Astrazeneca Share Discussion Threads

[buywell3] 02/7/2023 07:42

March 28th 2023

Potential Prion Involvement in Long COVID-19 Neuropathology, Including Behavior


Current work suggests that there is a link between the pathophysiologic sequelae of SARS-CoV-2 infection and the pathogenesis of prion diseases. Specifically, SARS-CoV-2 contributes to the long-term pathological outcome of prion disease, i.e., neurodegeneration. Here, we propose a mechanism in which SARS-CoV-2 targets mitochondria and promotes their dysfunction.

Likewise, SARS-CoV-2-mediated overproduction of ROS can lead to the misfolding of prion proteins that can then propagate in this environment, thereby accelerating the development of long-term pathology (Zhou et al. 2022; Yardeni et al. 2019) (Fig. 1). We note that certain tissues may be more susceptible to this mechanism, which may mask the true origin of the disease.

In this regard, we hypothesize that illnesses that have been attributed to the syndrome known as long-term COVID-19 may actually originate, in part, from spontaneous prion production.

We note that while fully developed prion disorders are universally fatal, misfolded proteins that accumulate in response to SARS-CoV-2 infection can most likely be cleared after a brief delay.

By contrast, in the absence of another immunological challenge, the clearance mechanisms are severely overwhelmed in the setting of full-blown prion disease. Put simply, virus infection alters the process via which prions reproduce. Although SARS-CoV-2 has not yet been widely localized in the CNS, its’ damage has been associated with the infection (Douaud et al. 2022; Stein et al. 2022). This phenomenon warrants additional attention given the clinical similarities exhibited by long-term COVID-19 and prion diseases.

[buywell3] 02/7/2023 07:09

Dec 16th 2022

Creutzfeldt-Jakob disease after COVID-19: infection-induced prion protein misfolding? A case report

Creutzfeldt-Jakob disease (CJD) is a rare, fatal disease presenting with rapidly progressive neurological deficits caused by the accumulation of a misfolded form (PrPSc) of prion protein (PrPc). Coronavirus disease 2019 (COVID-19) is a primarily respiratory syndrome caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); many diverse neurological complications have been observed after COVID-19. We describe a young patient developing CJD two months after mild COVID-19. Presenting symptoms were visuospatial deficits and ataxia, evolving into a bedridden state with preserved consciousness and diffuse myoclonus. Diagnostic work-up was suggestive of CJD. The early age of onset and the short interval between respiratory and neurological symptoms might suggest a causal relationship: a COVID-19-related neuroinflammatory state may have induced the misfolding and subsequent aggregation of PrPSc.

The present case emphasizes the link between neuroinflammation and protein misfolding. Further studies are needed to establish the role of SARS-CoV-2 as an initiator of neurodegeneration.






Confusion, memory problems and loss of smell are all symptoms of Long Covid

Plaques in the brains of Covid-19 patients have recently been identified, such similar plaques have also been identified in the brains of people suffering from dementia

SARS-CoV-2, the virus that causes COVID-19, can produce short-term and long-term symptoms.
Researchers of a new study found that amyloids, the abnormal proteins that are also known to cause Alzheimer’s, could be formed during SARS-CoV-2 infection, which could explain some of the symptoms experienced.
The research suggests that the immune system’s interaction with SARS-CoV-2 may be leading to the production of these misfolded spike proteins, resulting in blood clots and neurological symptoms.

[smcni1968] 29/6/2023 22:52

They have been saying even quite recently that they expect results from the trial for datopotumab in lung cancer by the end of June, expected to be good for a 10% move either way depending on if good or bad... 30th tomorrow!

[buywell3] 29/6/2023 10:05

Since Covid-19 is a VERY transmissible disease as we all now have experienced

buywell posits that this thread title

Alzheimer's can be caught .... It's a transmissible disease

Is in fact now proven by the following



----------------- Long Covid = Long Term Problem ---------------------


The Cleveland Clinic in the US is a well renowned and respected institution

100 Years of Cleveland Clinic

Cleveland Clinic: A Centennial History

Cleveland Clinic was at the forefront of modern medicine when it was first organized as a multi-specialty group practice in 1921. From a small outpatient clinic, it has grown to become the world’s first integrated international health system. With more than 65,000 caregivers worldwide, Cleveland Clinic has almost 6 million patient visits per year, at more than 200 locations.


