Scancell Share Discussion Threads

[the real lozan] 15/2/2019 09:40

Bob et al -
Would anyone like to bet on 'where the origin of the source re. 3 responders figure came from' ???
Would anyone care to further bet - that *WE ALL* won't be told/find-out ='where the origin of the source re. 3 responders figure came from' ???
BUT
*WE ALL* have a 'good idea' 'where the origin of the source re. 3 responders figure came from' ???

[wigwammer] 15/2/2019 09:39

Berm - calculus presentation, full length version, circa 22:15.. though I'm pretty sure it was covered at the AGM too.

[wigwammer] 15/2/2019 09:33

Gaz - you can debate the point there are "no risks" if you want to - no objections here - but I'm more interested in people's perceptions of your view that there WILL be responders to the vaccine. As mentioned, let's try and keep it civilised.

[wigwammer] 15/2/2019 09:28

Will have a look for the source. Let's try and keep it civilised though - I'm happy to be guided otherwise as long as it's done in an adult way!

[gazza] 15/2/2019 09:27

wiggy,

>Beyond that, your only concern is safety<<br />
Not true. We are debating the view "there are NO risks"
In order to prove this view WRONG you only need to find ONE risk. This disproves the theory but is not necessarily the only risk. It's like if you need 20 runs to win a cricket match, you stop when you have got 20, not carry on for a couple of hundred.

[bermudashorts] 15/2/2019 09:11

Wigwammer - where did you get the 3 responders figure from?

[wigwammer] 15/2/2019 08:59

Gaz - they only need 3 responders in the moditope trial, and you are sure they will get at least 2. Beyond that, your only concern is safety. If inanaco is suggesting the investment is "riskless", you do not sound far behind. Can I also suggest that if the market agreed and comprehended your point, the stock would be 10 fold higher than where it is now. Have a good day :)"I'm sure the statement is true there WILL be responders. She doesn't say how many or what percentage. What she DOESN'T say is that there WON'T be any adverse reactions. I'm not sure why some are finding this so difficult to comprehend."

[ivyspivey] 15/2/2019 08:58

Morning Gazza,
Yes is an open discussion.Certainly my point yesterday was as one persons ability to assess and deal with risk may well be different to others.
I took a serious haircut yesterday but will survive and I got the risk wrong.
Tried to highlight that had a lot of personal contact with others who took a big haircut and it has caused them serious financial and/ or personal issues like depression and marital problems.
Merely wanted to remind people there are very individual tragedy’s as a result of underestimating the risk on any share.
GLA

[gazza] 15/2/2019 07:51

Inan, "Gazza Does this post relate to Bermuda and my thread ?"It relates to the 'open' discussion (Inan, Bermuda, Gazza, ivy, wiggy, tosh) as to whether or not you can't rule out any possible reason for failure. The consensus is you can't. Case dismissed.Next?Ps. We do try to run an open board here, threads are not "owned" by any one individual or syndicate.

[gazza] 15/2/2019 07:45

TF, try and pay attention, I am always challenging him on LSE. As for "auditing" recs - I'm not. Merely passing a comment that Inan gets 4 recs for every post on LSE even when it is complete nonsense. I presume one is you?

[wigwammer] 15/2/2019 07:34

So the only risk for gaz is "how many" and safety, and he can't understand why the market is finding this difficult to comprehend. There was me thinking he sat with the cautious team.."I'm sure the statement is true there WILL be responders. She doesn't say how many or what percentage. What she DOESN'T say is that there WON'T be any adverse reactions. I'm not sure why some are finding this so difficult to comprehend."

[inanaco] 15/2/2019 01:24

Gazza Does this post relate to Bermuda and my thread ?

only you have not said

Gazza14 Feb '19 - 22:41 - 19750 of 19753
0 1 0
Prof Durrant has stated:
“There WILL be a cohort of patients that respond really well to this vaccine that have high levels of autophagy and high levels of citrullination.̶1;

Perhaps she is neither naive nor a genius just a very dedicated scientist carrying out her duties to the best of her ability.

I’m sure the statement is true there WILL be responders. She doesn’t say how many or what percentage. What she DOESN’T say is that there WON’T be any adverse reactions.

I’m not sure why some are finding this so difficult to comprehend.

[moljen] 14/2/2019 23:31

The worst in some people brings out the best in other, BS in particular today I enjoyed your posts and if this does pan out as we all hope I think you'd be a character I'd like to meet at the celebration. One or two others also but yet again there was one I didn't. Honestly when you think you ex wife has a better demeanour after you've had a run in with her then you really do wonder. I keep having visions of him doing a does not compute does not compute does not compute meltdown if it doesn't work out.

