrow Capital LLP, 25 
Southampton Buildings, London WC2A 1AL or from the Company's website at: 
 
www.biotechgt.com 
 
 
The Company's Annual Report for the year ended 31 March 2017 has been submitted 
to the UK Listing Authority, and will shortly be available for inspection on 
the National Storage Mechanism (NSM): 
 
www.morningstar.co.uk/uk/nsm 
 
(Documents will usually be available for inspection within two business days of 
this notice being given) 
 
 
Mark Pope, Frostrow Capital LLP, Company Secretary - 0203 008 4913 
 
25 May 2017 
 
 
 
Strategic Report / Company Performance 
 
Historic Performance Record for the years ended 31 March 
 
                                       2012    2013    2014    2015     2016    2017 
 
Net asset value per share             34.9%   48.1%   34.2%   67.4%  (24.8%)   27.5% 
performance 
 
Share price performance               42.2%   55.9%   26.9%   69.9%  (26.3%)   27.9% 
 
Benchmark performance                 23.6%   37.2%   34.7%   63.7%  (21.8%)   29.2% 
 
Net asset value per share            250.9p  371.7p  498.7p  834.7p   627.9p  800.8p 
 
Share price                          236.0p  368.0p  467.0p  793.5p   585.0p  748.0p 
 
Discount of share price to net         5.9%    1.0%    6.4%    4.9%     6.8%    6.6% 
asset value per share 
 
Ongoing charges*                       1.3%    1.3%    1.2%    1.2%     1.0%    1.1% 
 
Gearing*                                Nil     Nil    8.3%    9.4%    11.1%    3.2% 
 
*          See glossary. 
 
Strategic Report / Chairman's Statement 
 
Investment performance 
 
Your Company produced a good return in absolute terms for the year ended 31 
March 2017. The Company's net asset value per share rose by 27.5% during the 
year, which compares with the Company's benchmark, the NASDAQ Biotechnology 
Index (sterling adjusted), which rose by 29.2%. As this shows, the 
biotechnology sector performed well over the year in review, and in line with 
the broader U.S. stock market. Part of the performance reflects sterling's 
decline against other major currencies and in particular the U.S. dollar, which 
is the currency in which almost all the Company's holdings are denominated. 
Sterling fell 13.0% over the year. 
 
The Company's share price rose by 27.9%, a little more than the net asset 
value, reflecting a slight narrowing in the discount of the share price to net 
asset value per share, from 6.8% at the start of the Company's year, to 6.6% at 
31 March 2017. 
 
This was a year in which "macro" factors played a more significant part in 
performance than individual stock selection. The Biotechnology sector 
experienced considerable volatility during the long-running primary and 
Presidential campaigns in the U.S., running up to the election in November 
2016. Uncertainty persisted over both who might win the election and what 
policies the winner would adopt. Ultimately, the result was seen as positive 
for the market and in the case of the biotechnology sector, the rally already 
in train from the depressed levels in early 2016 was extended. 
 
The other principal "macro" factor affecting performance was the decline in 
sterling as noted above and in the Company's half year report, following the 
UK's referendum vote to leave the European Union. 
 
Looking at the contribution to performance from individual stocks, the 
Company's positive performance during the year was due in part to the holdings 
in Incyte, Celgene and Biogen. Negative performance came from holdings in Impax 
Laboratories, Achillion Pharmaceuticals and Shire. Further information on the 
Company's investments can be found in the Portfolio Manager's Review. 
 
I note that the Company underperformed its benchmark slightly despite the high 
absolute return. This was principally due to individual stock selection over 
the course of the year. 
 
Over the longer term, the Company's performance continues to remain strong, 
both on an absolute and relative basis. In the five-year period to 31 March 
2017, the Company's net asset value per share rose by 219.1% and the share 
price by 217.0%, both outperforming the Company's benchmark, which rose by 
205.5%. 
 
Capital structure 
 
The Board has continued to implement its policy of active discount management 
and to buy back shares when the discount of the share price against the net 
asset value per share is greater than 6%. During the year, a total of 4,455,561 
shares were repurchased by the Company at an average discount of 7.0% and at a 
cost of GBP29.7m (including expenses). Since the year-end, to the date of this 
report, no further shares have been repurchased by the Company. 
 
Return and dividend 
 
The total return per share amounted to 171.5p for the year (2016: loss of 
208.1p), comprising a revenue gain of 1.6p per share (2016: 1.3p) and a capital 
gain of 169.9p (2016: loss of 209.4p). No dividend is recommended in respect of 
the year ended 31 March 2017 (2016: nil). 
 
Board composition 
 
The process of refreshment of the Board has continued. As reported at the half 
year stage, one addition was made during the year with Julia Le Blan joining 
the Board on 12 July 2016. 
 
Julia is a Chartered Accountant and has worked in the financial services 
industry for over 30 years. She was formerly a tax partner at Deloitte and sat 
for two terms on the AIC's Technical Committee. We are pleased to have someone 
of her calibre and experience join the Board. She will succeed Peter Keen as 
Chairman of the Audit Committee upon his retirement. 
 
Peter Keen will be retiring from the Board at the conclusion of this year's 
Annual General Meeting. Peter has been a Director since the launch of the 
Company in 1997 and Chairman of the Audit Committee since 2005. His extensive 
knowledge of the biotechnology sector and his wise counsel will be greatly 
missed. 
 
As I said in the half-year report in November, I was honoured to succeed the Rt 
Hon Lord Waldegrave of North Hill as Chairman in July last year. Like Peter 
Keen, William had been a Director since the early days of the Company and with 
Peter's retirement in July this year there will now no longer be any of the 
original Directors on the Board. To William, Peter and all the original 
Directors, all shareholders owe a great debt of gratitude, not least for having 
had the wisdom to appoint OrbiMed as the Company's Portfolio Manager. Since 
that moment 12 years ago, the growth in the Company's net asset value per share 
has been 704.0%, comfortably ahead of the sterling adjusted NASDAQ 
Biotechnology Index. 
 
Outlook 
 
Despite continued uncertainty over drug pricing and also ongoing political 
concerns, our Portfolio Manager believes that the biotechnology sector is 
well-positioned for outperformance driven principally by merger and acquisition 
activity, current depressed valuations and sustained innovation. Their focus 
remains on the selection of stocks with strong prospects for capital 
enhancement and your Board strongly believes that the long-term investor will 
be well rewarded. 
 
Annual General Meeting 
 
The Annual General Meeting of the Company this year will be held at the 
Barber-Surgeons' Hall, Monkwell Square, Wood Street, London EC2Y 5BL on 
Wednesday, 12 July 2017 at 12 noon and we hope as many shareholders as possible 
will attend. This will be an opportunity to meet the Board and to receive a 
presentation from our Portfolio Manager. Shareholders who are unable to attend 
are encouraged to return their forms of proxy to ensure their votes are 
represented. 
 
Andrew Joy 
Chairman 
 
25 May 2017 
 
 
 
 
Strategic Report / Investment Portfolio 
 
Investments held as at 31 March 2017 
 
Security                                            Country/    Fair value          % of 
                                                      Region         GBP'000   investments 
 
Celgene                                        United States        61,217          13.3 
 
Biogen                                         United States        53,702          11.6 
 
Incyte                                         United States        42,909           9.3 
 
Alexion Pharmaceuticals                        United States        38,734           8.4 
 
Vertex Pharmaceuticals                         United States        36,673           8.0 
 
Amgen                                          United States        23,198           5.0 
 
Illumina                                       United States        19,064           4.1 
 
DBV Technologies                                      France        14,446           3.1 
 
Regeneron Pharmaceuticals                      United States        11,979           2.6 
 
BioMarin Pharmaceutical                        United States        11,941           2.6 
 
Ten largest investments                                            313,863          68.0 
 
Dermira                                        United States        11,603           2.5 
 
GW Pharmaceuticals                            United Kingdom        10,562           2.3 
 
Aurinia Pharmaceuticals                               Canada        10,536           2.3 
 
Shire                                                 Jersey        10,325           2.3 
 
Gilead Sciences                                United States        10,264           2.2 
 
Ironwood Pharmaceuticals                       United States         9,676           2.1 
 
Actelion                                         Switzerland         8,398           1.8 
 
Aerie Pharmaceuticals                          United States         7,876           1.7 
 
Array BioPharma                                United States         7,829           1.7 
 
Jazz Pharmaceuticals                                 Ireland         6,847           1.5 
 
Twenty largest investments                                         407,779          88.4 
 
Alkermes                                             Ireland         6,782           1.5 
 
Tesaro                                         United States         5,808           1.2 
 
OrbiMed Asia Partners L.P. (unquoted)*              Far East         5,069           1.1 
 
Achillion Pharmaceuticals                      United States         4,788           1.0 
 
Minerva Neurosciences                          United States         4,562           1.0 
 
Xencor                                         United States         4,512           1.0 
 
Insys Therapeutics                             United States         3,646           0.8 
 
Puma Biotechnology                             United States         3,538           0.8 
 
Alnylam Pharmaceuticals                        United States         3,368           0.7 
 
Acadia Pharmaceuticals                         United States         3,081           0.7 
 
Thirty largest investments                                         452,933          98.2 
 
BeiGene                                       Cayman Islands         2,443           0.5 
 
Clearside Biomedical                           United States         1,898           0.4 
 
Infinity Pharmaceuticals                       United States         1,646           0.4 
 
Fluidigm                                       United States         1,568           0.3 
 
Sarepta Therapeutics                           United States           890           0.2 
 
Total investments                                                  461,378         100.0 
 
All of the above investments are equities unless otherwise stated. 
 
*               Partnership interest 
 
Portfolio Breakdown 
 
                                                                  Fair value          % of 
 
Investments                                                            GBP'000   investments 
 
Equities                                                             456,309          98.9 
 
Partnership interest (unquoted)                                        5,069           1.1 
 
Total investments                                                    461,378         100.0 
 
Strategic Report / Portfolio Manager's Review 
 
Performance review 
 
The Company's net asset value per share increased 27.5% during the year. This 
compares to a 29.2% increase in the Company's benchmark, the NASDAQ 
Biotechnology Index (NBI) (measured on a sterling adjusted basis). 
 
Incyte, Celgene, Biogen, Vertex Pharmaceuticals, and Amgen were the leading 
positive contributors to performance in the portfolio during the year. 
 
  * Shares in Incyte appreciated due to the announcement of a strategic 
    collaboration with Merck to advance the combination of epacadostat/ 
    pembrolizumab to phase III trials in four new tumour types. Full data from 
    the trial that supported this decision to advance the combination will be 
    presented in June at the American Society of Clinical Oncology meeting. 
  * Shares in Celgene outperformed due to multiple positive catalysts including 
    strong financial results, the approval of Revlimid in the maintenance 
    setting of multiple myeloma, and positive Phase III data for ozanimod in 
    multiple sclerosis. 
  * Shares in Vertex Pharmaceuticals appreciated due to the announcement of 
    positive Phase III data of tezacaftor and ivacaftor in cystic fibrosis. 
    Initial data suggests that this combination has a greater tolerance and a 
    slightly better efficacy profile compared to their marketed CF product, 
    Orkambi. Tezacafor/Ivacaftor is also being combined with additional 
    corrector drugs which may provide additional efficacy to patients; 
    preliminary data from the triple-combination regimens are expected later 
    this year. 
  * Shares in Amgen outperformed due to strong financial results and a 
    favourable court decision regarding its PCSK9 patents litigation against 
    Sanofi/Regeneron Pharmaceuticals. The decision is currently being appealed. 
    A final victory later this year could lead to the permanent removal of 
    Sanofi/Regeneron's competing drug from the market. 
 
Impax Laboratories, Achillion Pharmaceuticals, Shire, Ono Pharmaceutical, and 
Gilead Sciences were the principal detractors. 
 
  * Shares in Impax Laboratories were weak due to disappointing quarterly 
    financial results and weak guidance. 
  * Shares in Achillion Pharmaceuticals underperformed due to an adverse safety 
    finding in the phase I study of its complement factor D program. However, 
    the company believes that it can achieve adequate efficacy with a lower 
    dose than previously planned. 
  * Shares in Shire underperformed due to investor concerns on upcoming 
    competition in the haemophilia market and a slower-than-expected launch of 
    Xiidra, a product for dry eye. 
  * Shares in Ono Pharmaceutical underperformed due to unexpected negative data 
    from a Phase III study of nivolumab in first-line lung cancer conducted by 
    its U.S. partner Bristol-Myers Squibb and investor concerns regarding a 
    potential government mandated cut in nivolumab's price in Japan. 
  * Shares in Gilead Sciences were weak due to negative sentiment after 
    hepatitis C sales and guidance missed investor expectations. 
 
Review of sector performance 
 
During the year, the portfolio and the broader biotechnology sector performed 
strongly, following a prior period of weakness largely caused by concerns over 
the sustainability of drug pricing in the U.S. These concerns persisted in the 
first half of the year, fuelled by Hillary Clinton's rhetoric on potential drug 
price regulation during the U.S. Election. Additionally, as we detailed in the 
previous report, the negative publicity of controversial pricing practices by 
some specialty pharmaceutical companies, such as Valeant and Mylan, caused 
worries among investors that enhanced scrutiny of pricing policies would spill 
over to the biotechnology sector, creating an overhang. The NBI remained down 
over 20% (in dollar terms) during the calendar year to early November. However, 
the unexpected election of Donald Trump as President and the Republican sweep 
in Congress caused an immediate positive reaction for biotechnology stocks, 
with the NBI index up 9% on the day following the election. Subsequently, Mr. 
Trump's public statements on drug pricing took on a more populist tone, 
including that drug companies "are getting away with murder" and that drug 
"pricing for the American people will come way down". The sector initially 
underperformed following these comments, but sentiment has improved as 
investors have concluded that actual legislation on drug pricing will be hard 
to enact, and the draft legislation for the repeal and replacement of the 
Affordable Care Act (ACA, or "Obamacare") did not contain significant proposals 
that would be considered hostile toward the pharmaceutical and biotechnology 
industries. 
 
Healthcare reform proving to be more difficult than expected 
 
In the past few years, the biotechnology sector has been a net beneficiary of 
Obamacare, as coverage expansion has increased drug utilisation. However, 
structural flaws in Obamacare have become evident, as lower than expected 
enrolment and a sicker patient pool have caused significant premium increases 
and large losses for insurance companies. This has prompted questions about the 
sustainability of the law and what can be done to fix the issues. Throughout 
the Obama administration, Republicans repeatedly advocated for the repeal of 
Obamacare. However, internal divisions within the party have delayed the 
process of repealing and replacing Obamacare. Importantly for biotechnology 
investors, the legislation ultimately passed in the House of Representatives 
made no mention of drug pricing reform, and in fact called for the removal of a 
tax on branded drug makers. At this time, the Senate is crafting its own 
legislation, and it is not clear how close the Senate version will be to the 
bill passed in the House. President Trump has suggested that drug pricing would 
be addressed at a later stage. However, the repeal and replace debate has 
highlighted the difficulty of passing new healthcare legislation. We believe 
there is not adequate Republican support in Congress to consider pricing 
reform, and that President Trump will pivot to other priorities where he may be 
more successful. 
 
New tax changes could be positive for the biotechnology sector 
 
Mr. Trump has also called for significant tax cuts, particularly for 
businesses. His initial proposal reduces the corporate tax rate to 15% from 
35%, and companies would pay little or no tax to the U.S. on foreign profits. 
While most biotechnology companies already enjoy lower effective tax rates 
given the multinational nature of the business and foreign domicile of 
intellectual property, a lower corporate tax as proposed will still benefit 
those that face high tax rates, such as Biogen and Regeneron in our portfolio. 
Tax reform is also expected to allow repatriation of cash that is held overseas 
at a low tax rate. As a result of current corporate tax laws, U.S. companies 
with international operations often hold cash overseas to avoid paying the top 
corporate tax rate of 35% on those foreign earnings. It is estimated that the 
eight U.S. major pharmaceutical and biotechnology companies collectively held 
over U.S.$130 billion in cash offshore at the end of 2016. This repatriation 
could fuel a new wave of merger & acquisition activity as this cash can be used 
to acquire U.S. emerging biotechnology companies. 
 
The regulatory climate is becoming more favourable for the industry 
 
President Trump has also pledged to streamline the drug approval process so 
effective drugs can reach patients more quickly. We see the recent appointment 
of Scott Gottlieb to head the U.S. Food & Drug Administration (FDA) as a 
positive development in that direction. Dr. Gottlieb has previously been 
critical of the FDA's "unreasonable hunger for statistical certainty" when 
reviewing orphan drugs and has advocated for modernising the generic drug 
framework to accommodate complex drugs, which could increase competition and 
potentially lower prices of off-patent drugs. We believe Dr. Gottlieb is a 
highly capable Commissioner who will take a more pragmatic approach to drug 
approvals. We would also highlight that the FDA continues to make progress 
expediting "breakthrough medicines" which allows more interaction between the 
agency and companies to speed the approval of new important medicines. Last 
year, 46 additional drugs received breakthrough designation, and nine drugs 
with this designation were approved. 
 
Innovation continues 
 
Drug approvals and pipeline progress will continue to be major themes for 
investment in the sector. Within the portfolio, there have been a number of 
promising new drugs recently approved including Biogen's Spinraza for spinal 
muscular atrophy (SMA) and Biomarin Pharmaceuticals' Brineura for Batten 
disease. These new drugs have shown profound benefits in the treatment of 
serious diseases lacking adequate treatment options. For example, Spinraza, the 
first-ever treatment for spinal muscular atrophy approved by the FDA, 
significantly improved the motor function and survival of young children with 
SMA who would otherwise have experienced rapid disease progression and high 
mortality. Thus far, the launch has been impressive. Biomarin's Brineura was 
recently approved for the treatment of Batten disease, a rare neurodegenerative 
disorder in children. Clinical data shows that Brineura nearly halts the 
progression of the disease. 
 
2017 is poised to be a landmark year for biotechnology drug development, as we 
should see the first U.S. approvals of two new classes of therapy: gene therapy 
and CAR-T cell therapy. We expect approval of Spark Therapeutics' gene therapy 
to treat a rare inherited form of blindness. We also expect approval of two 
CAR-T therapies (T-cells that are genetically modified to fight cancer), from 
Kite Pharma and Novartis. These new treatment modalities allow drug developers 
to address targets and diseases that are not easily treatable by more 
conventional means. We expect considerable advancement of these methods in the 
coming years as many biotechnology companies apply these technologies to create 
new therapeutics. 
 
We have previously highlighted the next wave of immuno-oncology (IO) as the 
development of combination regimens that further stimulate the immune response 
against cancer. This year, we are pleased to see significant progress in this 
field, particularly with portfolio company Incyte announcing expanded strategic 
collaborations with both Merck and Bristol-Myers to develop the combination of 
epacadostat, Incyte's investigational oral selective IDO1 enzyme inhibitor, 
with anti-PD1 therapy. These phase III trials will test epacadostat/PD-1 in 
non-small cell lung cancer, bladder cancer, head and neck cancer and renal cell 
cancer, in addition to melanoma that has been previously announced. We believe 
the strategic decisions made by Incyte and partners to move research into this 
type of therapy forward were based on solid clinical data from the phase II 
studies, which suggests IDO/PD1 has emerged as a very promising combination 
with broad activity as a next generation immunotherapy. We look forward to more 
data from Incyte's epacadostat/PD1 and other IO combos to further establish the 
future cancer treatment landscape. We continue to believe immuno-oncology 
combinations will be a major area of investor interest this year. 
 
 
Sven Borho 
OrbiMed Capital LLC, Portfolio Manager 
 
25 May 2017 
 
 
Principal contributors to and detractors from net asset value performance 
 
                                                               Contribution 
                                                                for year to  Contribution 
                                                              31 March 2017     per share 
 
Top five contributors                                                 GBP'000      (pence)* 
 
Incyte                                                               25,959          45.3 
 
Celgene                                                              15,875          27.7 
 
Biogen                                                               15,592          27.2 
 
Vertex Pharmaceuticals                                               13,837          24.1 
 
Amgen                                                                12,756          22.3 
 
                                                                     84,019         146.6 
 
Top five detractors 
 
Impax Laboratories?                                                 (4,943)         (8.6) 
 
Achillion Pharmaceuticals                                           (4,801)         (8.4) 
 
Shire                                                               (3,447)         (6.0) 
 
Ono Pharmaceutical?                                                 (3,446)         (6.0) 
 
Gilead Sciences                                                     (2,632)         (4.6) 
 
                                                                   (19,269)        (33.6) 
 
*          based on 57,315,305 ordinary shares being the weighted average 
number of shares in issue for the year ended 31 March 2017 
 
?          not held in the portfolio at 31 March 2017 
 
Strategic Report / Business Review 
 
The aim of the Strategic Report is to provide shareholders with the ability to 
assess how the Directors have performed their duty to promote the success of 
the Company during the year under review. 
 
Structure and objective of the Company 
 
The Biotech Growth Trust PLC is an investment trust and has a premium listing 
on the London Stock Exchange. Its investment objective is set out below. In 
seeking to achieve this objective, the Company employs Frostrow Capital LLP 
(Frostrow) as its Alternative Investment Fund Manager (AIFM), OrbiMed Capital 
LLC (OrbiMed) as its Portfolio Manager, J.P. Morgan Europe Limited as its 
Depositary and J.P. Morgan Clearing Corp. as its Prime Broker and Custodian. 
Further details about their appointments can be found in the Report of the 
Directors. The Board has determined an investment policy and related guidelines 
and limits, as described below. 
 
The Company is subject to UK and European legislation and regulations including 
UK company law, International Financial Reporting Standards, the Alternative 
Investment Fund Managers Directive, the UK Listing, Prospectus, Disclosure 
Guidance and Transparency Rules, taxation law and the Company's own Articles of 
Association. 
 
The Company is an investment company within the meaning of Section 833 of the 
Companies Act 2006 and has been approved by HM Revenue & Customs as an 
investment trust (for the purposes of Sections 1158 and 1159 of the Corporation 
Tax Act 2010). As a result, the Company is not liable for taxation on capital 
gains. The Directors have no reason to believe that approval will not continue 
to be retained. The Company is not a close company for taxation purposes. 
 
Investment objective and policy 
 
To seek capital appreciation through investment in the worldwide biotechnology 
industry. In order to achieve its investment objective, the Company invests in 
a diversified portfolio of shares and related securities in biotechnology 
companies on a worldwide basis. Performance is measured against the NASDAQ 
Biotechnology Index (sterling adjusted) (the Benchmark). 
 
Investment strategy 
 
The implementation of the Company's Investment Objective has been delegated to 
OrbiMed by Frostrow (as AIFM) under the Board's and Frostrow's supervision and 
guidance. 
 
Details of OrbiMed's investment strategy and approach are set out in the 
Portfolio Manager's review. While performance is measured against the Company's 
Benchmark, Frostrow and OrbiMed have been given the ability to manage the 
portfolio without regard to the Benchmark and its make-up. 
 