Regarding Oxygen Therapy the Cleveland Clinic state:

What is oxygen therapy?

Oxygen therapy helps people with lung diseases or breathing problems get the oxygen their bodies need to function.
This oxygen is supplemental (additional) to what you breathe in from the air.
You may also hear the term supplemental oxygen.


Who needs oxygen therapy?

You may need oxygen therapy if you have:

Asthma, bronchitis or emphysema.
Chronic obstructive pulmonary disease (COPD).
COVID-19.
Cystic fibrosis.
Heart failure.
Lung cancer or other cancers.
Pneumonia.
Pulmonary fibrosis.
Sleep apnea.


The Cleveland Clinic also state :

What are signs of low oxygen levels (hypoxia)?

You can’t always tell when your oxygen levels are low. When symptoms occur, you may experience:

Shortness of breath.
Bluish tint to skin, lips and nails.
Extreme fatigue.
Severe headaches.
Coughing or wheezing.
Fast pulse and heart rate.
Confusion.




buywell points out in recent posts the NHS state:

Home oxygen therapy can help with symptoms such as:

breathlessness
feeling tired all the time
memory problems
coughing



Note that ALL four in the NHS list above appear in the Cleveland Clinic list and ALL four are also symptoms of Long Covid

The US CDC goes further still stating:

Long Covid symptoms include

People with Long COVID may experience many symptoms.

People with Long COVID can have a wide range of symptoms that can last weeks, months, or even years after infection. Sometimes the symptoms can even go away and come back again. For some people, Long COVID can last weeks, months, or years after COVID-19 illness and can sometimes result in disability.

Long COVID may not affect everyone the same way. People with Long COVID may experience health problems from different types and combinations of symptoms happening over different lengths of time. Though most patients’ symptoms slowly improve with time, speaking with your healthcare provider about the symptoms you are experiencing after having COVID-19 could help determine if you might have Long COVID.

People who experience Long COVID most commonly report:

General symptoms (Not a Comprehensive List)

Tiredness or fatigue that interferes with daily life
Symptoms that get worse after physical or mental effort (also known as “post-exertional malaise”)
Fever
Respiratory and heart symptoms

Difficulty breathing or shortness of breath
Cough
Chest pain
Fast-beating or pounding heart (also known as heart palpitations)
Neurological symptoms

Difficulty thinking or concentrating (sometimes referred to as “brain fog”)
Headache
Sleep problems
Dizziness when you stand up (lightheadedness)
Pins-and-needles feelings
Change in smell or taste
Depression or anxiety
Digestive symptoms

Diarrhea
Stomach pain
Other symptoms

Joint or muscle pain
Rash
Changes in menstrual cycles


buywell concludes:

The WHO state that 36 Million people in the EU now suffer from Long Covid



The CDC state that around 20% of Americans acquiring Covid-19 develop Long Covid ie around 20 Million in the US.



IMO long term Home Oxygen Therapy will be a recognized treatment for Long Covid sufferers

When that happens the global market for oxygen concentrators will double --- and since new variants of Covid-19 continue --- so too does the number of long term sufferers with Long Covid.

This problem of Long Covid is NOT going away --- it is in fact getting worse

Increasing numbers of those that suffer this disease are now unable to work any more which also means long term unemployment issues are on the increase.

Worldwide -- Long Covid needs urgent government initiatives and solutions now

dyor


Addendum

Confusion, memory problems and loss of smell are all symptoms of Long Covid

Plaques in the brains of Covid-19 patients have recently been identified, such similar plaques have also been identified in the brains of people suffering from dementia

SARS-CoV-2, the virus that causes COVID-19, can produce short-term and long-term symptoms.
Researchers of a new study found that amyloids, the abnormal proteins that are also known to cause Alzheimer’s, could be formed during SARS-CoV-2 infection, which could explain some of the symptoms experienced.
The research suggests that the immune system’s interaction with SARS-CoV-2 may be leading to the production of these misfolded spike proteins, resulting in blood clots and neurological symptoms.

[buywell3] 29/6/2023 10:02

----------------- Long Covid = Long Term Problem ---------------------






The Cleveland Clinic in the US is a well renowned and respected institution

100 Years of Cleveland Clinic

Cleveland Clinic: A Centennial History

Cleveland Clinic was at the forefront of modern medicine when it was first organized as a multi-specialty group practice in 1921. From a small outpatient clinic, it has grown to become the world’s first integrated international health system. With more than 65,000 caregivers worldwide, Cleveland Clinic has almost 6 million patient visits per year, at more than 200 locations.


