Angle Share Discussion Threads

[muffster] 22/1/2024 23:23

Currently there are only two FDA-cleared medical devices for the enrichment of CTCs.These include the CellSearch® Circulating Tumor Cell (CTC) Test (Menarini-Silicon Biosys-tems, Huntingdon Valley, PA, USA): for the enumeration of CTCs of epithelial origin for themonitoring of prognostic information of patients with metastatic breast, colorectal, or prostate cancer,and the Parsortix® PC1 System (ANGLE plc, Guildford, UK): for the capture and harvestof CTCs from the blood of metastatic breast cancer (MBC) patients for subsequent, user-validatedanalysis. CellSearch® isolates and detects CTCs of epithelial origin via an immunoaffinity-based enrichment method

[radderssandy] 22/1/2024 23:21

Bone699, “Why don't you share the video with the time stamp of the incident.”

The “incident” you refer to happened at approximately 28:21 into a 30 minute presentation. It was done in good humour. If you watch the presentation, you will notice that Sarah Lowther requested the person who asked the last question to make it short due to time constraints.



PS You are filtered.

[bones699] 22/1/2024 23:14

It is unacceptable and clearly at odds with best medical practice to market a product claiming it can test all cancers with a caveat that its down to the clinically approved lab to either have accreditation or to seek accreditation to allow Parsortix to be used to test all cancers..Newland knows this won't wash with the FDA and few if any third party clinical labs are going to take that risk I can assure you!

The End!

[muffster] 22/1/2024 23:12

ANGLE's FDA cleared and patent protected circulating tumour cell (CTC) harvesting technology known as the Parsortix(R) PC1 System enables complete downstream analysis of the sample including whole cell imaging and proteomic analysis and full genomic and transcriptomic molecular analysis.

[radderssandy] 22/1/2024 23:09

Bones699, your statement “you simply can't use Parsortix to test any cancer other than breast cancers” is incorrect. As you well know, Parsortix has been widely used in multiple different cancer types.

AN gave this explanation in last April’s Investor Meet presentation.

“So our clearance is in metastatic breast cancer, and if we wish to sell the system with a clinical label on it to hospitals, we must limit what we talk about to metastatic breast cancer. However, there's a little bit of a nuance here, which is that the customer, if they are an accredited clinical lab, which in the United States, they pretty much all are, then they have the ability to validate their tests, their assays, in their own laboratory under their regulatory clearance. And it's perfectly acceptable for them to acquire our system and use it for prostate or lung or any other cancer that they feel they can verify and validate an appropriate test for in their lab. And so we’re actually seeing strong interest in multiple cancer types. So we can sell the system for research use in any cancer type, and if we want to make a claim in clinical we're limited to metastatic breast, but it does NOT stop our customer base implementing across multiple different cancers. And of course we've got the large number of peer reviewed publications in multiple cancers showing the value of it.”

[bones699] 22/1/2024 22:56

raddersSandy

It's not FDA approved which can take a very long time and even more so given the relatively recent Edison machine debacle with Thanotos.

Watched the Investor Meet video and it is evident that the Investor wasn't being allowed freely to ask the question regarding FDA approval as soon as he requested to ask a second question revolving around FDA approval she intervened to wrestle the mic from him..it was very rude and unprofessional and no there was plenty of time for his question...Why don't you share the video with the time stamp of the incident.

Newland goes on to say..

'It's up to the user to decide how they use it ['Parsortix']..Newland

'If they ['third party clinical lab'] want to use it for anything over than breast cancer they need to make sure they are happy with the results'..Newland

I was gob smacked I have never seem such a gung-ho CEO state this it was just like Thanotos a shudder went down my back..How on earth can you make that comment!!

You cannot sell a medical product to a third party pushing all the risks and associated costs of getting FDA approval onto the third party clinical lab..They want a safe, reliable, fully approved testing machine that can just be switched on and run!

[radderssandy] 22/1/2024 22:51

Bones699, to keep trying to compare Parsortix to Theranos is just desperate fudding, and you have deliberately ignored Miavoce’s posts - “This is literally the opposite situation to Theranos - surely you can see that ? The Parsortix machine has been proven by dozens of 3rd parties and KOL's.”

Your suggestion that the presenter (Sarah Lowther) “forcefully221; seized the mic out of the audience member’s hand because the question was FDA related is also ludicrous. Sarah Lowther was up against the clock and was clearly trying to fit in questions from as many members of the audience as possible. If you watch the presentation, you will note she signalled to the gentleman who asked the last question to make it short, and she then had to quickly wrap up the presentation.

[bones699] 22/1/2024 22:50

This is the issue Parsortix is not approved by the FDA the CEO confirmed that at the Investor Meet when questioned. In most cases of cancer it can only be used for research not testing thats the point.

[htrocka2] 22/1/2024 22:36

bones....There's no comparison with Theranos' 'Edison'.The FDA claimed that it was all built on a mountain of lies and false data.





