Scancell Share Discussion Threads

[supernumerary] 16/2/2021 00:17

20 years? How did you do in GCSE maths?

[the real lozan] 16/2/2021 00:17

Uncle Albert -
"I’ve been invested 3 weeks, 100% up already: more to come."
.
Maybe you could find your way to giving inane'n'co a 'few lessons' ???

[albert arthur] 16/2/2021 00:06

Yes invested. I’m and investor not a trader. Times change, maybe you should review your investments; if you’ve tailed one since 2012 and and going against their own grain of new opportunities when trying something new! Look back and reflect at these comments and wonder why you’ve been on here circa 20 years. No time to argue on an ADVFN thread, my investments are algo driven and precise. This is one of them. Watch the space.

[supernumerary] 15/2/2021 23:56

'invested' - lol

BS - you understand what I mean? I've got nothing against the idea of partnering, nor that sclp lacks the resources to conduct a large Ph 3 - I agree with you about that. But I continue to think the diversion into covid vaccines is a mistake, they should have focused on cancer. They'll struggle to get a covid vaccine through approval and are wasting momentum on cancer.

PS what do you think of these people?

[albert arthur] 15/2/2021 23:36

I've been invested 3 weeks, 100% up already: more to come.

[supernumerary] 15/2/2021 23:33

Well I've been following the story since 2012, so you'll understand my patience is (probably) limited only by my lifespan :¬)

Feel free to defend your nonsensical post should you so wish...

[albert arthur] 15/2/2021 23:26

Let's see how the story unfolds...

[supernumerary] 15/2/2021 22:59

BS When someone votes against the grain there's always a good chance it's me :¬)

I thought the AA post was nonsense (hence my down tick for that too), and was disappointed that you thought otherwise.

AA - not short, not sold, not awaiting reentry.

[albert arthur] 15/2/2021 22:32

Seems to be someone disliking genuine posts. Probably open short, or sold waiting re-entry. Sure we will find one, eyes will be all over us.

[bermudashorts] 15/2/2021 22:26

Not sure who voted down my 36761 - seems a pretty innocuous comment. Like it or not, Scancell simply don't have the infrastructure or resources to run randomised phase III studies in tens of thousands of patients.

[torquayfan] 15/2/2021 21:48

Familiar ? - "Killer cells - Alongside antibodies, the immune system produces a battalion of T cells that can target viruses. Some of these, known as killer T cells (or CD8+ T cells), seek out and destroy cells that are infected with the virus. Others, called helper T cells (or CD4+ T cells) are important for various immune functions, including stimulating the production of antibodies and killer T cells. T cells do not prevent infection, because they kick into action only after a virus has infiltrated the body. But they are important for clearing an infection that has already started. In the case of COVID-19, killer T cells could mean the difference between a mild infection and a severe one that requires hospital treatment, says Annika Karlsson, an immunologist at the Karolinska Institute in Stockholm. “If they are able to kill the virus-infected cells before they spread from the upper respiratory tract, it will influence how sick you feel,” she says. They could also reduce transmission by restricting the amount of virus circulating in an infected person, meaning that the person sheds fewer virus particles into the community.

T cells could also be more resistant than antibodies to threats posed by emerging variants. Studies by Sette and his colleagues have shown that people who have been infected with SARS-CoV-2 typically generate T cells that target at least 15–20 different fragments of coronavirus proteins1. But which protein snippets are used as targets can vary widely from person to person, meaning that a population will generate a large variety of T cells that could snare a virus. “That makes it very hard for the virus to mutate to escape cell recognition,” says Sette, “unlike the situation for antibodies.”

So when laboratory tests showed that the 501Y.V2 variant identified in South Africa (also called B.1.351) is partially resistant to antibodies raised against previous coronavirus variants, researchers wondered whether T cells could be less vulnerable to its mutations."