While the Board's strategy is to allow flexibility in managing the investments, 
in order to manage investment risk it has imposed various investment, gearing 
and derivative guidelines and limits, within which Frostrow and OrbiMed are 
required to manage the investments, as set out below. 
 
Any material changes to the investment Objective, Policy and Benchmark or the 
investment and gearing guidelines and limits require approval from 
shareholders. 
 
Investment limits and guidelines 
 
The Board seeks to manage the Company's risk by imposing various investment 
limits and restrictions as follows: 
 
  * The Company will not invest more than 10%, in aggregate, of the value of 
    its gross assets in other closed ended investment companies (including 
    investment trusts) listed on the London Stock Exchange, except where the 
    investment companies themselves have stated investment policies to invest 
    no more than 15% of their gross assets in other closed ended investment 
    companies (including investment trusts) listed on the London Stock 
    Exchange. 
  * The Company will not invest more than 15%, in aggregate, of the value of 
    its gross assets in other closed ended investment companies (including 
    investment trusts) listed on the London Stock Exchange. 
  * The Company will not invest more than 15% of the value of its gross assets 
    in any one individual stock at the time of acquisition. 
  * The Company will not invest more than 10% of the value of its gross assets 
    in direct unquoted investments at the time of acquisition. This limit does 
    not include any investment in private equity funds managed by the Portfolio 
    Manager or any affiliates of such entity. 
  * The Company may invest or commit for investment a maximum of U.S.$15 
    million, after the deduction of proceeds of disposal and other returns of 
    capital, in private equity funds managed by OrbiMed, the Company's 
    Portfolio Manager, or an affiliate thereof. 
  * The Company's borrowing policy is that borrowing will not exceed 20% of the 
    Company's net assets. The Company's borrowing requirements are met through 
    the utilisation of an overdraft facility, repayable on demand and provided 
    by J.P. Morgan Clearing Corp. This facility can be drawn at the discretion 
    of the AIFM. 
  * The Company may be unable to invest directly in certain countries. In these 
    circumstances, the Company may gain exposure to companies in such countries 
    by investing indirectly through swaps. Where the Company invests in swaps, 
    exposure to underlying assets will not exceed 5% of the gross assets of the 
    Company at the time of entering into the contract. 
 
In accordance with the requirements of the UK Listing Authority, any material 
change to the investment policy will only be made with the approval of 
shareholders by ordinary resolution. 
 
Dividend policy 
 
The Company invests with the objective of achieving capital growth and it is 
expected that dividends, if any, are likely to be small. The Board intends only 
to pay dividends on the Company's shares to the extent required in order to 
maintain the Company's investment trust status. 
 
Continuation of the Company 
 
An opportunity to vote on the continuation of the Company is given to 
shareholders every five years. The next such continuation vote will be held at 
the Annual General Meeting in 2020. 
 
Company promotion 
 
The Company has appointed Frostrow to provide marketing and investor relations 
services, in the belief that a well-marketed investment company is more likely 
to grow over time, have a more diverse, stable list of shareholders and its 
shares will trade at close to net asset value per share over the long run. 
Frostrow actively promotes the Company in the following ways: 
 
Engaging regularly with institutional investors, discretionary wealth managers 
and a range of execution-only platforms: Frostrow regularly meets with 
institutional investors, discretionary wealth managers and execution-only 
platform providers to discuss the Company's strategy and to understand any 
issues and concerns, covering both investment and corporate governance matters; 
 
Making Company information more accessible: Frostrow works to raise the profile 
of the Company by targeting key groups within the investment community, holding 
periodic investment seminars, overseeing PR output and managing the Company's 
website and wider digital offering, including Portfolio Manager videos and 
social media; 
 
Disseminating key Company information: Frostrow performs the Investor Relations 
function on behalf of the Company and manages the investor database. Frostrow 
produces all key corporate documents, distributes Monthly Factsheets, Annual 
Reports and updates from OrbiMed on the portfolio and market developments; and 
 
Monitoring market activity, acting as a link between the Company, shareholders 
and other stakeholders: Frostrow maintains regular contact with sector Broker 
Analysts and other research and data providers, and conducts periodic investor 
perception surveys, liaising with the Board to provide up-to-date and accurate 
information on the latest shareholder and market developments. 
 
Key performance indicators 
 
Net asset value return 
 
The Directors regard the Company's net asset value total return as being the 
overall measure of value delivered to shareholders over the long term. Total 
return reflects the net asset value growth of the Company. OrbiMed's investment 
style is such that performance is likely to deviate from that of the benchmark 
index. The Board considers the most important comparator to be the NASDAQ 
Biotechnology Index (sterling adjusted). 
 
During the year under review the Company's net asset value per share return was 
+27.5% underperforming the benchmark by 1.7%. 
 
A full description of performance during the year under review and the 
investment portfolio is contained in the Portfolio Manager's Review. 
 
Share price return 
 
The Directors also regard the Company's share price return to be a key 
indicator of performance. This is monitored closely by the Board. 
 
During the year under review the Company's share price return was +27.9%. 
 
Share price discount/premium to net asset value per share 
 
The Board undertakes a regular review of the level of discount/premium and 
consideration is given to ways in which share price performance may be 
enhanced, including the effectiveness of marketing and share issuance and 
buy-backs, where appropriate. The Board has a discount control mechanism in 
place intended to establish a target level of no more than a 6% discount of 
share price to the net asset value per share. Shareholders should note, 
however, that it remains possible for the share price discount to net asset 
value per share to be greater than 6% on any one day due to the fact that the 
share price continues to be influenced by overall supply and demand for the 
Company's shares in the secondary market. The volatility of the net asset value 
per share in an asset class such as biotechnology is another factor over which 
the Board has no control. The making and timing of any share buy-backs or share 
issuance is at the absolute discretion of the Board. 
 
During the year under review a total of 4,455,561 shares were repurchased by 
the Company for cancellation. 
 
The discount of the Company's share price to the net asset value per share at 
31 March 2017 stood at 6.6% (2016: 6.8%). 
 
Ongoing charges ratio 
 
The Board continues to be conscious of expenses and works hard to maintain a 
sensible balance between strong service and costs. 
 
As at 31 March 2017 the ongoing charges ratio was 1.1% calculated by taking the 
operating expenses of the Company divided by the average assets of GBP419.2m 
(2016: 1.0% (average assets of GBP474.6m)). 
 
(See glossary for further details). 
 
Board diversity 
 
The Board is supportive of the recommendations of Lord Davies's report that the 
performance of corporate boards can be improved by encouraging the appointment 
of the best people from a range of differing perspectives and backgrounds. The 
Company recognises the benefits of diversity on the Board, including gender, 
and takes this into account in its Board appointments. The Company is committed 
to ensuring that any Director search process actively seeks persons with the 
right qualifications so that appointments can be made, on the basis of merit, 
against objective criteria from a diverse selection of candidates. To this end 
the Board will dedicate time to considering diversity during any Director 
search process and keep in mind that the Davies Review of Women on Boards 
recommended that UK Listed Companies in the FTSE 100 should be aiming for a 
minimum of 25% of females on the Board. 
 
                                                                       Male        Female 
 
Directors of the Company                                                  5             2 
 
The Company does not have any employees. Therefore there is no employee 
information to disclose. 
 
Social, economic and environmental matters 
 
The Directors, through the Company's Portfolio Manager, encourage companies in 
which investments are made to adhere to best practice with regard to corporate 
governance. In light of the nature of the Company's business there are no 
relevant human rights issues and the Company does not have a human rights 
policy. 
 
The Company recognises that social and environmental issues can have an effect 
on some of its investee companies. 
 
The Company is an investment trust and so its own direct environmental impact 
is minimal. The Board of Directors consists of seven Directors, six of whom are 
resident in the UK and one resident in the United States. The Board holds the 
majority of its regular meetings in the United Kingdom and has a policy that 
travel, as far as possible, is minimal, thereby minimising the Company's 
greenhouse gas emissions. Further details concerning greenhouse gas emissions 
can be found within the Report of the Directors. 
 
Principal risks 
 
The Directors confirm that they have carried out a thorough assessment of the 
principal risks facing the Company, including those that would threaten its 
business model, future performance, solvency or liquidity. The risks identified 
and the ways in which they are managed or mitigated are summarised below. 
 
With the assistance of Frostrow, the Audit Committee has drawn up a risk 
matrix, which identifies the key risks to the Company. These are reviewed and 
noted on a regular basis. These key risks fall broadly under the following 
categories: 
 
Principal Risks and          Management/Mitigation 
Uncertainties 
 
Objective and strategy       The Board reviews regularly the Company's investment 
The Company becomes          objective and investment guidelines in the light of investor 
unattractive to investors.   sentiment monitoring closely whether the Company should 
                             continue in its present form. The Board also considers the 
                             size of the Company to ensure that it is at an optimum level. 
                             The Board, through the AIFM and the Portfolio Manager, holds 
                             regular discussions with major shareholders. Each month the 
                             Board receives a report which monitors the investments held 
                             in the portfolio compared against the benchmark index and the 
                             investment guidelines. Additional reports and presentations 
                             are regularly presented to investors by the Company's AIFM 
                             and Portfolio Manager. 
 
Volatility and level of      The Board undertakes a regular review of the level of 
discount/premium             discount/premium and consideration is given to ways in which 
The risk of the Company's    share price performance may be enhanced, including the 
share price not being        effectiveness of marketing and investor relations services 
representative of its        and also share issuance and buy-backs, if considered 
underlying net assets.       appropriate. The Board has an active discount management 
                             policy in place, buying back the Company's shares for 
                             cancellation if the market price is at a discount greater 
                             than 6% to the net asset value per share. The making and 
                             timing of any share issuance or buy-backs is at the absolute 
                             discretion of the Board. 
                             Shareholders should note, however, that it remains possible 
                             for the share price discount to the net asset value per share 
                             to be greater than 6% on any one day. This is due to the fact 
                             that the share price continues to be influenced by overall 
                             supply and demand for the Company's shares in the secondary 
                             market. The volatility of the net asset value per share in an 
                             asset class such as healthcare is another factor over which 
                             the Board has no control. 
 
Portfolio performance        The Board reviews regularly investment performance against 
Investment performance may   the benchmark and against the Company's peer group. The Board 
not be meeting shareholder   also receives regular reports that show an analysis of 
requirements.                performance compared to other relevant indices. The Portfolio 
                             Manager provides an explanation of significant stock 
                             selection decisions and an overall rationale for the make-up 
                             of the portfolio. The Portfolio Manager discusses current and 
                             potential investment holdings with the Board on a regular 
                             basis. 
 
Investment management key    The Board manage this risk by: 
person risk 
The risk that the 
individual(s) responsible 
for managing the Company's 
portfolio may leave their 
employment or may be 
prevented from undertaking 
their duties. 
 
Operational and regulatory   All transactions and income and expenditure forecasts are 
A breach of Sections 1158    reviewed by the Board at each Board Meeting. The Board 
and 1159 of the              considers regularly all major risks, the measures in place to 
Corporation Tax Act 2010     control them and the possibility of any other risks that 
could lead to the Company    could arise. The Board also ensures that satisfactory 
being subject to tax on      assurances are received from service providers. 
capital gains, whilst a      The Audit Committee has reviewed the cyber security policies 
serious breach of other      for the Company's principal services providers. 
regulatory rules             The Compliance Officer of the AIFM and of the Portfolio 
(including those             Manager produce regular reports for review at the Company's 
associated with the          Audit Committee meetings and are available to attend such 
Alternative Investment       meetings in person if required. 
Fund Managers Directive) 
may lead to suspension 
from the Stock Exchange or 
to a qualified Audit 
Report. Other control 
failures, including cyber 
crime, relating to the 
AIFM, the Portfolio 
Manager or any other of 
the Company's service 
providers, may result in 
operational and/or 
reputational problems, 
erroneous disclosures or 
loss of assets through 
fraud, as well as breaches 
of regulations. 
 
Market price risk            The Portfolio Manager has responsibility for selecting 
Uncertainty about future     investments in accordance with the Company's investment 
prices of financial          objective and policy and seeks to ensure that investment in 
instruments held.            individual stocks falls within acceptable risk levels. 
                             Compliance with the limits and guidelines contained in the 
                             Company's investment policy is monitored daily by Frostrow 
                             and OrbiMed and reported to the Board monthly. 
 
Liquidity risk               The Portfolio Manager has constructed the portfolio so that 
Ability to meet funding      funds can be raised at short notice if required. 
requirements when they 
arise. 
 
Shareholder profile          The AIFM provides a shareholder analysis at every Board 
Activist shareholders        meeting so that the Board can give consideration as to any 
whose interests are not      action required; this is in addition to regular reporting by 
consistent with the          the Company's Stockbroker. The Board has implemented an 
long-term objectives of      active discount management policy. 
the Company may be 
attracted onto the 
shareholder register. 
 
Currency risk                A significant proportion of the Company's assets is, and will 
Movements in exchange        continue to be, invested in securities denominated in foreign 
rates could adversely        currencies, in particular U.S. dollars. As the Company's 
affect the sterling          shares are denominated and traded in sterling, the return to 
performance of the           shareholders will be affected by changes in the value of 
portfolio.                   sterling relative to those foreign currencies. The Board has 
                             made clear the Company's position with regard to currency 
                             fluctuations which is that it does not currently hedge 
                             against currency exposure. 
 
Overdraft facility           The Board, the AIFM and the Portfolio Manager are kept fully 
The provider of the          informed of any likelihood of the withdrawal of the overdraft 
Company's overdraft          facility so that repayment can be effected in an orderly 
facility may no longer be    fashion. 
prepared to lend to the      The Company's borrowing requirements are met through the 
Company.                     utilisation of an overdraft facility, repayable on demand, 
                             provided by J.P. Morgan Clearing Corp. 
 
Credit risk                  The most significant counterparty the Company is exposed to 
The Company is exposed to    is J.P. Morgan Clearing Corp (the Company's Prime Broker) 
credit risk arising from     which is responsible for the safekeeping of the Company's 
the use of counterparties.   assets and provides the overdraft facility to the Company. As 
If a counterparty were to    part of the arrangements with J.P. Morgan Clearing Corp they 
fail, the Company could be   may take assets, up to 140% of the value of the drawn 
adversely affected through   overdraft, as collateral. Such assets taken as collateral by 
either a delay in            J.P. Morgan Clearing Corp may be used, loaned, sold, 
settlement or a loss of      rehypothecated or transferred. J.P. Morgan Clearing Corp is a 
assets.                      registered broker-dealer and is accordingly subject to limits 
                             on rehypothecation, in particular limitations set out in U.S. 
                             Securities and Exchange Commission Rule 15c3-3. In the event 
                             of J.P. Morgan Clearing Corp's insolvency, the Company may be 
                             unable to recover in full assets held by the J.P. Morgan 
                             Clearing Corp as Custodian. 
                             This risk is managed through the selection of a financially 
                             strong counterparty, through limitations on the use of 
                             gearing and through reliance on a robust regulatory regime 
                             (SEC). Furthermore, the external Auditor verifies the 
                             safekeeping of the assets or their equivalent by confirmation 
                             from the Depositary/Prime Broker. 
                             Further information on financial instruments and risk, as 
                             required by IFRS 7, can be found in note 13 to the financial 
                             statements. 
 
Long term viability 
 
The Board has carried out a robust assessment of the principal risks facing the 
Company including those that would threaten its business model, future 
performance, solvency or liquidity. The Board has drawn up a matrix of risks 
facing the Company and has put in place a schedule of investment limits and 
restrictions, appropriate to the Company's investment objective and policy, in 
order to mitigate these risks as far as practicable. 
 
Previously, the Board considered it appropriate to assess the Company's 
viability over rolling three-year time horizons. However, the Board now 
believes it to be more appropriate to make this assessment over a five-year 
period. This basis is deemed more appropriate due to our Portfolio Manager's 
long-term investment horizon and also what we believe to be investors' 
horizons, taking account of the Company's current position and the potential 
impact of the principal risks and uncertainties. 
 
The Directors also took into account the liquidity of the portfolio when 
considering the viability of the Company over a five-year period and its 
ability to meet liabilities as they fall due. In addition, the Board has noted 
that an opportunity to vote on the continuation of the Company is given to 
shareholders every five years. The next such continuation vote will be held at 
the Annual General Meeting in 2020. 
 
The Directors do not expect there to be any significant change in the principal 
risks that have been identified and the adequacy of the mitigating controls in 
place. Also the Directors do not envisage any change in strategy or objectives 
or any events that would prevent the Company from continuing to operate over 
that period as the Company's assets are liquid, its commitments are limited and 
the Company intends to continue to operate as an investment trust. The 
Directors believe that only a substantial financial crisis affecting the global 
economy and causing substantial falls in share prices could have an impact on 
this assessment. 
 
Based on this assessment, the Directors have a reasonable expectation that the 
Company will be able to continue in operation and meet its liabilities as they 
fall due over the next five-year period. 
 
Looking to the future 
 
The Board concentrates its attention on the Company's investment performance 
and OrbiMed's investment approach and on factors that may have an effect on 
this approach. Marketing reports are given to the Board at each Board meeting 
by the AIFM which include how the Company will be promoted and details of 
planned communications with existing and potential shareholders. The Board is 
regularly updated by the AIFM on wider investment trust industry issues and 
discussions are held at each Board meeting concerning the Company's future 
development and strategy. 
 
A review of the Company's year, its performance since the year-end and the 
outlook for the Company can be found in the Chairman's Statement and in the 
Portfolio Manager's Review. 
 
By order of the Board 
 
Frostrow Capital LLP 
Company Secretary 
 
25 May 2017 
 
 
 
Governance / Board of Directors 
 
Andrew Joy 
(Chairman of the Board and also Chairman of the Nominations Committee) 
A Director since 2012 
Seeks annual re-election by shareholders 
 
Andrew was one of the founding Partners of Cinven, a leading private equity 
firm investing in Europe and the U.S. He is a Senior Advisor of Stonehage 
Fleming Group and Chairman of the investment committee of FPE Capital. He has 
been Chairman or Director of numerous growing companies over the past 30 years. 
He is a former Chairman of the BVCA (British Venture Capital and Private Equity 
Association) and Director of the EVCA. 
 
Shareholding in the Company: 55,000 
 
Sven Borho 
A Director since 2006 
Seeks annual re-election by shareholders 
 
Sven is a founding Partner of OrbiMed, the Company's Portfolio Manager. He 
heads the public equity team and is the portfolio manager for OrbiMed's public 
equity and hedge funds. Sven has played an integral role in the growth of 
OrbiMed's asset management activities. In 1991 he joined OrbiMed's predecessor 
and was promoted to portfolio manager in 1993. He studied business 
administration at Bayreuth University in Germany and received a M.Sc. (Econs.), 
Accounting and Finance, from The London School of Economics. 
 
Shareholding in the Company: 236,218 
 
Peter Keen 
(Chairman of the Audit Committee) 
A Director since 1997 
Seeks annual re-election by shareholders 
 
A Chartered Accountant, Peter has over 30 years' experience in the management 
and financing of life science businesses and has served on the boards of many 
private and public companies. Peter is a Director of MRC Technology Ltd and 
Endomagnetics Limited and was previously Chief Executive of the technology 
investment firm Cambridge Innovation Capital plc. For nine years he was the 
Senior Independent Director of Abcam plc and was a co-founder of Chiroscience 
Group plc. 
 
Shareholding in the Company: 55,000 
 
Steven Bates 
(Chairman of the Management Engagement Committee) 
A Director since 2015 
Seeks annual re-election by shareholders 
 
Steven is chairman of F&C Capital and Income Investment Trust plc, Baring 
Emerging Europe plc and the Vinacapital Vietnam Opportunity Fund Limited. He is 
a non-executive director of British Empire Trust plc and is also a director of 
Guard Cap Asset Management Limited. He sits on, or is advisor to, various 
committees in the wealth management and pension fund areas. He was head of 
global emerging markets at J.P. Morgan Asset Management until 2002. 
 
Shareholding in the Company: Nil 
 
Professor Dame Kay Davies, CBE 
(Chairman of the Remuneration Committee and Senior Independent Director) 
A Director since 2012 
Seeks annual re-election by shareholders 
 
Professor Dame Kay Davies is the Dr. Lee's Professor of Anatomy and Associate 
Head of the Medical Sciences Division at the University of Oxford and a fellow 
of Hertford College. She is also Co-Director of the Oxford Neuromuscular 
Centre, an Independent Director of UCB Pharma S.A, Deputy Chairman of the 
Wellcome Trust and a member of the Scientific Advisory Board of 
biopharmaceutical company UCB Pharma S.A. As part of her role as Deputy 
Chairman of the Wellcome Trust she serves on the GRL Board (Sanger Institute) 
and the Genome England Board (NHS). 
 
Shareholding in the Company: 3,500 
 
The Rt Hon Lord Willetts 
A Director since 2015 
Seeks annual re-election by shareholders 
 
Lord Willetts is Executive Chairman of the Resolution Foundation and a Visiting 
Professor at King's College London. He is also a Governor of the Ditchley 
Foundation, a member of the Council of the Institute for Fiscal Studies and a 
Board member of the Francis Crick Institute and of the Biotech Industry 
Association. 
 
He was Minister for Universities and Science, attending Cabinet, from 
2010-2014. He was the Member of Parliament for Havant from 1992-2015. Before 
that, Lord Willetts worked at HM Treasury and the Number 10 Policy Unit. He 
also served as Paymaster General in the last Conservative Government. 
 
Shareholding in the Company: Nil 
 
Julia Le Blan 
A Director since July 2016 
Seeks annual re-election by shareholders 
 
A Chartered Accountant Julia has worked in the financial services industry for 
over 30 years. She was formerly a tax partner at Deloitte and sat for two terms 
on the AIC's technical committee. 
 
She is a non-executive Director of F&C UK High Income Trust plc, Impax 
Environmental Markets plc, J.P. Morgan US Smaller Companies Investment Trust 
plc and Aberforth Smaller Companies Trust plc. 
 
Shareholding in the Company: 4,000 
 
Meeting attendance 
 
The table below sets out the number of scheduled Board and Committee meetings 
held during the year ended 31 March 2017 and the number of meetings attended by 
each Director. 
 
                                     Management      Board  Audit and Nominations Remuneration 
                                     Engagement            Management   Committee    Committee 
                                     Committee*            Engagement 
                                                            Committee 
 
Number of meetings held in 2016/17:           1          4          2           1            1 
 
The Rt Hon Lord Waldegrave of North           -          2          1           -            - 
Hill? 
 
Steven Bates                                  1          4          2           1            1 
 
Sven Borho^                                   -          4          -           -            - 
 
Professor Dame Kay Davies, CBE                1          4          2           1            1 
 
Andrew Joy                                    1          4          2           1            1 
 
Peter Keen                                    1          4          2           1            1 
 
Julia Le Blan**                               1          3          1           1            1 
 
The Rt Hon Lord Willetts                      1          4          2           1            1 
 
All of the serving Directors attended the Annual General Meeting held on 12 
July 2016. 
 