AGL have stated that the machine for 'harvesting the circulating cancer cells' has been given FDA clearance. If this was rubbish and not true....the FDA would close them down in an instant not allowing them to profit from the FDA 'Coat-tails'...so there's no need fo you to do anything.

ps...The share share price slid badly today....There are intelligent people behind this company. Do you think, maybe, just maybe, this 'slip' may have been by design?.... prepping for another TR1 Application? thereby eliminating a few day-traders into the bargain.....Watch this space.

[bones699] 22/1/2024 22:07

The Edison Theranos machine comparison is a good comparison to Parsortix why is the CEO at the Investor Meet ramping a testing machine that is far away from being fully approved by the FDA and is reliant on third party machines..

You simply can't use Parsortix to test any cancer other than breast cancers so why when asked by an Investor he states you can use it if you have a 'handle on it to test for other cancers so long as you are an accredited lab'...Nonsense the correct answer is 'No you can't use Parsortix to test cancers other than for testing breast cancer'..

So why the waffle when answering the Investors very pertinent question!

And why did that women monitoring questions as soon as he asked about FDA approval try and forcefully seize the mick out of his hand...Anything you would like to add Newland?

[bones699] 22/1/2024 21:53

Yet the share price continues to dive why is that?...

Why does Newland allow these ramping RNS's to be released which contain nothing in terms of financials.

What's the rational did we learn anything new today...no we didn't..so what was the real purpose are we on the way for an imminent cash raise because the projected £6m revenues that he himself communicated to the market are at risk, more so, aren't going to happen, why because they were never likely to happen and the CEO is playing for time..

With remaining cash balance probably only £12m at best in December and a high monthly cash burn rate over £1.5m is he now in a hole..running out of both cash and time...

Audited year end financials can't be signed off unless there is a minimum 12 months cash flow to meet the 'Going Concern' requirements..is this the issue, AGL, is running out of cash faster than expected and an imminent cash raise is on the cards, hence all these bizarre rampy RNS's with little substance to them..to try and prop the share price up before the inevitable cash raise and subsequent and inevitable shareholder dilution.

It seems the market thinks the same judging by the share price reaction!..all the Day Traders have vanished and current investors appear anxious judging by the snide comments on this BB and with very good reasons I would say!

[zeus19] 22/1/2024 17:32

Well now he spends his time posting on here and on the LSE board under his alias Twogood2die, even on the weekends like a sad little child

[atmysignal] 22/1/2024 17:10

He's a disgruntled ex-employee.I have it on good authority. I am unable to say anymore.

[zeus19] 22/1/2024 17:09

Unfortunately it's a very sad story. A poster called bones698 was posting on the nano forum (dont blame him considering nano is a real basket case with minimal revenue and the only reason they're still around is because they sued Samsung) that there's no way they were going to receive £750m from a law suit which proved to be correct. Paulplanetearth didn't like what he was hearing as it made him look like a bigger muppet than he already was so he made a new alias called bones699 and now spends his days trolling the AGL board to make himself feel better

[miavoce] 22/1/2024 16:38

This is literally the opposite situation to Theranos - surely you can see that ? The Parsortix machine has been proven by dozens of 3rd parties and KOL's.

[muffster] 22/1/2024 16:35

Have you listened to Bones recently?You could be due thousands in lost potential gains.Click here to register your no win no fee claim

[kilijarslan] 22/1/2024 16:08

Have you been burnt by AGL in the past? The ceo? Holding average at 170p? Showing a big paper loss? Got dumped by your gf or wife left you?Want to understand why you spend your days negatively bashing this stock?

[bones699] 22/1/2024 15:58

Great how many small cap aim firms would jump at the chance of being bought out at many multiples of market cap..and that's your ..'dd'...trusting the words of the CEO given his track record to date....seriously deluded!

I could seriously contend that the Parsortix machine could fall into the realms of the Edison machine from Theranos the similarities are uncanny!

[kilijarslan] 22/1/2024 15:50

Bum squad trying incredibly hard here to get people selling/not buying.It's probably one of the easiest stocks to be in atm.This will either be valued at £200million plus or bought out closer to 100p soon enough. Ceo himself stated buyout by big pharma or much higher valuation.Ignore the noise and do your own dd.No cash is required as funded to Q2 2025!!

[astra1vision] 22/1/2024 15:36

Fools Gold. Only greed or stupidity would entice someone to invest in this scam which will likely go the way of 90% of AIM stocks. AN must be laughing.

[bones699] 22/1/2024 15:28

John

I have to agree if you re-read today's RNS and try jotting down the facts there is very little to go by but plenty of caveats in case things go awry!

There is also no financials to judge funny that same technique AN used at the recent investor meet no slides on expected financials just lots of guff with no substance to it!

[zeus19] 22/1/2024 15:21

Have a look at his other alias. PaulPlanetEarth on ADVFN and toogood2die on LSE. He actually copies posts from toogood2die and posts them on here acting like it's someone else CLOWN

[john henry] 22/1/2024 15:20

50 MA sits at the top of the gap, MAGNET TO THE share price