Immupharma Share Discussion Threads

[teddy boy1] 20/5/2018 10:13

FOR INFORMATION ONLY - Nobby is now posting on the Evgen Pharma site .He reckons that he has invested £20000 recently.


As he was one of the few people who were right about IMM ,should we be following his example?


I haven,t yet, but am keeping a close eye on things.

[nobbygnome] 20/5/2018 08:17

LOL

What I am obsessed about is running! Just off to do a 10k race where I aim to break 47mins for the first time. I would rather have the moderate pain of a marathon for 4 hours to the acute pain for 45 mins of a 10k especially when it is as warm as it is going to be today!

Have a nice Sunday y'all.

Nobby

[brad44] 19/5/2018 23:57

Add the short big fat small large bald Hairy fella and the last no mark to his list of "chirpy characters"Total fantasist

[turbotrader2] 19/5/2018 23:07

Who cares who nobby is?The results will do the talking ffs

[thebigshortfella] 19/5/2018 19:57

The Merlion - what are you on about?

Nobby was the only one who got it right with regards to IMM & their P3 results.

He was right & (pretty much) everyone else was wrong. Capiche?

[rnsday] 19/5/2018 16:39

Good work @the_ merlion for putting the gnome back in his place in the garden ....lol I have thought for a while nobby and dr biotech are the same crazy character 😂😂

[the_merlion] 19/5/2018 11:18

LOL may grab two, although I have a sneaky feeling old Nobby Mitty still views the posts, either from this Nobbygnome account or another. We should not believe everything he says, historically he has been found out several times.

We can always tell when he is lying - His lips move.

[coldspring] 19/5/2018 10:42

Nobby has you on filter merlion you lucky boy. Buy a lottery ticket!

[the_merlion] 19/5/2018 10:12

Keep a look out for our Nobby at the royal wedding, he should be one of the special invited PHD scientist at the reception or the parade according to him on Monday LOL.

[the_merlion] 19/5/2018 08:26

LMFAO - Are my posts hurting you Nobby now, maybe it is the truth within that you cannot stand.

You have been found wanting quite a few times on here, you have also been caught blatantly lying. You are in some type of Walter Mitty character, but the issue is I think you are actually now believing the persona, or like it to be reality LOL.

The truth at the end of the day, is you are a failed investor, having to spread bet these days as you have no real financial cash to place into an investment. To improve your social standing in your eyes, you have created various multi alias's and some extravagant back story's, that are making readers wince.

You are simply a giro punter, with a fantasy portfolio. The reality is hard to take for you, as you do enjoy the character you made and long to be. Away from the social media, real life must be very boring and inconsequential for you.

Just the cards that get thrown at you Nobby, best to be yourself and keep it low key.

LMFAO.

[nobbygnome] 19/5/2018 08:15

The_Merlion19 May '18 - 08:14 - 31331 of 31331 (Filtered)

Silence is bliss!

[the_merlion] 19/5/2018 08:14

Nobby, you have copied and pasted that post now 22 times LOL. Is it your favorite? You are fast becoming the clown of this board, at your age and apparent education (Walter Mitty), that must be hurting you.

Time for you to stand in the garden and let the sun run across your brow Nobby, Macdonald shift starts soon.

[nobbygnome] 19/5/2018 08:10

>> cud

LOL I was asked a question so it is only polite to reply.

Anyway science is my life 🙄.....

[dr biotech] 19/5/2018 08:00

It was 7% that went into remission. That 1:14. Also worth bearing in mind that none of the 100 or so patients in the trial arms of the P2 trial were reported to have gone into remission.

I’ve still not seen anyone answer the simple question of why the P2 results were much better than the P3. Other than just randomness. A month on from the results we haven’t seen any detailed analysis. Not sure it’s going to be released..



SCRUTABLE18 May '18 - 17:56 - 31323 of 31326
0 3 2
Despite the regulatory and commercial/financial barriers now raised to lupozor it remains that still one sufferer out of seven on the trial went into remission. How are similar victims of lupus going to get the drug in future?

Though not the majority, a large number of sufferers will now not get a drug which would change their lives.

[cudmore] 19/5/2018 07:58

Nobby

😂😂😂

Get a life mate

[nobbygnome] 19/5/2018 07:19

>> lerichman

I paste my post from September which explains the crux of my argument. The in vitro experiments showed you needed a higher concentration of drug to get an effect than can possibly be achieved in patients. And this is why knowing which cells you need to hit and where is so important because otherwise you are guessing about the dose. However, it is clear that not nearly enough drug is injected in patients to reach cells in the spleen, lymph nodes etc at a meaningful concentration. In the mice they showed spleen was the site of action but they injected over a 1000 times more on a volume basis plus it was given iv so you know all of it reaches the blood and can get to the spleen easily. In humans it is injected sub cu and only a small proportion will reach the blood. They have admitted that the concentration is so low in blood that they can't measure the drug level. The half-life of the peptide is a few hours so by the end of the first day after dosing there will effectively be nothing left in the body. So for the remaining 27days there is no drug present yet you are expecting efficacy when it didn't even reach the necessary cells in spleen etc in the first place. No wonder it has never got a single positive result on the primary endpoint in any study.

So overall the muddled thinking concerning the science and dosing was where it all went horribly wrong! The drug has some pharmacological activity but not at the concentration it reaches in humans in blood and the tissues. Hence Muller changing to say it works in skin where it is injected......but that is just not credible, contradicts her published data and exemplifies the muddled thinking!