  * At a Board meeting held in November 2016 it was agreed to split the 'audit' 
    and 'management engagement' functions of the Audit and Management 
    Engagement Committee and to create two new committees to be responsible for 
    these areas. The newly constituted Audit Committee did not meet during the 
    year. However, the Audit and Management Engagement Committee met twice. 
 
?          Retired on 12 July 2016. 
 
^          Sven Borho is not a member of any of the Company's committees. 
 
**         Appointed on 12 July 2016. 
 
Governance / Corporate Governance 
 
The Board and Committees 
 
Responsibility for effective governance lies with the Board. The governance 
framework of the Company reflects the fact that as an investment company it has 
no employees. Portfolio management is delegated to OrbiMed and risk management, 
company management, company secretarial, administrative and marketing services 
are delegated to Frostrow. During the year, in order to strengthen its 
governance structure, the Board agreed to split the 'audit' and 'management 
engagement' functions of the Audit and Management Engagement Committee and to 
create two new committees (an Audit Committee and a Management Engagement 
Committee) to be responsible for these areas. This structure is reflected in 
the diagram below. 
 
                                       The Board 
                                 Chairman - Andrew Joy 
                Senior Independent Director - Professor Dame Kay Davies 
    Five additional non-executive Directors, all considered independent, except for 
                                      Sven Borho. 
                                 Key responsibilities: 
 
Remuneration          Audit Committee       Nominations Committee Management Engagement 
Committee             Chairman              Chairman              Committee 
Chairman              Peter Keen*           Andrew Joy            Chairman 
Professor Dame        All Independent       All Independent       Steven Bates 
Kay Davies            Directors             Directors             All Independent 
All Independent       Key responsibilities: Key responsibilities: Directors 
Directors                                   to make               Key responsibilities: 
Key responsibilities:                       recommendations for 
                                            any changes or new 
                                            appointments. 
 
*        The Directors believe that Peter Keen has the necessary recent and 
relevant financial experience to Chair the Company's Audit Committee. 
 
Copies of the full terms of reference, which clearly define the 
responsibilities of each Committee, can be obtained from the Company Secretary, 
will be available for inspection at the Annual General Meeting, and can be 
found on the Company's website at 
 
Corporate Governance 
 
The Directors are accountable to shareholders for the governance of the 
Company's affairs. The UK Listing Rules require all listed companies to 
disclose how they have applied the principles and complied with the provisions 
of the UK Corporate Governance Code (the 'UK Code') issued by the Financial 
Reporting Council (the 'FRC'). The UK Code can be viewed at www.frc.org.uk. 
 
The Association of Investment Companies ('AIC') publishes a Code of Corporate 
Governance ('AIC Code') and a Corporate Governance Guide for Investment 
Companies ('AIC Guide'). In July 2016 the AIC published a revised AIC Code and 
AIC Guide. 
 
The Financial Reporting Council has confirmed that by following the AIC Code 
and the AIC Guide, boards of investment companies will meet their obligations 
in relation to the UK Code and paragraph 9.8.6 of the UK Listing Rules. 
 
The AIC Code and AIC Guide address the principles set out in the UK Code as 
well as additional principles and recommendations on issues that are specific 
to investment trusts. The AIC Code can be viewed at www.theaic.co.uk. 
 
The Board considers that reporting against the principles and recommendations 
of the AIC Code, and by reference to the AIC Guide (which incorporates the UK 
Code), will provide better information to shareholders. 
 
Statement of Compliance 
 
The Company has complied with the recommendations of the AIC Code and the 
relevant provisions of the UK Corporate Governance Code, except as follows: 
 
The UK Code includes certain provisions relating to: 
 
  * the role of the chief executive 
  * executive directors' remuneration 
  * the need for an internal audit function 
 
For the reasons set out in the AIC Guide, and as explained in the UK Code, the 
Board considers these provisions are not relevant to the position of the 
Company, being an externally managed investment company. In particular, all of 
the Company's day-to-day management and administrative functions are outsourced 
to third parties. As a result, the Company has no executive directors, 
employees or internal operations. Therefore with the exception of the need for 
an internal audit function, the Company has not reported further in respect of 
these provisions. 
 
The principles of the AIC Code 
 
The AIC Code is made up of 21 principles split into three sections covering: 
 
  * The Board 
  * Board Meetings and relations with AIFM and Portfolio Manager 
  * Shareholder Communications 
 
AIC Code Principle           Compliance Statement 
 
The Board                    The Chairman, Andrew Joy is responsible for the leadership of 
1. The Chairman should be    the Board and for ensuring its effectiveness. 
independent.                 The Chairman continues to be independent of the AIFM and the 
                             Portfolio Manager. There is a clear division of 
                             responsibility between the Chairman, the Directors, the AIFM, 
                             the Portfolio Manager and the Company's other third party 
                             service providers. The Chairman is responsible for the 
                             leadership of the Board and for ensuring its effectiveness in 
                             all aspects of its role. There are no relationships that may 
                             create a conflict of interest between the Chairman's 
 
2. A majority of the Board   Mr. Sven Borho is a Founding General Partner of OrbiMed, the 
should be independent of     Company's Portfolio Manager and has served on the Board for 
the Manager.                 more than nine years from the date of his first election. He 
                             is not considered to be an Independent Director. Mr Borho 
                             submits himself for annual re-election by shareholders. 
                             The Board consists of six other non-executive Directors, each 
                             of whom is independent of the AIFM and the Portfolio Manager. 
                             None of the Board members is or has been an employee of the 
                             Company. 
 
3. Directors should be       All Directors (who are not retiring from the Board) submit 
submitted for re-election    themselves for annual re-election by shareholders. 
at regular intervals.        The individual performance of each Director standing for 
Nomination for re-election   re-election is evaluated annually by the remaining members of 
should not be assumed but    the Board and, if considered appropriate, a recommendation is 
be based on disclosed        made that shareholders vote in favour of their re-election at 
procedures and continued     the Company's Annual General Meeting to be held in July 2017. 
satisfactory performance.    Peter Keen will be retiring from the Board and will therefore 
                             not be seeking re-election at this year's Annual General 
                             Meeting. 
                             Julia Le Blan joined the Board on 12 July 2016. Accordingly, 
                             her appointment will be proposed to shareholders for 
                             ratification at the Annual General Meeting 
 
4. The Board should have a   The Board, meeting as the Nominations Committee, considers 
policy on tenure, which is   the structure of the Board and recognises the need for 
disclosed in the annual      progressive refreshing of its members. 
report.                      The Board subscribes to the view expressed within the AIC 
                             Code that long-serving Directors should not be prevented from 
                             forming part of an independent majority. It does not consider 
                             that a Director's tenure necessarily reduces his or her 
                             ability to act independently and, following formal 
                             performance evaluations, believes that each of those 
                             Directors is independent in character and judgment and that 
                             there are no relationships or circumstances which are likely 
                             to affect their judgment. The Board's policy on tenure is 
                             that continuity and experience are considered to add 
                             significantly to the strength of the Board and, as such, no 
                             limit on the overall length of service of any of the 
                             Company's Directors, including the Chairman, has been 
                             imposed. In view of its non-executive nature, the Board 
                             considers that it is not appropriate for the Directors to be 
                             appointed for a specified term, although new Directors are 
                             appointed with the expectation that they will serve for a 
                             minimum period of three years subject to shareholder 
                             approval. 
                             The AIC Code states that any Director who has served for more 
                             than nine years is subject to annual re-appointment. All of 
                             the Company's Directors (who are not retiring from the Board) 
                             seek re-appointment at each Annual General Meeting. 
                             The terms and conditions of the Directors' appointments are 
                             set out in letters of engagement which are available for 
                             inspection on request at the office of Frostrow, the 
                             Company's AIFM and from the Company Secretary at the 
                             Company's Annual General Meeting to be held in July 2017. 
 
5. There should be full      The Directors' biographical details demonstrate the wide 
disclosure of information    range of skills and experience that they bring to the Board 
about the Board.             together with details of their other directorships and 
                             employment. 
                             Further details of Board composition and succession planning 
                             can be found within the Chairman's Statement. 
 
6. The Board should aim to   The Nominations Committee considers annually the skills 
have a balance of skills,    possessed by the Board and identifies any skill shortages to 
experience, length of        be filled by new Directors. 
service and knowledge of     When considering new appointments, the Board reviews the 
the company.                 skills of the Directors and seeks to add persons with 
                             complementary skills or who possess the skills and experience 
                             which fill any gaps in the Board's knowledge or experience 
                             and who can devote sufficient time to the Company to carry 
                             out their duties effectively. 
                             The experience of the current Directors is detailed in their 
                             biographies. 
                             The Company is committed to ensuring that any vacancies 
                             arising are filled by the most qualified candidates and 
                             recognises the value of diversity in the composition of the 
                             Board. When Board positions become available as a result of 
                             retirement or resignation, the Company will ensure that a 
                             diverse group of candidates is considered. 
 
7. The Board should          During the year the performance of the Board, its committees 
undertake a formal and       and individual Directors (including each Director's 
rigorous annual evaluation   independence) was evaluated through a formal assessment 
of its own performance and   process led by the Senior Independent Director. This involved 
that of its committees and   the circulation of a Board effectiveness checklist, tailored 
individual directors.        to suit the nature of the Company, followed by discussions 
                             between the Senior Independent Director and each of the 
                             Directors where necessary. The performance of the Chairman 
                             was evaluated by the other Directors under the leadership of 
                             the Senior Independent Director. The review concluded that 
                             the Board was working well. 
                             The Board is satisfied that the structure of skills, mix, 
                             experience, independence, knowledge, diversity and operation 
                             of the Board continue to be effective and relevant for the 
                             Company. 
 
8. Directors' remuneration   The Remuneration Committee annually reviews the fees paid to 
should reflect their         the Directors and compares these with the fees paid by the 
duties, responsibilities     Company's peer group and the investment trust industry 
and the value of their       generally, taking into account the level of commitment and 
time spent.                  responsibility of each Board member. Details on the 
                             remuneration arrangements for the Directors of the Company 
                             can be found in the Directors' Remuneration Policy Report and 
                             Directors' Remuneration Report. 
                             As all of the Directors are non-executive, the Board 
                             considers that it is acceptable for the Senior Independent 
                             Director of the Company to chair meetings when discussing 
                             Directors' fees. The Senior Independent Director takes no 
                             part in discussions regarding her own remuneration. 
 
9. The independent           The Nominations Committee is comprised of all directors who 
directors should take the    are independent and chaired by the Chairman of the Board. 
lead in the appointment of   Subject to there being no conflicts of interest, all members 
new directors and the        of the Committee are entitled to vote on candidates for the 
process should be            appointment of new directors and on recommending for 
disclosed in the annual      shareholders' approval the Directors seeking re-election at 
report.                      the Annual General Meeting. 
                             The Chairman does not Chair the meeting when the committee is 
                             dealing with matters concerning the appointment of a 
                             successor to the Chairmanship. 
                             Details of the Board's commitment to diversity is set out 
                             within the Business Review. 
                             As part of the process to appoint Julia Le Blan, the Board 
                             engaged the services of a specialist recruitment consultant, 
                             Nurole. Nurole prepared a list of potential candidates for 
                             consideration by a sub-committee appointed by the Nominations 
                             Committee. A short list was then arrived at, the candidates 
                             were interviewed and Julia Le Blan was subsequently 
                             appointed. Nurole has no other connection with the Company. 
 
10. Directors should be      New appointees to the Board are provided with a full 
offered relevant training    induction programme. The programme covers the Company's 
and induction.               investment strategy, policies and practices. The Directors 
                             are also given key information on the Company's regulatory 
                             and statutory requirements as they arise including 
                             information on the role of the Board, matters reserved for 
                             its decision, the terms of reference for the Board 
                             Committees, the Company's corporate governance practices and 
                             procedures and the latest financial information. It is the 
                             Chairman's responsibility to ensure that the Directors have 
                             sufficient knowledge to fulfil their role and Directors are 
                             encouraged to participate in training courses where 
                             appropriate. 
                             The Directors have access to the advice and services of a 
                             Company Secretary through its appointed representative which 
                             is responsible to the Board for ensuring that Board 
                             procedures are followed and that applicable rules and 
                             regulations are complied with. The Company Secretary is also 
                             responsible for ensuring good information flows between all 
                             parties. 
 
11. The Chairman (and the    Principle 11 applies to the launch of new investment 
Board) should be brought     companies and is therefore not applicable to the Company. 
into the process of 
structuring a new launch 
at an early stage. 
 
Board Meetings and relations with Frostrow and OrbiMed 
 
12. Boards and managers      The Board meets regularly throughout the year and a 
should operate in a          representative of the AIFM and Portfolio Manager is in 
supportive, co-operative     attendance at each meeting and Committee meetings. The 
and open environment.        Chairman encourages open debate to foster a supportive and 
                             co-operative approach for all participants. 
 
13. The primary focus at     The Board has agreed a schedule of matters specifically 
regular Board meetings       reserved for decision by the Board. This includes 
should be a review of        establishing the investment objectives, strategy and 
investment performance and   benchmarks, the level of borrowing, the permitted types or 
associated matters, such     categories of investments, the markets in which transactions 
as gearing, asset            may be undertaken, the amount or proportion of the assets 
allocation, marketing/       that may be invested in any category of investment or in any 
investor relations, peer     one investment, and the Company's share issuance, share 
group information and        buy-back and treasury share policies. 
industry issues.             The Board, at its regular meetings, undertakes reviews of key 
                             investment and financial data, revenue projections and 
                             expenses, analysis of asset allocation, transactions and 
                             performance comparisons, share price and net asset value 
                             performance, marketing and shareholder communication 
                             strategies, the risks associated with pursuing the investment 
                             strategy, peer group information and industry issues. 
                             The Chairman is responsible for ensuring that the Board 
                             receive accurate, timely and clear information. Where 
                             appropriate representatives of the AIFM report on issues 
                             affecting the company. 
                             All Directors have access to independent professional advice 
                             where they judge it necessary to discharge their 
                             responsibility properly. 
                             The Audit Committee reviews the Company's risk matrix and the 
                             performance and cost of the Company's third party service 
                             providers. 
 
14. Boards should give       The Board is responsible for strategy and has established an 
sufficient attention to      annual programme of agenda items under which it reviews the 
overall strategy.            objectives and strategy for the Company at each meeting. 
 
15. The Board should         The Management Engagement Committee reviews annually the 
regularly review both the    performance of the AIFM and Portfolio Manager. The Committee 
performance of, and          considers the quality, cost and remuneration method 
contractual arrangements     (including the performance fee) of the service provided by 
with, the AIFM and the       the AIFM and the Portfolio Manager against their contractual 
Portfolio Manager (or        obligations and the Board receives monthly reports on 
executives of a              compliance with the investment restrictions which it has set. 
self-managed company).       It also considers the performance analysis provided by the 
                             AIFM and the Portfolio Manager. 
                             The Management Engagement Committee reviews the compliance 
                             and control systems of both the AIFM and the Portfolio 
                             Manager in operation insofar as they relate to the affairs of 
                             the Company and the Board undertakes periodic reviews of the 
                             arrangements with and the services provided by the 
                             Depositary, to ensure that the safeguarding of the Company's 
                             assets and security of the shareholders' investment is being 
                             maintained. 
                             All Directors act in what they consider to be in the best 
                             interests of the Company, consistent with their statutory 
                             duties set out in the Companies Act 2006. 
 
16. The Board should agree   The Portfolio Management Agreement between the Company, the 
policies with the AIFM and   AIFM and Portfolio Manager sets out the limits of Portfolio 
the Portfolio Manager        Manager's authority, beyond which Board approval is required. 
covering key operational     The Board has also agreed detailed investment guidelines with 
issues.                      the AIFM and the Portfolio Manager, which are considered at 
                             each Board meeting. 
                             A representative of the AIFM and Portfolio Manager attends 
                             each meeting of the Board to address questions on specific 
                             matters and to seek approval for specific transactions which 
                             the Portfolio Manager is required to refer to the Board. 
                             Frostrow in their capacity as the Company's AIFM have 
                             delegated the management of the portfolio and subsequent 
                             proxy voting to OrbiMed as Portfolio Manager, who retain the 
                             services of Broadridge and Glass Lewis to undertake 
                             operational and administrative duties relating to proxy 
                             voting. The Portfolio Manager notifies the Board of any 
                             contentious issues that require voting upon. 
                             The Board has reviewed the Portfolio Manager's Proxy Voting & 
                             Class Action Policy. Reports on commissions paid by the 
                             Portfolio Manager are submitted to the Board regularly. 
 
17. Boards should monitor    The Board considers any imbalances in the supply of and the 
the level of the share       demand for the Company's shares in the market and takes 
price discount or premium    appropriate action when considered necessary. 
(if any) and, if             The Board considers the discount or premium to net asset 
desirable, take action to    value of the Company's share price at each Board meeting and 
reduce it.                   reviews the changes in the level of discount or premium and 
                             in the share price since the previous Board meeting and over 
                             the previous twelve months. 
                             At each meeting the Board reviews reports from the AIFM on 
                             marketing and shareholder communication strategies. It also 
                             considers their effectiveness as well as measures of investor 
                             sentiment and any recommendations on share issuance and share 
                             buy-backs. 
                             The Board does not consider that any conflicts arose from the 
                             AIFM and Portfolio Manager promoting the Company alongside 
                             their other clients. 
 
18. The Board should         The Management Engagement Committee reviews, at least 
monitor and evaluate other   annually, the performance of all the Company's third party 
service providers.           service providers, including the level and structure of fees 
                             payable and the length of the notice period, to ensure that 
                             they remain competitive and in the best interests of 
                             shareholders. 
                             The Committee also reviews reports from the principal service 
                             providers on compliance and the internal and financial 
                             control systems in operation and relevant independent audit 
                             reports thereon, as well as reviewing service providers' 
                             anti-bribery and corruption policies to address the 
                             provisions of the Bribery Act 2010. 
                             The Board is satisfied that the Company's Auditor does not 
                             carry out any work for the AIFM and therefore no potential 
                             conflict will arise. 
 
Shareholder Communications 
 
19. The Board should         A detailed analysis of the substantial shareholders in the 
regularly monitor the        Company is provided to the directors at each Board meeting. 
shareholder profile of the   Representatives of the AIFM and the Portfolio Manager 
company and put in place a   regularly meet with institutional shareholders and private 
system for canvassing        client asset managers to discuss strategy and to understand 
shareholder views and for    their issues and concerns and, if applicable, to discuss 
communicating the Board's    corporate governance issues. The results of such meetings are 
views to shareholders.       reported at the following Board meeting. 
                             Regular reports from the Company's broker are submitted to 
                             the Board on investor sentiment and industry issues. 
                             Shareholders wishing to communicate with the Chairman, the 
                             Senior Independent Director or any other member of the Board, 
                             may do so by writing to the Company, for the attention of the 
                             Company Secretary at the offices of the AIFM. All 
                             shareholders are encouraged to attend the Annual General 
                             Meeting, where they are given the opportunity to question the 
                             Chairman, the Board and representatives of the Portfolio 
                             Manager. The Portfolio Manager will make a presentation to 
                             shareholders covering the investment performance and strategy 
                             of the Company at the forthcoming Annual General Meeting to 
                             be held in July 2017. 
                             The Directors welcome the views of all shareholders and place 
                             considerable importance on communications with them. The 
                             Chairman will ensure that all members of the Board are made 
                             aware of the issues and concerns raised by shareholders and 
                             that the appropriate steps are taken so that the Board has an 
                             adequate understanding of these views, through communication 
                             with the Company's AIFM (e-mail address: info@frostrow.com) 
                             and advisers. 
 
20. The Board should         All substantive communications regarding any major corporate 
normally take                issues are discussed by the Board taking into account 
responsibility for, and      representations from the AIFM, the Portfolio Manager, the 
have a direct involvement    Auditor, legal advisers and stockbroker. 
in, the content of 
communications regarding 
major corporate issues 
even if the manager is 
asked to act as spokesman. 
 
21. The Board should         The Company places great importance on communication with 
ensure that shareholders     shareholders and aims to provide them with a full 
are provided with            understanding of the Company's investment objective, policy 
sufficient information for   and activities, its performance and the principal investment 
them to understand the       risks by means of informative annual and half-year reports. 
risk/reward balance to       This is supplemented by the daily publication, through the 
which they are exposed by    London Stock Exchange, of the net asset value per share of 
holding the shares.          the Company's shares. 
                             The Board is responsible for the overall management of the 
                             Company, approval of the Company's long-term objectives and 
                             commercial strategy and the review of the Company's 
                             Investment Policy. The Board continues to review the setting 
                             of maximum borrowing limits under which the AIFM and 
                             Portfolio Manager operates within. 
                             The Annual Report provides information on Portfolio Manager's 
                             investment performance, portfolio risk and operational and 
                             compliance issues. Further details on the risk/reward balance 
                             are set out in note 13 to the Financial Statements. 
                             The Company's website, www.biotechgt.com, is regularly 
                             updated with monthly fact sheets and provides useful 
                             information about the Company including the Company's 
                             financial reports and announcements. 
 
The Board has considered the position of all of the Directors as part of the 
evaluation process, and believes that it would be in the Company's best 
interests to propose them, with the exception of Peter Keen who will be 
retiring from the Board at the conclusion of the forthcoming Annual General 
Meeting, for election or re-election at the forthcoming Annual General Meeting 
for the following reasons: 
 
Mr Andrew Joy, has been a Director since March 2012 and Chairman since July 
2016. He has extensive knowledge of the financial sector and was one of the 
founding Partners of Cinven, a leading private equity firm investing in Europe 
and the U.S. He has been Chairman or Director of numerous growing companies 
over the past 30 years. 
 
Professor Dame Kay Davies, CBE, who has been a Director since March 2012. She 
is Senior Independent Director and Chairman of the Remuneration Committee, has 
extensive knowledge of the biopharmaceutical sector and is the Dr Lee's 
Professor of Anatomy and Associate Head of the Medical Science Division at the 
University of Oxford. 
 
Julia Le Blan joined the Board in July 2016. A Chartered Accountant and a 
former tax partner at Deloitte, she has a wealth of financial services industry 
experience. Julia will succeed Peter Keen as Chairman of the Audit Committee 
upon his retirement from the Board. 
 
Mr Sven Borho, who has been a Director since March 2006 is one of the founding 
partners of OrbiMed the Company's Portfolio Manager. He heads public equity and 
hedge funds and has played an integral role in the growth of OrbiMed's asset 
management activities. 
 
Mr Steven Bates joined the Board in July 2015. He has a wealth of experience as 
an investment manager. He is Chairman of the Management Engagement Committee. 
 
The Rt Hon Lord Willetts joined the Board in November 2015. A former government 
minister, he has extensive and relevant experience and a strong interest in the 
biotechnology sector. 
 
The Chairman is pleased to report that following a formal performance 
evaluation, the Directors' performance continues to be effective and they 
continue to demonstrate commitment to the role. 
 