Full script here (hopefully) - mentions of Karolinska

[bermudashorts] 15/2/2021 21:28

Albert Arthur

Good post, but I very much hope Scancell partner after phase I but before phase II/III.

[flc] 15/2/2021 20:46

Always gives me some comfort when Vulpes and Mr Diggle are involved.

[emptyend] 15/2/2021 20:44

To be fair, today's announcement should take precedence over weekend press comment:"...goal of starting a Phase 1 clinical trial, to determine safety and immune responses to the vaccine, as soon as possible during 2021. Subject to the result of the Phase 1 clinical trial future studies would be undertaken to establish efficacy."I suggest that the timeframes for all this work are highly dependent on the extent of government support/backing and/or a manufacturing partnership. It may well be a matter of weeks.....just as long as the pieces fall into place.....

[albert arthur] 15/2/2021 20:37

P.S I know this is not just a covid Vax stock

[albert arthur] 15/2/2021 20:37

This is how I see SCLP: The current vaccination process in the UK will not be a silver bullet, by the time the next segments are vaccinated, the under 50s will have been spreading the vaccine through mutation for 8 months; in parallel, the first vaccinated vulnerable people will potentially be wearing out the longevity of the vaccine (As per single dose), we don't know the second dose will do anything to some of the global mutations, and new mutations. Now, during this time, we should be moving into phase two trials for the universal N and S protein DNA vaccine. Moving into fall. If this is successful, phase 3 is cleared. There is potential, for SCLP on a intraday cap of 170m (5% float), to replace the vaccines and align forces. With AZN 97b cap. "If" this happens. This will be the one of the largest risers most of us have invested in.Above purely my thoughts and speculation. Not investment advice. All thoughts opinions welcome.

[banshee] 15/2/2021 20:24

The most pertinent quote at the w/e was on the one from LD on sky posted by emptyend, ie testing to start in a few weeks, close to the original Q1 timescale.

[emptyend] 15/2/2021 19:22

A total of about 7mn shares in those late-reported trades, including many chunky 200,000+ buys from early in the day.....

[golden number] 15/2/2021 18:15

943k corporate trade at 21p after close.

[gooosed] 15/2/2021 18:15

"Subject to the result of the Phase 1 clinical trial future studies would be undertaken to establish efficacy."



Covidity funding (Innovate) to date was to enable the UoN/Scancell/Notts Trent collaboration to initiate a Phase I trial. Covidity Phase I trial then has to be paid for - the assumption being Scancell matching funds would meet these costs. The quoted remark seems to suggest that IF safety is established in the Phase I - then funds are attainable & perhaps waiting for a Phase II.

[mcrudden] 15/2/2021 16:42

Agree.....they don't close borders and bring in strict quarantine rules 12 months after the horse is bolted, unless they are seriously worried about the variants.Like you say, the government will tell jo public soon enough

[emptyend] 15/2/2021 16:22

So.....volume closing in at 50mn for the day vs free float of 330mn or so.And that is just on hope.I suspect we will soon see that there is growing interest in "the right places". Watch carefully what the government does......I think they are looking to get new vaccines moving faster, before they are forced to admit that the South African variant is spreading. I've been watching Bloomberg TV quite a bit today. Next generation vaccines have been mentioned in at least three interviews today, most recently Cambridge's Prof Gupta (just now).........there is no smoke without fire!

[mcrudden] 15/2/2021 14:48

I'd say so yes easily, company was valued over 15p without the potential of the vaccine. That goes through all bets are off imo

[amrishbhim] 15/2/2021 14:28

Should reach 25p to 30p. Very possible and positive

[inanaco] 15/2/2021 13:41

i see Gazza going off on one about £8 again .. Ruckrover LSE


mind you some posts of his, i do like ...

example


Gazza - 27 Jul 2020 - 08:42:32 - 31085 of 36747 Using immunology to fight cancer. - SCLP
“even your orange juice post was incorrect gazza”

Yes it was, I admit I made a mistake there.