Evgen Pharma Share Discussion Threads

[moneymunch] 23/12/2020 13:26

Looking nice for Christmas and beyond....;-)))

[wanobi] 23/12/2020 13:15

ooh eerr, thanx guys, lookin much better here now :-) Cheers Wan :-)

[moneymunch] 23/12/2020 13:08

Takes all sorts Bumpa, even the sad little scrote troll type... ha ha ha .....in the meantime , news on the first 100 patients recruited and assessed in the Covid trial could be close, as well as disclosure of the solid tumour callaborator and multiple potential news on the rest of the pipeline.....a potential stellar year ahead for little old EVG and its shareholders with any luck...Gl ;-)

[bumpa33] 23/12/2020 12:33

mm - pointless 🤷‍a94;️

[moneymunch] 23/12/2020 12:10

Lol Bumpa, what a life the sad little blue so and so must live...Ho Ho Ho ;-)))

[bumpa33] 23/12/2020 12:04

Literally nothing available anywhere @ 11.

[bumpa33] 23/12/2020 11:51

The phantom red ticker of old London Town is busy I see...

[moneymunch] 23/12/2020 11:46

Sooner or later this is going to pop!!! ;-)

[moneymunch] 23/12/2020 09:56

and a 250k delayed trade from 9.23am which certainly looks like a buy. ;-)

[moneymunch] 23/12/2020 09:47

Wow...maybe the same buyer who had the 3 x 300k's on Monday???? hopefully someone in the know....Gl ;-)

[on target] 23/12/2020 09:44

And another :)

[moneymunch] 23/12/2020 09:41

A nice 335k buy just in....the smart money is accumulating by the looks of it....Gla ;-)

[moneymunch] 23/12/2020 08:45

More compelling research on the panacea potential of Sulforaphane. Gla ;-)

Research

Reductive stress in neuroblastoma cells aggregates protein and impairs neurogenesis

December 07, 2020

In the current study, the researchers used sulforaphane to establish RS in proliferating and differentiating Neuro 2a neuroblastoma cells grown in culture. Sulforaphane activates Nrf2/ARE signaling, leading to antioxidant augmentation. Specifically, they found that sulforaphane-mediated Nrf2 activation diminished reactive oxygen species in a dose-dependent manner leading to RS. The resulting RS abrogated oxidant signaling and impaired endoplasmic reticulum function, which promoted protein aggregation and proteotoxicity, and impaired neurogenesis. This included elevated Tau and α-synuclein and their co-localization with other protein aggregates in the cells.

Namakkal-Soorappan says they were also surprised to see that acute RS impaired neurogenesis, as measured by reduced neurite outgrowth and length, and that maintaining the cells in sustained RS conditions for five consecutive generations dramatically reduced differentiation and prevented the formation of axons.

This impairment of neurogenesis occurs through activation of the pathogenic GSK3β/Tau cascade to promote phosphorylation of Tau and create proteotoxicity.

Intriguingly, there have been reports of increased levels of enzymes that can promote RS, both in the brains of Alzheimer’s patients and in the post-mortem brains of Alzheimer’s and Parkinson’s patients. Also, attempts to promote neurogenesis in neurodegenerative diseases using small molecule antioxidants have had poor outcomes.

stress.3Rajasekaran Namakkal-Soorappan, Ph.D.“Therefore, clinical evidence warrants a closer investigation and further understanding of redox changes and their impact at the onset and progression of neurodegeneration,” Namakkal-Soorappan said.

[moneymunch] 22/12/2020 16:37

Perfectly poised for news....Gla ;-)

[mesquida] 22/12/2020 14:02

Yes, that comment by Huw was very interestng. To be frank i am surprised that he said what he did, but he is no fool and he must be fairly certain of the facts to say what he did.

[kingalf] 22/12/2020 13:43

mesquida - looking strong and nice to see some good momentum behind it. Any pull back should be limited to the 200 dma currently 10.21p. That non public preclinical news regarding tumors that the CEO eluded to the other week has got me interest.

[moneymunch] 22/12/2020 13:07

Sorry peanut, i'm only joking mate, but half hoping/expecting Piers to comment along those lines, if indeed SFX-01 was proven to be a therapuetic benefit for ARDS/pnuemonia Covid-19 and no doubt the share price would be sailing past £1 and more .....and potentially we could find out very soon, just as soon as the first 100 patients are recruited and assessed. Gl ;-)

ps the pick up in volume suggests that some sort of news from Evgen's multiple pipeline could be coming. ;-)

[mesquida] 22/12/2020 13:07

Well, kingalf, it does really now look like a decisive break above the 200 day moving average, do you agree ?

[peanut100] 22/12/2020 12:59

When was this MM?

[yus777] 22/12/2020 12:02

absolutely zilch to buy

[yus777] 22/12/2020 11:39

nt trade only hmm

[moneymunch] 22/12/2020 11:24

Piers Morgan on Good Morning Britain, interviewing a member of the public..."let's get this straight, your 90 year old Granny was on deaths door with ARDS/ pneumonia and Covid-19 and she was given a course of pills derived from Broccoli and she's now made a full recovery and planning to do the London Marathon...whatever next...well you heard it here first viewers...SFX-01...the wonder drug"....:-)))

[yus777] 22/12/2020 11:17

total of 400k plus bought at 11p load up gents

[moneymunch] 22/12/2020 11:01

Every chance of a commercial JV in the pipeline and every chance of a sudden and significant re-rate to reflect fair value on Evgen's undoubted transformational potential. Gla ...On and UP!!! ;-)