The Board's responsibilities 
 
The Board meets regularly and four Board meetings were held during the year to 
deal with the stewardship of the Company and other matters. There is a formal 
schedule of matters specifically reserved for decision by the Board; it is 
responsible for all aspects of the Company's affairs, including the setting of 
parameters for and the monitoring of the investment strategy and the review of 
investment performance and investment policy. It also has responsibility for 
all corporate strategy issues, dividend policy, share buy-back and issuance 
policy, borrowing, share price and discount/premium monitoring and corporate 
governance matters. 
 
Conflicts of interest 
 
Directors have a duty to avoid a situation in which he or she has, or can have, 
a direct or indirect interest that conflicts, or possibly may conflict, with 
the Company's interests (a "situational conflict"). 
 
It is the responsibility of each individual Director to avoid an unauthorised 
conflict situation arising. He or she must request authorisation from the Board 
as soon as he or she becomes aware of the possibility of a situational conflict 
arising. 
 
The Board is responsible for considering Directors' requests for authorisation 
of situational conflicts and for deciding whether they should be authorised. 
The factors to be considered will include whether the situational conflict 
could prevent the Director from performing his or her duties, whether it has, 
or could have, any impact on the Company and whether it could be regarded as 
likely to affect the judgment and/or actions of the Director in question. When 
the Board is deciding whether to authorise a conflict or potential conflict, 
only Directors who have no interest in the matter being considered are able to 
take the relevant decision, and in taking the decision the Directors must act 
in a way they consider, in good faith, will be most likely to promote the 
Company's success. The Directors are able to impose limits or conditions when 
giving authorisation if they think this is appropriate in the circumstances. 
 
A register of conflicts is maintained by the Company Secretary and is reviewed 
at each Board meeting, to ensure that any authorised conflicts remain 
appropriate. Directors are required to confirm at these meetings whether there 
has been any change to their position. 
 
The Directors must also comply with the statutory rules requiring company 
directors to declare any interest in an actual or proposed transaction or 
arrangement with the Company. 
 
Anti-Bribery and corruption policy 
 
The Board has adopted a zero tolerance approach to instances of bribery and 
corruption. Accordingly it expressly prohibits any Director or associated 
persons when acting on behalf of the Company, from accepting, soliciting, 
paying, offering or promising to pay or authorise any payment, public or 
private, in the United Kingdom or abroad to secure any improper benefit for 
themselves or for the Company. 
 
A copy of the Company's anti-bribery and corruption policy can be found on its 
website at www.biotechgt.com. The policy is reviewed regularly by the Audit 
Committee. 
 
Relationship with shareholders 
 
The Board, the AIFM and the Portfolio Manager consider maintaining good 
communications with shareholders and engaging with larger shareholders through 
meetings and presentations a key priority. Shareholders are being informed by 
the publication of annual and half year reports which include financial 
statements. These reports are supplemented by the daily release of the net 
asset value per share to the London Stock Exchange and the publication of 
monthly fact sheets. All this information including interviews with the 
Portfolio Manager is available on the Company's website at www.biotechgt.com. 
 
The Board is also keen that the Annual General Meeting ("AGM") be a 
participative event for all shareholders. The Portfolio Manager makes a 
presentation and shareholders are encouraged to attend. The Chairmen of the 
Board and of the Committees attend the AGM and are available to respond to 
queries and concerns from shareholders. Twenty working days' notice of the AGM 
has been given to shareholders and separate resolutions are proposed in 
relation to each substantive issue. Shareholders may submit questions for the 
AGM in advance of the meeting or make general enquiries of the Company via the 
Company Secretary at the registered office of the Company. The Directors make 
themselves available after the AGM to meet shareholders. 
 
Where the vote is decided on a show of hands, the proxy votes received are 
relayed to the meeting and subsequently published on the Company's website. 
Proxy forms have a 'vote withheld' option. The Notice of Meeting sets out the 
business of the AGM together with the full text of any special resolutions. 
 
The Board monitors the share register of the Company; it also reviews 
correspondence from shareholders at each meeting and maintains regular contact 
with major shareholders. Shareholders who wish to raise matters with a Director 
may do so by writing to them at the registered office of the Company. 
 
Exercise of voting powers 
 
The Board has delegated authority to the Portfolio Manager to vote the shares 
owned by the Company. The Board has instructed that the Portfolio Manager 
submit votes for such shares wherever possible. This accords with current best 
practice whilst maintaining a primary focus on financial returns. The Portfolio 
Manager may refer to the Board on any matters of a contentious nature. The 
Company does not retain voting rights on any shares that are subject to 
rehypothecation in connection with the overdraft facility provided by J.P. 
Morgan Clearing Corp. 
 
Nominee share code 
 
Where shares are held in a nominee company name and where the beneficial owner 
of the shares is unable to vote in person, the Company nevertheless undertakes: 
 
  * to provide the nominee company with multiple copies of shareholder 
    communications, so long as an indication of quantities has been provided in 
    advance; and 
  * to allow investors holding shares through a nominee company to attend 
    general meetings, provided the correct authority from the nominee company 
    is available. 
 
Nominee companies are encouraged to provide the necessary authority to 
underlying shareholders to attend the Company's general meetings. 
 
Beneficial owners of shares - information rights 
 
Beneficial owners of shares who have been nominated by the registered holder of 
those shares to receive information rights under section 146 of the Companies 
Act 2006 are required to direct all communications to the registered holder of 
their shares rather than to the Company's registrar, Capita Asset Services, or 
to the Company directly. 
 
By order of the Board 
 
Frostrow Capital LLP 
Company Secretary 
 
25 May 2017 
 
 
 
Governance / Report of the Directors 
 
The Directors present this Annual Report on the affairs of the Company together 
with the Audited Financial Statements and the Independent Auditor's Report for 
the year ended 31 March 2017. 
 
Company management 
 
Alternative Investment Fund Manager 
 
Frostrow under the terms of its AIFM agreement with the Company provides, inter 
alia, the following services: delegation (subject to the oversight of Frostrow 
and the Board) of the portfolio management function to OrbiMed; investment 
portfolio administration and valuation; risk management services; marketing and 
shareholder services; share price discount and premium management; 
administrative and secretarial services; advice and guidance in respect of 
corporate governance requirements; maintenance of the Company's accounting 
records; preparation and dispatch of annual and half year reports and monthly 
fact sheets; ensuring compliance with applicable legal and regulatory 
requirements; and maintenance of the Company's website. 
 
Frostrow receives a periodic fee equal to 0.30% per annum of the Company's 
market capitalisation, plus a fixed amount equal to GBP60,000 per annum. Either 
party may terminate the AIFM Agreement on not less than 12 months' notice. 
 
Portfolio Manager 
 
OrbiMed under the terms of its portfolio management agreement with the AIFM and 
the Company provides, inter alia, the following services: the seeking out and 
evaluating of investment opportunities; recommending the manner by which monies 
should be invested, disinvested, retained or realised; advising on how rights 
conferred by the investments should be exercised; analysing the performance of 
investments made; and advising the Company in relation to trends, market 
movements and other matters which may affect the investment objective and 
policy of the Company. OrbiMed receives a periodic fee equal to 0.65% per annum 
of the Company's net asset value. The proportion of the Company's assets 
committed for investment in OrbiMed Asia Partners L.P., a limited partnership 
managed by OrbiMed Asia G.P., L.P., an affiliate of the Portfolio Manager, is 
excluded from the fee calculation. The Portfolio Management Agreement may be 
terminated by either Frostrow or the Portfolio Manager giving notice of not 
less than 12 months. 
 
Performance fee 
 
Dependent on the level of long-term outperformance of the Company, the AIFM and 
Portfolio Manager are entitled to the payment of a performance fee. The 
performance fee is calculated by reference to the amount by which the Company's 
net asset value ('NAV') performance has outperformed the NASDAQ Biotechnology 
Index (sterling adjusted), the Company's benchmark index. 
 
The fee is calculated quarterly by comparing the cumulative performance of the 
Company's NAV with the cumulative performance of the benchmark since the 
commencement of the performance fee arrangement on 30 June 2005. The 
performance fee amounts to 16.5% of any outperformance over the benchmark, the 
AIFM receiving 1.5% and the Portfolio Manager receiving 15% respectively. 
Provision is also made within the daily NAV per share calculation as required 
and in accordance with generally accepted accounting standards. 
 
In order to ensure that only sustained outperformance is rewarded, at each 
quarterly calculation date any performance fee is based on the lower of: 
 
(i)      The cumulative outperformance of the portfolio over the benchmark as 
at the quarter end date; and 
 
(ii)     The cumulative outperformance of the portfolio over the benchmark as 
at the corresponding quarter end date in the previous year. 
 
In addition, a performance fee only becomes payable to the extent that the 
cumulative outperformance gives rise to a total fee greater than the total of 
all performance fees paid to date. 
 
The proportion of the Company's assets invested in OrbiMed Asia Partners L.P. 
is excluded from the Portfolio Manager's performance fee calculation. 
 
Depositary and Prime Broker 
 
The Company appointed J.P. Morgan Europe Limited (the "Depositary") as its 
depositary. Under the terms of the Depositary Agreement the Company has agreed 
to pay the Depositary a fee calculated at 1.75 bps on net assets up to GBP150 
million, 1.50 bps on net assets between GBP150 million and GBP300 million, 1.00 bps 
on net assets between GBP300 million and GBP500 million and 0.50 bps on net assets 
above GBP500 million. 
 
The Depositary has delegated the custody and safekeeping of the Company's 
assets to J.P. Morgan Clearing Corp (the "Prime Broker"). 
 
Under the terms of a Delegation Agreement, liability has been transferred under 
Article 21(12) of the AIFMD for the loss of the Company's financial instruments 
held in custody by the Prime Broker to the Prime Broker in accordance with 
Article 21(13) of the AIFMD. While the Depositary Agreement prohibits the 
re-use of the Company's assets by the Depositary or the Prime Broker without 
the prior consent of the Company or Frostrow, the Company has consented to the 
transfer and re-use of its assets by the Prime Broker (known as 
"rehypothecation") in accordance with the terms of an institutional account 
agreement between the Company, the Prime Broker and certain other J.P. Morgan 
Entities (as defined therein) (the "Institutional Account Agreement"). This 
activity is undertaken in order to take advantage of lower financing costs on 
the Company's overdraft and also lower custody charges. 
 
The Prime Broker is a registered broker-dealer and is accordingly subject to 
limits on rehypothecation, in particular limitations set out in U.S. SEC Rule 
15c3-3. In the event of the Prime Broker's insolvency, the Company may be 
unable to recover in full all assets held by the Prime Broker as Custodian. 
(See note 13 for further details.) 
 
AIFM and Portfolio Manager evaluation and re-appointment 
 
The performance of the AIFM and the Portfolio Manager is reviewed by the 
Company's Management Engagement Committee (the "Committee") with a formal 
evaluation being undertaken each year. As part of this process, the Committee 
monitors the services provided by the AIFM and the Portfolio Manager and 
receives regular reports and views from them. The Committee also receives 
comprehensive performance measurement reports to enable it to determine whether 
or not the performance objectives set by the Board have been met. The Committee 
reviewed the appropriateness of the appointment of the AIFM and the Portfolio 
Manager in February 2017 with a recommendation being made to the Board. 
 
The Board believes the continuing appointment of the AIFM and the Portfolio 
Manager, under the terms described above and on the previous page, is in the 
interests of shareholders as a whole. In coming to this decision, it also took 
into consideration the following additional reasons: 
 
  * the quality and depth of experience allocated by the Portfolio Manager to 
    the management of the portfolio and the level of performance of the 
    portfolio in absolute terms and also by reference to the benchmark index; 
    and 
  * the quality and depth of experience of the company management, company 
    secretarial, administrative and marketing team that the AIFM allocates to 
    the management of the Company. 
 
Overdraft facility 
 
The Company's borrowing requirements are met through the utilisation of an 
overdraft facility, repayable on demand, provided by J.P. Morgan Clearing Corp. 
(Further details can be found in notes 1 and 13. 
 
Share capital 
 
As part of the package of measures adopted in 2005 by the Board to improve the 
attraction of the Company's shares to new investors and also to provide the 
prospect of a sustained improvement in the rating of the Company's shares, an 
active discount management policy was implemented to buy-back shares to either 
hold in treasury or for cancellation if the market price is at a discount 
greater than 6% to net asset value per share. As at 31 March 2017, the discount 
was 6.6%. The making and timing of any share buy-back remains at the absolute 
discretion of the Board. Authority to buy-back up to 14.99% of the Company's 
issued share capital is sought at each Annual General Meeting. 
 
Shareholders should note, however, that it remains possible for the share price 
discount to the net asset value per share to be greater than 6% on any one day. 
This is due to the fact that the share price continues to be influenced by 
overall supply and demand for the Company's shares in the secondary market. The 
volatility of the net asset value per share in an asset class such as 
healthcare is another factor over which the Board has no control. 
 
During the year a total of 4,455,561 shares were bought back representing 7.4% 
of the issued share capital at the beginning of the year. The purchases were 
made at a total cost of GBP29.7 million (including expenses). No shares have been 
repurchased by the Company since the year-end. As at 25 May 2017 there were 
55,839,913 shares in issue. 
 
Annual General Meeting 
 
THE FOLLOWING INFORMATION TO BE DISCUSSED AT THE FORTHCOMING ANNUAL GENERAL 
MEETING IS IMPORTANT AND REQUIRES YOUR IMMEDIATE ATTENTION. 
 
If you are in any doubt about the action you should take, you should seek 
advice from your stockbroker, bank manager, solicitor, accountant or other 
financial adviser authorised under the financial services and markets act 2000 
(as amended). if you have sold or transferred all of your ordinary shares in 
the company, you should pass this document, together with any other 
accompanying documents, including the form of proxy, at once to the purchaser 
or transferee, or to the stockbroker, bank or other agent through whom the sale 
or transfer was effected, for onward transmission to the purchaser or 
transferee. 
 
Resolutions relating to the following items of special business will be 
proposed at the forthcoming Annual General Meeting. 
 
Resolution 11 Authority to allot shares 
 
Resolution 12 Authority to disapply pre-emption rights 
 
Resolution 13 Authority to buy back shares 
 
Resolution 14 Authority to hold General Meetings (other than the AGM) on at 
least 14 working days' notice 
 
The full text of the resolutions can be found in the Notice of Annual General 
Meeting. 
 
Directors 
 
Directors' & Officers' liability insurance cover 
 
Directors' & Officers' liability insurance cover was maintained by the Board 
during the year ended 31 March 2017. It is intended that this policy will 
continue for the year ended 31 March 2018 and subsequent years. 
 
Directors' indemnities 
 
As at the date of this report, indemnities are in force between the Company and 
each of its Directors under which the Company has agreed to indemnify each 
Director, to the extent permitted by law, in respect of certain liabilities 
incurred as a result of carrying out his/her role as a Director of the Company. 
The Directors are also indemnified against the costs of defending any criminal 
or civil proceedings or any claim by the Company or a regulator as they are 
incurred provided that where the defence is unsuccessful the Director must 
repay those defence costs to the Company. The indemnities are qualifying third 
party indemnity provisions for the purposes of the Companies Act 2006. 
 
A copy of each deed of indemnity is available for inspection at the Company's 
registered office during normal business hours and will be available for 
inspection at the Annual General Meeting. 
 
Substantial shareholdings 
 
The Company was aware of the following substantial interests in the voting 
rights of the Company as at 30 April 2017, the latest practicable date before 
publication of the annual report. 
 
                                            30 April 2017           31 March 2017 
 
                                                          % of                    % of 
 
                                                        Issued                  Issued 
 
                                            No. of       share      No. of       share 
 
Shareholders                                shares     capital      shares     capital 
 
Hargreaves Lansdown                      5,278,037         9.5   5,335,384         9.6 
 
East Riding of Yorkshire                 4,698,000         8.4   4,698,000         8.4 
 
Alliance Trust Savings                   2,895,039         5.2   2,939,133         5.3 
 
Standard Life Wealth                     1,860,553         3.3   1,870,613         3.3 
 
Veritas Investment Management            1,706,202         3.1   1,703,752         3.1 
 
Hansa Capital Partners                   1,677,615         3.0   2,073,415         3.7 
 
As at 31 March 2017 the Company had 55,839,913 shares in issue. As at 30 April 
2017 the Company had 55,839,913 shares in issue. 
 
Financial instruments 
 
The Company's financial instruments comprise its portfolio, cash balances, 
debtors and creditors that arise directly from its operations, such as sales 
and purchases awaiting settlement and accrued income. The financial risk 
management and policies arising from its financial instruments are disclosed in 
note 13 to the Financial Statements. 
 
Results and dividend 
 
The results attributable to shareholders for the year and the transfer from 
reserves are shown in the Income Statement. No dividend is proposed in respect 
of the year ended 31 March 2017 (2016: nil). 
 
Alternative performance measures 
 
The Financial Statements set out the required statutory reporting measures of 
the Company's financial performance. In addition, the Board assesses the 
Company's performance against a range of criteria which are viewed as 
particularly relevant for investment trusts are explained in greater detail in 
the Strategic Report, under the heading 'Key Performance Indicators'. 
 
Awareness and disclosure of relevant audit information 
 
So far as each of the Directors is aware, there is no relevant audit 
information (as defined in the Companies Act) of which the Company's auditors 
are unaware. 
 
Each of the Directors has taken all the steps that he or she ought to have 
taken as a Director in order to make himself or herself aware of any relevant 
audit information (as defined) and to establish that the Company's auditors are 
aware of that information. 
 
The above confirmation is given and should be interpreted in accordance with 
the provision of Section 418(2) of the Companies Act 2006. 
 
S.1 2007/1093 C.49 Commencement No2. Order 2007 
 
The following disclosures are made in accordance with S.1 2007/1093 C.49 
Commencement No2. Order 2007 
 
Capital structure 
 
The Company's capital structure is composed solely of Ordinary Shares. Details 
are given in note 11 to the Financial Statements. 
 
Voting rights in the Company's shares 
 
Details of the voting rights in the Company's shares at the date of this Annual 
Report are given in note 9 to the Notice of Annual General Meeting. 
 
Political and charitable donations 
 
The Company has not in the past and does not intend in the future to make 
political or charitable donations. 
 
Modern Slavery Act 2015 
 
The Company does not provide goods or services in the normal course of 
business, and as a financial investment vehicle does not have customers. The 
Directors do not therefore consider that the Company is required to make a 
statement under the Modern Slavery Act 2015 in relation to slavery or human 
trafficking. 
 
Global greenhouse gas emissions 
 
The Company has no greenhouse gas emissions to report from its operations, nor 
does it have responsibility for any other emissions producing sources under 
Large and Medium sized Companies and Groups (Accounts and Reports) Regulations 
2008 (as amended), (including those within our underlying investment 
portfolio). 
 
Common Reporting Standard (CRS) 
 
CRS is a global standard for the automatic exchange of information commissioned 
by the Organisation for Economic Cooperation and Development and incorporated 
into UK law by the International Tax Compliance Regulations 2015. CRS requires 
the Company to provide certain additional details to HMRC in relation to 
certain shareholders. The reporting obligation began in 2016 and will be an 
annual requirement going forward. The Registrars, Capita Asset Services, have 
been engaged to collate such information and file the reports with HMRC on 
behalf of the Company. 
 
Corporate governance 
 
The Corporate Governance Statement forms part of the Report of the Directors. 
 
Listing Rule 9.8.4 
 
Listing Rule 9.8.4 requires the Company to include certain information in a 
single identifiable section of the Annual Report or a cross reference table 
indicating where the information is set out. The Directors confirm that there 
are no disclosures to be made in this regard. 
 
By order of the Board 
 
Frostrow Capital LLP 
 
Company Secretary 
 
25 May 2017 
 
Governance / Statement of Directors' Responsibilities 
 
The Directors are responsible for preparing the Annual Report and the Financial 
Statements in accordance with applicable United Kingdom law and regulations. 
 
Company law requires the directors to prepare Financial Statements for each 
financial year. Under that law, the Directors are required to prepare Financial 
Statements under International Financial Reporting Standards ("IFRSs") as 
adopted by the European Union. Under Company Law the Directors must not approve 
the Financial Statements unless they are satisfied that they give a true and 
fair view of the state of affairs of the Company and of the profit or loss of 
the Company for that period. In preparing these Financial Statements the 
Directors are required to: 
 
  * select suitable accounting policies and then apply them consistently; 
  * make judgements and accounting estimates that are reasonable and prudent; 
  * state whether applicable IFRSs as adopted by the European Union have been 
    followed, subject to any material departures disclosed and explained in the 
    financial statements; and 
  * prepare the financial statements on a going concern basis unless it is 
    inappropriate to presume that the Company will continue in business. 
 
The Directors are responsible for keeping adequate accounting records that are 
sufficient to show and explain the Company's transactions and disclose with 
reasonable accuracy at any time the financial position of the Company and to 
enable them to ensure that the financial statements and the Directors' 
Remuneration Report comply with the Companies Act 2006. They are also 
responsible for safeguarding the assets of the Company and hence for taking 
reasonable steps for the prevention and detection of fraud and other 
irregularities. 
 
The Directors consider that the Annual Report, taken as a whole, is fair, 
balanced and understandable and provides the information necessary for 
shareholders to assess the Company's performance, business model and strategy. 
 
Going concern 
 
The Directors believe that it is appropriate to adopt the going concern basis 
in preparing the Financial Statements as the assets of the Company consist 
mainly of securities that are readily realisable and, accordingly, the Company 
has adequate financial resources to continue in operational existence for the 
foreseeable future. 
 
Statement under DTR 4.1.12 
 
Each of the Directors confirms that, to the best of his or her knowledge: 
 
  * the Company's financial statements, which have been prepared in accordance 
    with IFRSs as adopted by the European Union on a going concern basis, give 
    a true and fair view of the assets, liabilities, financial position and 
    loss of the Company; and 
  * the Strategic Report includes a fair review of the development and 
    performance of the business and the position of the Company together with a 
    description of the principal risks and uncertainties that it faces. 
 
We consider the Annual Report and the financial statements, taken as a whole, 
is fair, balanced and understandable and provides the information necessary for 
shareholders to assess the Company's position and performance, business model 
and strategy. 
 
On behalf of the Board 
 
Andrew Joy 
Chairman 
 
25 May 2017 
 
 
 
Governance / Audit Committee Report 
 
for the year ended 31 March 2017 
 
Introduction from the Chairman 
 
I present my last formal report to shareholders as Chairman of the Audit 
Committee, for the year ended 31 March 2017. I shall be retiring from the Board 
at the conclusion of this year's Annual General Meeting at which time Julia Le 
Blan, a Chartered Accountant, will succeed me as Chairman of the Audit 
Committee. 
 
