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DDDD 4d Pharma Plc

16.36
0.00 (0.00%)
Last Updated: 01:00:00
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Share Name Share Symbol Market Type Share ISIN Share Description
4d Pharma Plc LSE:DDDD London Ordinary Share GB00BJL5BR07 ORD 0.25P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  0.00 0.00% 16.36 0.00 01:00:00
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
0 0 N/A 0

4d Pharma PLC Interim results (0275S)

28/09/2017 7:00am

UK Regulatory


4d Pharma (LSE:DDDD)
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TIDMDDDD

RNS Number : 0275S

4d Pharma PLC

28 September 2017

The information contained within this announcement is deemed by the Company to constitute inside information stipulated under the Market Abuse Regulation (EU) No. 596/2014. Upon the publication of this announcement via the Regulatory Information Service, this inside information is now considered to be in the public domain.

("4D", "4D Pharma" or "the Company")

Interim results for the six months ended 30 June 2017

4D pharma plc (AIM: DDDD), a pharmaceutical company focussing on the development of live biotherapeutics targeting important new therapeutic areas, is pleased to announce the interim results for the Company and its subsidiaries (together "the Group") for the six months ended 30 June 2017.

Financial highlights

-- Net assets as at 30 June 2017 of GBP75.3 million (30 June 2016: GBP92.1 million and 31 December 2016: GBP86.5 million)

-- Cash and cash equivalents and short-term deposits at 30 June 2017 of GBP59.8 million (30 June 2016: GBP75.4 million and 31 December 2016: GBP68.8 million)

-- Loss attributable to the owners of the parent undertaking for the six months ended 30 June 2017 of GBP11.3 million* (30 June 2016: GBP4.6 million and 31 December 2016: GBP10.3 million)

-- Research and development expenditure for the six months ended 30 June 2017 of GBP8.3 million (30 June 2016: GBP4.1 million and 31 December 2016: GBP10.2 million)

Operational and clinical highlights

-- In relation to MicroDx, 4D Pharma Cork's diagnostic platform enabling the stratification of IBS patients, interim analysis of data generated in a clinical study demonstrating the ability to differentiate between IBS patients and healthy volunteers, the commonalities of microbiome across all IBS subtypes, and the ability to differentiate between IBS patients and healthy volunteers based on metabolite profiles

Since the period end

-- Completion of the first clinical trial of the MicroDx diagnostic platform, validating the platform and representing achievement of the initial milestone from the acquisition of 4D Pharma Cork Limited in February 2016

* Note: this includes a GBP3.5 million non-recurring charge in relation to the successful completion of the first milestone for 4D Pharma Cork Limited.

Chairman's statement

David Norwood, Chairman of 4D pharma, commented: "2017 has seen 4D continue to make significant progress expanding the scope of our research, developing our manufacturing capability and progressing through the clinic towards our aim of delivering live biotherapeutics in a number of exciting disease areas. I would once again like to thank the Board, our employees and our shareholders for their continued support."

For further information please contact:

 
4D                           +44 (0)113 895 0130 
Duncan Peyton, Chief Executive Officer 
Zeus Capital Limited - Nomad and Broker 
Dan Bate / Jordan Warburton  +44 (0)161 831 1512 
Hugh Kingsmill Moore         +44 (0)203 829 5000 
 

For further information please also visit: www.4dpharmaplc.com.

Chairman and Chief Executive Officer's Joint Review

David Norwood, Non-executive Chairman and Duncan Peyton, Chief Executive Officer

Overview

The development of the microbiome and its exploitation as a therapeutic continues at an unprecedented pace, and 4D continues to lead this exciting new area through developing science and delivering therapies.

For over a century it has been well understood that a single bacteria can affect our health; Robert Koch, the founding father of microbiology, identified pathogenic bacteria as the causative agents of several important diseases, demonstrating the negative impact of a single strain on our health. However, through recent advances made by 4D we are now starting to understand the positive impact of a single strain on our health.

Whilst there has long been a correlation between the presence or absence of certain bacteria and disease, it is only now that we are starting to see the influence that specific strains of bacteria can have on our immune system, increasingly acknowledged as being central to the pathology of many diseases. It is only with the advent of groundbreaking technological advances in the fields of genetics and molecular and cell biology that 4D is starting to uncover the key role bacteria play in our health, through the development and maintenance of a healthy immune system.

