Synairgen Share Discussion Threads

[milliecusto] 22/7/2020 07:43

A balanced view, which obviously most of the board don't want to hear, phase 3 trails will need a larger group of people and with Covid levels low now, that may be a challenge to get the required numbers in a timely manner, however in keeping with the theme of this BB, £10 next week

[vikingwarrier] 22/7/2020 07:42

FQR seems to think this is a vaccine. Wrong!

[best1467] 22/7/2020 07:36

I have to agree as with most trials the lower the number the the greater risk of failure these results were better than I expected the only caveat I would add is the extreme levels of selective patient enrolment could make it time consuming for a larger patient number trial in the UK .
It was mentioned in the results they were finding numbers hard to come buy in the current at home trial But hopefully if the expected deal/ buyout occurs it’s irrelevant from an investor view.

[dave444] 22/7/2020 07:35

What a clown you are FQR and also one who can string a sentence together in English

[fqr714bhp] 22/7/2020 07:23

This is only PHASE II trials completed another 3 years to go. LOL! and that is if it get marketing approval!

Let me advice some people on here. " THERE ARE 6 STRAINS OF COVID-19 OUT THERE "

The remote chance of finding a cure for this virus is almost " ZERO "

[nobbygnome] 22/7/2020 07:21

>> milliecusto

What a disengenuos post. The results were statistically significant even though the number of participants were relatively low. That is the whole point of statistics to tell you if the result were significant. Those in the know were expecting only a strong trend towards efficacy because of the low numbers so the fact the results were statically significant was absolutely amazing! And just to add the regulators will well understand the significance of this data given the limitations of the trial......

[amaretto1] 22/7/2020 07:13

What's the next hurdle ?

[nobbygnome] 22/7/2020 07:07

>> Zen

The remdesivir situation was different. That is an already approved drug so all the safety issues are well known. Therefore, it is much easier to just add an extra indication to the existing label. SNG001 is a investigatory drug in phase II so there is no label to add to....

[daveboy1] 22/7/2020 06:59

Munchkin and Millie, Millie and Munchkin. Mullie and Minchkin - names to conjure with. Poor shorts desperate as the new day dawns.

[saint in exile] 22/7/2020 06:52

Its what America needs right now and very quickly.Could save thousands of lives

[ic0gcds00] 22/7/2020 05:10

Us will be taking this up surely after trumps latest statement

[yet another final] 22/7/2020 02:02

Right my attempts at numbers needed to treat (NNT) to prevent one patient going onto to a ventilator!Based on some assumptions cos we don't know the actual number going on to ventilators in the study (yet) but the study was carried out during the peak of the pandemic whereby 10 to 20 percent needed supportive ventilation, and that's excluding the patients that where deemed not suitable before getting worse (due to age and coexisting conditions)So if 20 percent needed venting in placebo arm and 4 % in treatment arm, then you need to treat 6 patients to prevent one patient needing a ventilator. If 10 percent need venting then u need to treat 12.5 patients..... Not many drugs can do that now!!!Can't apply this to the death rate (just yet) cos need to know a bit more info re the 6% in placebo and 0 rate in treatment group

[dudishes] 22/7/2020 01:47

boothy.

If Jenner can get phase III through, would expect vaccine combined with flu jab, but very much fingers crossed. Doubt obviously, but we do need a way out.

[yet another final] 22/7/2020 01:37

I despair...This pandemic has created too many pseudomedics/scientistsFirst they ahd no clue about the difference between antigen and antibody testingNow they have no clue about the difference between prevention (using the vaccine--if one is ever found to be good enough) and treatment of disease (once you are ill!!)I guess next week we will all be experts in the statistics of double blind studies, odds ratios and confidence intervals (btw a larger study will narrow the confidence intervals, making the benefits more dramatic).... I will introduce the NNT (numbers to treat) concept in my next lecture! I can only imagine what the conversations are like in the pub. Who cares about footy, let's talk study size and stuff! We should rejoice we have a treatment that can avert any further lockdown, and keep the economy growing. Additionally, on its own, SNG001 could potentially save the NHSThis will become part of the SOC (standard of care) for anyone presenting with suspected Covid (just like aspirin therapy for anyone presenting with a suspected heart attack)

[boothy2003] 22/7/2020 01:10

Even if a vaccine were to be available in autumn (doubtful), how long would it take to give to to the entire population..

[90005nelson] 22/7/2020 00:39

Bidding war hopefully

[milliecusto] 22/7/2020 00:24

Only actually trialed on 50 people of which 79% had a success, so 1 in 5 no difference, with a bigger trial those fluctuations can get better or worse, reminds me of the avct bb, ramping galore. No one is spending billions on a trial of 50 people with a 20% fail rate, before I get shouted down the other 50 people had a placebo.The consideration if a vaccine comes out in autumn, this becomes less beneficial.

[zen12] 22/7/2020 00:06

Remember FDA took only 2 days to EUS approve Remdesivir drug - results announced 29th April, FDA EUA granted 1st May...so it can be done in days!