Synairgen Share Discussion Threads

[spartan attack] 02/6/2020 07:45

gbh22 Jun '20 - 07:36 - 8715 of 8716
0 1 0
SP suffered a 30% drop during May and that's unlikely to be PI led!.

....

Threads like these delay 5p. In a way that a good. They can enjoy the pain for longer

[waterloo01] 02/6/2020 07:42

Clinical trials with various interferons have been started. Studies with cells and preliminary results in people support these trials. Studies with cultured cells that showed a reduction in viral replication in cells pretreated with IFN-α or IFN-β (Mantlo and colleagues, and Lokugamage and colleagues). A study with primary intestinal epithelial cells or organoids (cultures of mixed cell types that form structures like those in the body) also showed that viral infection was reduced by treatment of the cells with either IFN-β or IFN-λ.

[gbh2] 02/6/2020 07:36

SP suffered a 30% drop during May and that's unlikely to be PI led!

[makendon] 02/6/2020 06:08

ACCORD aims to accelerate the development of new drugs for patients hospitalised with COVID-19 and is reducing the time taken to set up clinical studies for new therapies from months to weeks.

ACCORD-2 sites
Clinical trials run as part of the ACCORD platform will test several different drugs for how well they slow or stop the progression of COVID-19 in hospital patients across several NHS hospitals nationwide:

Addenbrooke’s Hospital, Cambridge
Barts Health NHS Trust
Glasgow Royal Infirmary
Guy's Hospital
John Radcliffe Hospital, Oxford
Kings College Hospital NHS Foundation Trust
Leeds General Infirmary
Manchester University NHS Foundation Trust
Newcastle University Hospitals NHS Foundation Trust
Nottingham University Hospitals NHS Trust
Royal Brompton Hospital
Royal Infirmary of Edinburgh
Royal Liverpool University Hospital
Royal Victoria Hospital, Belfast
University College London Hospitals NHS Foundation Trust
University Hospitals Birmingham NHS Foundation Trust
University Hospitals of Leicester NHS Trust
University Hospital Southampton NHS Foundation Trust
University Hospital of Wales, Cardiff

[s120896] 02/6/2020 03:58

Some useful information regarding the importance of Interferons with the bodies response to Covid. www.medium.com/swlh/interferon-responses-could-explain-susceptibility-to-severe-covid-19-cc69a654b999

[itshenderz] 01/6/2020 23:05

We go again tomorrow, praying for a day out the red! Lol.

[spartan attack] 01/6/2020 22:58

Not at all. I'd double up at 55.

Bulls like drops to value

Obviously I need bounces for value

Any chance tomorrow? Save me waiting

[sharestingoriginal] 01/6/2020 22:29

Expecting a TR1 this week. Then a strong bounce, at which point the resident idiot will vanish.

[spartan attack] 01/6/2020 22:08

Could be a stock rotation for shorting it out.

[spartan attack] 01/6/2020 22:06

The more you buy, the harder she falls (ramped up distribution)

So the less you buy to july, higher price will be, into the results

[the real capitalcity] 01/6/2020 22:06

Someone working the night shift?I just took a look on ADVFN trades pages at the final couple of buys recorded today. They were both the same volume and value, once again at a small discount to the offer price at the time of the trade, as we have become all too familiar with. The strange thing for me was the time they were recorded was 18:00hrs and 11 seconds, then another at 18:00hrs and 49 seconds? This seems very late to me, and has all the signs of someone working late to clear the decks. I have a feeling we're going to see a Tr1 in the morning stating someone has exited or significantly sold down. Time will tell...The other intriguing part of this is who is buying all of these? The volumes in total are not exactly small.

[spartan attack] 01/6/2020 22:05

Im plugged into the funds, laughin at ya all

[waterloo01] 01/6/2020 19:40

We've seen evidence over the last few days that not only does it play a key role in why COVID is so devastating but might also provide protection against COVID, key seems to give it early before the 'storm'.

Short of results, not sure what more confirmation is needed that SNG are onto something that makes a difference.

I also note that the Govt are advertising that if you have symptoms you can now get a test. I hope SNG are plugged into their local testing network as they will identify the target patients very efficiently

[peachie 74] 01/6/2020 19:10

Great post above. More evidence of the importance of Interferon

[waterloo01] 01/6/2020 18:51

Interesting science blog for those that are minded. Be short if you wish, but I think that will prove very foolish.



"They were able to check circulating levels of these in a larger number of patients (24 infected cases versus 24 uninfected controls), and these results were also consistent: they tested negative for interferon, but showed elevation of CXCL9 (which attracts T cells) and CXCL16 (which attracts NK cells), CCL8 and CCL2 (recruiting monocytes and/or macrophages), and CXCL8 (which attracts neutrophils). A sudden oversupply of these cell types might be behind the pathology of the disease, which could be characterized, if these hypotheses are correct, as a uniquely imbalanced response: far too little interferon and far too many cytokines, too early.

I expect we’ll see quite a few other papers in this area; we’ll see if this picture holds up. But it certainly seems consistent with what people have been seeing in the clinic, and it bodes well for the therapies that are aiming to dampen the cytokine response pathways. Does this mean that administration of IFN-I or IFN-III would also be beneficial?"

[l0ngterm] 01/6/2020 18:49

Is it me or with all the evidence supplied thus far, it looks like the drug has some great benefits. It's just hopefully, right company right timing GLA

[pdt] 01/6/2020 18:44

More research highlighting Interferon suppression by COVID-19

"Targeted Immunosuppression Distinguishes COVID-19 from Influenza in Moderate and Severe Disease"



From the abstract;

Single cell transcriptional profiling of COVID-19 and influenza subjects with respiratory failure identified profound suppression in type I and type II interferon signaling in COVID-19 patients across multiple clusters .... The majority of COVID-19 patients with acute respiratory failure do not have a cytokine storm phenotype but instead exhibit profound type I and type II IFN immunosuppression when compared to patients with acute influenza.

[spartan attack] 01/6/2020 18:15

Poor D1NGBAT

[l0ngterm] 01/6/2020 17:54

To be frank and if all are serious, then all paid users should contact admin and state you will cancel any subscriptions, as this verges on harassment/bullying .. and the organisation ADVFN has a duty of care.. bet I get booted off for this :-)..

[the real capitalcity] 01/6/2020 17:39

1,962,333 "?" Shares changed hands today, most of those after the final call and large trades above the Offer price at the time they were reported, either late reported or someone is buying these up on the quiet...

I share the view there will be a TR1 shortly...(hopefully tomorrow morning)

We suspect we know who is offloading their shares, but do we think they are for the most part going to the same buyer by way of warehousing first...

It doesn't make sense if Lansdowne knows someone is buying that they would let them have them for a knockdown fire-sale price, normally discounted by around 10% to the market value at the time of the transaction.

There is also the case of the "1 Code" earlier around 11.30am today, was that a case of someone getting a TR1 RNS ready?

[l0ngterm] 01/6/2020 17:37

And can you let some of us know how to join it please, if possible. Thanks