Alltracel Pharmaceuticals Share Discussion Threads

[wes1] 18/2/2008 22:29

Viking - anyone could do the PR - there's nothing to it, as they constantly demonstrate! Still, surprising there was no announcement about the patent given it's importance.

I think that I wrote about post-operative adhesions a year or so ago - this is from my notes -

Adhesions develop as the body attempts to repair itself. This normal response can occur after surgery, infection, trauma such as organs being handled and moved to one side during surgery, or radiation.

Repair cells within the body cannot tell the difference between one organ and another. If an organ undergoes repair and comes into contact with another part of itself, or another organ, scar tissue, fibrin, may form to connect the two surfaces. They may appear as thin sheets of tissue similar to plastic wrap or as thick fibrous bands.

They are a serious and frequent complication of abdominal and gynaecological surgery and have major implications both for the patient and the health service.

They occur in more than 90% of patients following major abdominal surgery and 55-100% of women undergoing pelvic surgery.

The anti-adhesion Nano-m•doc mesh would be biodegradable and could be impregnated with an anti-microbial to make sure there was no chance of an infection. It could even be impregnated with painkillers or perhaps medicines.

Colic is the no1 killer of horses, (partly because their intestine is 70ft long) it can be successfully treated by conventional means 95% of the time but the other 5% requires surgery and 8-20% of those will have adhesions. And vets don't come cheap – we're talking in the £thousands here.

The anti-adhesion market is worth well in excess of $1billion.

[4web] 18/2/2008 20:01

Wes great find!

[viking1066] 18/2/2008 19:20

Wes perhaps you should take up their public relations position as you put out far more than they ever seem to with regard to inforamtion that is important for any would be investor to evaluate. Now how is that spreadsheet on last years sales coming along? :-)

[wes1] 18/2/2008 18:53

Just found the patent for Nano-m•doc™ (published 24/01/2008) - It explains the advantages of the nano version of M.Doc over the current micro version.

1/ Haemostatic effects - an efficacy of more than five times the micronised form of the M.Doc when equal quantities of the products were used by weight. Such an advantageous result could also mean one fifth of the product could be used in nano form to retain the same efficacy. This nano form of the PAGA technology therefore has efficacy and cost benefits

2/ Wound healing benefits - The nanofibre form of PAGA stops bleeding faster than the native micron sized PAGA. As this haemostatic effect is the first stage of wound healing, the nanofibre PAGA format may also have a greater effect on wound healing.

3/ Anti-adhesion benefits - Currently in its native form PAGA can be used to help prevent adhesions in the body. Simply put nano versions of these barriers would perform better. Almost all of human tissues and organs are created in nanofibrous forms or structures for example bone, collagen, cartilage and skin. When the cells involved in the healing process are in contact with nanofibre sized structures they can attach and function normally to repair the damaged area with greater efficiency and less scarring. The nanofibre form of the PAGA technology therefore would have a greater efficacy than the native micro sized PAGA in reducing adhesions.

4/ Tissue engineering benefits - Utilising PAGA containing nanofϊbres for the creation of these scaffolds provides many advantages over the current scaffolds. The PAGA containing nanofibre scaffolds have a high surface-to-volume ratio which enhances cell adhesion. Cell migration, proliferation, and differentiated function are dependant on adhesion and should be enhanced on nano- fϊbrous scaffolds. These are also enhanced by the presence of PAGA and based on this, nanofibre scaffolds should serve as a better environment for cell attachment, proliferation and function than traditional current scaffolds.

[wes1] 18/2/2008 11:44

Czech nanotechnology designer Elmarco plans a listing on the Prague bourse within the coming years to fund further expansion, with entry on the bourse timed to coincide with the launch of production at Elmarco's new CZK 250 mln plant, construction on which begins this April, Czech media reported Wednesday.

"We want to enter the bourse as soon as production starts at our new plant, currently under construction," Elmarco CEO Ladislav Mares told daily Mlada fronta Dnes (MfD), adding that the new plant near company headquarters in Liberec, North Bohemia, should come online within three years.

The company said it plans to invest a total of CZK 750 mln into projects developed at its nanofiber R&D and production center in the Liberec North Business and Industrial Park, business daily Hospodarske noviny (HN) reported, with production sites of 2,500 square meters (sqm) and 2,000 sqm to be built in two phases.

"We will employ several hundred in the first phase [of the plant]," Mares told HN, adding that in the second phase, new equipment will be installed for use in producing nanofiber products used in filtration systems.

Last week, Elmarco announced it had teamed up with NYSE-listed Cummins Filtration, a U.S. filtration, exhaust and coolant producer for engine-powered systems, to jointly develop applications for motor vehicles.

In October, the Czech company got a cash injection with the entry of a Swiss-French association of investment funds (including Banexi Ventures, TAT Capital Partners and Alpha Associates), which acquired a minority stake in Elmarco for EUR 11 mln.

Founded in 2000, Elmarco is the first company to supply an industrial electro-spinning production line for nanofibers. Its NanospiderTM technology can produce a consistent web of nanofibers with diameters of 50-300 nanometers, or approximately 1,000 times smaller than a human hair.

Elmarco currently has annual revenues of CZK 500 mln and expects sales to reach CZK 890 mln in 2009.

