Share Name Share Symbol Market Type Share ISIN Share Description
Silence Therapeutics Plc LSE:SLN London Ordinary Share GB00B9GTXM62 ORD 5P
  Price Change % Change Share Price Bid Price Offer Price High Price Low Price Open Price Shares Traded Last Trade
  16.00 5.26% 320.00 312.00 324.00 330.00 304.00 304.00 2,325,145 16:35:23
Industry Sector Turnover (m) Profit (m) EPS - Basic PE Ratio Market Cap (m)
Pharmaceuticals & Biotechnology 0.0 -20.5 -26.2 - 250

Silence Therapeutics Share Discussion Threads

Showing 50326 to 50350 of 51475 messages
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DateSubjectAuthorDiscuss
04/6/2018
11:26
Or if Ali sells on his stake, to whom?
callumross
04/6/2018
11:20
Perhaps the fall from 200p was due at least in part to some selling on a rumour of this event? And now we're getting some buying on the news?
1gw
04/6/2018
11:02
Wonder why the shares have jumped 9% on this announcement?
callumross
04/6/2018
10:49
Unlikely re an offer and more likely that they have rather lost their way in putting most effort onto legal cases with little else actually happening.
waterloo01
04/6/2018
09:46
Is this a prelude to an offer being made?
mirabeau
01/6/2018
18:01
In April the status of the trial was "not recruiting yet"
callumross
01/6/2018
18:01
Study completion date for AKI phase 3 is 3 years away though!
callumross
01/6/2018
17:38
In fact, this is what Silence said in the annual report about QPI-1002 / AKI: "Silence awaits news from Quark as to the next steps in development of QPI-1002 in AKI." So that sounds to me like they might well consider a release when they get or notice the news...
1gw
01/6/2018
17:35
Interesting. Might there be a Silence release on that then, if not a milestone payment? This is what they put out when Phase 2 concluded successfully. hTtp://www.silence-therapeutics.com/media/1691/rns-quark-aki-results-270717.pdf A further release couldn't hurt sentiment, which appears in need of a bit of a boost. Not quick are they these phase 3 studies? DGF started in December 2015 as far as I can see, and is due to conclude June (Primary completion) / December (study completion) next year. hTtps://clinicaltrials.gov/ct2/show/NCT02610296
1gw
01/6/2018
15:27
Just noticed that Quark have put QPI-1002 into phase 3 trials for AKI; https://clinicaltrials.gov/ct2/show/NCT03510897 It has been in phase 3 for a while for DGF
callumross
31/5/2018
14:39
And buying some more today at 142p. While clearly high risk as a biotech investment, I like Silence over the next 1-2 years for: - 2 programmes moving towards clinical development (late 2018 and 1H 2019) - things potentially coming to a head with Alnylam (High Court on, or around, 3rd Dec) - Positive sentiment elsewhere in the sector (cf ARWR) - Objective to secure further strategic collaboration / out-licensing in 2018 - Potential for Nasdaq listing - Concentrated shareholder base (RG,RK, Invesco)
1gw
24/5/2018
11:32
All gone very quiet over here, waiting for news on the patent battle I suppose. ARWR continues to fly (wish I had held on a bit longer) while ALNY has dropped back significantly from its recent high. Anyway, I've bought some more Silence today at 153p, hoping the shareprice can bounce from around this level.
1gw
21/4/2018
14:10
Hmmm. Allows Alny to focus a bit more on Silence then. AGM on Monday.
1gw
20/4/2018
17:00
htTps://www.businesswire.com/news/home/20180420005589/en/Dicerna-Pharmaceuticals-Announces-Settlement-Litigation-Alnylam
waterloo01
06/4/2018
04:43
Well that jolted the calm seas of the first quarter then! Court action not until December I believe, so unless there's unexpected good news in the meantime a drift down for a while?
ukeagle2aus
03/4/2018
09:38
The hope is that ALYN will at some point find it easier to buy them than fight in court, but little evidence of that to date, just years ahead of suit/counter suit and money to the lawyers and very little actual scientific progress.
waterloo01
09/3/2018
10:43
Topped up this morning after checking the valuations over the pond for SLN's peers and the sharp rises over there. Presenting next week, too, which may generate some interest. Any NASDAQ listing should get an increased valuation for SLN. Bet Ali wishes he had held onto ARWR for a bit longer though!
callumross
08/3/2018
11:43
No it wouldn't but I suspect many of the companies in this space would rather disagree.
waterloo01
08/3/2018
11:19
Are you discounting the fact that they might hold fundamental IP that underlies all of the RNAi companies (not just ALNYLAM/MDCO),which could be the best new drug modality since monoclonals? Does the market cap sufficiently reflect this potential?
rnainvestor
07/3/2018
11:31
On reflection, while Nasdaq listing might be interesting, it will be at least 6 months off (it takes that amount of time) and any move by ALNY isn't likely till they get results in summer or nearer the case if they were to settle. However the rest of the business really hasn't moved on at all (except for all the extra people). They seem not much further forward, despite the spend on R&D than they were all those many years ago when AUT027 was the big hope. Once again they are too scatter gun in approach IMO. Only had a tiny holding but have decided to cash it in. Will keep an eye though on any movements. best of luck to the many old names here.
waterloo01
06/3/2018
08:32
I missed the Nasdaq reference at first glance. Interesting. I get the impression this is a management team with more than half an eye focused on the share price and the potential to support the price with the carefully managed release of information.
1gw
06/3/2018
07:20
Better cash than expected (due to Arrowhead sales) and looking at Nasdaq listing. Case not expected till end 2018. Might ALNY make a move?
waterloo01
02/3/2018
12:46
Summer I think, so not imminent.
waterloo01
02/3/2018
12:23
Any idea on the timescales for these ALNY approvals Waterloo?
callumross
02/3/2018
11:37
Bought back very small position. Less on results but more bounce from any ALNY approvals due. Would be milestone for RNAI.
waterloo01
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