Sdi Share Discussion Threads

[buywell3] 18/11/2018 01:40

Readers of my posts here might think I'm nuts re my prion disease and ProReveal posts

Which brings me to the USA and human consumption of squirrel brains ... something I was going to post on ... but buried it for later use

So we have

Prion expert: ‘A link between consumption of squirrel brain and human prion disease is unjustifiably speculative’

October 22, 2018

In a follow-up to a report of a poster presented at IDWeek2018 concerning a relatively recent case of vCJD linked to the consumption of squirrel brains, an expert from National Prion Disease Pathology Surveillance Center at Case Western Reserve University School of Medicine said the link was “unjustifiably speculative”.


“This diagnosis was based on MRI results that reportedly appeared similar to those of patients with variant CJD (vCJD). However, all other clinical and demographic evidence (triphasic EEG pattern, patient age, disease duration, and, subsequently, prion protein codon 129 genotype) strongly suggested that this was a case of sporadic Creutzfeldt-Jakob disease (sCJD). Indeed, through national human prion disease surveillance, the patient was confirmed through autopsy as sCJD, not vCJD. The reporting of this case as probable vCJD — a disease linked to consumption of beef contaminated with bovine spongiform encephalopathy (BSE, also known as “mad cow disease”) — and suggesting that this case might be etiologically linked to squirrel consumption is inappropriate and may cause undue alarm.

“While prion diseases have been identified in several other types of mammals, they have never been identified in squirrels. Without additional experimental or epidemiological evidence, a link between consumption of squirrel brain and human prion disease is unjustifiably speculative.”

[buywell3] 17/11/2018 23:32

The NHS is Scotland and England need to wake up and smell the coffee

What the University Hospital Wales have achieved here is ....... BIG ........

By using ProReveal in just six months, that Hospital has been able to reduce residual proteins from 3µg to 400ng


This means in percentage terms the University Hospital Wales have reduced in-situ residual protein levels ie the protein residue 'left overs' on the cleaned/washed surgical instrument that is now ready to be used on the next patient

By a staggering 86.7%


This is because 1µg = 1000 ng


To say this again in another way

By utilizing ProReveal , Mark Campbell, Decontamination Service Manager to the University Hospital Wales has reduced the potential risk of passing prion disease (vJCD ) and others by the use of contaminated surgical instruments

By a factor of ....................... 87%


This information should be emailed and disseminated across the whole of the NHS in the united kingdom

IT IS A NO BRAINER

The new NHS Health Minister should be shown this













University Hospital Wales uses ProReveal in-situ protein detection test
2/11/2018

Synoptics Health, a part of the Scientific Digital Imaging Group of companies and a manufacturer of innovative digital imaging systems for healthcare applications, is delighted to announce that ProReveal, its sensitive test to detect proteins on surgical instruments, is now in use at the University Hospital of Wales (UHW).
ProReveal is being used at UHW for routine monitoring and process improvement of surgical instrument decontamination protocols to help prevent inadvertent exposure to prion infections associated with conditions such as vCJD (Creutzfeldt Jakob Disease).

The HSDU Department at UHW is using ProReveal in-situ fluorescence detection daily to precisely quantify how much protein remains on reprocessed surgical instruments and is the first in Wales to adopt the technology.

Additionally, ProReveal is being used as part of continuous process improvement research where staff are assessing a range of decontamination parameters such as manual pre-washing and ultrasonic cleaning, as well as different types of washer/disinfectors and detergents to develop the optimum process for removing residual protein on neurosurgical instruments.

Mark Campbell, Decontamination Service Manager at UHW said: “The HTM 01-01 is quite clear that instruments used in neurosurgery should be tested for proteins using in-situ methods rather than swabs because potentially they aren’t sensitive enough to detect low levels of proteins or indeed prion proteins. We have been trialling ProReveal since 2016 and decided that as this is currently the only in-situ test, we purchased a system in 2017 to ensure compliance to the updated WHTM and bring further safety factors for managing high risk sets.”