Regarding Oxygen Therapy the Cleveland Clinic state:

What is oxygen therapy?

Oxygen therapy helps people with lung diseases or breathing problems get the oxygen their bodies need to function.
This oxygen is supplemental (additional) to what you breathe in from the air.
You may also hear the term supplemental oxygen.


Who needs oxygen therapy?

You may need oxygen therapy if you have:

Asthma, bronchitis or emphysema.
Chronic obstructive pulmonary disease (COPD).
COVID-19.
Cystic fibrosis.
Heart failure.
Lung cancer or other cancers.
Pneumonia.
Pulmonary fibrosis.
Sleep apnea.


The Cleveland Clinic also state :

What are signs of low oxygen levels (hypoxia)?

You can’t always tell when your oxygen levels are low. When symptoms occur, you may experience:

Shortness of breath.
Bluish tint to skin, lips and nails.
Extreme fatigue.
Severe headaches.
Coughing or wheezing.
Fast pulse and heart rate.
Confusion.




buywell points out in recent posts the NHS state:

Home oxygen therapy can help with symptoms such as:

breathlessness
feeling tired all the time
memory problems
coughing



Note that ALL four in the NHS list above appear in the Cleveland Clinic list and ALL four are also symptoms of Long Covid

The US CDC goes further still stating:

Long Covid symptoms include

People with Long COVID may experience many symptoms.

People with Long COVID can have a wide range of symptoms that can last weeks, months, or even years after infection. Sometimes the symptoms can even go away and come back again. For some people, Long COVID can last weeks, months, or years after COVID-19 illness and can sometimes result in disability.

Long COVID may not affect everyone the same way. People with Long COVID may experience health problems from different types and combinations of symptoms happening over different lengths of time. Though most patients’ symptoms slowly improve with time, speaking with your healthcare provider about the symptoms you are experiencing after having COVID-19 could help determine if you might have Long COVID.

People who experience Long COVID most commonly report:

General symptoms (Not a Comprehensive List)

Tiredness or fatigue that interferes with daily life
Symptoms that get worse after physical or mental effort (also known as “post-exertional malaise”)
Fever
Respiratory and heart symptoms

Difficulty breathing or shortness of breath
Cough
Chest pain
Fast-beating or pounding heart (also known as heart palpitations)
Neurological symptoms

Difficulty thinking or concentrating (sometimes referred to as “brain fog”)
Headache
Sleep problems
Dizziness when you stand up (lightheadedness)
Pins-and-needles feelings
Change in smell or taste
Depression or anxiety
Digestive symptoms

Diarrhea
Stomach pain
Other symptoms

Joint or muscle pain
Rash
Changes in menstrual cycles


buywell concludes:

The WHO state that 36 Million people in the EU now suffer from Long Covid



The CDC state that around 20% of Americans acquiring Covid-19 develop Long Covid ie around 20 Million in the US.



IMO long term Home Oxygen Therapy will be a recognized treatment for Long Covid sufferers

When that happens the global market for oxygen concentrators will double --- and since new variants of Covid-19 continue --- so too does the number of long term sufferers with Long Covid.

This problem of Long Covid is NOT going away --- it is in fact getting worse

Increasing numbers of those that suffer this disease are now unable to work any more which also means long term unemployment issues are on the increase.

Worldwide -- Long Covid needs urgent government initiatives and solutions now

dyor




Addendum

Confusion, memory problems and loss of smell are all symptoms of Long Covid

Plaques in the brains of Covid-19 patients have recently been identified, such similar plaques have also been identified in the brains of people suffering from dementia

SARS-CoV-2, the virus that causes COVID-19, can produce short-term and long-term symptoms.
Researchers of a new study found that amyloids, the abnormal proteins that are also known to cause Alzheimer’s, could be formed during SARS-CoV-2 infection, which could explain some of the symptoms experienced.
The research suggests that the immune system’s interaction with SARS-CoV-2 may be leading to the production of these misfolded spike proteins, resulting in blood clots and neurological symptoms.

[dudishes] 28/6/2023 05:18

G'day,

Maybe moves off shore, Ireland, even China, a threat?

Long.

[blue59] 23/6/2023 11:36

I expect an apology in due course!

