Clontarf Energy Share Discussion Threads

[1lilac] 28/6/2018 12:46

Chaps

Farn just moved 10%. delayed reaction.



Faron Pharmaceuticals Oy Clevegen successful toxicity studies
28/06/2018 7:01am
RNS Non-Regulatory

TIDMFARN

Faron Pharmaceuticals Oy

28 June 2018

Faron Pharmaceuticals Ltd

("Faron" or the "Company")

Clevegen shows good safety and potential to block Clever-1 on circulating monocytes

-- Wholly-owned Clevegen (FP-1305) shows no toxicity in dose escalation studies in large preclinical models

-- The no-observed-adverse-effect-level (NOAEL) was 100 mg/kg, which is roughly 30 times higher concentration than needed for Clever-1 occupancy in vivo

-- Clevegen also blocked Clever-1 on circulating monocytes as expected. The duration of blocking was dose dependent and resumed to normal level in 20 days in the highest dose

-- The Company expects CTA filing for MATINS study in Q3 2018 and first patient recruitment in Q4 2018

TURKU - FINLAND, 28 June 2018 - Faron Pharmaceuticals Ltd ("Faron") (AIM: FARN), the clinical stage biopharmaceutical company, today announces successful toxicity studies and control of blood Clever-1 positive monocytes, precursor cells to tumour associated macrophages (TAM) in large preclinical models.

The toxicity studies were designed to fulfil regulatory requirements for 3-week interval intravenous administration of Clevegen, typical for other anti-cancer antibodies currently in use. FP-1305 is a humanized IgG4 monoclonal antibody produced in CHO -cells by Faron collaborator Abzena. The FP-1305 drug product in its final formulation was administered as a single dose at 3, 30 and 100 mg/kg.

No toxicologically relevant changes were observed in any subject. No major changes were observed after treatment with FP-1305 in T lymphocytes subsets. The binding of Clevegen to its receptor on circulating CD14+ monocytes was confirmed by investigating the receptor occupancy, the recovery of which occurred between 3 to 20 days after dosing in a dose-dependent manner. No relevant changes were present in cytokines and no anti-drug antibodies (ADA) were detected in any subject. Therefore, the highest dose of 100 mg/kg was considered the no-observed-adverse-effect-level (NOAEL).

[nicky21] 28/6/2018 12:44

talks must have gone well this week hence the leak for buying this morning.

[nicky21] 28/6/2018 12:33

this could be the real deal..

NPP was the government which gave Clon the licences and now they are back in power.

[lippe] 28/6/2018 11:45

Pumped and dumped more times than Jordan ...

[hope67] 28/6/2018 11:15

Paf is up aswell

[nicky21] 28/6/2018 11:00

do not understand why peeops bailing out when wecould have transformal news any time.

[nicky21] 28/6/2018 10:50

Ghana talks progreesing well.or have progressed well
our main man is in Ghana this week.

Ghana is a billion plus barrel prospect.

also AGM tom so we may get some kind of update on state of play.

[dave4545] 28/6/2018 10:31

764,046 pays 0.278p sells for 0.218p

Holding for minutes taking substantial losses. Thousands are going to get wiped out
playing the game this way

[dave4545] 28/6/2018 10:25

LOL !

906,153 pays 0.26p sells for 0.215p
714,285 pays 0.28p sells for 0.2114

Fancy selling that low on the mm shake, at least wait for a mini rally and take a
much smaller loss.

2018 the year of the no clue Aim trader. I reckon £5-10 million a day goes from their
pockets to mm's in the city.

Thousands of stocks out there and it's happening everywhere

[letmepass] 28/6/2018 10:23

ROCK taking off

[dave4545] 28/6/2018 10:20

mm's making their usual killing

[dave4545] 28/6/2018 10:17

649565 made 0.03p or £200..risky game

[dave4545] 28/6/2018 10:16

Feel for those buying now about to get trapped in.

So many people wanting their millions in a week, chasing and impaling on spikes every day

[letmepass] 28/6/2018 10:13

Dave here. Always a good sign

[currypasty] 28/6/2018 10:13

What's going on here then.. A few chancers on a pump and dump,
Or something actually going on..
Long term holders will have seen many false dawns, but one day Clon will
Get something and surprise all.
Ghana is a hot favourite for progress, but if you read the finals here and
PET there is mention of other avenues..Couple that with the recent broker rns. Ask yourself why they would do that?
Fall from .4 was imo overdone, we all knew the state of play in the projects

[herb clark] 28/6/2018 10:12

Sell off starting!

[joosepi] 28/6/2018 10:12

Short position holders very disgruntled

[herb clark] 28/6/2018 10:12

What news?

[alia] 28/6/2018 10:11

wait till the news drops

[miahkaysor] 28/6/2018 10:09

Someone paid 0.2898!!!!

[miahkaysor] 28/6/2018 10:08

100% rise today???

[dave4545] 28/6/2018 10:06

Pump and dump.

Look at Prem yesterday, they chased it to 0.28p high, within the day it was back to 0.17-0.18p bid

Those in early doing the pump will escape but most will lose money to the mm's

[herb clark] 28/6/2018 10:05

What news or is it just a pump?

[alia] 28/6/2018 10:05

boom time , news coming