Mark added: “We now use ProReveal for routine testing and as a research improvement tool to help us reduce the amount of residual protein on neurosurgical instruments. By reviewing and making changes to our decontamination process, in just six months, we have been able to reduce our residual proteins from 3µg to 400ng and have set our ProReveal to detect nanogram rather than microgram levels as we were getting results of 0µg. The ProReveal is now key to assuring us that we have done everything practically possible to reduce patients’ risk of exposure to prion related diseases.”

Guy Fiddian, of Synoptics Health’s commented: “We’re pleased that the largest hospital in Wales is also the first to be routinely using ProReveal for in-situ detection of proteins on reprocessed surgical instruments. Their rigorous approach to continuous quality improvement has shown some very impressive results in reducing residual proteins on neurosurgical instruments and demonstrates that minimizing patients’ exposure to prions is viewed very seriously by this hospital.”

[cfro] 05/11/2018 10:04

Movement in the share price this morning. Not surprised to see the firmness here given the fundamentals.

[cfro] 30/10/2018 14:06

Fantastic rivaldo, many thanks for posting that.

I like their confidence which is very reassuring in todays highly volatile and challenging markets. It is also very encouraging to see that 'if' we see any sort of downturn in the economy here in the UK then the group will not be too effected.

Finally it is interesting that they are currently looking at another four possible acquisitions.

[michaelmouse] 30/10/2018 12:47

Very interesting rivaldo. Thanks for taking the time to post.

[hastings] 30/10/2018 10:35

Also had the pleasure to attend last night and absolutely concur with rivaldo's excellent summary.

[rhomboid] 30/10/2018 10:33

Thanks Rivaldo - that’s a really helpful summary

[rivaldo] 30/10/2018 10:30

Mike Creedon presented at Blackthorn Focus last night. I hadn't seen him present before, and I came away impressed. He has a direct style which may not appeal to older City types who prefer smooth rather than rough edges, but it certainly does appeal to me.

A few quick notes I made:

- SDI are throwing off cash at £150k-£200k per month, plus they have the £5m HSBC facility, so lots of room for more acquisitions
- SDI have 30% recurring revenues from service and consumables
- Synbiosis should see growth from new antibiotics and vaccines
- prospects for ProReveal were heavily downplayed at first, noting that the NHS had no money, but then at the end he noted that they were seeing "good interest" and were looking for growth in the USA (where no FDA approval is needed) and China
- Astles has 50% recurring revenues
- 21% of Sentek's sales go to Siemens, and they're seeing such growth in overall demand that they're increasing their production facilities. Sentek and Atik are growing 20% year on year

SDI have a potential list of 17 acquisitions, with 4 on the go at the moment.

MC was also notably confident about prospects, stating that growth was continuing nicely and that with only 20% of sales being UK-focused a downturn here wouldn't be a problem.

[soundbuy] 26/10/2018 10:24

Back to where I sold out of a while back after buying in the mid 20's......only to watch it race away......with the Co. in far better shape........and no quote.......zzzzzzzz

[xajorkith] 20/10/2018 19:00

Have been adding here recently on general market weakness.

First appeared on my screens last year but dilution concerned me & the share price always seemed to get away when I considered buying.

Late to the party then, but still believe there’s a long way to go, with strong margins, excellent ROC / FCF & consistently upgraded eps forecasts.

All the hallmarks of a long term growth stock.

[rivaldo] 18/10/2018 13:39

Good news re ProReveal...great to see it being used for routine testing:



"Wednesday 17th October, 2018
UHW uses ProReveal in-situ protein detection test

Cambridge, UK: Synoptics Health, a manufacturer of innovative digital imaging systems for healthcare applications is delighted to announce that ProReveal, its sensitive test to detect proteins on surgical instruments is now in use at the University Hospital of Wales (UHW). ProReveal is being used at UHW for routine monitoring and process improvement of surgical instrument decontamination protocols to help prevent inadvertent exposure to prion infections associated with conditions such as vCJD (Creutzfeldt Jakob Disease).

The HSDU Department at UHW is using ProReveal in-situ fluorescence detection daily to precisely quantify how much protein remains on reprocessed surgical instruments and is the first in Wales to adopt the technology. Additionally, ProReveal is being used as part of continuous process improvement research where staff are assessing a range of decontamination parameters such as manual pre-washing and ultrasonic cleaning, as well as different types of washer/disinfectors and detergents to develop the optimum process for removing residual protein on neurosurgical instruments.

