ADVFN Logo ADVFN

We could not find any results for:
Make sure your spelling is correct or try broadening your search.

Trending Now

Toplists

It looks like you aren't logged in.
Click the button below to log in and view your recent history.

Hot Features

Registration Strip Icon for default Register for Free to get streaming real-time quotes, interactive charts, live options flow, and more.

SCLP Scancell Holdings Plc

9.65
-0.10 (-1.03%)
07 Jun 2024 - Closed
Delayed by 15 minutes
Share Name Share Symbol Market Type Share ISIN Share Description
Scancell Holdings Plc LSE:SCLP London Ordinary Share GB00B63D3314 ORD 0.1P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  -0.10 -1.03% 9.65 9.30 10.00 9.75 9.65 9.75 542,863 10:14:22
Industry Sector Turnover Profit EPS - Basic PE Ratio Market Cap
Pharmaceutical Preparations 5.27M -11.94M -0.0129 -7.48 89.53M
Scancell Holdings Plc is listed in the Pharmaceutical Preparations sector of the London Stock Exchange with ticker SCLP. The last closing price for Scancell was 9.75p. Over the last year, Scancell shares have traded in a share price range of 7.65p to 18.125p.

Scancell currently has 927,819,977 shares in issue. The market capitalisation of Scancell is £89.53 million. Scancell has a price to earnings ratio (PE ratio) of -7.48.

Scancell Share Discussion Threads

Showing 63201 to 63221 of 67275 messages
Chat Pages: Latest  2535  2534  2533  2532  2531  2530  2529  2528  2527  2526  2525  2524  Older
DateSubjectAuthorDiscuss
20/9/2023
09:04
i would say the one that is sweating now is BioNtech
inanaco
20/9/2023
08:56
One other aspect of BMS etc....BMS may have a particular interest in SCIB1, but a whole company deal might enable them to develop new revenue streams that might otherwise accrue to other major pharmas. So taking everything may strengthen a company's competitive position versus other major pharmas.To me, that indicates a very large bid premium, especially from a baseline share price that is even more "derisory" than it was six months ago.
markingtime
20/9/2023
08:54
Inan thanks for that update on Inovio - maybe they'll be consigned to history in due course !
torquayfan
20/9/2023
08:44
I do not envisage Scancell being an independent entity for much longer. Maybe next year?
phoenixs
20/9/2023
08:43
I am still concerned over long term safety of the mRNA covid vaccines. My daughter has not been the same since her last shot.
Thant’s not for discussion here though.
I would like to see a Scancell Covid vaccine, but it will have to wait for resources.

rogerbridge
20/9/2023
08:40
Take inovio ........ its DNA vaccine has consumed some £700m in development costs and trials ... each failure promoting further additions to try and make it work IL-12 for instance

but the end result ... Inovio Mcap is now smaller than scancell

all Hype i am afraid driven like punny7 does .. Marketing snake oil

BioNtech are doing the same adding more complexity to try and get it to work

they are not there yet

inanaco
20/9/2023
08:36
That’s positive then.
rogerbridge
20/9/2023
08:36
and so far MRNA has not produced significant efficacy in cancer
inanaco
20/9/2023
08:32
mRNA personalised vaccines have their uses and are in favour with regulators and government.

?

no different to us mate ......

Biontech did a deal with the government .... but its not a cash give away deal just easier access to trials with the NHS

but look how adaptable MHRA is being Iscib1 pretty much been nodded through hopefully

inanaco
20/9/2023
08:27
It’s going to be very interesting (and profitable) to see how the Scancell off the shelf vaccines and the more expensive personalised mRNA vaccines compare in the years ahead.
Currently, Scancell, score well on effectiveness, safety, cost and ease of use.

mRNA personalised vaccines have their uses and are in favour with regulators and government.

Could a scancell Covid vaccine enter the market in due course. Maybe in future years?

rogerbridge
20/9/2023
08:24
miavoce

Posts: 573

Price: 15.875

No Opinion

RE: Bristol Myers Squibb...Today 08:23
How would buying SCIB1 allow BMS to extend their YERVOY patent ?


SCIB1 would be approved to use with Yervoy


you would have to run another trial if you used a bio similar

and because Opdiva is not out of patent adds a further layer of complexity

inanaco
20/9/2023
07:11
i don't think folks have fully comprehended the significance and opportunity that this gives to the immunobody platform

Lindy is a diamond .....

inanaco
20/9/2023
07:02
just remember keytruda ... is linking arms with moderna to create the competitive advantage

but its short lived as i feel vaccines like scib1 will reduce market share considerably against personalised vaccine but a market will still exist .....

but can moditope break that market ? those that fail iscib1 ..... and could potentially be given a personal vaccine .... instead be given a moditope combo ?