The understanding of the interaction between the host and the bacteria in the gut is central to the approach at 4D. As with traditional drug development, we look at the host, understanding the pathways associated with disease; we then look at bacteria isolated from a healthy human microbiome and understand whether or not they can impact those pathways. If we can overlay the bacteria and the pathway, we have the starting point for a 4D therapeutic.

This targeted approach is the backbone of 4D's proprietary platform, MicroRx. To date, MicroRx has led 4D to identify 17 therapeutic single strains that act individually across a wide range of diseases including cancer, asthma and autoimmune disorders. This research has shown that whilst some bacteria act on the same pathways as "traditional" blockbuster drugs, others appear to act via novel mechanisms. This discovery opens up the possibility of developing better ways to treat diseases where conventional therapies have significant side effects or low efficacy, in addition to breaking new ground in areas of significant unmet clinical need.

In addition to direct therapeutic effect, 4D is beginning to understand the wider impact of our single-strain therapeutics. Leading from our pre-clinical work we are seeing how a single strain can positively impact the microbiome in patients, increasing the stability and diversity of the range of bacteria found in the gut. This may provide answers as to how to improve the efficacy and response rates of existing traditional pharmaceuticals and newer immunotherapies.

Our recent progress and continued investigations into the microbiome are fundamentally changing our understanding of disease in terms of causation, diagnosis and potential therapeutic approaches.

The microbiome may be a new breakthrough for the pharmaceutical industry, but unlike so many potential new breakthroughs, through our understanding of research, development, manufacturing and delivery, we believe manipulation of the microbiome and our health through 4D's novel therapeutics is within reach in the next few years.

Developing science

We continue to invest in our understanding of the microbiome.

We have over 65 scientists in house and collaborations with leading academic institutions, working to uncover new possibilities for therapeutics as well as how we translate this research though the clinic to the patient.

We are targeting a new, safer approach to drug development.

One of the key areas of interest within the development of 4D's therapeutics is their exceptional safety profile.

Traditionally, the pharmaceutical industry struggled with the issue of relative benefit over side effects and toxicity. It is common within the pharmaceutical industry that drug development fails due to safety and toxicity issues; it is also common that those drugs that do gain approval and come to the market do so with severe warnings over side effects. This is not restricted to those drugs that treat rare or life-threatening conditions, but includes diseases that are becoming more commonplace, such as Crohn's and rheumatoid arthritis, that are treated by some of the biggest selling drugs on the market.

At 4D, our bacteria are commensal, being isolated from healthy humans, and therefore present a lower risk from a safety standpoint. Throughout the development of this novel and emerging field, 4D has continually interacted with the regulators, particularly on matters of safety, as we target bringing our drugs to market. This position has been further reinforced by our findings from patients in the clinic, where our products have presented a similar safety profile to placebo.

Our learning of disease continues.

We have seen from 4D Pharma Cork's work in irritable bowel syndrome ("IBS") the importance of the role of the microbiome both in the causative element of the disease and also in identifying signatures to enable us to diagnose and stratify patients efficiently. This work is not only important in the upcoming phase II trial of Blautix, our treatment for IBS, but will also allow 4D to look at using the microbiome as a diagnostic across our portfolio.

Through our collaboration with Baylor College of Medicine, 4D is furthering the understanding of the role of the microbiome as a key protagonist in diseases such as asthma. This work and learning has led our team to accelerate the asthma programme through development, targeting the clinic next year.

We are actively targeting cancer.

4D will aim to start a first-in-man cancer monotherapy trial later this year. This trial is unusual in that, rather than beginning our clinical studies in patients who have received multiple conventional therapies, we are planning to dose patients who have recently been diagnosed with cancer and are "treatment naïve". This approach is possible due to the anticipated safety profile of our therapeutic and will allow us to investigate the potential impact of our drug on the immune system at an earlier stage of the disease.

The trial is the culmination of just over two years' work from the point when our research team in Aberdeen first identified strains within the human gut that were immune-stimulatory and hypothesised the potential role of these strains in immuno-oncology. Since this discovery in May 2015, the team has been able to take that work forward from discovery, through industry standard models, to understand the potential efficacy, to the point where 4D has drug product ready for trial.