[torquayfan] 14/2/2019 23:28

Gazza / Ruck Rover 19751 - ''this has puzzled (you) as well'' ?
Why, (as 'no one' has questioned Inan on LSE), don't you do so ?
And now you are trying to 'audit' reccers - that should be fun over there LOL

Ivy - 19749. ''Days like today on MTFB . . . . bring real heartache to some.''
Well said - amidst all the sparring, people's deep hopes are locked up in MTFB and Scancell. Being in SCLP is bad enough - commiserations to MTFB holders . .

Bermuda - 19728 ''FWIW I am sure that Inanaco genuinely believes what he is posting and is also genuine in his utter faith in Scancell. There is no doubt that he has spent a huge amount of time researching Scancell and its tech. and I have found his posts useful in the past.'' Well said - respect. To you and to Inan.

Just MHO, for the record, nothing in life is without a risk is it ?
There's definitely a risk in this investment of course, BUT with an enthusiastic insight into the science, it would be easy to feel that the project should indeed be home and dry.

GLA

[gazza] 14/2/2019 22:45

Bermuda 19735"Proven, no risk, no mechanism of failure - simply NOT TRUE and I'm surprised that nobody on lse has challenged your posts."Yes, this has puzzled me as well. He posts the most ridiculous drivel and gets 4 recs. I have asked who these people are, as yet no one has owned up.

[gazza] 14/2/2019 22:41

Prof Durrant has stated:"There WILL be a cohort of patients that respond really well to this vaccine that have high levels of autophagy and high levels of citrullination."Perhaps she is neither naive nor a genius just a very dedicated scientist carrying out her duties to the best of her ability. I'm sure the statement is true there WILL be responders. She doesn't say how many or what percentage. What she DOESN'T say is that there WON'T be any adverse reactions. I'm not sure why some are finding this so difficult to comprehend.

[ivyspivey] 14/2/2019 20:48

We have to understand that people can lose huge amounts of money and cause real personal issues of family break up,depression,etc and some of us experience it with people that have invested an awful lot into a small bio.
Days like today on MTFB( similar fall to here except in happened in one day)bring real heartache to some and yes sheer joy to others.
Not to likes of me and Bermuda,Wigwammer,Inanaco and many others on here who probably are fairly able to survive these events.
But many others cannot and to suggest that not quantifying the risk is of no consequence to some of these individuals is to do the wider community a big disservice imo

[wigwammer] 14/2/2019 20:36

There's no agenda, bermuda. I'm just interested in your perception. I've looked at many biotechs over many years, and I know you have too. My perception is LD uses rhetoric which appears relatively uncompromising. There "WILL" be. Agree? Little wonder therefore that the discussion of risk becomes so polarised - is she naive or is she a genius...

[bermudashorts] 14/2/2019 20:26

Wigwammer I'm not sure what point you're trying to make.

[wigwammer] 14/2/2019 20:21

Bermuda - LD's words are unusually uncompromising, aren't they? I'm not saying this to claim she is naive, or that we can have enhanced confidence of positive efficacy, simply that the words do appear that way.

[bermudashorts] 14/2/2019 20:19

Inanaco,

I simply can't face bickering with you tonight - point me to the successful clinical results of a SCIB1/PD1 combination trial and I'll admit that I don't get it. Until then please stop encouraging people to build large holdings based on the fact that you believe the combination is proven and there is no risk because it's not and there is.

[inanaco] 14/2/2019 20:00

LOL ...

Trial investigator

""""" Furthermore, the stimulation of potent de novo immune responses by SCIB1 """"

Keytruda

Mechanism of action. Pembrolizumab is a therapeutic antibody that binds to and blocks the PD-1, programmed cell death protein 1 located on lymphocytes. This receptor is generally responsible for preventing the immune system from attacking the body's own tissues; it is a so-called immune checkpoint.

Bermuda you still don't get it ...

which trial has failed ....

SCIB1

or

Keytruda

[bermudashorts] 14/2/2019 19:46

wigwammer - and her confidence gives us the confidence to buy and to continue to hold however, I don't believe LD would state that anything was proven until it had been through clinical trials, nor would she claim to be able to rule out in advance any mechanism of failure. If LD with her level of expertise can't then for sure none of us can.

[bermudashorts] 14/2/2019 18:56

Inanaco,

The risks are most definitely identifiable and explicit and that is why your denial of them is baffling.

Anyway bump my 19735 because all you keep doing is repeating the mechanism of action.