Synairgen Share Discussion Threads

[74tom] 20/7/2020 08:59

Fincapp reiterate their £3.60 target, however they emphasise there is significant upside depending on regulatory discussions... talk of a sales pipeline valued at £2-3b as governments stockpile...

Personally I’d much rather my elderly relatives took this than a rushed through vaccine with questionable safety implications...

Anyone else feel the same?

[mdchand] 20/7/2020 08:56

Interested to see how Syn price this now. Remdesivir charge approx $3000 for a 5 oourse treatment plan.



No need to Syn to undercut the market leader, so let us assume $600 per vial for Syn.

Multiply that by the number of doses required per patient and what numbers do we get? Also, how quickly can Syn ramp up production?

[mikro1] 20/7/2020 08:54

I bought some today. Seems strange to buy a share that has just gone up 180% but good news is good news and can’t be ignored

[paraguay] 20/7/2020 08:52

This should continue up trend thru Tuesday as well. BBC reporter was clearly broadcasting from premier inn hotel Southampton, so probably be more coverage on the telly after press conference- this evening and tomorrow's breakfast news. Also rag tops will pick this up and we'll see write up tomorrow. My plan is to top slice late Tuesday or Early Wednesday. As by then I think we'll be over bought by then

[amrishbhim] 20/7/2020 08:52

The preliminary results of a clinical trial suggest a new treatment for Covid-19 dramatically reduces the number of patients needing intensive care, according to the UK company that developed it.The treatment from Southampton-based biotech Synairgen uses a protein called interferon beta which the body produces when it gets a viral infection. The protein is inhaled directly into the lungs of patients with coronavirus, using a nebuliser, in the hope that it will stimulate an immune response.The initial findings suggest the treatment cut the odds of a Covid-19 patient in hospital developing severe disease - such as requiring ventilation - by 79%.Patients were two to three times more likely to recover to the point where everyday activities were not compromised by their illness, Synairgen claims.It said the trial also indicated "very significant" reductions in breathlessness among patients who received the treatment.In addition, the average time patients spent in hospital is said to have been reduced by a third, for those receiving the new drug - down from an average of nine days to six days.? UK hospital trials new coronavirus treatment drug? Life-saving coronavirus drug 'major breakthrough'? Coronavirus anti-viral drug 'biggest step forward'? How near are we to curing coronavirus?The double-blind trial involved 101 volunteers who had been admitted for treatment at nine UK hospitals for Covid-19 infections.Half of the participants were given the drug, the other half got what is known as a placebo - an inactive substance.Unconfirmed resultsStock market rules mean Synairgen is obliged to report the preliminary results of the trial. The results have not been published in a peer-reviewed journal, nor has the full data been made available; so the BBC cannot confirm the claims made for the treatment.But if the results are as the company says, it will be a very important step forward in the treatment of coronavirus infections.The scientist in charge of the trial, Tom Wilkinson, says if the results are confirmed in larger studies the new treatment will be "a game changer".The trial was relatively small but the signal that the treatment benefits patients was unusually strong, he says."We couldn't have expected much better results than these," Synairgen chief executive Richard Marsden told the BBC.He described the results as "a major breakthrough in the treatment of hospitalised Covid-19 patients".What happens next?Mr Marsden said the company will be presenting its findings to medical regulators around the world in the next couple of days to see what further information they require in order to approve the treatment.That process could take months, although the British government, like many others, has said it will work as fast as possible to get promising coronavirus treatments approved.It is possible it could be given emergency approval, as the anti-viral drug remdesivir was in May. Another possibility is that permission will be given for more patients to receive the treatment with the effects being carefully monitored to confirm it is safe and effective.If it does get approval, the drug and the nebulisers used to deliver it would then need to be manufactured in large quantities.Mr Marsden says he instructed companies to start producing supplies back in April to ensure they would be available should the results be positive.He says he expects Synairgen to be able to deliver "a few 100,000" doses a month by the winter.How does the treatment work?Interferon beta is part of the body's first line of defence against viruses, warning it to expect a viral attack.The coronavirus seems to suppress its production as part of its strategy to evade our immune systems.The new drug is a special formulation of interferon beta delivered directly to the airways via a nebuliser which makes the protein into an aerosol. The idea is that a direct dose of the protein in the lungs will trigger a stronger anti-viral response, even in patients whose immune systems are already weak.Interferon beta is commonly used in the treatment of multiple sclerosis.Previous clinical trials conducted by Synairgen have shown that it can stimulate an immune response and that patients with asthma and other chronic lung conditions can comfortably tolerate the treatment.How was the treatment tested?No-one involved in the trial knew which patients have been given which treatment until it was over."If you know it's a drug, your mind might have a bias," explained Sandy Aitken, one of the nurses who administered the new drug to patients at Southampton Hospital.Synairgen's drug trial was the template for the Accord programme, a fast-track clinical trial scheme set up by the UK government in April to accelerate the development of new drugs for patients with Covid-19.The Synairgen team believes the drug could be even more effective at the early stages of infection.A trial exploring the effects of giving patients who are in high-risk groups the new drug as soon as they are confirmed as having Covid-19 has struggled to find volunteers because there are so few new infections at the moment.

[dovey21] 20/7/2020 08:50

I Do hope the II's are puking today! ?? They sold a goldmine for Pennies.