[riskonricky] 22/6/2023 18:47

Even artificial intelligence has more than you.ChatGBT:The text you shared contains several inaccuracies, and I'd be happy to clarify some of them for you. Firstly, the claim that COVID-19 vaccines are causing the largest blood clots ever seen is a misleading and unsupported statement. While some rare blood clotting events have been reported with certain COVID-19 vaccines, the likelihood of getting these complications is extremely low, and the benefits of getting vaccinated far outweigh the risks.Secondly, the idea that blood clots caused by COVID-19 vaccines are resistant to blood thinners is also incorrect. In most cases, standard treatments for blood clots, such as blood thinners, are effective in managing symptoms and preventing further complications.Thirdly, the assertion that the spike protein is inside the blood clots and forming amyloid structures is also unfounded. While the spike protein plays a role in the COVID-19 disease, it has not been shown to cause amyloid formation or to contribute to blood clotting in any way.Lastly, the claim that vaccinated individuals have increased rates of blood clots in the retinal arteries and veins compared to the unvaccinated is also baseless. The COVID-19 vaccines have undergone rigorous clinical trials and have been shown to be safe and effective in reducing the risk of severe illness and hospitalization due to COVID-19. In conclusion, it's crucial to rely on credible and trustworthy sources for accurate information about COVID-19 vaccines not some guy in a tinfoil hat with an O-level in science and too much time on their hands.

[descartes244238] 14/6/2023 20:26

Dead covid infected people have an eternity effect.

[paulruss1] 14/6/2023 08:13

Scarey findings. I know quite few friends who are suffering with blood clots since the covid Jab..Dr. McCullough @P_McCulloughMD: The COVID Vaccines Are Causing the ‘Largest Blood Clots We’ve Ever Seen’

“My experience with these blood clots are they’re enormously resistant to blood thinners,” disclosed Dr. Peter McCullough. “Wuhan spike protein is inside the blood clots, and it’s folding, forming what’s called amyloid structures.”

“They [researchers] found astronomical rates of blood clots in the retinal arteries and retinal veins in those vaccinated compared to the unvaccinated. And that was only with two shots back in 2021,” he detailed.

“Two years later ... the risk is there. So, what I’m telling you is these vaccines have a very long effect in the human body. And when we see blood clots in the arteries, small arteries, and veins of the eyes, they’re reflecting what’s going on in the body.”

[diku] 11/6/2023 15:30

Compare AZN chart with VOD chart since 2016...complete opposite...AZN in bull run while VOD in bear run....

[alphorn] 04/6/2023 10:04

AstraZeneca defies geopolitics to bet on China. AstraZeneca's chief executive returned from a recent trip to China exuberant about an “explosionR21; of biotech companies in the country. (FT)
A good move?

[philanderer] 09/5/2023 13:03

Berenberg raises AstraZeneca price target to 13,500 (12,400) pence - 'buy'

[hotfinance14] 09/5/2023 07:20

Huge news :

Farxiga extended in the US to reduce risk of cardiovascular death and hospitalisation for heart failure to a broader range of patients



FDA approval means patients with heart failure can benefit from Farxiga

regardless of left ventricular ejection fraction status

[1knocker] 28/4/2023 09:11

Nothing announced to justify the recent sudden spike in the share price Rather the reverse.

Once again the virtue of patience is demonstrated. Kicking myself that I allowed myself to be spooked into buying back too soon. Never mind, I did make a profit on the 24 hr round trip, albeit smaller than it should and would have been had I stuck with my initial buyback intentions. Just have to console myself with the adage 'small fish are sweet'. I hope others did better than I did out of the share price spike and retracement.

[philanderer] 28/4/2023 00:09

'Very unattractive' Britain leaves drugmaker AstraZeneca eyeing China as the next big growth region

[our haven] 27/4/2023 08:07

Opening positive after the results.I was unsure how they would be received after the lack of guidance due to a number of issues that they flagged up.Fingers crossed for the day.

[gregb] 27/4/2023 06:55

More like the FDA having a problem with LYNPARZA for prostate indication.

[smcni1968] 26/4/2023 23:50

Down today on some new policy from the EU

[philanderer] 26/4/2023 15:25

Q1 update tomorrow.

[mayers] 21/4/2023 14:48

It's looking as though you did right to get back in 1knocker. This despite the revised Coroner's judgement concerning the poor man who suffered the cerebrovascular event related to the vaccine.