[viking1066] 18/2/2008 08:56

Perhaps because they wanted to drive the price lower to buy us out and let the larger shareholders soak up the shares so that when it came time to dump us all we would go quietly. Or maybe not :-)

[james t kirk] 18/2/2008 07:12

Whay are we not seeing more revenue info regularly now then? I dont understand why they stopped puttings sales revenue into a quarterly update. In fact why did quarterly updates themselves dry up?

[4web] 18/2/2008 06:04

Jelly, we were first. Where do you think all others come from?

I wouldn't be surprised if there were more products with m-doc inside than you think.

[wes1] 17/2/2008 12:02

jelly - Savlon Advanced and Boots own brand are both selling and both have M.Doc as an ingredient.

But the share price (lack of) is down to management.

[wes1] 16/2/2008 17:38

m.doc dressings with nanofibres.(Wound treatment)

From: Medical Textiles | Date: 2/1/2008

Alltracell's m.doc wound dressing products incorporating nanofibre layers are expected to appear on the market before the middle of 2008.

Jana Ruzickova of Nanopeutics said that, while current m.doc products weigh approximately 35 g/[m.sup.2], the nanofibre versions will only need to be around 8-10 g/[m.sup.2] for the same efficacy.

In addition to allowing either greater efficacy or reduced materials usage, the new nanofibre versions are also able to incorporate different ...

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(Anyone subscribed? I'm not brave enough ...)

[wes1] 15/2/2008 12:01

I guess this site was automatically generated by a bot

[alimo] 15/2/2008 11:17

buywell2, I'm sure you are a nice guy, and I'm sure you have your agenda for making so many posts for MLS, but I for one would happily go to the MLS board to read up on them. I'm invested in AP. and happy to read and make relevant contributions (perhaps a bit long winded, some might say)about AP. here. I don't really want to read all about MLS here, unless you think there is a real reason for your recommendation, which can be summed up ONCE saying - take a look at MLS chaps and DYOR (just as I did once, a couple of weeks ago, for CRA, which I repeat DYOR).

Back to reality - the worth 75p mentioned above, is still less than £100m (very affordable to many of our competitors). This is still probably less than all that has been spent over all the years of development of the intellectual property up until now, and now having major prospects for large streams of future revenue.

[wes1] 15/2/2008 10:06

buywell2 - 15 Feb'08 - 07:58 - 1846 of 1847 (Filtered)


buywell2 - 15 Feb'08 - 08:13 - 1847 of 1847 (Filtered)

[puffin tickler] 15/2/2008 06:37

If you think the silence and length of time is unusual, take a look at Fayrewood and be comforted.

[alimo] 15/2/2008 00:57

The more of us who sell, are making it easier for the big yins to buy a bigger %age of the cake, and eventually have control to do whatever they like with AP. If that happens then we can only blame ourselves. I'm sure they are quite happily hoovering up all that we sell, in fact they need us to sell so that they can come to us with a fait accomplis(spelling not my forte and I haven't time to search the dictionary!). So my advice is hold on, at least until you get the outcome of the negotiations, and an update of the fundamentals.

I'm surprised that not one of the directors, or employees has broken ranks, to leak information to the media. Man, it's over three weeks now! Something odd is up for such a tiddler of a company to have such protracted negotiations. I mean, why does it take so long to agree their offer of 75p per share. (I'll be in S--- Street if a cash offer of this size comes in. Tell me quick, how do I avoid paying the CGT? Simple instructions only, please.)

Where are all the meetings taking place? How do they avoid the army of financial journalists?

[jellyman2] 14/2/2008 18:00

buy and that means WHAT to ap.?????????????????????????????????????????

[buywell2] 14/2/2008 08:47

Another RNS at MLS

14 February 2008 Medical Solutions plc (the "Company")

Proposed change of name to Source BioScience plc

Medical Solutions plc, a leading provider of expert, quality services and
products to the healthcare, pharma biotech and life sciences research sectors,
announces that it is proposing to change its name to Source BioScience plc.


The Board believes that the Company's existing name no longer reflects the
broad portfolio of activities of the group, nor the nature of its business, and
that Source BioScience plc is a more appropriate name for the Company.


The change of name is conditional on shareholder approval and the Company is
sending a notice to shareholders convening a general meeting for 10.00am on
Monday 10 March 2008 at the offices of the Company at 1 Orchard Place,
Nottingham Business Park, Nottingham NG8 6PX.

[viking1066] 14/2/2008 07:31

Yeah Jelly it's my new year resolution. Look on it positively. Alltracel's glass is half full (of sh) and not half empty :-) It's even a struggle to get news of any offer out. Probably in late stage discussions again.

[jellyman2] 13/2/2008 17:53

viking only six you must have NEW faith lol

[viking1066] 13/2/2008 07:46

Sorry Alimo at the rate these guys move it is likely to be another 6 years, to be sure to be sure :-)

[viking1066] 11/2/2008 19:28

Ah Jelly. Give them a little time. 3 weeks since the confirmation that someone is interested. If it wasn't for the leak then it would be six months before we knew that some one was interested. Or maybe they have been interested for six months and that is what caused them to drive the price down to these levels in the first place?