Constitution Composition and Meetings 
 
During the year, in order to strengthen the Company's governance structure, the 
Board agreed to split the 'audit' and 'management engagement' functions of the 
Audit and Management Engagement Committee and to create two new Committees (an 
Audit Committee and a Management Engagement Committee) to be responsible for 
these areas. The Audit and Management Engagement Committee, met twice during 
the year. Membership comprises the independent Directors. I was appointed 
Chairman of the Committee in 2005. The Board has taken note of the requirements 
that the Committee as a whole should have competence relevant to the sector in 
which the Company operates and that at least one member of the Committee should 
have recent and relevant financial experience. The Committee is satisfied that 
the Committee is properly constituted in both respects: I am a Chartered 
Accountant and have over 30 years' experience in the management and financing 
of life science businesses; the other Committee members have a combination of 
financial, investment and other relevant experience gained throughout their 
careers. 
 
Responsibilities 
 
The Committee's main responsibilities during the year were: 
 
1.      To review the Company's half year and annual financial statements 
together with announcements and other filings relating to the financial 
performance of the Company and issues of the Company's shares. In particular, 
the Committee considered whether the annual financial statements are fair, 
balanced and understandable, allowing shareholders to more easily assess the 
Company's strategy, investment policy, business model and financial 
performance. 
 
2.      To review the risk management and internal control processes of the 
Company and its key service providers. As part of this review the Committee 
again reviewed the appropriateness of the Company's anti-bribery and corruption 
policy. During the year the Committee reviewed the Internal Controls in place 
at the Company's AIFM, Frostrow, its Portfolio Manager, OrbiMed, its Registrar, 
Capita Asset Services and its custodian J.P. Morgan Clearing Corp. Further 
information concerning risk management can be found within the Strategic 
Report. 
 
3.      To recommend the appointment of an external auditor, and agreeing the 
scope of its work and its remuneration, reviewing its independence and the 
effectiveness and objectivity of the audit process. 
 
4.      To consider any non-audit work to be carried out by the auditor. The 
Committee reviews the need for non-audit services and authorises such fees on a 
case by case basis, having consideration to the cost effectiveness of the 
services and the independence and objectivity of the Auditors. Non-audit fees 
of GBP6,825 were paid to Ernst & Young LLP for their review of the Company's 
half-year accounts. In addition fees totalling GBP1,300 were earned in relation 
to taxation services. The external auditor carried out no other non-audit work 
during the year. 
 
5.      To consider the need for an internal audit function. Since the Company 
delegates its day-to-day operations to third parties and has no employees, the 
Committee has determined there is no requirement for such a function. 
 
The Committee's terms of reference are available for review on the Company's 
website at www.biotechgt.com. 
 
Financial statements 
 
The financial statements, and the Annual Report as a whole, are the 
responsibility of the Board. The Board looks to the Audit Committee to advise 
them in relation to the Financial Statements both as regards their form and 
content, issues which might arise and on any specific areas requiring judgment. 
 
Significant reporting matters 
 
During the year the Committee considered key accounting issues, matters and 
judgments in relation to the Company's financial statements and disclosures 
relating to: 
 
Company's Investments - valuation and ownership of the Company's investments 
 
The Committee approached and dealt with this area of risk by: 
 
  * reconfirming its understanding of the processes in place to record 
    investment transactions and to value the investment portfolio; 
  * gaining an overall understanding of the performance of the investment 
    portfolio both in capital and revenue terms through comparison to a 
    suitable benchmark; and 
  * ensuring that all investment holdings and cash/deposit balances have been 
    agreed to confirmation from the custodian or relevant bank. 
 
Taxation - ensuring that the regulations for the Company to maintain its 
investment trust status have been observed 
 
The Committee approached and dealt with the area of risk, surrounding 
compliance with section 1158 of the Corporation Tax Act 2010, by: 
 
  * seeking confirmation from the AIFM that the Company continues to meet the 
    eligibility conditions as outlined in section 1158 through reports received 
    at each Board meeting and also as part of the monthly Compliance Monitoring 
    Report sent to the Board; 
  * by obtaining written confirmation from HMRC, evidencing the approval of the 
    Company as an investment trust under the regime; and 
  * understanding the risks and consequences if the Company breaches this 
    approval in future years. 
 
Terms of Reference and Non-Audit Services Policy 
 
The Committee undertook a review of the Committee's Terms of Reference and the 
Company's non-audit services policy in light of the change in the nature of the 
Committee's responsibilities and also of the new ethical standards. 
 
Internal controls 
 
The Board has established an ongoing process for identifying, evaluating and 
managing any major risks faced by the Company. The process accords with advice 
issued by the FRC and is subject to regular review by the Audit Committee. The 
Board has overall responsibility for the Company's system of internal controls 
and for reviewing its effectiveness. However, such a system is designed to 
manage rather than eliminate risks of failure to achieve the Company's business 
objectives and can only provide reasonable and not absolute assurance against 
material misstatement or loss. The Audit Committee has reviewed the 
effectiveness of the Company's system of internal controls for the year ended 
31 March 2017. During the course of its review the Audit Committee has not 
identified or been advised of any failings or weaknesses that have been 
determined as significant. All business risks faced by the Company are recorded 
in a detailed risk map which is reviewed periodically. In arriving at its 
judgement of what constitutes a sound system of internal control, the Directors 
considered the following factors: 
 
  * the nature and extent of risks which it regards as acceptable for the 
    Company to bear within its overall business objective; 
  * the threat of such risks becoming a reality; and 
  * the Company's ability to reduce the incidence and impact of risk on its 
    performance. 
 
Against this background, the Board has split the review of risk and associated 
controls into five sections reflecting the nature of the risks being addressed. 
These sections are as follows: 
 
  * corporate strategy; 
  * investment activity; 
  * published information, compliance with laws and regulations; 
  * service providers; and 
  * financial activity. 
 
The Company has obtained from its various service providers assurances and 
information relating to their internal systems and controls to enable the Board 
to make an appropriate risk and control assessment, including the following: 
 
  * details of the control environment in operation; 
  * identification and evaluation of risks and control objectives; 
  * review of communication methods and procedures; and 
  * assessment of the control procedures. 
 
All of the Company's management functions are performed by third parties whose 
internal controls are reviewed by the Board or on its behalf by Frostrow. 
 
In accordance with guidance issued to directors of listed companies, the 
Directors confirm that they have carried out a review of the effectiveness of 
the system of internal financial control and risk management during the year, 
as set out above and that the ongoing process for identifying, evaluating and 
managing significant risks faced by the Company, has been in place for the year 
under review and up to 25 May 2017. 
 
Non-Audit Services 
 
The Company operates on the basis whereby the provision of all non-audit 
services by the Auditor has to be pre-approved by the Audit Committee. Such 
services are only permissible where no conflicts of interest arise, the service 
is not expressly prohibited by audit legislation, where the independence of the 
Auditor is not likely to be impinged by undertaking the work and the quality 
and the objectivity of both the non-audit work and audit work will not be 
compromised. In particular, non-audit services may be provided by the Auditor 
if they are inconsequential or would have no direct effect on the Company's 
financial statements and the audit firm would not place significant reliance on 
the work for the purposes of the statutory audit. 
 
Audit Tendering 
 
As a public company listed on the London Stock Exchange, the Company is subject 
to the mandatory Auditor rotation requirements of the European Union. The 
Company will put the external audit out to tender at least every 10 years and 
change Auditor at least every 20 years. Ernst & Young LLP have been in post 
since July 2014, which was the last occasion an audit tender was held. Formal 
Audit tender guidelines have been adopted to govern the Audit tender process. 
 
Auditor Reappointment 
 
Ernst & Young LLP have indicated their willingness to continue to act as 
Auditor to the Company for the forthcoming year and a resolution for their 
re-appointment will be proposed at the Annual General Meeting. 
 
The Committee reviews the scope and effectiveness of the audit process, 
including agreeing the Auditor's assessment of materiality and monitors the 
Auditor's independence and objectivity. It conducted a review of the 
performance of the Auditor during the year and concluded that performance was 
satisfactory and there were no grounds for change. 
 
Peter Keen 
Chairman of the Audit Committee 
 
25 May 2017 
 
 
 
Governance / Directors' Remuneration Report 
 
for the year ended 31 March 2017 
 
Statement from the Chairman of the Remuneration Committee 
 
I am pleased to present the Directors' Remuneration Report to shareholders. 
 
This report has been prepared in accordance with the requirements of Section 
421 of the Companies Act 2006 and the Enterprise and Regulatory Reform Act 
2013. A non-binding Ordinary Resolution for the approval of this report was 
last put to the shareholders at the 2016 Annual General Meeting. 
 
The law requires the Company's Auditor to audit certain of the disclosures 
provided in this report. Where disclosures have been audited, they are 
indicated as such and the Auditor's opinion is included in their report to 
shareholders. The Remuneration Policy Report forms part of this report. 
 
The Remuneration Committee considers the framework for the remuneration of the 
Directors on an annual basis. It reviews the ongoing appropriateness of the 
Company's remuneration policy and the individual remuneration of Directors by 
reference to the activities of the Company and comparison with other companies 
of a similar structure and size. This is in line with the AIC Code. 
 
At the most recent review held on 28 February 2017, the following increases to 
the fees paid to the Directors were agreed with effect from 1 April 2017: 
Chairman GBP36,500 pa; Chairman of the Audit Committee GBP28,000 pa; Senior 
Independent Director GBP28,000 pa; Director GBP25,500 pa. The last increase took 
effect from 1 April 2015. 
 
In the year to 31 March 2017, the Directors' fees were paid at the following 
annual rates: the Chairman of the Company GBP35,500, Peter Keen as Chairman of 
the Audit Committee and myself as the Senior Independent Director received an 
annual fee of GBP27,000. The remaining Directors received GBP25,000. 
 
All levels of remuneration reflect both the time commitment and responsibility 
of the role. 
 
Directors' fees 
 
The Directors, as at the date of this report, and who all served throughout the 
year (unless where stated), received the fees listed in the table below. These 
exclude any employers' national insurance contributions, if applicable. 
 
As noted in the Strategic Report, all of the Directors are non-executive and 
therefore there is no Chief Executive Officer. The Company does not have any 
employees. There is therefore no CEO or employee information to disclose. 
 
Directors' emoluments for the year (audited) 
 
The Directors who served in the year received the following emoluments in the 
form of fees: 
 
                                         Year ended 31 March 2017    Year ended 31 March 2016 
 
                                Date of     Base   Taxable              Base   Taxable 
                            Appointment 
 
                                 to the   Salary Benefits+    Total   Salary Benefits+    Total 
                                  Board 
 
                                               GBP         GBP        GBP        GBP         GBP        GBP 
 
The Rt Hon Lord Waldegrave 
of 
 
North Hill (retired 12 July 6 June 1998    9,967         -    9,967   35,500         -   35,500 
2016) 
 
Steven Bates                8 July 2015   25,000         -   25,000   18,397         -   18,397 
 
Sven Borho                     23 March   25,000         -   25,000   25,000         -   25,000 
                                   2006 
 
Professor Dame Kay Davies^     15 March   26,369       439   26,808   25,000       231   25,231 
                                   2012 
 
Paul Gaunt (retired on 8                       -         -        -    4,744       506    5,250 
July 2015) 
 
Andrew Joy (Chairman)?         15 March   33,022         -   33,022   27,000         -   27,000 
                                   2012 
 
Peter Keen (Chairman of the 
 
Audit Committee)               23 June   27,000     1,164   28,164   27,000       561   27,561 
                                   1997 
 
Julia Le Blan**                 12 July   18,013         -   18,013        -         -        - 
                                   2016 
 
The Rt Hon Lord Willetts    11 November   25,000         -   25,000    9,679         -    9,679 
                                   2015 
 
                                         189,371     1,603  190,974  172,320     1,298  173,618 
 
  * Taxable benefits primarily comprise travel and associated expenses incurred 
    by the Directors in attending Board and Committee meetings in London. These 
    are re-imbursed by the Company and, under a new interpretation of HMRC 
    Rules, are subject to tax and National Insurance and therefore are treated 
    as a Benefit in Kind with this table. 
 
^          Appointed Senior Independent Director on 12 July 2016. 
 
?          Appointed as Chairman on 12 July 2016. Prior to this he was the 
Senior Independent Director. 
 
          Will retire from the Board on 12 July 2017. He will be succeeded as 
Chairman of the Audit Committee by Julia Le Blan. 
 
**         Appointed on 12 July 2016. 
 
The Directors are entitled to be re-imbursed for reasonable expenses incurred 
by them in connection with the performance of their duties and attendance at 
Board and General Meetings. 
 
In certain circumstances, under HMRC rules, travel and other out of pocket 
expenses reimbursed to the Directors may be considered as taxable benefits. 
Where expenses are classed as taxable under HMRC guidance they are shown in the 
Taxable Benefits column of the table on the previous page. 
 
Relative cost of directors' remuneration for the year ended 31 March 2017 
 
To enable shareholders to assess the relative cost of directors' remuneration, 
this has been shown in the table below compared with the Company's AIFM, 
Portfolio Management and other expenses. 
 
                                                                2017        2016  Difference 
 
                                                                GBP000        GBP000        GBP000 
 
Fees of non-executive directors (base salary)                    189         172          17 
 
AIFM, Portfolio management fees and other expenses             4,608       4,943       (335) 
(excluding performance fee provisions) 
 
Performance fee provision/(write back)                             -     (1,854)       1,854 
 
*          During the year ended 31 March 2017 no performance fees were paid 
(2016: GBPnil). 
 
At the Annual General Meeting held in July 2016 the results in respect of the 
non-binding resolution to approve the Directors' Remuneration Report were as 
follows: 
 
Directors' remuneration report 
 
                                                     Percentage Percentage  Number of 
                                                             of         of 
 
                                                     votes cast votes cast      votes 
 
                                                            For    Against   withheld 
 
                                                         99.20%      0.80%     53,991 
 
At the Annual General Meeting held in July 2014 the results in respect of the 
binding resolution to approve the Directors' Remuneration Policy were as 
follows: 
 
Directors' remuneration policy 
 
                                                          Percentage  Percentage   Number of 
                                                                  of          of 
 
                                                          votes cast  votes cast       votes 
 
                                                                 For     Against    withheld 
 
                                                               77.15       22.85      68,430 
 
Further details concerning Director Remuneration can be found in the Corporate 
Governance section. 
 
A copy of the Directors' Remuneration Policy may be inspected by shareholders 
by either contacting the Company Secretary or visiting the Company's website at 
www.biogtechgt.com. 
 
Loss of office 
 
Directors do not have service contracts with the Company but are engaged under 
Letters of Appointment. These specifically exclude any entitlement to 
compensation upon leaving office for whatever reason. 
 
Share price return 
 
Share price versus the NASDAQ Biotechnology Index (sterling adjusted). The 
chart overleaf illustrates the shareholder return for a holding in the 
Company's shares as compared to the NASDAQ Biotechnology Index (sterling 
adjusted), which the Board has adopted as the measure for both the Company's 
performance and that of the Portfolio Manager for the period. 
 
Directors' interests in ordinary shares (audited) 
 
The Directors interests in the share capital of the Company are shown in the 
table below: 
 
                                                             Number of shares held as at 
 
                                                              25 May    31 March    31 March 
 
                                                                2017        2017        2016 
 
Andrew Joy (Chairman)                                         55,000      55,000      55,000 
 
The Rt Hon Lord Waldegrave of North Hill                         N/A         N/A      58,716 
 
Steven Bates                                                     nil         nil         nil 
 
Sven Borho                                                   236,218     236,218     236,218 
 
Professor Dame Kay Davies, CBE                                 3,500       3,500         nil 
 
Peter Keen                                                    55,000      55,000      55,000 
 
Julia Le Blan                                                  4,000       4,000         N/A 
 
The Rt Hon Lord Willetts                                         nil         nil         nil 
 
None of the Directors was granted or exercised rights over shares during the 
year. Sven Borho is a Partner at OrbiMed, the Company's Portfolio Manager, 
which is party to the Portfolio Management Agreement with the Company and 
receives fees. 
 
Annual statement 
 
On behalf of the Board I confirm that the Remuneration Policy and Remuneration 
Report summarise, as applicable, for the year to 31 March 2017: 
 
(a)     the major decisions on Directors' remuneration; 
 
(b)     any substantial changes relating to Directors' remuneration made during 
the year; and 
 
(c)     the context in which the changes occurred and decisions have been 
taken. 
 
Professor Dame Kay Davies CBE 
Senior Independent Director and Chairman of the Remuneration Committee 
 
27 May 2017 
 
 
 
Governance / Directors' Remuneration Policy 
 
The Company follows the recommendations of the AIC Code that Directors' 
remuneration should reflect their duties, responsibilities and the value of 
their time spent. The Board's policy is that the remuneration of the Directors 
should reflect the experience of the Board as a whole, and is determined with 
reference to comparable organisations and appointments. There are no 
performance conditions attaching to the remuneration of the Directors as the 
Board does not believe that this is appropriate for non-executive Directors. 
This policy is reviewed annually and it is intended that it will continue for 
the year ending 31 March 2017 and for subsequent financial years. 
 
The fees for the Directors are determined within the limits set out in the 
Company's Articles of Association, the maximum aggregate limit currently being 
GBP250,000 per annum, and they are not eligible for bonuses, pension benefits, 
share options, long-term incentive schemes or other benefits. The current and 
projected Directors' fees are shown in the following table. The Company does 
not have any employees. 
 
Directors' remuneration year ended 31 March 2017 
 
None of the Directors has a service contract. The terms of their appointment 
provide that Directors shall retire and be subject to election at the first 
Annual General Meeting after their appointment and to re-election annually 
thereafter. The terms also provide that a Director may be removed without 
notice and that compensation will not be due on leaving office. 
 
No communications have been received from shareholders regarding Directors' 
remuneration. 
 
In accordance with best practice recommendations the Board will put the 
Remuneration Policy to shareholders at the Annual General Meeting at least once 
every three years. 
 
Approval of this policy was granted by shareholders at the Annual General 
Meeting held in July 2014 and so shareholder approval will again be sought at 
this year's Annual General Meeting. 
 
Governance / Independent Auditor's Report to the Members of The Biotech Growth 
Trust PLC 
 
Our opinion on the financial statements 
 
In our opinion the accompanying financial statements: 
 
  * give a true and fair view of the financial position of the Company as at 31 
    March 2017 and of its financial performance and its cash flows for the year 
    then ended; 
  * have been properly prepared in accordance with IFRSs as adopted by the 
    European Union; and 
  * the financial statements have been prepared in accordance with the 
    requirements of the Companies Act 2006. 
 
What we have audited 
 
We have audited the financial statements of The Biotech Growth Trust PLC which 
comprise: 
 
  * Income Statement for the year ended 31 March 2017 
  * Statement of Financial Position as at 31 March 2017 
  * Statement of Changes in Equity for the year ended 31 March 2017 
  * Statement of Cash Flows for the year ended 31 March 2017 
  * The related notes 1 to 17 
 
The financial reporting framework that has been applied in their preparation is 
applicable law and International Financial Reporting Standards (IFRSs) as 
adopted by the European Union. 
 
Overview of our audit approach 
 
Risks of material misstatement 
 
  * Incorrect valuation of the investment portfolio. 
 
Audit Scope 
 
  * We performed an audit of the complete financial information of The Biotech 
    Growth Trust PLC. 
 
Materiality 
 
  * GBP4.4 million which represents 1% of total equity (2016: GBP3.8 million) as at 
    31 March 2017. 
 
Our assessment of risk of material misstatement 
 
We identified the risks of material misstatement described below as those that 
had the greatest effect on our overall audit strategy, the allocation of 
resources in the audit and the direction of the efforts of the audit team. In 
addressing these risks, we have performed the procedures below which were 
designed in the context of the financial statements as a whole and, 
consequently, we do not express any opinion on these individual areas. 
 
Risk                            Our response to the risk       What we concluded to the 
                                                               Audit Committee 
 
Incorrect valuation of the      We performed the following 
investment portfolio            procedures: 
 
The valuation of the assets     For quoted investments, we     The results of our 
held in the investment          agreed  100% of the year end   procedures identified no 
portfolio is the key driver     prices to independent          material error in the 
of the Company's investment     pricing sources. For the       valuation of the investment 
return. Incorrect valuation     unquoted investment, we have   portfolio assets. 
of assets by the Company        assessed the Company's         Based on the work performed, 
could have a significant        estimation of fair value and   we have no matters to 
impact on portfolio             have obtained independent      report. 
valuation and, therefore,       confirmation that the fair 
the return generated for        value, as at the year-end 
shareholders.                   date, is in accordance with 
                                the Company's valuation 
                                policy. We have ensured that 
                                there is no material 
                                difference between 
                                management's valuation and 
                                the company's partner's 
                                capital as at 31 March 2017. 
                                We have also assessed the 
                                reasonableness of the FX 
                                used to an independent 
                                source. No issues noted. 
 
The scope of our audit 
 
Our assessment of audit risk, our evaluation of materiality and our allocation 
of performance materiality determine our audit scope for the company. Taken 
together, this enables us to form an opinion on the financial statements. We 
take into account size, risk profile, the organisation of the Company and 
effectiveness of controls, including controls at Frostrow Capital LLP and J.P. 
Morgan Chase Bank, changes in the business environment and other factors such 
as recent Service Organisation Control ('SOC') Reports when assessing the level 
of work to be performed at Company level. 
 
Our application of materiality 
 
We apply the concept of materiality in planning and performing the audit, in 
evaluating the effect of identified misstatements on the audit and in forming 
our audit opinion. 
 
Materiality 
 
The magnitude of an omission or misstatement that, individually or in the 
aggregate, could reasonably be expected to influence the economic decisions of 
the users of the financial statements. Materiality provides a basis for 
determining the nature and extent of our audit procedures. 
 
We determined materiality for the company to be GBP4.4 million (2016: GBP3.8 
million), which is 1% of total equity as at 31 March 2017. We believe that 
total equity is the most important financial metric on which shareholders judge 
the performance of the Company. 
 
Performance materiality 
 
The application of materiality at the individual account or balance level. It 
is set at an amount to reduce to an appropriately low level the probability 
that the aggregate of uncorrected and undetected misstatements exceeds 
materiality. 
 
On the basis of our risk assessments, together with our assessment of the 
Company's overall control environment, our judgement was that performance 
materiality (i.e. our tolerance for misstatement in an individual account or 
balance) was 75% (2016: 75%) of our planning materiality, namely GBP3.4 million 
(2016: GBP2.8 million). We have set performance materiality at this percentage 
due to our past experience of the audit that indicates a lower risk of 
misstatements, both corrected and uncorrected. 
 
Given the importance of the distinction between revenue and capital for the 
Company we also applied a separate testing threshold of GBP60k (2016: GBP54k) for 
the revenue column of the income statement, being 5% of the revenue profit 
before taxation. 
 
Reporting threshold 
 
An amount below which identified misstatements are considered as being clearly 
trivial. 
 
We agreed with the audit committee that we would report to them all uncorrected 
audit differences in excess of GBP224k (2016: GBP189k), which is set at 5% of 
planning materiality, as well as differences below that threshold that, in our 
view, warranted reporting on qualitative grounds. 
 
We evaluate any uncorrected misstatements against both the quantitative 
measures of materiality discussed above and in light of other relevant 
qualitative considerations in forming our opinion. 
 