To put this achievement of the 4D team in perspective, the majority of cancer drugs can take up to eight years (and perhaps longer) before they can be given to a patient, and generally those patients have had several failed therapeutic interventions prior to this, and are therefore compromised in terms of the response of the immune system. The speed of progress to the clinic and design of the trial is a signal of the safe, cost-effective and rapid development of this new generation of drugs.

At 4D we believe that the microbiome has a greater role to play in immunology, not only in how our drugs can potentially impact cancer as a standalone therapy, but also in understanding their potential as adjuvants or combinations to existing therapies, and 4D will continually look at how to expand and integrate into this space over the coming months.

We continue to lead the way in targeting new disease areas.

The microbiome is associated with the gut; linking this to diseases of the gut, such as IBS, inflammatory bowel disease or C. difficile infections, is common sense, and in a sense obvious. Indeed, 4D's initial research and development programmes targeted IBS, Crohn's disease and ulcerative colitis.

However, at 4D, as we grew our understanding of the role bacteria play and the impact they have with the immune system, we developed our research and learning to investigate the impact beyond the gut, moving into autoimmune conditions and cancer. This drive forward has not stopped; 4D, alongside many leading institutions, has begun investigations into how our microbiota interact with the gut-brain axis. This work could lead to new approaches to those diseases which to date science has simply failed to address, such as Parkinson's disease, Alzheimer's and autism. Whilst this work is still at an early stage, at 4D we are beginning to observe similar patterns to our earlier work, with single strains being able to influence many known pathways associated with these diseases, as well as opening up new possibilities.

Our intellectual property estate is the largest in the field.

With our ongoing efforts across research, development and clinical studies, 4D continues to build on our extensive patent portfolio. 4D now holds 32 patent families, with 86 granted patents and 170 patent applications, including our most recent filings in the neurodegeneration space.

Delivering therapies

Central to the development of any new scientific breakthrough is the ability to reliably and repeatedly manufacture product.

From inception, 4D understood the need for manufacturing to keep pace with the momentum generated by our research teams. After working with a number of outsourced partners on the initial projects, 4D acquired the production assets of Instituto Biomar in León, now our primary site for development and manufacturing.

4D pharma León is hugely significant, as it is a cGMP-approved site for the manufacture of live biotherapeutics. It has the capacity to run to 20 million capsules per annum, as well as the infrastructure and capability to perform scale-up from glassware in the research labs, through development and pilot scale.

To date our development team at 4D has taken five different programmes from the research lab to clinical/production scale, resulting in a product with up to 24 months' stability. The ability to control our development schedules and end up with stable, reproducible product gives 4D the confidence that going forward we can address all issues within our existing and future programmes to deliver product to the clinic and ultimately the patient.

Our understanding of the relationship between the bacteria in our gut and the ability to translate this into a stable therapeutic demonstrates that 4D's therapeutics are a reality. The ability at this stage of our development to be confident of succeeding in taking our research to reliably and repeatedly deliver drug to patients is a strong position on which to build.

Going forward

4D has a busy schedule of clinical trials coming up.

The next 12-18 months includes commencement of first-in-man trials in cancer and asthma, and commencement of the phase II trial for Blautix, as well as the conclusion of our phase I study in Paediatric Crohn's and commencement of a phase II study.

We will also continue our work in new fields, further exploring and understanding our efforts in areas such as neurodegeneration, and how our therapeutics can work alongside and potentially improve existing therapeutic approaches.

From inception in 2014, 4D has made solid progress. The Company has a class-leading platform which to date has generated 17 programmes across many disease areas. Two programmes have already been in patients and we have two first-in-man studies about to commence in cancer and asthma, and importantly 4D has the ability to develop, manufacture and deliver our products.

4D has a strong position to build on. We recognise that the field is still evolving, but we also recognise that 4D is leading its evolution.

