Immupharma Share Discussion Threads

[a_2_b] 17/5/2018 17:07

Surprised nobody is banging on about it being 28p and below yet lol. Tomorrow and the following week should be better times esp if that was aviva out of the picture today.

[a_2_b] 17/5/2018 15:14

It's good the day before it started there was a lecture by a UK doctor questioning the use of steroids in autoimmune disorders. Let us know if you notice p140 mentioned about at all anywhere else, it's interesting to have it brought up by people who have no connection to it. The only two speakers I was aware of were connected to the company or helped write the scientific papers.

[che7win] 17/5/2018 15:08

The P140 platform is getting an awful lot of exposure this week in Portugal!

[che7win] 17/5/2018 15:06

Another talk should be happening right now:

Abstract:
COGNITIVE DEFICITS IN A MURINE MODEL OF LUPUS AND EFFECTS OF THERAPEUTIC PEPTIDE P140
Background
Lupus is frequently accompanied by behavioral deficits of unknown etiology, which are severe complications of the illness with no specific treatment. The aim of this study was to characterize the neurobehavioral outcomes of MRL/lpr mice, which develop an accelerated form of lupus-like disease, and to evaluate the effects of P140, a therapeutic phosphopeptide developed in our laboratory, on these defects.

Method
Motricity, anxiety-like behavior and cognitive function (T-maze alternation; task known for its sensitivity to hippocampal damage) have been evaluated in 60 female MRL mice (30 MRL/lpr and 30 MRL+/+ -used as controls- treated or not with P140). The serum levels of several cytokines were measured by ELISA, and at sacrifice, brain and spleen were collected and used for flow cytometry evaluation to check cellular infiltration.

Results
Neither overt manifestations (dermatitis, alopecia) nor premature deaths were seen. Compared to 17-week-old MRL+/+ controls, MRL/lpr mice display splenomegaly and increased proteinuria (normalized by P140), reduced brain weight (indicative of brain atrophy), and cerebral infiltration of lymphoid cells and macrophages. They show diurnal hyperactivity but no sensorimotor deficit nor clear-cut anxiety-like signs. However, we found that they are significantly impaired in alternation behavior, likely reflecting a hippocampal failure. This defect was totally compensated by P140 administration.

Conclusion
Collectively, these data are in line with the view that hippocampal neurodegeneration, at least impaired hippocampal function, accompanies lupus disease. They also demonstrate that the peptide P140 exerts central effects with cognitive expression, and arouse hope for patients suffering from neurolupus for which there is nowadays no specific treatment.


Co-authors
H. Jeltsch-David 1, V. Pallage 2, N. Schall 1, S. Muller 1,3
1CNRS, UPR 3572- Institut de biologie moléculaire et cellulaire IBMC, Strasbourg, France
2CNRS, Institut des neurosciences cellulaires et intégratives INCI, Strasbourg, France
3Université de Strasbourg, University of Strasbourg Institute for Advanced Study USIAS, Strasbourg, France

[a_2_b] 17/5/2018 15:05

It's probably someone who was in towards the top bullied themselves out with the crowd and will be extremely bitter if it does well. I hope it does well, especially for anyone suffering from a autoimmune disorder steroid treatments are horrible.

[rnsday] 17/5/2018 14:30

Why would someone put a thumbs down to che s post really is some sad creatures here

[wigwammer] 17/5/2018 11:18

A tick down - but no explanation. Amusing. Btw be careful people about being party to exchanging accusations and personal details using the pm function. The expression tonne of bricks comes to mind.

[rnsday] 17/5/2018 11:05

Lol wigwammer it's ok it's only a dud so we are led to believe...🤔so will do no harm to them 😂

[youngharry2] 17/5/2018 11:04

I recommend that investors read Francis Galton's post 31188.

It provides what academics call explanatory heavy lifting, in this case it helps to explain the reason why IMM are not saying its game over, rather the reverse, they are saying:
- we are looking at the data,
- taking advice in advance of discussions with the FDA in respect of a regulatory pathway and in the light of the above
- considering the options

From all of this it is possible join up the dots and colour in as follows:
- the data for the positive ds DNA anti body patient group is attractive
- there is an unmet need for Lupus patients that is safe and affordable and furthermore the P140 platform has promising pre clinical data for other autoimmune indications
- on the basis of the ds DNA data we have seen it is reasonable to anticipate a helpful regulatory pathway and for pharma interest (as it would appear to be just a matter of kicking the ball over the line with a well designed and powered trial)
- the company has shown it can close a deal with pharma on good terms and failing that raise cash

[wigwammer] 17/5/2018 11:02

Another day, and the extension trial continues. Perhaps the naysayers believe the regulators would allow dead duck to be served to lupus sufferers each month.

[rnsday] 17/5/2018 10:56

Think you best re read that chart nobby 😂Below nobbys post this morning

I usually refrain from posting about the share price as I have no interest long or short. However, for information for those who don't have level two access, it is looking incredibly weak this morning. Essentially there is nothing below 27p....and not much above either.
😂😂😂😂8514;😂ԅ14;😂😂;😂

[bmcb5] 17/5/2018 10:49

hamila0116 May '18 - 18:31 - 31212 of 31231 0 8 0
...even the posts wanting Lupozor to get to market for the benefit of Lupus sufferers get voted down. There are some complete sickos floating about on this forum....
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a_2_b16 May '18 - 18:38 - 31213 of 31231 0 5 1
Yeah it's disgusting what a waste of life
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Brad4417 May '18 - 09:28 - 31228 of 31231 0 4 1
teddy boy nobby etc all the same person imho they should all be injected with Benlysta and then we would see how fekin safe it is...
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rnsday17 May '18 - 09:40 - 31230 of 31231 0 2 1
@brad44 let all the believers take this drug and the none benlysta would change a few opinions I guess ....if they are still around after 😂
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Ends.

[che7win] 17/5/2018 09:54

Morning,
looking forward to more detailed results.

[rnsday] 17/5/2018 09:40

@brad44 let all the believers take this drug and the none benlysta would change a few opinions I guess ....if they are still around after 😂

[rnsday] 17/5/2018 09:37

Ps what charts you been reading 😂looks like it may well be going north to me

[brad44] 17/5/2018 09:28

teddy boy nobby etc all the same person imho they should all be injected with Benlysta and then we would see how fekin safe it is...

[nobbygnome] 17/5/2018 09:01

I usually refrain from posting about the share price as I have no interest long or short. However, for information for those who don't have level two access, it is looking incredibly weak this morning. Essentially there is nothing below 27p....and not much above either.

Nobby

[brad44] 17/5/2018 08:59

good for you, so why are saying here we come..

[teddy boy1] 17/5/2018 08:36

22p here we come! I am pleased to be well out of this one

[brad44] 17/5/2018 06:02

Pit of misery for Alan or is it another nobby

dilly dilly

[alaneagle] 17/5/2018 02:33

Watch out you guys,Many others in this area including Hemo who have just signed a deal with a Rockerfeller for major research. Hemo has VG scientific base, which is not as dubious as Immu and not propelled by a convolouted Marketing Dept!