Scope of the audit of the financial statements 
 
An audit involves obtaining evidence about the amounts and disclosures in the 
financial statements sufficient to give reasonable assurance that the financial 
statements are free from material misstatement, whether caused by fraud or 
error. This includes an assessment of: whether the accounting policies are 
appropriate to the Company's circumstances and have been consistently applied 
and adequately disclosed; the reasonableness of significant accounting 
estimates made by the Directors; and the overall presentation of the financial 
statements. In addition, we read all the financial and non-financial 
information in the Annual Report to identify material inconsistencies with the 
audited financial statements and to identify any information that is apparently 
materially incorrect based on, or materially inconsistent with, the knowledge 
acquired by us in the course of performing the audit. If we become aware of any 
apparent material misstatements or inconsistencies we consider the implications 
for our report. 
 
Respective responsibilities of directors and auditor 
 
As explained more fully in the Statement of Directors' Responsibilities, the 
Directors are responsible for the preparation of the financial statements and 
for being satisfied that they give a true and fair view. Our responsibility is 
to audit and express an opinion on the financial statements in accordance with 
applicable law and International Standards on Auditing (UK and Ireland). Those 
standards require us to comply with the Auditing Practices Board's Ethical 
Standards for Auditors. 
 
This report is made solely to the Company's members, as a body, in accordance 
with Chapter 3 of Part 16 of the Companies Act 2006. Our audit work has been 
undertaken so that we might state to the Company's members those matters we are 
required to state to them in an auditor's report and for no other purpose. To 
the fullest extent permitted by law, we do not accept or assume responsibility 
to anyone other than the Company and the Company's members as a body, for our 
audit work, for this report, or for the opinions we have formed. 
 
Opinion on other matters prescribed by the Companies Act 2006 
 
In our opinion: 
 
  * the part of the Directors' Remuneration Report to be audited has been 
    properly prepared in accordance with the Companies Act 2006; and 
  * based on the work undertaken in the course of the audit: 
  * the information given in the Strategic Report and the Directors' Report for 
    the financial year for which the financial statements are prepared is 
    consistent with the financial statements. 
  * the Strategic Report and the Directors' Report have been prepared in 
    accordance with applicable legal requirements; 
 
Matters on which we are required to report by exception 
 
ISAs (UK and   We are required to report to you if, in our opinion,      We have no 
Ireland)       financial and non-financial information in the annual     exceptions to 
reporting      report is:                                                report. 
               In particular, we are required to report whether we have 
               identified any inconsistencies between our knowledge 
               acquired in the course of performing the audit and the 
               directors' statement that they consider the annual 
               report and accounts taken as a whole is fair, balanced 
               and understandable and provides the information 
               necessary for shareholders to assess the entity's 
               performance, business model and strategy; and whether 
               the annual report appropriately addresses those matters 
               that we communicated to the audit committee that we 
               consider should have been disclosed. 
 
Companies Act  In light of the knowledge and understanding of the        We have no 
2006           Company and its environment obtained in the course of     exceptions to 
reporting      the audit, we have identified no material misstatements   report. 
               in the Strategic Report, Directors' Report or Corporate 
               Governance Report. 
               We are required to report to you if, in our opinion: 
 
Listing Rules  We are required to review:                                We have no 
review                                                                   exceptions to 
requirements                                                             report. 
 
Statement on the Directors' assessment of the principal risks that would 
threaten the solvency or liquidity of the entity 
 
ISAs (UK and   We are required to give a statement as to whether we       We have 
Ireland)       have anything material to add or to draw attention to in   nothing 
reporting      relation to:                                               material to 
                                                                          add or to draw 
                                                                          attention to. 
 
AMARJIT SINGH 
SENIOR STATUTORY AUDITOR 
FOR AND ON BEHALF OF ERNST & YOUNG LLP 
STATUTORY AUDITOR 
LONDON 
 
25 May 2017 
 
 
 
Financial Statements / Income Statement 
 
for the year ended 31 March 2017 
 
                                                 2017                        2016 
 
                                     Revenue  Capital    Total  Revenue   Capital     Total 
 
                              Notes    GBP'000    GBP'000    GBP'000    GBP'000     GBP'000     GBP'000 
 
Investment Income 
 
Investment income                 2    1,905        -    1,905    1,820         -     1,820 
 
Total income                                                      1,820         -     1,820 
 
Gains/(losses) on 
investments 
 
Gains/(losses) on 
investments held at fair 
value 
 
through profit or loss            8        -  103,813  103,813        - (125,284) (125,284) 
 
Exchange losses on                         -  (2,252)  (2,252)        -   (1,802)   (1,802) 
currency balances 
 
Expenses 
 
AIFM, Portfolio management 
and 
 
performance fees                  3        -  (3,905)  (3,905)        -   (2,353)   (2,353) 
 
Other expenses                    4    (703)        -    (703)    (736)         -     (736) 
 
Profit/(loss) before                   1,202   97,656   98,858    1,084 (129,439) (128,355) 
finance costs and taxation 
 
Finance costs                     5        -    (280)    (280)        -     (340)     (340) 
 
Profit/(loss) before                   1,202   97,376   98,578    1,084 (129,779) (128,695) 
taxation 
 
Taxation                          6    (281)        -    (281)    (254)         -     (254) 
 
Profit/(loss) for the year               921   97,376   98,297      830 (129,779) (128,949) 
 
Basic and diluted earnings        7     1.6p   169.9p   171.5p     1.3p  (209.4)p  (208.1)p 
/(loss) per share 
 
The Company does not have any income or expenses which are not included in the 
profit for the year. Accordingly the "profit for the year" is also the "total 
comprehensive income for the year", as defined in IAS 1 (revised) and no 
separate Statement of Comprehensive Income has been presented. 
 
The "Total" column of this statement represents the Company's Income Statement, 
prepared in accordance with International Financial Reporting Standards (IFRS) 
as adopted by the EU. The "Revenue" and "Capital" columns are supplementary to 
this and are prepared under guidance published by the Association of Investment 
Companies. 
 
The accompanying notes are an integral part of this statement. 
 
Financial Statements / Statement of Financial Position 
 
as at 31 March 2017 
 
                                                                             2017       2016 
 
                                                                 Notes      GBP'000      GBP'000 
 
Non current assets 
 
Investments held at fair value through profit or loss                8    461,378    420,427 
 
Current assets 
 
Other receivables                                                    9        117      4,718 
 
                                                                              117      4,718 
 
                                                                          461,495    425,145 
 
Current liabilities 
 
Other payables                                                      10      1,235     10,389 
 
Bank overdraft                                                             13,083     36,189 
 
                                                                           14,318     46,578 
 
Net assets                                                                447,177    378,567 
 
Equity attributable to equity holders 
 
Ordinary share capital                                              11     13,960     15,074 
 
Share premium account                                                      43,021     43,021 
 
Capital redemption reserve                                                  8,839      7,725 
 
Capital reserve                                                     16    383,283    315,594 
 
Revenue reserve                                                           (1,926)    (2,847) 
 
Total equity                                                              447,177    378,567 
 
Net asset value per share                                           12     800.8p     627.9p 
 
The financial statements were approved by the Board on 25 May 2017 and were 
signed on its behalf by: 
 
Andrew Joy 
Chairman 
 
The accompanying notes are an integral part of this statement. 
 
The Biotech Growth Trust PLC - Company Registration Number 3376377 (Registered 
in England) 
 
 
 
Financial Statements / Statement of Changes in Equity 
 
for the year ended 31 March 2017 
 
                            Ordinary     Share              Capital 
 
                               share   premium   Special redemption   Capital   Revenue 
 
                             capital   account   reserve    reserve   reserve   reserve     Total 
 
                               GBP'000     GBP'000     GBP'000      GBP'000     GBP'000     GBP'000     GBP'000 
 
At 31 March 2016              15,074    43,021         -      7,725   315,594   (2,847)   378,567 
 
Net profit for the year            -         -         -          -    97,376       921    98,297 
 
Repurchase of own shares     (1,114)         -         -      1,114  (29,687)         -  (29,687) 
for cancellation* 
 
At 31 March 2017              13,960    43,021         -      8,839   383,283   (1,926)   447,177 
 
*               Further details can be found in note 11. 
 
for the year ended 31 March 2016 
 
                            Ordinary     Share              Capital 
 
                               share   premium   Special redemption   Capital   Revenue 
 
                             capital   account   reserve    reserve   reserve   reserve     Total 
 
                               GBP'000     GBP'000     GBP'000      GBP'000     GBP'000     GBP'000     GBP'000 
 
At 31 March 2015              17,222    43,021       252      5,577   470,907   (3,677)   533,302 
 
Net (loss)/profit for the          -         -         -          - (129,779)       830 (128,949) 
year 
 
Repurchase of own shares           -         -     (252)          -  (10,241)         -  (10,493) 
to be held in treasury* 
 
Repurchase of own shares       (570)         -         -        570  (15,293)         -  (15,293) 
for cancellation* 
 
Cancellation of own shares   (1,578)         -         -      1,578         -         -         - 
held in treasury* 
 
At 31 March 2016              15,074    43,021         -      7,725   315,594   (2,847)   378,567 
 
The accompanying notes are an integral part of this statement. 
 
Financial Statements / Statement of Cash Flows 
 
for the year ended 31 March 2017 
 
                                                                             2017      2016 
 
                                                                            GBP'000     GBP'000 
 
Operating activities 
 
Profit/(loss) before taxation*                                             98,578 (128,695) 
 
Finance costs                                                                 280       340 
 
(Gains)/losses on investments held at fair value through profit or loss (103,813)   125,284 
 
Decrease/(increase) in other receivables                                       45      (24) 
 
Increase/(decrease) in other payables                                         186   (2,218) 
 
Net cash outflow from operating activities before interest and taxation   (4,724)   (5,313) 
 
Finance costs - interest paid                                               (280)     (340) 
 
Taxation paid                                                               (281)     (254) 
 
Net cash outflow from operating activities                                (5,285)   (5,907) 
 
Investing Activities 
 
Purchases of investments held at fair value through profit or loss      (298,295) (378,906) 
 
Sales of investments held at fair value through profit or loss            356,373   422,793 
 
Net cash inflow from investing activities                                  58,078    43,887 
 
Financing activities 
 
Repurchase of own shares to be held in treasury                                 -  (10,493) 
 
Repurchase of own shares for cancellation                                (29,687)  (15,293) 
 
Net cash outflow from financing activities                               (29,687)  (25,786) 
 
Net increase in cash and cash equivalents                                  23,106    12,194 
 
Cash and cash equivalents at start of year                               (36,189)  (48,383) 
 
Cash and cash equivalents at end of year                                 (13,083)  (36,189) 
 
*          Includes dividends and other income earned during the year of GBP 
1,905,000 (2016: GBP1,820,000). 
 
The accompanying notes are an integral part of this statement. 
 
Financial Statements / Notes to the Financial Statements 
 
1. Accounting policies 
 
(a) Basis of preparation 
 
The financial statements of the Company have been prepared in accordance with 
International Financial Reporting Standards ("IFRS"). These comprise standards 
and interpretations approved by the International Accounting Standards Board 
("IASB"), together with interpretations of the International Accounting 
Standards and Standing Interpretations Committee approved by the International 
Accounting Standards Committee ("IASC") that remain in effect, to the extent 
that IFRS have been adopted by the European Union. 
 
The principal accounting policies adopted are set out below. 
 
The financial statements have been prepared under the historical cost 
convention, except for the measurement at fair value of investments. Where 
presentational guidance set out in the Statement of Recommended Practice ("the 
SORP") for Investment Trust Companies and Venture Capital Trusts produced by 
the Association of Investment Companies ("AIC") revised November 2014 is 
consistent with the requirements of IFRS, the Directors have sought to prepare 
the financial statements on a basis compliant with the recommendations of the 
SORP. 
 
The Company's financial statements are presented in sterling and all values are 
rounded to the nearest thousand pounds (GBP'000) except when otherwise indicated. 
The accounts have been prepared on a going concern basis as the Directors 
consider that in the foreseeable future (at least 12 months from the date of 
approval of the financial statements) the Company will continue to be able to 
meet its liabilities as they fall due. 
 
The accounting policies adopted are consistent with those of the previous 
financial year. 
 
Judgements and key sources of estimation and uncertainty 
 
The preparation of the financial statements requires the Directors to make 
judgements, estimates and assumptions that affect the amounts reported for 
assets and liabilities as at the statement of financial position date and the 
amounts reported for revenues and expenses during the year. However, the nature 
of estimation means that actual outcomes could differ from those estimates. In 
the process of applying the Company's accounting policies, the Directors have 
made the following estimate: 
 
Fair value of the unquoted investments estimate 
 
The unquoted investment OrbiMed Asia Partners L.P., has been valued using the 
Net Asset Value as presented in the partnership's Consolidated Financial 
Statements as at 31 December 2016. The statements were audited by KPMG LLP (New 
Jersey Headquarters) and were approved on 28 March 2017.The Directors believe 
that the NAV as at 31 March 2017 is not materially different. 
 
(b) Investments 
 
Investments are recognised and de-recognised on the trade date. 
 
As the entity's business is investing in financial assets with a view to 
profiting from their total return in the form of dividends or increases in fair 
value, investments are designated as fair value through profit or loss and are 
initially recognised at fair value. The entity manages and evaluates the 
performance of these investments on a fair value basis in accordance with its 
investment strategy, and information about the investments is provided 
internally on this basis to the Board. 
 
Investments designated as at fair value through profit or loss, which are 
quoted investments, are measured at subsequent reporting dates at fair value 
which is either the bid or the last trade price, depending on the convention of 
the exchange on which it is quoted. 
 
In respect of unquoted investments, or where the market for a financial 
instrument is not active, fair value is established by using valuation 
techniques which may include using recent arm's length market transactions 
between knowledgeable, willing parties, if available, reference to the current 
fair value of another instrument that is substantially the same, discounted 
cash flow analysis and option pricing models. Where there is a valuation 
technique commonly used by market participants to price the instrument and that 
technique has been demonstrated to provide reliable estimates of prices 
obtained in actual market transactions, that technique is utilised. 
 
Gains and losses on disposal and fair value changes are also recognised in the 
Income Statement. 
 
(c) Presentation of Income Statement 
 
In order to better reflect the activities of an investment trust company, and 
in accordance with guidance issued by the AIC, supplementary information which 
analyses the Income Statement between items of a revenue and capital nature has 
been presented alongside the Income Statement. Net revenue is the measure the 
Directors believe appropriate in assessing the Company's compliance with 
certain requirements set out in section 1158 of the Corporation Tax Act 2010. 
The requirements are to distribute net revenue but only so far as there are 
positive revenue reserves. 
 
(d) Income 
 
Dividends receivable on equity shares are recognised on the ex-dividend date. 
Where no ex-dividend date is quoted, dividends are recognised when the 
Company's right to receive payment is established. 
 
Dividends from investments in unquoted shares and securities are recognised 
when they become receivable. Income from stock re-hypothecation is recognised 
when the Company's right to receive payment is established. 
 
(e) Expenses and finance costs 
 
All expenses are accounted for on an accruals basis. Expenses are charged 
through the Income Statement as follows: 
 
  * expenses which are incidental to the acquisition or disposal of an 
    investment are charged to the capital column of the Income Statement; 
  * expenses are charged to the capital column of the Income Statement where a 
    connection with the maintenance or enhancement of the value of the 
    investment can be demonstrated, and accordingly; 
  * AIFM and Portfolio management fees are charged to the capital column of the 
    Income Statement as the Directors expect that in the long term virtually 
    all of the Company's returns will come from capital; and 
  * bank overdraft interest is charged through the Income Statement on an 
    effective rate basis and allocated to the capital column, as the Directors 
    expect that in the long-term virtually all of the Company's returns will 
    come from capital. 
 
(f) Taxation 
 
In line with the recommendations of the SORP, the allocation method used to 
calculate tax relief on expenses presented against capital returns in the 
supplementary information in the Income Statement is the "marginal basis". 
Under this basis, if taxable income is capable of being offset entirely by 
expenses presented in the revenue column of the Income Statement, then no tax 
relief is transferred to the capital column. 
 
Investment trusts which have approval under Section 1158 Corporation Tax Act 
2010 are not liable for taxation on capital gains. 
 
Deferred tax is the tax expected to be payable or recoverable on differences 
between the carrying amounts of assets and liabilities in the financial 
statements and the corresponding tax bases used in the computation of taxable 
profit, and is accounted for using the Balance Sheet liability method. Deferred 
tax liabilities are recognised for all taxable temporary differences and 
deferred tax assets are recognised to the extent that it is probable that 
taxable profits will be available against which deductible temporary 
differences can be utilised. 
 
Deferred tax is calculated at the tax rates that are expected to apply in the 
period when the liability is settled or the asset is realised. Deferred tax is 
charged or credited in the Income Statement, except when it relates to items 
charged or credited directly to equity, or Other Comprehensive Income (OCI), in 
which case the deferred tax is also dealt with in equity or OCI respectively. 
 
(g) Foreign currencies 
 
The currency of the primary economic environment in which the Company operates 
(the functional currency) is sterling, which is also the presentational 
currency of the Company. Transactions involving currencies other than sterling 
are recorded at the exchange rate ruling on the transaction date. At each 
Statement of Financial Position date, monetary items and non-monetary assets 
and liabilities that are fair valued, which are denominated in foreign 
currencies, are retranslated at the closing rates of exchange. 
 
Exchange differences are included in the Income Statement and allocated as 
capital if they are of a capital nature, or as revenue if they are of a revenue 
nature. 
 
(h) Functional and presentational currency 
 
The financial information is shown in sterling, being the Company's 
presentational currency. In arriving at the functional currency the Directors 
have considered the following: 
 
(i)      the primary economic environment of the Company; 
 
(ii)     the currency in which the original capital was raised; 
 
(iii)     the currency in which distributions are made; 
 
(iv)     the currency in which performance is evaluated; and 
 
(v)      the currency in which the capital would be returned to shareholders on 
a break up basis. 
 
The Directors have also considered the currency to which the underlying 
investments are exposed and liquidity is managed. The Directors are of the 
opinion that sterling best represents the functional currency. 
 
(i) Reserves 
 
Equity share capital 
 
  * represents the nominal value of the issued share capital 
 
Capital reserves 
 
The following are credited or charged to the capital column of the Income 
Statement and then transferred to the Capital Reserve: 
 
  * gains or losses on disposal of investments 
  * exchange differences of a capital nature 
  * expenses allocated to this reserve in accordance with the above referred 
    policies 
  * increases and decreases in the valuation of investments held at year end 
 
Capital redemption reserve 
 
  * a transfer will be made to this reserve on cancellation of the Company's 
    own shares purchased, equal to the nominal value of the Shares 
 
Special reserve 
 
During the financial year ended 31 March 2004, a Special Reserve was created, 
following the cancellation of the Share Premium account, in order to provide an 
increased distributable reserve out of which to purchase the Company's own 
shares. 
 
  * a transfer will be made from this reserve on cancellation of the Company's 
    own shares purchased or when the Company repurchases its own shares to be 
    held in treasury. 
 
(j) Cash and cash equivalents 
 
Cash and cash equivalents are defined as cash in hand, demand deposits and 
short-term deposits with a majority of three months or less, highly liquid 
investments readily convertible to known amounts of cash and subject to 
insignificant risk of changes in value. Bank overdrafts that are repayable on 
demand, which form an integral part of the Company's cash management, are 
included as a component of cash and cash equivalents for the purpose of the 
statement of cash flows. 
 
(k) Bank overdraft 
 
The Company has an overdraft facility repayable on demand, provided by J.P. 
Morgan Clearing Corp. Interest on the facility is charged at the Federal Funds 
open rate plus 45 basis points. Finance costs are apportioned 100% to capital 
in accordance with the policy set out under note 1(e) Expenses and finance 
costs. 
 
(l) Operating segments 
 
IFRS 8 requires entities to define operating segments and segment performance 
in the financial statements based on information used by the Board of 
Directors. The Directors are of the opinion that the Company is engaged in a 
single segment of business, being the investments business. The results 
published in this report therefore correspond to this sole operating segment. 
 
In line with IFRS 8, additional disclosure by geographical segment has been 
provided in note 14. 
 
(m) Financial instruments 
 
Financial assets and financial liabilities are recognised on the statement of 
financial position when the Company becomes a party to the contractual 
provisions of the instrument. Financial assets are de-recognised when the 
Company's contractual right to the cash flows from the asset expires or 
substantially all the risks and rewards of ownership are transferred. Financial 
liabilities are de-recognised when the contractual obligation is discharged, 
with gains and losses recognised in the income statement. 
 
(n) Standards, amendments and interpretations to existing standards become 
effective in future accounting periods and have not been adopted by the 
Company: 
 
  * IFRS 9 Financial Instruments - The standard introduces new requirements for 
    classification and measurement, impairment, and hedge accounting. IFRS 9 is 
    effective for annual periods beginning on or after 1 January 2018. It is 
    not practicable to provide a reasonable estimate of the effect of the 
    standard until a detailed review has been completed, however the adoption 
    of IFRS 9 is unlikely to have a material effect on the classification and 
    measurement of the Company's financial assets or liabilities. 
  * IFRS 15 Revenue from contracts with customers - The objective of IFRS 15 is 
    to establish the principles that an entity shall report useful information 
    to users of financial statements about the nature, amount, timing, and 
    uncertainty of revenue and cash flows arising from a contact with a 
    consumer. Application of the standard of mandatory for annual reporting 
    periods starting from 1 January 2018. 
 
2. Income 
 
                                                                            2017      2016 
 
                                                                           GBP'000     GBP'000 
 
Investment income 
 
Overseas dividend income                                                   1,823     1,820 
 
Other income 
 
Other fee income                                                              82         - 
 
Total income                                                               1,905     1,820 
 
3. AIFM, portfolio management and performance fees 
 
                                                             2017                          2016 
 
                                      Revenue   Capital     Total   Revenue   Capital     Total 
 
                                        GBP'000     GBP'000     GBP'000     GBP'000     GBP'000     GBP'000 
 
AIFM fee                                    -     1,190     1,190         -     1,266     1,266 
 
Portfolio management fee                    -     2,715     2,715         -     2,941     2,941 
 
Performance fee/(provision written          -         -         -         -   (1,854)   (1,854) 
back) 
 
                                            -     3,905     3,905         -     2,353     2,353 
 
Further details of the AIFM, portfolio management fee and the performance fee 
basis can be found in the Report of the Directors. 
 