David Norwood

Non-executive Chairman

Duncan Peyton

Chief Executive Officer

27 September 2017

Group Statement of Total Comprehensive Income

For the six months to 30 June 2017

 
                                              Unaudited    Unaudited 
                                             six months   six months       Audited 
                                                  ended        ended       year to 
                                                30 June      30 June   31 December 
                                                   2017         2016          2016 
                                     Notes       GBP000       GBP000        GBP000 
------------------------------------------  -----------  -----------  ------------ 
Research and development costs                  (8,305)      (4,060)      (10,220) 
Administrative expenses                         (1,047)      (2,423)       (2,866) 
Foreign currency (losses)/gains                   (439)          650           799 
------------------------------------------  -----------  -----------  ------------ 
Operating loss before non-recurring 
 costs                                          (9,791)      (5,833)      (12,287) 
------------------------------------------  -----------  -----------  ------------ 
Non-recurring costs                        5    (3,474)            -             - 
-----------------------------------------   -----------  -----------  ------------ 
Operating loss after non-recurring 
 costs                                         (13,265)      (5,833)      (12,287) 
Finance income                                      287          353           652 
Finance expense                                    (17)            -          (71) 
------------------------------------------  -----------  -----------  ------------ 
Loss before taxation                           (12,995)      (5,480)      (11,706) 
Taxation                                   3      1,179          897         1,843 
-----------------------------------------   -----------  -----------  ------------ 
Loss for the year                              (11,816)      (4,583)       (9,863) 
------------------------------------------  -----------  -----------  ------------ 
Other comprehensive income 
Exchange differences on translating 
 foreign operations                                 566            -         (389) 
------------------------------------------  -----------  -----------  ------------ 
Loss for the year and total comprehensive 
 income for the year                           (11,250)      (4,583)      (10,252) 
------------------------------------------  -----------  -----------  ------------ 
Loss per share 
Basic and diluted for the year             4   (17.35)p      (7.07)p      (15.81)p 
-----------------------------------------   -----------  -----------  ------------ 
 

Group Statement of Financial Position

At 30 June 2017

 
                                         At        At            At 
                                    30 June   30 June   31 December 
                                       2017      2016          2016 
                            Notes    GBP000    GBP000        GBP000 
---------------------------------  --------  --------  ------------ 
Assets 
Non-current assets 
Property, plant and equipment         4,782     3,958         3,859 
Intangible assets                    14,604    13,316        14,299 
Taxation receivables                     23         -            23 
---------------------------------  --------  --------  ------------ 
                                     19,409    17,274        18,181 
-------------------------------------------  --------  ------------ 
Current assets 
Inventories                             194         -           238 
Trade and other receivables           2,813     2,902         2,651 
Taxation receivables                  3,892     2,525         3,315 
Short-term investments and cash 
 on deposit                          10,000    73,611        40,111 
Cash and cash equivalents            49,772     1,836        28,661 
---------------------------------  --------  --------  ------------ 
                                     66,671    80,874        74,976 
-------------------------------------------  --------  ------------ 
Total assets                         86,080    98,148        93,157 
---------------------------------  --------  --------  ------------ 
Liabilities 
Current liabilities 
Trade and other payables        6     7,899     4,726         4,937 
------------------------------     --------  --------  ------------ 
                                      7,899     4,726         4,937 
-------------------------------------------  --------  ------------ 
Non-current liabilities 
Deferred tax                            963       628           963 
Other payables                  6     1,875       703           774 
------------------------------     --------  --------  ------------ 
                                      2,838     1,331         1,737 
-------------------------------------------  --------  ------------ 
Total liabilities                    10,737     6,057         6,674 
---------------------------------  --------  --------  ------------ 
Net assets                           75,343    92,091        86,483 
---------------------------------  --------  --------  ------------ 
Capital and reserves 
Share capital                           162       162           162 
Share premium account               105,909   105,909       105,909 
Merger reserve                          958       958           958 
Translation reserve                     177         -         (389) 
Other reserve                         (864)     (864)         (864) 
Share-based payments reserve            248        77           138 
Retained earnings                  (31,247)  (14,151)      (19,431) 
---------------------------------  --------  --------  ------------ 
Total equity                         75,343    92,091        86,483 
---------------------------------  --------  --------  ------------ 
 

Approved by the Board and authorised for issue on 27 September 2017.

