Avacta Share Discussion Threads

[viking24] 11/6/2024 08:09

Stifel exit.AGM next and business update, Diagnostic disposal, Therapeutic inc, US listing. US shareholders joining.

[amanitaangelicus] 10/6/2024 15:40

Blackhorse ...bit like a stuck cd.

[goforgold1] 10/6/2024 12:31

Big fall coming here char telling fast down to 30p to 35p very very fast total Scam .

[blackhorse23] 10/6/2024 10:00

Money moved to APH [alliance Pharma]

[amanitaangelicus] 06/6/2024 21:51

Playground still open i see.

[pareden] 04/6/2024 15:32

Christina Coughlin:

'We have three upcoming key milestones catalysts in the second half of 2024, and we remain on track for all three of these deliveries. The first is to initiate those expansion cohorts moving from phase one into disease specific expansion cohorts.

The second is to update the AVA6000 clinical data, including that every two week regimen arm.

And third, to release our pipeline update. We will be looking at the updated pipeline of the Avacta Therapeutics assets with both their stage and their timing to the clinic.'

[pareden] 04/6/2024 15:29

Avacta definitely sending a message that there is lots going on to look forwards to:

Christina Coughlin, talking through the story.

[exter] 04/6/2024 13:08

Are you 'stalking' again Pete ?

[pwhite73] 04/6/2024 12:47

I have no intention of pursuing this line of discussion any further. I have explained why other parts of the body in close proximity to the tooth including the tongue are affected by the local anaesthetic. If you know why they are affected then say so. If not then don't argue you with me and reflect on what I said about AVA6000 research papers being open to laboratory replication.

[rajraj b] 04/6/2024 12:14

PWhite- "but gets into the bloodstream that's why other parts in close proximity are also numbed like your lips and the side of your face." That is also wrong. If any anaesthetic gets into your bloodstream (either through direct injection or through a diffusive/absorption process) it would be carried away immediately and have zero effect locally. Leave it PWhite. You're not going to win this one.

[festario] 04/6/2024 11:58

VRS PWhite? You've cost people a lot of money over there with your bad advice.

[pwhite73] 04/6/2024 11:54

Once again you have misinterpreted me. I never said the local anaesthetic was injected into the bloodstream I said it was injected into the tooth but gets into the bloodstream that's why other parts in close proximity are also numbed like your lips and the side of your face.

Rajraj b - "If AVCT solely put out a load of papers explaining the biochemistry behind their tech nobody would believe them."

Now that's a very important statement, in fact extremely important. The purpose of research papers is that other medics that are sceptica can go away with the information and attempt to replicate it themselves under laboratory conditions or even with their own patients. That is what academic peer review is about and why the FDA insists on it before drug approval.

AVCT cannot subject AVA6000 to academic peer review. But they can give presentations and interviews until the cows come home.

[festario] 04/6/2024 11:51

You're oddly quiet on VRS? Care to admit defeat there?Cut your losses have you?

[rajraj b] 04/6/2024 10:37

You could always be a 'man' and admit you were wrong. Have more respect for you in that case.

[rajraj b] 04/6/2024 10:33

PWhite is frantically looking online to find proof that local anaesthetics are injected into the blood stream to prove his point.

[rajraj b] 04/6/2024 10:05

I think the best proof you can get is the biopsy results, the lack of dose limiting toxicities, the lack of a maximum tolerated dose and the fact that patients are seeing improvement in their condition from scans. If AVCT solely put out a load of papers explaining the biochemistry behind their tech nobody would believe them. Hence the trial. The proof is always in the pudding. BTW local anaesthetics are not injected into the blood stream. That's the quickest way to get them NOT to work locally or even systemically.

[rajraj b] 04/6/2024 09:57

If the anaesthetic gets injected into the blood stream ( according to you) how does the anaesthetic work locally. Wouldn't it just pumped everywhere in your body? Like I said use a better analogy. It's rubbish

[pwhite73] 04/6/2024 08:52

Rajraj b "You sure about this?"

100% sure. It's called a local anaesthetic but its not really local at all that's why you can't smile with one half of your face when the dentist gives you an injection into your gum before drilling into your tooth. The local anaesthetic spreads across the whole area.

Now a peptide that could localise the drug solely to the tooth nerve, we're talking big money here.

I've been investing in pharma stocks over many years and know what I'm talking about.

I do believe you are beginning to understand what's going on now. How does the peptide work. How it is able to keep AVA6000 inert until it comes into contact with FAP. The results are meaningless until AVCT says to the pharma industry - "here is the proof if you don't believe us try it for yourselves".

If the pharma industry endorses the functionality of the AVA6000 peptide bids of £100s of millions would come in for the peptide alone. Its applications would be limitless.

[pwhite73] 04/6/2024 06:52

05:15 - 05:19 "With that peptide attached to it, it can't get into cells." - Dr Christina Coughlin.

Yes Dr Coughlin but the question the pharmaceutical industry wants to know is how does the peptide work at the molecular structural level. If such a peptide existed it could be deployed on a whole host of other drugs.

Take dental surgery for instance. When the dental surgeon injects a local anaesthetic into your back tooth half your face goes numb. This is because the drug gets into the bloodstream and has the same affect across half your face as it does on the nerve in your back tooth. Now imagine if the numbing effect was localised purely to the nerve in the tooth. People could return to work immediately as opposed to having to wait until the effects of the drug wears off.

The June interview and webinar has given temporary relief to the falling share price but it won't last. It's not PI shareholders AVCT need to convince at this late stage its the pharmaceutical industry.

Come on Dr Coughlin publish the research paper and subject it to academic peer review. Powerpoint and Excel are not going to save the company as a stand alone unit.

[fieldhouse] 03/6/2024 18:11

It works !!

I guess owf will disagree with his expert knowledge!!