4. Other expenses 
 
                                                             2017                          2016 
 
                                      Revenue   Capital     Total   Revenue   Capital     Total 
 
                                        GBP'000     GBP'000     GBP'000     GBP'000     GBP'000     GBP'000 
 
Directors' emoluments                     189         -       189       172         -       172 
 
AIFM fixed fee                             60         -        60        60         -        60 
 
Auditor's remuneration for the             27         -        27        26         -        26 
audit of the Company's financial 
statements 
 
Auditor's remuneration for                  7         -         7         7         -         7 
independent review of the half year 
accounts 
 
Auditor's remuneration for tax                        -                             - 
 
compliance services                         1         -         1         3         -         3 
 
Legal and professional fees                 1         -         1        25         -        25 
 
Registrar fees                             44         -        44        61         -        61 
 
Depositary fees                            61         -        61        66         -        66 
 
Listing fees                               27         -        27        26         -        26 
 
Other costs                               286         -       286       290         -       290 
 
Total expenses                            703         -       703       736         -       736 
 
Details of the amounts paid to Directors are included in the Directors' 
Remuneration Report and the Directors' Remuneration Policy Report. 
 
5. Finance costs 
 
                                                             2017                          2016 
 
                                      Revenue   Capital     Total   Revenue   Capital     Total 
 
                                        GBP'000     GBP'000     GBP'000     GBP'000     GBP'000     GBP'000 
 
Bank overdraft interest                     -       280       280         -       340       340 
 
                                            -       280       280         -       340       340 
 
6. Taxation 
 
(a) Analysis of charge in the year: 
 
                                                             2017                          2016 
 
                                      Revenue   Capital     Total   Revenue   Capital     Total 
 
                                        GBP'000     GBP'000     GBP'000     GBP'000     GBP'000     GBP'000 
 
Overseas tax suffered                     281         -       281       254         -       254 
 
Total taxation for the year (see          281         -       281       254         -       254 
note 6(b)) 
 
(b) Factors affecting total tax charge for year 
 
Approved investment trusts are exempt from tax on capital gains made within the 
Company. 
 
The tax assessed for the year is lower than the standard rate of corporation 
tax in the UK of 20% (2016: 20%). The differences are explained below: 
 
                                                           2017                            2016 
 
                                   Revenue    Capital     Total    Revenue    Capital     Total 
 
                                     GBP'000      GBP'000     GBP'000      GBP'000      GBP'000     GBP'000 
 
Net profit on ordinary               1,202     97,376    98,578      1,084  (129,779) (128,695) 
activities before taxation 
 
Corporation tax at 20%                 240     19,475    19,715        217   (25,956)  (25,739) 
(2016: 20%) 
 
Effects of: 
 
Non-taxable (gains)/losses 
on 
 
investments                              -   (20,312)  (20,312)          -     25,417    25,417 
 
Non-taxable overseas                 (365)          -     (365)      (364)          -     (364) 
dividends 
 
Overseas taxes                         281          -       281        254          -       254 
 
Excess expenses unused                 125        837       962        147        539       686 
 
Total tax charge                       281          -       281        254          -       254 
 
(c) Provision for deferred tax 
 
No provision for deferred taxation has been made in the current or prior year. 
 
The Company has not provided for deferred tax on capital gains or losses 
arising on the revaluation or disposal of investments, as it is exempt from tax 
on these items because of its status as an investment trust company. 
 
The Company has not recognised a deferred tax asset of GBP7,311,000 (17% tax 
rate) (2016: GBP6,876,000 (18% tax rate)) arising as a result of excess 
management expenses and loan relationship deficits. These excess expenses will 
only be utilised if the Company generates sufficient taxable income in the 
future. 
 
7. Basic and diluted earnings/(loss) per share 
 
The Return/(loss) per Ordinary Share is as follows: 
 
                                                         2017                             2016 
 
                                Revenue    Capital      Total    Revenue    Capital      Total 
 
                                  pence      pence      pence      pence      pence      pence 
 
Earnings/(loss) per share           1.6      169.9      171.5        1.3    (209.4)    (208.1) 
 
The total earnings per share of 171.5p (2016: loss 208.1p) is based on the 
total earnings attributable to equity shareholders of GBP98,297,000 (2016: loss GBP 
128,949,000). 
 
The revenue gain per share 1.6p (2016: gain 1.3p) is based on the revenue gain 
attributable to equity shareholders of GBP921,000 (2016: revenue gain of GBP 
830,000). The capital gain per share of 169.9p (2016: loss 209.4p) is based on 
the capital gain attributable to equity shareholders of GBP97,376,000 (2016: loss 
GBP129,779,000). 
 
The total earnings per share are based on the weighted average number of shares 
in issue during the year of 57,315,305 (2016: 61,972,355). 
 
8. Investments held at fair value through profit and loss 
 
All investments are designated as fair value through profit or loss on initial 
recognition, therefore all gains and losses arise on investments designated as 
fair value through profit or loss. 
 
As at 31 March 2017, all investments with the exception of the unquoted 
investment in OrbiMed Asia Partners L.P. fund have been classified as level 1. 
OrbiMed Asia Partners L.P. fund has been classified as level 3. See note 13 for 
further details. 
 
                                                                   2017                  2016 
 
                                                      Listed 
 
                                                      Equity   Unquoted      Total      Total 
 
                                                       GBP'000      GBP'000      GBP'000      GBP'000 
 
Cost at 1 April 2016                                 376,651      2,614    379,265    346,840 
 
Investment holding gains at 1 April 2016              39,762      1,400     41,162    236,369 
 
Valuation at 1 April 2016                            416,413      4,014    420,427    583,209 
 
Movement in the year 
 
Purchases at cost                                    288,955          -    288,955    386,664 
 
Sales - proceeds                                   (351,431)      (386)  (351,817)  (424,162) 
 
          - gains on disposal                         79,321         73     79,394     69,923 
 
Net movement in investment holding gains              23,051      1,368     24,419  (195,207) 
 
Valuation at 31 March 2017                           456,309      5,069    461,378    420,427 
 
Closing book cost at 31 March 2017                   393,496      2,301    395,797    379,265 
 
Investment holding gains at 31 March 2017             62,813      2,768     65,581     41,162 
 
Valuation at 31 March 2017                           456,309      5,069    461,378    420,427 
 
 
 
                                                                            2017       2016 
 
                                                                           GBP'000      GBP'000 
 
Gains/(losses) on investments: 
 
Gains on disposal based on historical cost                                79,394     69,923 
 
Amounts recognised as investment holding loss in previous year          (48,986)  (105,360) 
 
Gains(losses) on disposal based on carrying value at previous             30,408   (35,437) 
financial position date 
 
Net movement in investment holding gains in the year                      73,405   (89,847) 
 
Gains/(losses) on investments                                            103,813  (125,284) 
 
The total transaction costs for the year were GBP472,000 (31 March 2016: GBP 
453,000) broken down as follows: purchase transaction costs for the year to 31 
March 2017 were GBP238,000, (31 March 2016: GBP187,000), sale transaction costs 
were GBP234,000 (31 March 2016: GBP266,000). These costs consist mainly of 
commission. 
 
9. Other receivables 
 
                                                                            2017       2016 
 
                                                                           GBP'000      GBP'000 
 
Future settlements - sales                                                     -      4,556 
 
Other debtors                                                                 15         26 
 
Prepayments and accrued income                                               102        136 
 
                                                                             117      4,718 
 
10. Other payables 
 
                                                                            2017       2016 
 
                                                                           GBP'000      GBP'000 
 
Future settlements - purchases                                                 -      9,340 
 
Other creditors and accruals                                               1,235      1,049 
 
                                                                           1,235     10,389 
 
11. Ordinary share capital 
 
                                                                            2017       2016 
 
                                                                           GBP'000      GBP'000 
 
Allotted, issued and fully paid: 
 
55,839,913 shares of 25p (2016: 60,295,474)                               13,960     15,074 
 
No shares were held in treasury at 31 March 2017 (2016: nil)                   -          - 
 
                                                                          13,960     15,074 
 
 
 
                                                   2017                                2016 
 
                                     Issued &  Treasury Outstanding    Issued &    Treasury Outstanding 
 
                                   fully paid    Shares      Shares  fully paid      Shares      Shares 
 
At 1 April                         60,295,474         -  60,295,474  68,886,347   4,997,831  63,888,516 
 
Repurchase of own shares to be              -         -           -           -   1,313,257 (1,313,257) 
held in treasury 
 
Cancellation of own shares held             -         -           - (6,311,088) (6,311,088)           - 
in treasury 
 
Repurchase of own shares for      (4,455,561)         - (4,455,561) (2,279,785)           - (2,279,785) 
cancellation 
 
At 31 March                        55,839,913         -  55,839,913  60,295,474           -  60,295,474 
 
As at 31 March 2017 the Company had 55,839,913 shares of 25p in issue, no 
shares were held in treasury (2016: 60,295,474). During the year a total of 
4,455,561 share were repurchased for cancellation by the Company at a cost of GBP 
29.7 million. Subsequent to the year end and to the date of this report no 
further shares were repurchased for cancellation. 
 
12. Net asset value per share 
 
                                                                             2017      2016 
 
Net asset value per share                                                  800.8p    627.9p 
 
The net asset value per share is based on the net assets attributable to equity 
shareholders of GBP447,177,000 (2016: GBP378,567,000) and on 55,839,913 (2016: 
60,295,474) shares in issue at 31 March 2017. 
 
13. Risk management policies and procedures 
 
As an investment trust, the Company invests in equities and other investments 
for the long term in order to achieve its investment objective. In pursuing its 
investment objective, the Company is exposed to a variety of risks that could 
result in either a reduction or increase in the Company's net assets or in 
profits. 
 
The Company's financial instruments comprise securities and other investments, 
cash balances, debtors and creditors and an overdraft facility that arise 
directly from its operations (for example, in respect of sales and purchases 
awaiting settlement). 
 
The main risks the Company faces from its financial instruments are (i) market 
price risk (comprising currency risk, interest rate risk and other price risk 
(i.e. changes in market prices other than those arising from interest rate or 
currency risk)), (ii) liquidity risk and (iii) credit risk. 
 
The Board reviews and agrees policies regularly for managing and monitoring 
each of these risks. 
 
I. Market price risk: 
 
The fair value or future cash flows of a financial instrument held by the 
Company may fluctuate because of changes in market prices. This market risk 
comprises three elements - currency risk, interest rate risk and other price 
risk. 
 
The Company's portfolio is exposed to market price fluctuations which are 
monitored by the AIFM and the Portfolio Manager in pursuance of the investment 
objective. 
 
No derivatives or hedging instruments are utilised to manage market price risk. 
 
(a) Currency risk: 
 
The Company's portfolio is denominated in currencies other than sterling (the 
Company's functional currency, and in which it reports its results). As a 
result, movements in exchange rates can significantly affect the sterling value 
of those items. 
 
Management of risk 
 
The AIFM and Portfolio Manager monitor the Company's exposure to foreign 
currencies on a continuous basis and report to the Board regularly. The Company 
does not hedge against foreign currency movements. 
 
Income denominated in foreign currencies is converted into sterling on receipt. 
The Company does not use financial instruments to mitigate the currency 
exposure in the period between the time that the income is included in the 
financial statements and its receipt. 
 
Foreign currency exposure 
 
At the date of the Statement of Financial Position the Company held GBP 
452,980,000 (2016: GBP387,367,000) of investments denominated in U.S. dollars and 
GBP8,398,000 (2016: GBP33,060,000) in other non-sterling currencies. 
 
Currency sensitivity 
 
The following table details the sensitivity of the Company's profit or loss 
after taxation for the year to a 10% increase and decrease in the value of 
sterling compared to the U.S. dollar and other non-sterling currencies (2016: 
10% increase and decrease). 
 
The above percentages have been determined based on market volatility in 
exchange rates over the previous twelve months. The analysis is based on the 
Company's foreign currency financial instruments held at each Statement of 
Financial Position date, after adjusting for an increase/decrease in management 
fees. Movements in the performance fee accruals have been excluded from the 
analysis below. 
 
If sterling had weakened against the U.S. dollar and other non-sterling 
currencies, as stated above, this would have had the following effect: 
 
                                                                            2017       2016 
 
                                                                           GBP'000      GBP'000 
 
Impact on revenue return                                                       -          - 
 
Impact on capital return                                                  50,777     42,761 
 
Total return after tax/effect on shareholders' funds                      50,777     42,761 
 
If sterling had strengthened against the U.S. dollar, as stated above, this 
would have had the following effect: 
 
                                                                            2017       2016 
 
                                                                           GBP'000      GBP'000 
 
Impact on revenue return                                                       -          - 
 
Impact on capital return                                                (41,545)   (34,986) 
 
Total return after tax/effect on shareholders' funds                    (41,545)   (34,986) 
 
(b) Interest rate risk: 
 
Interest rate risk is the risk that the fair value of future cash flows of a 
financial instrument will fluctuate because of changes in market interest 
rates. 
 
Interest rate exposure 
 
The Company's main exposure to interest rate risk is through its overdraft 
facility with J.P. Morgan Clearing Corp. which is repayable on demand. 
 
At the year end financial liabilities subject to interest rate risk were as 
follows (there were no assets subject to interest rate risk). 
 
                                                                            2017       2016 
 
                                                                           GBP'000      GBP'000 
 
Financial liabilities: 
 
Overdraft facility                                                        13,083     36,189 
 
Interest rate sensitivity 
 
The majority of the Company's financial assets are equity shares and other 
investments which neither pay interest nor have a maturity date. The Company 
has an overdraft facility with J.P.Morgan Clearing Corp. disclosed above. The 
amount overdrawn at 31 March 2017 was GBP13,083,000 (2016: GBP36,189,000). Interest 
is charged at the Federal Funds Open rate plus 45 basis points. The level of 
interest fluctuates in line with the Federal Funds open rate and the amount of 
the overdraft. If the open rate increased by 1%, the impact on the profit or 
loss and net assets would be expected to be GBP131,000 (2016: GBP362,000). 
 
(c) Other price risk 
 
Other price risk may affect the value of the quoted investments. 
 
If market prices at the date of the Statement of Financial Position had been 
20% higher or lower (2016: 20% higher or lower) while all other variables had 
remained constant, the return and net assets attributable to shareholders for 
the year ended 31 March 2017 would have increased/decreased by GBP91,399,000 
(2016: GBP83,287,000), after adjusting for an increase or decrease in the AIFM 
and Portfolio management fees. The calculations are based on the portfolio 
valuations as at the respective Statement of Financial Position dates. 
 
2. Liquidity risk: 
 
This is the risk that the Company will encounter difficulty in meeting 
obligations associated with financial liabilities. 
 
Management of the risk 
 
Liquidity risk is not significant as the majority of the Company's assets are 
investments in quoted equities that are readily realisable within one week, in 
normal market conditions. 
 
The Board gives guidance to the Portfolio Manager as to the maximum amount of 
the Company's resources that should be invested in any one company. 
 
Liquidity exposure and maturity 
 
Contractual maturities of the financial liabilities as at 31 March 2017, based 
on the earliest date on which payment can be required, are as follows: 
 
                                                                            2017       2016 
 
                                                                        3 months   3 months 
 
                                                                         or less    or less 
 
                                                                           GBP'000      GBP'000 
 
Overdraft facility                                                        13,083     36,189 
 
Amounts due to brokers and accruals                                        1,235     10,389 
 
                                                                          14,318     46,578 
 
3. Credit risk: 
 
Credit risk is the risk of failure of a counterparty to discharge its 
obligations resulting in the Company suffering a loss. 
 
J.P. Morgan Clearing Corp. may take assets with a value of up to 140% of the 
overdraft as collateral. Such assets held by J.P. Morgan Clearing Corp. are 
available for rehypothecation? . As at 31 March 2017, the maximum value of 
assets available for rehypothecation was GBP18.3 million (31 March 2016: GBP50.7 
million). As at this date, assets with a total market value of GBP7.8m were 
rehypothecated (2016: GBP49.3 million). 
 
See the Business Review for further details on the overdraft facility and the 
associated credit risk. 
 
?          See glossary. 
 
Management of the risk 
 
The risk is not significant and is managed as follows: 
 
  * by only dealing with brokers which have been approved by OrbiMed Capital 
    LLC and banks with high credit ratings; and 
  * by investing in markets that operate DVP (delivery versus payment) 
    settlement. 
  * all cash balances are held with approved counterparties. J.P. Morgan 
    Clearing Corp. is the custodian of the Company's assets and all assets are 
    segregated from J.P. Morgan's own assets. 
 
At 31 March 2017 the Company's exposure to credit risk amounted to GBP117,000 and 
was in respect of amounts due from brokers in relation to future settlements 
and other receivables, such as amounts due from brokers and accrued income 
(2016: GBP4,718,000). 
 
Hierarchy of investments 
 
As required under IFRS 13 "Fair Value Measurement", the Company has classified 
its financial assets designated at fair value through profit or loss using a 
fair value hierarchy that reflects the significance of the inputs used in 
making the fair value measurements. The hierarchy has the following levels: 
 
  * Level 1 - quoted prices (unadjusted) in active markets for identical assets 
    or liabilities; 
  * Level 2 - inputs other than quoted prices included with Level 1 that are 
    observable for the asset or liability, either directly (i.e. as prices) or 
    indirectly (i.e. derived from prices); and 
  * Level 3 - inputs for the asset or liability that are not based on 
    observable market data (unobservable inputs). 
 
As at 31 March 2017 the investment in OrbiMed Asia Partners LP fund has been 
classified as Level 3. The fund has been valued at the net asset value as at 31 
December 2016 and it is believed that the value of the fund as at 31 March 2017 
will not be materially different. If the value of the fund was to increase or 
decrease by 10%, while all other variables had remained constant, the return 
and net assets attributable to Shareholders for the year ended 31 March 2017 
would have increased/decreased by GBP507,000 (2016: GBP401,000). 
 
                                                     Level 1    Level 2   Level 3      Total 
 
As of 31 March 2017                                    GBP'000      GBP'000     GBP'000      GBP'000 
 
Assets 
 
Financial investments designated at fair value       456,309          -     5,069    461,378 
through profit or loss 
 
                                                     Level 1    Level 2   Level 3      Total 
 
As of 31 March 2016                                    GBP'000      GBP'000     GBP'000      GBP'000 
 
Assets 
 
Financial investments designated at fair value       416,413          -     4,014    420,427 
through profit or loss 
 
Level 3 Reconciliation 
 
Please see on the previous page a reconciliation disclosing the changes during 
the year for the financial assets and liabilities designated at fair value 
through profit or loss classified as being Level 3. There has been no transfer 
between fair value hierarchy levels. 
 
                                                                             2017       2016 
 
                                                                            GBP'000      GBP'000 
 
Assets 
 
As at 1 April                                                               4,014      3,439 
 
Net movement in investment holding gains during the year                    1,441        789 
 
Return of capital                                                           (386)      (214) 
 
Assets as at 31 March                                                       5,069      4,014 
 
Fair value of financial assets and financial liabilities: 
 
Financial assets and financial liabilities are either carried in the Statement 
of Financial Position at their fair value or at a reasonable approximation of 
fair value. 
 
Capital management 
 
The Board considers the capital of the Company to be its issued share capital 
and reserves. 
 
The Company's capital management objectives are: 
 
  * to ensure that it will be able to continue as a going concern; and 
  * to maximise the total return to its equity shareholders. 
 
The Company's capital is disclosed in the Statement of Financial Position and 
is managed on a basis consistent with its investment objective and policy. 
 
Shares may be repurchased by the Company. 
 
The Company's objectives, policies and processes for managing capital are 
unchanged from the preceding accounting period. 
 
14. Segment reporting 
 
Geographical segments 
 
                                                                              2017        2016 
 
                                                                          Value of    Value of 
 
                                                                       investments investments 
 
Region                                                                       GBP'000       GBP'000 
 
North America                                                              398,949     359,328 
 
Europe                                                                      57,360      26,276 
 
Asia                                                                         5,069      34,823 
 
Total                                                                      461,378     420,427 
 
15. Related parties 
 
The following are considered to be related parties: 
 
  * Frostrow Capital LLP (under the Listing Rules) 
  * OrbiMed Capital LLC 
  * The Directors of the Company 
 
A number of the partners at, and a former partner of OrbiMed Capital LLC have a 
minority financial interest totalling 20% in Frostrow Capital LLP, the 
Company's AIFM. 
 
Further details of the relationship between the Company and Frostrow Capital 
LLP, the Company's AIFM and OrbiMed Capital LLC, the Company's Portfolio 
Manager, are disclosed in the Report of Directors. During the year ended 31 
March 2017 Frostrow Capital LLP earned GBP1,250,000 in respect of AIFM fees of 
which GBP309,000 was outstanding at the year end; during the year ended 31 March 
2017, OrbiMed Capital LLC earned GBP2,715,000 in respect of Portfolio Management 
fees, of which GBP710,000 was outstanding at the year end. Mr Sven Borho is a 
Director of the Company, as well as a Partner at OrbiMed Capital LLC. During 
the year no performance fees crystallised (2016: nil). All material related 
party transactions have been disclosed. Details of the remuneration of all 
Directors can be found in the Directors' Remuneration Report. 
 
16. Capital reserve 
 
                                               2017                           2016 
 
                                            Capital                        Capital 
 
                                          reserve -                      reserve - 
 
                                 Capital investment             Capital investment 
 
                                reserves   holdings            reserves   holdings 
                                       -                              - 
 
                                   other     gains/     Total     other     gains/     Total 
                                           (losses)                       (losses) 
 
                                   GBP'000      GBP'000     GBP'000     GBP'000      GBP'000     GBP'000 
 
At 1 April                       274,432     41,162   315,594   234,538    236,369   470,907 
 
Transfer on disposal of           48,986   (48,986)         -   105,360  (105,360)         - 
investments 
 
Net gains/(losses) on             30,408     73,405   103,813  (35,437)   (89,847) (125,284) 
investments 
 
Exchange losses                  (2,252)          -   (2,252)   (1,802)          -   (1,802) 
 
Expenses charged to capital      (4,185)          -   (4,185)   (2,693)          -   (2,693) 
 
Repurchase of own shares to be 
 
held in Treasury                       -          -         -  (10,241)          -  (10,241) 
 
Repurchase of own shares for    (29,687)          -  (29,687)  (15,293)          -  (15,293) 
cancellation 
 
At 31 March                      317,702     65,581   383,283   274,432     41,162   315,594 
 
Profits arising out of a change in fair value of assets, recognised in 
accordance with Accounting Standards, may be distributed provided the relevant 
assets can be readily convertible into cash. Securities listed on a recognised 
stock exchange are generally regarded as being readily convertible into cash. 
Under the terms of the revisions made to the Company's Articles of Association 
in 2013, sums within "Capital reserves - other" are also available for 
distribution. 
 
17. Contingent liabilities and capital commitments 
 
As at 31 March 2017 there were no contingent liabilities or capital commitments 
for the Company (2016: GBPnil). 
 
Further Information / AIFMD Related Disclosure 
 
Alternative Investments Fund Managers Directive (AIFMD) Disclosures (Unaudited) 
 
Investment objective and leverage 
 
A description of the investment strategy and objectives of the Company, the 
types of assets in which the Company may invest, the techniques it may employ, 
any applicable investment restrictions, the circumstances in which it may use 
leverage, the types and sources of leverage permitted and the associated risks, 
any restrictions on the use of leverage and the maximum level of leverage which 
the AIFM and Portfolio Manager are entitled to employ on behalf of the Company 
and the procedures by which the Company may change its investment strategy and/ 
or the investment policy can be found in the Business Review within the 
Strategic Report. 
 