Duncan Peyton

Director

27 September 2017

Group Statement of Changes in Equity

For the six months to 30 June 2017

 
                                                                                          Share- 
                                                                                           based 
                                      Share     Share    Merger  Translation     Other   payment   Retained 
                                    capital   premium   reserve      reserve   reserve   reserve   earnings     Total 
                                     GBP000    GBP000    GBP000       GBP000    GBP000    GBP000     GBP000    GBP000 
-------------------------------------------  --------  --------  -----------  --------  --------  ---------  -------- 
At 1 January 2016                       161   102,003       958            -     (864)         7    (9,568)    92,697 
Issue of share capital (net of 
 expenses)                                1     3,906         -            -         -         -          -     3,907 
--------------------------------------  ---  --------  --------  -----------  --------  --------  ---------  -------- 
Total transactions with owners 
 recognised in equity for the period      1     3,906         -            -         -         -          -     3,907 
Loss and total comprehensive income 
 for the period                           -         -         -            -         -         -    (4,583)   (4,583) 
Issue of share-based compensation         -         -         -            -         -        70          -        70 
--------------------------------------  ---  --------  --------  -----------  --------  --------  ---------  -------- 
At 30 June 2016                         162   105,909       958            -     (864)        77   (14,151)    92,091 
Loss and total comprehensive income 
 for the period                           -         -         -            -         -         -    (5,280)   (5,280) 
Foreign currency gains/losses arising 
 on consolidation of subsidiaries         -         -         -        (389)         -         -          -     (389) 
--------------------------------------  ---  --------  --------  -----------  --------  --------  ---------  -------- 
Loss and total comprehensive income 
 for the period                           -         -         -        (389)         -         -    (5,280)   (5,669) 
Issue of share-based compensation         -         -         -            -         -        61          -        61 
--------------------------------------  ---  --------  --------  -----------  --------  --------  ---------  -------- 
At 31 December 2016                     162   105,909       958        (389)     (864)       138   (19,431)    86,483 
Issue of share capital (net of 
 expenses)                                -         -         -            -         -         -          -         - 
Loss and total comprehensive income 
 for the period                           -         -         -            -         -         -   (11,816)  (11,816) 
Foreign currency gains/losses arising 
 on consolidation of subsidiaries         -         -         -          566         -         -          -       566 
--------------------------------------  ---  --------  --------  -----------  --------  --------  ---------  -------- 
Loss and total comprehensive income 
 for the period                           -         -         -        (206)         -         -   (11,816)  (11,250) 
Issue of share-based compensation         -         -         -            -         -       110          -       110 
--------------------------------------  ---  --------  --------  -----------  --------  --------  ---------  -------- 
At 30 June 2017                         162   105,909       958          177     (864)       248   (31,247)    75,343 
--------------------------------------  ---  --------  --------  -----------  --------  --------  ---------  -------- 
 