fascinating to finally see what cutting edge vaccines can achieve

and surely Big Pharma must now look at the Covid vaccine

inanaco
20/9/2023
06:35
something Lindy said about patient numbers ............

because the efficacy is so high we don't need as many patients to prove up the data

that would also apply to the registrational trial

jt may be possible that Scancell could go it alone ...

however i suspect Bristol Myers to be very interested in bringing the treatment in house as they also have new products entering the market that would also have synergy

interesting times ......... but patient numbers go down on trial to achieve statistical evidence .... value increases

and we are talking big numbers ...

inanaco
20/9/2023
05:19
cancer is not a virus

however a virus can cause cancer

type virus into google you will find many isolated you cannot argue that point

punny7 ... go to Dr

inanaco
19/9/2023
22:06
That’s very strong data with excellent selling points, effective, low cost and off the
shelf.

There is more than one arrow in the SCLP quiver.

rogerbridge
19/9/2023
22:03
Inane, is Cancer a virus ? can you name a virus that has been purified and isolated. You really do need to do more Science homework. Maybe check out Dr Burzynski .
panama7
19/9/2023
21:42
9 out of these 11 pts have shown an objective response equating to an ORR of 82% with no increase in toxicity. This is better than the trial’s target and better than the 50% ORR reported in patients receiving current standard of care alone.

In addition, a 69%-94% reduction in tumour volume was seen for the 4 patients who reached the 25 weeks evaluation and an 87%-94% reduction for the 2 patients who reached the 37 weeks evaluation.

marcusl2
19/9/2023
21:30
Some of the highlights include:

9 out of these 11 pts have shown an objective response equating to an ORR of 82% with no increase in toxicity. This is better than the trial’s target and better than the 50% ORR reported in patients receiving current standard of care alone.

In addition, a 69%-94% reduction in tumour volume was seen for the 4 patients who reached the 25 weeks evaluation and an 87%-94% reduction for the 2 patients who reached the 37 weeks evaluation.

marcusl2
19/9/2023
18:43
Interest expressed by 3 biotechs for
ADC and CART applications

I did not realise this about unvalidated epitopes;

Personalised mRNA vaccines (e.g., Moderna, BioNTech) pose economic and technical challenges
► Not off the shelf, several weeks to prepare, need a biopsy, adding to cost to make and distribute
► Uses multiple unvalidated epitopes which limits efficacy

Why should we get excited about… 11 patients?
► Recruitment is strong because of high demand from investigators
► 9 responders allows us to declare non-futility i.e. we should proceed
► Literature shows that CPIs alone give a 50% ORR in the real-world setting and not the 82%
seen here
► An earlier study using SCIB1 monotherapy showed clinical activity
► Greater than 90% probability of replicating this data in the full cohort of 43 patients
► Potential $1.5bn market opportunity


iSCIB1+ second generation technology is the next best thing :
► No HLA screening, can access 100% of the addressable market
► AvidiMab® modification increases potency and gives 15 years extended patent protection
► Very little risk of iSCIB1+ not working as it the same as SCIB1 but with more epitopes expressed by melanoma
► A study amendment has been submitted to the MRHA to add a new cohort of iSCIB1+ patients to the SCOPE trial
► SCIB1 currently in Phase 2 in combination with ipilimumab and nivolumab, delivered with needle free device, and will
transit to iSCIB1+ in Q4 2023
► Phase 2/3 adapted registration trial being planned

marcusl2
19/9/2023
18:30
Scancell trial results back strong value prospects - broker

Published: 16:01 19 Sep 2023


Scancell Holdings PLC (AIM:SCLP, OTC:SCNLF)’s expectation-busting initial results from the phase II SCOPE trial in advanced melanoma backs Stifel’s view that the firm is looking at near-term value growth.

Discussing the vaccine trial results, which were released on Tuesday, Stifel analysts backed the AIM-listed biopharmaceutical company with a “buy” rating.

“These results continue to support our view that Scancell has a highly innovative approach to cancer vaccine development,” the investment bank said in a note.

“With a number of key potential catalysts across its platforms in the first half and beyond, we see significant potential for value creation in the near to mid-term.”

As recruitment for the second stage of the trial gets underway, Stifel dubbed the first batch of results “highly encouraging,” suggesting they could be the first of a number of catalysts to be expected this year.

“In addition to further data from the SCOPE trial, we expect data from the ongoing phase I ModiFY trial,” analysts noted.

“There is also the potential for further out-licensing opportunities from both the GlyMab and AvidiMab platforms in the future.”

Stifel offered up a 30p share price target for Scancell, which would see the stock more than double from Monday’s closing value.

The stock enjoyed a strong day on Tuesday meanwhile, jumping 21% to 15.9p on the back of the results.

marcusl2
Chat Pages: Latest  2535  2534  2533  2532  2531  2530  2529  2528  2527  2526  2525  2524  Older

Your Recent History

Delayed Upgrade Clock