The table below sets out the current maximum permitted limit and actual level 
of leverages for the Company: 
 
                                                                       As a percentage of 
                                                                       net assets 
 
                                                                           Gross Commitment 
                                                                          Method     Method 
 
Maximum level of leverage                                                 130.0%     130.0% 
 
Actual level at 31 March 2017                                             103.2%     103.2% 
 
Remuneration of AIFM staff 
 
Following completion of an assessment of the application of the proportionality 
principle to the FCA's AIFM Remuneration Code, the AIFM has disapplied the 
pay-out process rules with respect to it and any of its delegates. This is 
because the AIFM considers that it carries out non-complex activities and is 
operating on a small scale. 
 
Further disclosures required under the AIFM Rules can be found within the 
Investor Disclosure Document on the Company's website: www.biotechgt.com. 
 
Further Information / Glossary of Terms 
 
AIC 
 
Association of Investment Companies. 
 
Alternative Investment Fund Managers Directive (AIFMD) 
 
Agreed by the European Parliament and the Council of the European Union and 
transported into UK legislation, the AIFMD classifies certain investment 
vehicles, including investment companies, as Alternative Investment Funds 
(AIFs) and requires them to appoint an Alternative Investment Fund Manager 
(AIFM) and depositary to manage and oversee the operations of the investment 
vehicle. The Board of the Company retains responsibility for strategy, 
operations and compliance and the Directors retain a fiduciary duty to 
shareholders. 
 
Discount or Premium 
 
A description of the difference between the share price and the net asset value 
per share. The size of the discount or premium is calculated by subtracting the 
share price from the net asset value per share and is usually expressed as a 
percentage (%) of the net asset value per share. If the share price is higher 
than the net asset value per share the result is a premium. If the share price 
is lower than the net asset value per share, the shares are trading at a 
discount. 
 
Gearing 
 
Calculated using the Association of Investment Companies definition. 
 
Gearing represents borrowings less cash and cash equivalents expressed as a 
percentage of shareholders' funds. 
 
Leverage 
 
The AIFM Directive (the "Directive") has introduced the obligation on the 
Company and its AIFM in relation to leverage as defined by the Directive. The 
Directive leverage definition is slightly different to the Association of 
Investment Companies method of calculating gearing and is as follows: any 
method by which the AIFM increases the exposure of an AIF it manages whether 
through borrowing of cash or securities, or leverage embedded in derivative 
positions. 
 
There are two methods for calculating leverage under the Directive - the Gross 
Method and the Commitment Method. The process for calculating exposure under 
each methodology is largely the same, except, where certain conditions are met, 
the Commitment Method enables instruments to be netted off to reflect 'netting' 
or 'hedging' arrangements and the entity exposure is effectively reduced. 
 
Net Asset Value (NAV) 
 
The value of the Company's assets, principally investments made in other 
companies and cash being held, less any liabilities. The NAV is also described 
as 'shareholders' funds'. The NAV is often expressed in pence per share after 
being divided by the number of shares which have been issued. The NAV per share 
is unlikely to be the same as the share price which is the price at which the 
Company's shares can be bought or sold by an investor. The share price is 
determined by the relationship between the demand and supply of the shares in 
the secondary market. 
 
Ongoing Charges 
 
Ongoing charges are calculated by taking the Company's annualised operating 
expenses expressed as a proportion of the average daily net asset value of the 
Company over the year. 
 
The costs of buying and selling investments are excluded, as are interest 
costs, taxation, performance fees, cost of buying back or issuing ordinary 
shares and other non-recurring costs. 
 
Rehypothecation 
 
Rehypothecation is the practice by banks and brokers of using, for their own 
purposes, assets that have been posted as collateral by clients. 
 
Treasury Shares 
 
Shares previously issued by a company that have been bought back from 
Shareholders to be held by the Company for potential sale or cancellation at a 
later date. Such shares are not capable of being voted and carry no rights to 
dividends. 
 
Further Information / Notice of the Annual General Meeting 
 
Notice is hereby given that the Annual General Meeting of The Biotech Growth 
Trust PLC will be held at Barber-Surgeons' Hall, Monkwell Square, Wood Street, 
London EC2Y 5BL on Wednesday 12 July 2017 at 12 noon, for the following 
purposes: 
 
Ordinary business 
 
To consider and, if thought fit, pass the following as ordinary resolutions: 
 
1.      To receive and, if thought fit, to accept the Audited Financial 
Statements and the Report of the Directors for the year ended 31 March 2017 
 
2.      To approve the Directors' Remuneration Report for the year ended 31 
March 2017 
 
3.      To approve the Directors' Remuneration Policy 
 
4.      To re-elect Andrew Joy as a Director of the Company 
 
5.      To re-elect Professor Dame Kay Davies, CBE as a Director of the Company 
 
6.      To re-elect Sven Borho as a Director of the Company 
 
7.      To re-elect Steven Bates as a Director of the Company 
 
8.      To re-elect The Rt Hon Lord Willetts as a Director of the Company 
 
9.      To elect Julia Le Blan as a Director of the Company 
 
10.    To re-appoint Ernst & Young LLP as Auditor to the Company and to 
authorise the Audit Committee to determine their remuneration 
 
Special business 
 
To consider and, if thought fit, pass the following resolutions of which 
resolutions 12, 13 and 14 will be proposed as special resolutions: 
 
Authority to allot shares 
 
11.    THAT in substitution for all existing authorities the Directors be and 
are hereby generally and unconditionally authorised in accordance with Section 
551 of the Companies Act 2006 (the "Act") to exercise all powers of the Company 
to allot relevant securities (within the meaning of Section 551 of the Act) up 
to a maximum aggregate nominal amount of GBP1,395,997 (being 10% of the issued 
share capital of the Company at the date of the notice convening the meeting at 
which this resolution is proposed) and representing 5,583,991 shares of 25 
pence each (or, if less, the number representing 10% of the issued share 
capital of the Company at the date at which this resolution is passed), 
provided that this authority shall expire at the conclusion of the Annual 
General Meeting of the Company to be held in 2018 or 15 months from the date of 
passing this resolution, whichever is the earlier, unless previously revoked, 
varied or renewed, by the Company in general meeting and provided that the 
Company shall be entitled to make, prior to the expiry of such authority, an 
offer or agreement which would or might require relevant securities to be 
allotted after such expiry and the Directors may allot relevant securities 
pursuant to such offer or agreement as if the authority conferred hereby had 
not expired. 
 
Disapplication of pre-emption rights 
 
12.    THAT in substitution of all existing powers the Directors be and are 
hereby generally empowered pursuant to Sections 570 and 573 of the Companies 
Act 2006 (the "Act") to allot equity securities (within the meaning of section 
560 of the Act) including if immediately before the allotment, such shares are 
held by the Company as treasury shares (as defined in Section 724 of the Act) 
for cash pursuant to the authority conferred on them by resolution 13 set out 
in the notice convening the Annual General Meeting at which this resolution is 
proposed or otherwise as if section 561(1) of the Act did not apply to any such 
allotment and to sell relevant shares (within the meaning of section 560 of the 
Act) for cash as if section 561(1) of the Act did not apply to any such sale, 
provided that this power shall be limited to the allotment of equity securities 
pursuant to: 
 
(a)     an offer of equity securities open for acceptance for a period fixed by 
the Directors where the equity securities respectively attributable to the 
interests of holders of shares of 25 pence each in the Company ("Shares") are 
proportionate (as nearly as may be) to the respective numbers of Shares held by 
them but subject to such exclusions or other arrangements in connection with 
the issue as the Directors may consider necessary, appropriate, or expedient to 
deal with equity securities representing fractional entitlements or to deal 
with legal or practical problems arising in any overseas territory, the 
requirements of any regulatory body or stock exchange, or any other matter 
whatsoever; and 
 
(b)     (otherwise than pursuant to sub-paragraph (a) above) up to an aggregate 
nominal value of GBP1,395,997 or, if less, the number representing 10% of the 
issued share capital of the Company at the date of the meeting at which this 
resolution is passed, and expires at the conclusion of the next Annual General 
Meeting of the Company after the passing of this resolution or 15 months from 
the date of passing this resolution, whichever is the earlier, unless 
previously revoked, varied or renewed by the Company in general meeting and 
provided that the Company shall be entitled to make, prior to the expiry of 
such authority, an offer or agreement which would or might require equity 
securities to be allotted after such expiry and the Directors may allot equity 
securities pursuant to such offer or agreement as if the power conferred hereby 
had not expired. 
 
Authority to repurchase ordinary shares 
 
13.    THAT the Company be and is hereby generally and unconditionally 
authorised in accordance with section 701 of the Companies Act 2006 (the "Act") 
to make one or more market purchases (within the meaning of section 693(4) of 
the Act) of ordinary shares of 25 pence each in the capital of the Company 
("Shares") either for retention as treasury shares for future reissue, resale, 
transfer or for cancellation provided that: 
 
(a)     the maximum aggregate number of Shares authorised to be purchased is 
8,370,402 (representing approximately 14.99% of the issued share capital of the 
Company at the date of the notice convening the meeting at which this 
resolution is proposed); 
 
(b)     the minimum price (exclusive of expenses) which may be paid for a Share 
is 25 pence; 
 
(c)     the maximum price (exclusive of expenses) which may be paid for a Share 
is an amount equal to the greater of (i) 105% of the average of the middle 
market quotations for a Share as derived from the Daily Official List of the 
London Stock Exchange for the five business days immediately preceding the day 
on which that Share is purchased and (ii) the higher of the price of the last 
independent trade in shares and the highest then current independent bid for 
shares on the London Stock Exchange as stipulated in Article 5(1) of Regulation 
No. 2233/2003 of the European Commission (Commission Regulation of 22 December 
2003 implementing the Market Abuse Directive as regards exemptions for buy-back 
programmes and stabilisation of financial instruments); 
 
(d)     the authority hereby conferred shall expire at the conclusion of the 
Annual General Meeting of the Company to be held in 2018 or, if earlier, on the 
expiry of 15 months from the date of the passing of this resolution unless such 
authority is renewed prior to such time; and 
 
(e)     the Company may make a contract to purchase Shares under this authority 
before the expiry of such authority which will or may be executed wholly or 
partly after the expiration of such authority, and may make a purchase of 
Shares in pursuance of any such contract. 
 
General meetings 
 
14.    THAT the Directors be authorised to call general meetings (other than 
Annual General Meetings) on not less than 14 working days' notice, such 
authority to expire at the conclusion of the next Annual General Meeting of the 
Company or, if earlier, until expiry of 15 months from the date of the passing 
of this resolution. 
 
By order of the Board                         Registered office: 
 
Frostrow Capital LLP                          One Wood Street 
Company Secretary                             London EC2V 7WS 
25 May 2017 
 
Notes 
 
1.         Members are entitled to appoint a proxy to exercise all or any of 
their rights to attend and to speak and vote on their behalf at the meeting. A 
shareholder may appoint more than one proxy in relation to the meeting provided 
that each proxy is appointed to exercise the rights attached to a different 
share or shares held by that shareholder. A proxy need not be a shareholder of 
the Company. A proxy form which may be used to make such appointment and give 
proxy instructions accompanies this notice. 
 
2.         A vote withheld is not a vote in law, which means that the vote will 
not be counted in the calculation of votes for or against the resolutions. If 
no voting indication is given, a proxy may vote or abstain from voting at his/ 
her discretion. A proxy may vote (or abstain from voting) as he or she thinks 
fit in relation to any other matter which is put before the meeting. 
 
3.         To be valid any proxy form or other instrument appointing a proxy 
must be completed and signed and received by post or (during normal business 
hours only) by hand at Capita Asset Services, PXS1, 34 Beckenham Road, 
Beckenham, Kent BR3 4ZF no later than 12 noon on 10 July 2017. 
 
4.         In the case of a member which is a company, the instrument 
appointing a proxy must be executed under its seal or signed on its behalf by a 
duly authorised officer or attorney or other person authorised to sign. Any 
power of attorney or other authority under which the instrument is signed (or a 
certified copy of it) must be included with the instrument. 
 
5.         The return of a completed proxy form, other such instrument or any 
CREST Proxy Instruction (as described below) will not prevent a shareholder 
attending the meeting and voting in person if he/she wishes to do so. 
 
6.         Any person to whom this notice is sent who is a person nominated 
under section 146 of the Companies Act 2006 to enjoy information rights (a 
"Nominated Person") may, under an agreement between him/her and the shareholder 
by whom he/she was nominated, have a right to be appointed (or have someone 
else appointed) as a proxy for the meeting. If a Nominated Person has no such 
proxy appointment right or does not wish to exercise it, he/she may, under any 
such agreement, have a right to give instructions to the shareholder as to the 
exercise of voting rights. 
 
7.         The statement of the rights of shareholders in relation to the 
appointment of proxies in paragraphs 1 and 3 above does not apply to Nominated 
Persons. The rights described in these paragraphs can only be exercised by 
shareholders of the Company. 
 
8.         Pursuant to regulation 41 of the Uncertificated Securities 
Regulations 2001, only shareholders registered on the register of members of 
the Company (the "Register of Members") at the close of business on 10 July 
2017 (or, in the event of any adjournment, on the date which is two days before 
the time of the adjourned meeting) will be entitled to attend and vote or be 
represented at the meeting in respect of shares registered in their name at 
that time. Changes to the Register of Members after that time will be 
disregarded in determining the rights of any person to attend and vote at the 
meeting. 
 
9.         As at 25 May 2017 (being the last business day prior to the 
publication of this notice) the Company's issued share capital consists of 
55,839,913 ordinary shares, carrying one vote each. Therefore, the total voting 
rights in the Company as at 25 May 2017 are 55,839,913. 
 
10.       CREST members who wish to appoint a proxy or proxies through the 
CREST electronic proxy appointment service may do so by using the procedures 
described in the CREST Manual. CREST Personal Members or other CREST sponsored 
members, and those CREST members who have appointed a service provider(s), 
should refer to their CREST sponsor or voting service provider(s), who will be 
able to take the appropriate action on their behalf. 
 
11.       In order for a proxy appointment or instruction made using the CREST 
service to be valid, the appropriate CREST message (a "CREST Proxy 
Instruction") must be properly authenticated in accordance with the 
specifications of Euroclear UK and Ireland Limited ("CRESTCo"), and must 
contain the information required for such instruction, as described in the 
CREST Manual. The message, regardless of whether it constitutes the appointment 
of a proxy or is an amendment to the instruction given to a previously 
appointed proxy must, in order to be valid, be transmitted so as to be received 
by the issuer's agent (ID RA10) no later than 48 hours before the time 
appointed for holding the meeting. For this purpose, the time of receipt will 
be taken to be the time (as determined by the timestamp applied to the message 
by the CREST Application Host) from which the issuer's agent is able to 
retrieve the message by enquiry to CREST in the manner prescribed by CREST. 
After this time any change of instructions to proxies appointed through CREST 
should be communicated to the appointee through other means. 
 
12.       CREST members and, where applicable, their CREST sponsors, or voting 
service providers should note that CRESTCo does not make available special 
procedures in CREST for any particular message. Normal system timings and 
limitations will, therefore, apply in relation to the input of CREST Proxy 
Instructions. It is the responsibility of the CREST member concerned to take 
(or, if the CREST member is a CREST personal member, or sponsored member, or 
has appointed a voting service provider, to procure that his CREST sponsor or 
voting service provider(s) take(s)) such action as shall be necessary to ensure 
that a message is transmitted by means of the CREST system by any particular 
time. In this connection, CREST members and, where applicable, their CREST 
sponsors or voting system providers are referred, in particular, to those 
sections of the CREST Manual concerning practical limitations of the CREST 
system and timings. 
 
13.       The Company may treat as invalid a CREST Proxy Instruction in the 
circumstances set out in Regulation 35(5)(a) of the Uncertificated Securities 
Regulations 2001. 
 
14.       In the case of joint holders, where more than one of the joint 
holders purports to appoint a proxy, only the appointment submitted by the most 
senior holder will be accepted. Seniority is determined by the order in which 
the names of the joint holders appear in the Register of Members in respect of 
the joint holding (the first named being the most senior). 
 
15.       Members who wish to change their proxy instructions should submit a 
new proxy appointment using the methods set out above. Note that the cut-off 
time for receipt of proxy appointments (see above) also applies in relation to 
amended instructions; any amended proxy appointment received after the relevant 
cut-off time will be disregarded. 
 
16.       Members who have appointed a proxy using the hard-copy proxy form and 
who wish to change the instructions using another hard-copy form, should 
contact Capita Asset Services on 0871 664 0300 or 0371 664 0300 if calling from 
outside the United Kingdom. Calls cost 12p per minute plus your phone company's 
access charge. Calls outside the United Kingdom will be charged at the 
applicable international rate. Lines are open between 09.00-17.30, Monday to 
Friday excluding public holidays in England and Wales. 
 
17.       If a member submits more than one valid proxy appointment, the 
appointment received last before the latest time for the receipt of proxies 
will take precedence. 
 
18.       In order to revoke a proxy instruction, members will need to inform 
the Company. Members should send a signed hard copy notice clearly stating 
their intention to revoke a proxy appointment to Capita Asset Services, PXS1, 
34 Beckenham Road, Beckenham, Kent BR3 4ZF. 
 
In the case of a member which is a company, the revocation notice must be 
executed under its common seal or signed on its behalf by an officer of the 
company or an attorney for the company. Any power of attorney or any other 
authority under which the revocation notice is signed (or a duly certified copy 
of such power of attorney) must be included with the revocation notice. If a 
member attempts to revoke their proxy appointment but the revocation is 
received after the time for receipt of proxy appointments (see above) then, 
subject to paragraph 4, the proxy appointment will remain valid. 
 
Further Information / Explanatory Notes to the Resolutions 
 
Resolution 1 - To receive the Annual Report and Accounts 
 
The Annual Report and Accounts for the year ended 31 March 2017 will be 
presented to the Annual General Meeting. These accounts accompanied this Notice 
of Meeting and shareholders will be given an opportunity at the meeting to ask 
questions. 
 
Resolutions 2 and 3 - Remuneration Report and Remuneration Policy 
 
The Report on Directors' Remuneration is set out in full in the Directors' 
Remuneration Report. The Remuneration Policy is also set out separately 
following this report. 
 
Resolutions 4 to 9 - Re-election of Directors 
 
Resolutions 4 to 9 deal with the election and re-election of each Director. 
 
The Board has confirmed, following a performance review, that the Directors 
standing for election and re-election continue to perform effectively. 
 
Resolution 10 - Re-Appointment of Auditor and the determination of their 
remuneration 
 
Resolution 10 relates to the re-appointment of Ernst & Young LLP as the 
Company's independent auditor to hold office until the next Annual General 
Meeting of the Company and also authorises the Audit Committee to set their 
remuneration. 
 
Resolutions 11 and 12 - Issue of Shares 
 
Ordinary Resolution 11 in the Notice of Annual General Meeting will renew the 
authority to allot the unissued share capital up to an aggregate nominal amount 
of GBP1,395,997 (equivalent to 5,583,991 shares, or 10% of the Company's existing 
issued share capital on 25 May 2017, being the nearest practicable date prior 
to the signing of this Report). Such authority will expire on the date of the 
next Annual General Meeting or after a period of 15 months from the date of the 
passing of the resolution, whichever is earlier. This means that the authority 
will have to be renewed at the next Annual General Meeting. 
 
When shares are to be allotted for cash, Section 551 of the Companies Act 2006 
(the "Act") provides that existing shareholders have pre-emption rights and 
that the new shares must be offered first to such shareholders in proportion to 
their existing holding of shares. However, shareholders can, by special 
resolution, authorise the Directors to allot shares otherwise than by a pro 
rata issue to existing shareholders. Special Resolution 12 will, if passed, 
give the Directors power to allot for cash equity securities up to 10% of the 
Company's existing share capital on 25 May 2017, as if Section 551 of the Act 
does not apply. This is the same nominal amount of share capital which the 
Directors are seeking the authority to allot pursuant to Resolution 11. This 
authority will also expire on the date of the next Annual General Meeting or 
after a period of 15 months, whichever is earlier. This authority will not be 
used in connection with a rights issue by the Company. 
 
The Directors intend to use the authority given by Resolutions 11 and 12 to 
allot shares and disapply pre-emption rights only in circumstances where this 
will be clearly beneficial to shareholders as a whole. The issue proceeds would 
be available for investment in line with the Company's investment policy. No 
issue of shares will be made which would effectively alter the control of the 
Company without the prior approval of shareholders in general meeting. 
 
Resolution 13 - Share Repurchases 
 
The Directors wish to renew the authority given by shareholders at the previous 
Annual General Meeting. The principal aim of a share buy-back facility is to 
enhance shareholder value by acquiring shares at a discount to net asset value, 
as and when the Directors consider this to be appropriate. The purchase of 
shares, when they are trading at a discount to net asset value per share, 
should result in an increase in the net asset value per share for the remaining 
shareholders. This authority, if conferred, will only be exercised if to do so 
would result in an increase in the net asset value per share for the remaining 
shareholders and if it is in the best interests of shareholders generally. Any 
purchase of shares will be made within guidelines established from time to time 
by the Board. It is proposed to seek shareholder authority to renew this 
facility for another year at the Annual General Meeting. 
 
Under the current Listing Rules, the maximum price that may be paid on the 
exercise of this authority must not exceed the higher of (i) 105% of the 
average of the middle market quotations for the shares over the five business 
days immediately preceding the date of purchase and (ii) the higher of the last 
independent trade and the highest current independent bid on the trading venue 
where the purchase is carried out. The minimum price which may be paid is 25p 
per share. Shares which are purchased under this authority will either be 
cancelled or held as treasury shares. 
 
Special Resolution 13 in the Notice of Annual General Meeting will renew the 
authority to purchase in the market a maximum of 14.99% of shares in issue on 
25 May 2017, being the nearest practicable date prior to the signing of this 
Report, (amounting to 8,370,402 shares). Such authority will expire on the date 
of the next Annual General Meeting or after a period of 15 months from the date 
of passing of the resolution, whichever is earlier. This means in effect that 
the authority will have to be renewed at the next Annual General Meeting or 
earlier if the authority has been exhausted. 
 
Resolution 14 - General Meetings 
 
Special Resolution 14 seeks shareholder approval for the Company to hold 
General Meetings (other than the Annual General Meeting) on not less than at 14 
working days' notice. 
 
Recommendation 
 
The Board considers that the resolutions relating to the above items of special 
business, are in the best interests of shareholders as a whole. Accordingly, 
the Board unanimously recommends to the shareholders that they vote in favour 
of the above resolutions to be proposed at the forthcoming Annual General 
Meeting as the Directors intend to do in respect of their own beneficial 
holdings totaling 353,718 shares. 
 
Frostrow Capital LLP, 
Company Secretary 
25 May 2017 
 
ANNOUNCEMENT ENDS 
 
 
 
END 
 

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