Group Cash Flow Statement

For the six months to 30 June 2017

 
                                                 Unaudited    Unaudited 
                                                six months   six months       Audited 
                                                     ended        ended       year to 
                                                   30 June      30 June   31 December 
                                                      2017         2016          2016 
                                        Notes       GBP000       GBP000        GBP000 
---------------------------------------------  -----------  -----------  ------------ 
Loss after taxation                               (11,816)      (4,583)       (9,863) 
Adjustments for: 
Depreciation of property, plant 
 and equipment                                         324          134           405 
Amortisation of intangible assets                      117          101           213 
Loss/(profit) on disposal of property, 
 plant and equipment                                    78            -           (2) 
Finance income                                       (287)        (353)         (652) 
Finance expense                                         17            -            71 
Non-recurring costs                         5        3,474            -             - 
Share-based compensation                               110           70           131 
---------------------------------------------  -----------  -----------  ------------ 
Cash flows from operations before 
 movements in working capital                      (7,983)      (4,631)       (9,697) 
Changes in working capital: 
Decrease/(increase) in inventories                      44           28         (210) 
Increase in trade and other receivables               (23)        (457)         (762) 
Increase in taxation receivables                     (578)        (197)         (715) 
Decrease/(increase) in trade and 
 other payables                                        519      (2,004)       (2,142) 
---------------------------------------------  -----------  -----------  ------------ 
Cash outflow from operating activities             (8,021)      (7,261)      (13,526) 
---------------------------------------------  -----------  -----------  ------------ 
Cash flows from investing activities 
Purchases of property, plant and 
 equipment                                         (1,122)      (1,089)       (2,243) 
Purchase of software and other intangibles            (43)        (243)          (76) 
Acquisition of subsidiaries net 
 of cash acquired                                        -      (1,615)       (1,615) 
Cash received on disposal of assets                      -            -            15 
Interest received                                      147          214           776 
Monies placed on deposit                            30,111       10,053        43,553 
---------------------------------------------  -----------  -----------  ------------ 
Net cash inflow from investing activities           29,093        7,320        40,410 
---------------------------------------------  -----------  -----------  ------------ 
Cash flows from financing activities 
Finance lease cash flows                                40            -             - 
Interest paid                                          (1)            -             - 
---------------------------------------------  -----------  -----------  ------------ 
Net cash inflow from financing activities               39            -             - 
---------------------------------------------  -----------  -----------  ------------ 
Increase in cash and cash equivalents               21,111           59        26,884 
Cash and cash equivalents at the 
 start of the year                                  28,661        1,777         1,777 
---------------------------------------------  -----------  -----------  ------------ 
Cash and cash equivalents at the 
 end of the year                                    49,772        1,836        28,661 
---------------------------------------------  -----------  -----------  ------------ 
 
 

Notes to the Interim Financial Report

For the six months ended 30 June 2017

1. Basis of preparation

The Group's half-yearly financial information, which is unaudited, consolidates the results of 4D pharma plc and its subsidiary undertakings up to 30 June 2017. The Group's accounting reference date is 31 December. 4D pharma plc's shares are quoted on the AIM Market of the London Stock Exchange (AIM).

The Company is a public limited liability company incorporated and domiciled in the UK. The consolidated financial information is presented in round thousands of Pounds Sterling (GBP000).

The financial information contained in this half-yearly financial report does not constitute statutory accounts as defined in section 434 of the Companies Act 2006. It does not therefore include all of the information and disclosures required in the annual financial statements.

The financial information for the six months ended 30 June 2016 and 30 June 2017 is unaudited.

Full audited financial statements of the Group in respect of the year ended 31 December 2016, which received an unqualified audit opinion and did not contain a statement under sections 498(2) or (3) of the Companies Act 2006, have been delivered to the Registrar of Companies.

The accounting policies used in the preparation of the financial information for the six months ended 30 June 2017 are in accordance with the recognition and measurement criteria of International Financial Reporting Standards as adopted by the European Union ("IFRS") and are consistent with those which will be adopted in the annual financial statements for the year ending 31 December 2017.

Whilst the financial information included has been prepared in accordance with the recognition and measurement criteria of IFRS, the financial information does not contain sufficient information to comply with IFRS.

4D pharma plc has not applied IAS 34 Interim Financial Reporting, which is not mandatory for UK AIM-listed groups, in the preparation of this interim financial report.

2. Going concern

Having prepared management forecasts and made appropriate enquiries, the directors are satisfied that the Group has adequate resources for the foreseeable future as the Group is in the start-up stage of its business lifecycle. Accordingly they have adopted the going concern basis in preparing the financial information.

3. Taxation

The tax credit is made up as follows:

 
                                   Unaudited    Unaudited 
                                  six months   six months       Audited 
                                       ended        ended       year to 
                                     30 June      30 June   31 December 
                                        2017         2016          2016 
                                      GBP000       GBP000        GBP000 
--------------------------------------------  -----------  ------------ 
Current income tax 
Total current income tax               1,169          897         1,843 
Adjustment in respect of prior years      10            -             - 
-------------------------------------  -----  -----------  ------------ 
Total income tax credit recognised 
 in the year                           1,179          897         1,843 
-------------------------------------  -----  -----------  ------------ 
 

4. Loss per ordinary share

(a) Basic and diluted

 
                                     Unaudited    Unaudited 
                                    six months   six months       Audited 
                                         ended        ended       year to 
                                       30 June      30 June   31 December 
                                          2017         2016          2016 
                                        GBP000       GBP000        GBP000 
----------------------------------------------  -----------  ------------ 
Loss for the year attributable to 
 equity shareholders                  (11,250)      (4,583)      (10,252) 
----------------------------------  ----------  -----------  ------------ 
Weighted average number of shares 
Ordinary shares in issue            64,858,150   64,791,053    64,858,150 
----------------------------------  ----------  -----------  ------------ 
Basic loss per share (pence)          (17.35)p      (7.07)p      (15.81)p 
----------------------------------  ----------  -----------  ------------ 
 

The basic and diluted loss per share are the same as the effect of share options is anti-dilutive.

