Synairgen Share Discussion Threads

[likya123] 04/4/2020 21:43

Nobby, this is all very fast moving and I'm expecting some very decent panic buying on Monday morning and with the seller finished Monday will be an incredible day.

Keep up the fantasic board and glad to be back!

[likya123] 04/4/2020 21:40

What you make of the documents being dated 23rd March? (Bottom of each page)

[nobbygnome] 04/4/2020 21:39

>> super

It's a long story. Essentially it was down to poor trial design rather than the drug didn't work. Not enough of the asthma sufferers got a viral induced respiratory infection. In the COPD trial they have used a new test to identify viral infections which removed this issue as a problem.

[nobbygnome] 04/4/2020 21:37

So I think we are guaranteed an RNS on Monday morning. Hopefully all the muppets who were selling out in the last couple of days will rush to buy back in....

[supernumerary] 04/4/2020 21:37

So why did AZ give it back? And yes, I do appreciate I'm being lazy...

[nobbygnome] 04/4/2020 21:33

Interesting. If you look at page 16, the document suggests interferon beta is better than interferon alpha as I have suggested!

Courtesy of timbo; as usual I scan read the document and missed that part!

[crookie3634] 04/4/2020 21:32

Since the outbreak of COVID-19, Synairgen has been approached by, and is in discussion with, a number of other medical, scientific, and Governmental bodies (both in the UK, US and internationally) seeking to investigate novel therapeutics in this area.

Ties in with the above

[bountyhunter] 04/4/2020 21:26

Ah, that makes sense now given they are to recruit 100 patients.

Not good for those who end up in hospital:
(hopefully better for 50% of those on the trial!)

mortality for hospitalised patients may be around 10% (or more in those who are older or have significant co-morbidity).

an effective treatment could be a game changer but may take a while especially given the rather slow rate of recruitment to date which has surprised me given the current circumstances. Maybe that will be fast-tracked going forwards?

[crookie3634] 04/4/2020 21:25

It all looks positive, funding by Gates can only be a big positive

[nobbygnome] 04/4/2020 21:25

Yes but not yet announced. SNG001 is arm 3 of the trial

[bountyhunter] 04/4/2020 21:21

Yes it's the SNG trial based at Southanpton which I am talking about, not read back on all but the last few posts as been too busy.
I don't know anything about the Oxford trial, does that also involve SNG? Presumably not?

[likya123] 04/4/2020 21:20

From lse board...





On page 12/13 on the document I have copied and pasted a segment. If you look, Bill Gates is backing the trial, he also funds so research for the WHO. 

6 OPERATIONAL AND ADMINISTRATIVE DETAILS
6.1 Sponsor and coordination
The University of Oxford will act as the trial Sponsor. The trial will be coordinated by a
Central Coordinating Office within the Nuffield Department of Population Health staffed by 
members of the two registered clinical trials units – the Clinical Trial Service Unit and the 
National Perinatal Epidemiology Unit Clinical Trials Unit. The data will be collected, 
analysed and published independently of the source of funding. 
6.2 Funding
This study is supported by a grant to the University of Oxford from UK Research and 
Innovation/National Institute for Health Research (NIHR) and by core funding provided by 
NIHR Oxford Biomedical Research Centre, the Wellcome Trust, the Bill and Melinda Gates 
Foundation, Health Data Research UK, and the Medical Research Council Population 
Health Research Unit, and NIHR Clinical Trials Unit Support Funding.

[nobbygnome] 04/4/2020 21:20

SG016 is the SNG trial which is different from the Recovery trial which is described in this document. The former is double blind whilst the latter is open label.

[bountyhunter] 04/4/2020 21:18

That's for the SNG phase IIb trial for inhaled interferon. Which trial are you talking about?

[crookie3634] 04/4/2020 21:16

Different trial Bounty

[bountyhunter] 04/4/2020 21:14

They began recruiting a week or two ago with at least 6 patients now recruited. Still some way to go though with 100 to be recruited in total. Might not take too long though as imagine you were in hospital and were offered the best treatments available or the same + a 50% chance of a promising new treatment, which would you choose?

[crookie3634] 04/4/2020 21:08

The larger report seems clearer, looks like we will get an update early part of the week, I suspect it may not just be this as we know discussions are ongoing with a number of interested parties. Look at the opening page of the website basically saying stop calling us for our drug until it passes the trials! Lots of interest!

[lunus1] 04/4/2020 21:04

Crookie It’s not in use..yet. But it says they are starting to recruit people for it starting on Monday!

[crookie3634] 04/4/2020 20:57

Just read it on the LSE link thank you, can see ours is ARM 3, development in the last 24 hours you think? Must be an update Monday or Tuesday and I wonder if we are involved in the US we know people were there last week or week before. We need the drug to work though! And show significant results.

[torreskid] 04/4/2020 20:56

Tell u now, dexamethasone will disappoint as usual

Money is on both Inhaled Interferon and the HIV combination therapy.... they work differently, and unfortunately they have not considered combinations of some of the therapies (eg interferon and Antiviral therapy) as the benefits may be additive (greater than the sum of all the parts)
Perhaps that would be the next phase of the trial (baby steps)

[lunus1] 04/4/2020 20:53

hxxp://www.isrctn.com/ISRCTN50189673

[nobbygnome] 04/4/2020 20:50

Page 7. Inhaled interferon beta is arm 3 in the trial...

[crookie3634] 04/4/2020 20:49

Lunus where does it say we have been added? I read it that ours was not in use in this recovery programme?