If what I write is not clear, please point out what you don't understand and I will try to explain further. I am more than happy to do this! Now I have given up work I am going to be giving scientific talks to patient associations (for free!) and so need to know the layman's level of understanding!


'S_k and I met up for a discussion last night and as a result ahead of that meeting I did some further research. During that research I unearthed some pretty shocking revelations about Lupuzor which I will explain.

Two of the 3 papers this infomation is based on were referenced in Prof Muller's talk last year and the third is cross referenced from one of those. The full references are below for you all to read if you want.

So this concerns the concentration of the P140 peptide used in the in vitro experiments and the animal models. First of all let's work out the maximum possible concentration of Lupuzor in humans after the monthly dose of 200ug. For this calculation I have assumed that 100% of the drug reaches the blood which is actually very unlikely and that the meaningful body compartment is blood. Again that is being very generous because really the drug would have to get into the tissue so the volume of distribution would be higher. However, to make the calculation easy I will use the figure the drug is diluted into as the 5 litres of blood found in an average person.

So if you punch the figures into a molarity calculator which you can find on line, using a molecular weight of 2.8kDa, the maximum possible concentration of drug in humans is 15nMolar. I got my son who is doing a biochemistry PhD. to independently verify this figure.

Now if we go to the papers I wonder what concentrations all the experiments are performed at? Well the lowest concentration used is 5 uMolar, so over 300 times higher than the maximum possible concentration in the blood. Shocking!

So what about the animal experiments? Surely they use a proportional amount of drug taking into account the size of a mouse relative to a human. Mice are roughly 1/3000 of a human so a proportionate dose in mice would be 66ng. But no, the dose actually used in the mouse experiments was 100 ug per mouse so 1500 times more than a proportionate amount. Again truly shocking.

So what this means is that all the experimental data and animal model data generated with the P150 peptide has absolutely no relevance for what is going on in humans. Essentially you can't use any of that data to justify a mode of action in humans. The really astonishing aspect to me is how on earth did they decide that 200ug once a month is the right dose taking into account the experiments they had performed. Perhaps someone can help here but I find it truly amazing.

So the bottom line is that the company has a lot of explaining to do.....

I am sorry to be the bearer of bad tidings for the zealots here but again do not shoot the messenger; I am just reporting scientific facts, which anyone with a basic scientific knowledge could have extracted from the papers.

Nobby

Refs
1. Page et al (2011) Ann. Rheum. Dis.70:837-843
2. Marci et al (2015) Autophagy 11:472-486
3. Wang and Muller (2015) Frontiers in Immunlogy Volume 6, Article 252'

[lerichman] 18/5/2018 19:52

Nobby: You continually blaber on about how a higher dose will be reuired to achieve efficacy in Lupupzor. (I happen to believe efficacy has already been achieved with current dosing)
I have seen no data that would support this argument, and from what I can tell the only basis you have offered in support of your position is akin to the old adage of more is better. Do you acutally have any scientific evidence to support your assertions?

[brad44] 18/5/2018 19:33

Yes The_Merlion, have a good weekend! Will you be having a takeaway of the Chinese variety this weekend?

[scrutable] 18/5/2018 17:56

Despite the regulatory and commercial/financial barriers now raised to lupozor it remains that still one sufferer out of seven on the trial went into remission. How are similar victims of lupus going to get the drug in future?

Though not the majority, a large number of sufferers will now not get a drug which would change their lives.

Furthermore what is the evidence that a further number of trialists actually had palpable benefits , whilst not achieving a full cure? And just what proportion of those getting benlysta are getting that full remission?. Is it more than one in seven?

And what tests are recorded at different dosages? Perhaps some different range of dosages exist, which would increase efficacy

There is much more work to be done.

Surely Sylviaine Muller is not giving up? Tim owes it to shareholders to share his thoughts on the above, and how he is tackling the aftermath of his misleading confidence.

[the_merlion] 18/5/2018 17:04

Any how, have a great weekend folks. Always remember there are people like Nobby ''google it'' head working on the weekends. So the next time you pull up to the drive window at your local Macdonalds, spare a thought for our Nobby.

God bless people like him, without them, our shopping trips would be much less rewarding, plus we would be hungry PMSL.

[the_merlion] 18/5/2018 17:00

Took a few at the 28 and 28.50 level again. We should be very close to data RNS (IMO). While Nobby plays fantasy portfolio, I will show the old fool how it is done (again).

These spread bet folks are too funny though. No cash, so take a bet LOL.

[the_merlion] 18/5/2018 16:58

>> Nobbyhead

The only ire is you, with your constant childish trolling of this forum. For some reason you are fascinated by this share, perhaps that is because the other dog shares you have are either not performing or have a silent board. Yet I would actually guess you get some power element here. I can see in the outside world you may well be a timid fellow, a little friendless and most likely very boring. But here you get some attention, thus the constant need to post repetitive drivel whilst creating a false character at the same time.

Where are the fictitious emails between you and the company, where are the fictitious proof of your past employment and experience as you so declare several times a week here. Send us some proof Nobby, but until that time you will be known as the boards very own liar. If you have the time, you must seek help old chap, here is a good word to google at the weekend:

Pathological lying (also called pseudologia fantastica and mythomania)

We have seen past you Nobby, you are not what you say, but simply a google user LOL. Now get back to MacDonald drive through window station, I expect my big mac to be ready, and do not go easy on the fries LMFAO.