(b) Adjusted

Adjusted loss per share is calculated after adjusting for the effect of non-recurring expenses in relation to the reassessment of the contingent liability.

Reconciliation of adjusted loss after tax:

 
                                         30 June  30 June  31 December 
                                            2017     2016         2016 
                                          GBP000   GBP000       GBP000 
------------------------------------------------  -------  ----------- 
Reported loss after tax                 (11,250)  (4,583)     (10,252) 
Non-recurring costs                        3,474        0            0 
--------------------------------------  --------  -------  ----------- 
Adjusted loss after tax                  (7,776)  (4,583)     (10,252) 
--------------------------------------  --------  -------  ----------- 
Adjusted basic loss per share (pence)   (11.99)p  (7.07)p     (15.81)p 
--------------------------------------  --------  -------  ----------- 
 

5. Non-recurring costs

As detailed in post-balance sheet events (see note 7) and other payables (see note 6) on 23 August 2017 contingent consideration became due following the achievement of 4D Pharma Cork Ltd's initial milestone.

The contingent liability was initially calculated upon the acquisition based on the discounted probability of the potential liability at the time of acquisition. With the successful completion of the first milestone the management have had to re-assess the probability of success of subsequent milestones and therefore increase the contingent liability. This has resulted in the non-recurring cost in the period to 30 June 2017 of GBP3.474 million.

6. Other payables

Contingent consideration:

 
                                            GBP000  GBP000 
--------------------------------------------------  ------ 
As at 31 December 2015                                   - 
Included in trade and other payables is a contingent 
 consideration as follows: 
Contingent consideration                       985 
Discounting of estimated future cash flows   (282)     703 
Unwinding of discount                                   71 
--------------------------------------------------  ------ 
As at 31 December 2016                                 774 
Unwinding of discount                           16 
Reassessment of contingent consideration 
 to be satisfied in shares                   4,395 
Discounting of estimated future cash flows   (921)   3,490 
-------------------------------------------  -----  ------ 
As at 30 June 2017                                   4,264 
--------------------------------------------------  ------ 
Analysed as follows: 
Within one year                                      2,389 
After more than one year                             1,875 
--------------------------------------------------  ------ 
                                                     4,264 
---------------------------------------------------------- 
 

The above contingent consideration relates to the amounts due on the remaining contingent milestones in relation to the acquisition of Tucana Health Limited (now 4D Pharma Cork Limited) on 10 February 2016. As detailed in note 7, the first milestone has been achieved and so a reassessment has been made of the potential liability arising on the discounted probability of the remaining milestones.

7. Post-balance sheet events

On 23 August 2017 635,692 new ordinary shares were issued. The allotment represents contingent consideration in respect of the acquisition of the entire issued share capital of 4D Pharma Cork Limited (formerly Tucana Health Limited), which completed in February 2016, and follows the achievement of 4D Pharma Cork's initial milestone.

The milestone achieved reflects the technical validation of the MicroDx diagnostic platform, enabling the stratification of IBS patients. MicroDx has been designed to diagnose, stratify and monitor the treatment of patients based on their gut microbiome, the bacteria which colonise the human gastrointestinal tract.

The new 4D ordinary shares have been allotted for an aggregate value of EUR2.6 million (at GBP3.7575 per 4D share, being the average mid-market price of a 4D share for the five business days immediately preceding the date of allotment) and were admitted on 31 August 2017.

Following Admission, the Company's issued share capital is 65,493,842 ordinary shares.

This information is provided by RNS

The company news service from the London Stock Exchange

END

IR PGUMWBUPMGMM

(END) Dow Jones Newswires

September 28, 2017 02:00 ET (06:00 GMT)

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