Mark Campbell, Decontamination Service Manager at UHW said: “The HTM 01-01 is quite clear that instruments used in neurosurgery should be tested for proteins using in-situ methods rather than swabs because potentially they aren’t sensitive enough to detect low levels of proteins or indeed prion proteins. We have been trialling ProReveal since 2016 and decided that as this is currently the only in-situ test, we purchased a system in 2017 to ensure compliance to the updated WHTM and bring further safety factors for managing high risk sets.”

Mark added: “We now use ProReveal for routine testing and as a research improvement tool to help us reduce the amount of residual protein on neurosurgical instruments. By reviewing and making changes to our decontamination process, in just six months, we have been able to reduce our residual proteins from 3µg to 400ng and have set our ProReveal to detect nanogram rather than microgram levels as we were getting results of 0µg. The ProReveal is now key to assuring us that we have done everything practically possible to reduce patients’ risk of exposure to prion related diseases.”

Guy Fiddian, of Synoptics Health’s commented: “We’re pleased that the largest hospital in Wales is also the first to be routinely using ProReveal for in-situ detection of proteins on reprocessed surgical instruments. Their rigorous approach to continuous quality improvement has shown some very impressive results in reducing residual proteins on neurosurgical instruments and demonstrates that minimizing patients’ exposure to prions is viewed very seriously by this hospital.”

[edscoville] 11/10/2018 15:02

Also topped up with another 90K shares today - for the long term. A solid, well run company.

[johnv] 11/10/2018 14:34

Topped up today, hopefully no more drops

[rivaldo] 11/10/2018 09:14

Bargain time imo. Just £80k of trades have caused a 10% fall - some are getting ripped off by the MMs.

The CFO and two other NEDs have now purchased shares within the last 2 weeks at 41p and above. This would seem to me to be a far more important signal than today's fall :o))

[cfro] 09/10/2018 17:36

V good news to see the Non-exec buy today. Good ol' Isabel Napper certainly not napping! :0))

[pireric] 09/10/2018 15:56

NED bought around 35k shares at a shade over 42p, around £15k. Not bad :0).

[nw99] 08/10/2018 07:19

SDI strong bolt on eps from the dealStrong rate of recruited radiologist all looks good.

[cfro] 03/10/2018 13:57

Thanks for that interview Rivaldo.

[rivaldo] 03/10/2018 12:37

An interview with Ken Ford re the new acquisition not posted before:



Extract:

"SDI chairman Ken Ford told Business Weekly the deal set up a great fit for global growth.

He told me: “From our point of view it's a global exporting company with a niche product.

“We believe we can increase sales and reduce costs of manufacture and opening up new territories thanks to our global distribution networks through this acquisition.”

SDI is revelling in its own niche sector, focusing on the design and manufacture of scientific products for use in applications including life science, healthcare, astronomy, consumer manufacturing and art conservation.

Ford revealed to Business Weekly earlier this year that SDI was hungry for more synergistic acquisitions with potential for growth.

He said: “The Fistreem deal is a small but important step in our group acquisition strategy. Fistreem is another business that fits into the group and its brands.

“The acquisition is in line with our previously announced acquisition strategy and is expected to be earnings enhancing in its first full year of ownership.”

[noble3r] 02/10/2018 12:19

some chunky trades going through (some delayed). Activity and volume showing as increased. More exposure to come from presentation end of October.

[puffet] 27/9/2018 12:06

All sells today yet the price remains steady looks like there may be some large orders to fill out there.

[michaelmouse] 27/9/2018 07:34

Yes thanks I agree rivaldo after reading it again. I probably didn't emphasise the forward projections as much as I should have. Great little company and I'll be holding short, medium and long term.

[rivaldo] 26/9/2018 23:09

Good spot hastings - glad I didn't read about the stool samples until after dinner....

Michaelmouse, nice write-up, though perhaps better to concentrate on (1) current year forecasts rather than prior year P/E's given both organic and acquisition-led growth, and (2) on how conservative future analyst forecasts are in terms of growth assumptions etc.

[michaelmouse] 26/9/2018 18:25

Just my two penn'orth:-



Thanks for posting your feedback from the AGM Hastings.