Scancell Share Discussion Threads

[geckotheglorious] 28/12/2021 11:16

In better news,

"”South Africa jubilant as Omicron wave subsides rapidly with minimal Covid hospital admissions and Delta killed off: ‘Expect the same in other countries’"

[geckotheglorious] 28/12/2021 11:15

Plenty of examples of Ivermectins efficacy.

Here's another

”Dying COVID-19 patient recovers after Court orders hospital to administer Ivermectin”

An elderly COVID-19 patient has recovered after a court order allowed him to be treated with ivermectin, despite objections from the hospital in which he was staying, according to the family’s attorney

After an Illinois hospital insisted on administering expensive remdesivir to the patient and the treatment failed, his life was saved after a court ordered that an outside medical doctor be allowed to use the inexpensive ivermectin to treat him, over the hospital’s strenuous objections.

[geckotheglorious] 28/12/2021 11:14

Gazza,

Also, wonder why Covid cases,hospitalisations and deaths are so so so low in Japan.

"Ivermectin in Japan"

Antivirals in Japan
Ivermectin allowed as a treatment on August 13

Doctors can prescribe without restrictions
People can buy it legally from India

Dr. Haruo Ozaki, Chairman of the Tokyo Medical Association

[geckotheglorious] 28/12/2021 11:13

Fun fact re Ivermectin.

-"Fun fact: Between 100-200 United States Congress Members (plus many of their staffers & family members) with COVID.. were treated by a colleague over the past 15 months with ivermectin & the I-MASK+ protocol at hxxp://flccc.net. None have gone to hospital. Just sayin' "

[geckotheglorious] 28/12/2021 11:12

Gazza,


Re Ivermectin.


”New Pfizer drug and Ivermectin – Dr John Campbell” 22mins

New Pfizer antiviral and ivermectin, a pharmacodynamic analysis
“Modality of action exactly the same!”

New Pfizer antiviral, PF-07321332, C₂₃HS23;₂F₃N₅O₄
PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
(“3CL protease” breaks down the proteins” and inhibits viral replication)

PFIZER’S NOVEL COVID-19 ORAL ANTIVIRAL TREATMENT CANDIDATE REDUCED RISK OF HOSPITALIZATION OR DEATH BY 89% IN INTERIM ANALYSIS OF PHASE 2/3 EPIC-HR STUDY
hxxps://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate

So, what is a protease?
So what is a protease inhibitor?

And, what is 3CL?
Chymotrypsin-like protease (3CL main protease, or 3CL Mpro)


Identification of SARS-CoV‑2 3CL Protease Inhibitors by a Quantitative High-Throughput Screening (3rd September 2020)
hxxps://pubs.acs.org/doi/abs/10.1021/acsptsci.0c00108#

The activity of the anti-SARS-CoV-2 viral infection was confirmed in 7 of 23 compounds



Microscopic interactions between ivermectin and key human and viral proteins involved in SARS-CoV-2 infection
hxxps://pubs.rsc.org/en/content/articlehtml/2021/cp/d1cp02967c

the strength and persistency of the interaction between IVE and the binding site of 3CLpro indicate that a partial inhibition of the catalytic activity could have place as the drug interacts with the main subdomains that define the enzyme binding pocket:
(ie Ivermectin blocks protease)


Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents


as shown in Fig. 4, out of 13 OTDs only ivermectin completely blocked ( more than 80%) the 3CLpro activity at 50 µM concentration.

Development, validation, and approval of COVID-19 specific drugs takes years. Therefore, the idea of drug repositioning, also known as repurposing, is an important strategy to control the sudden outbreak of life-threatening infectious agents that spread rapidly.


Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
hxxps://pubs.rsc.org/en/content/articlehtml/2020/ra/d0ra06379g


From the docking analysis, ivermectin showed the highest docking score with an average energy of −8.5 kcal mol−1 among all the compounds. Remdesivir showed the lowest binding energy and highest docking score of −9.9 kcal mol−1
hxxps://bnf.nice.org.uk/medicinal-forms/remdesivir.html

Ritonavir, C37H48N6O5S2 - £340/vial (UK hospital only)
Ivermectin, C48H74O14 (WHO – 6 cents a dose)

Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach (in silico – computer modelling)
hxxps://bnf.nice.org.uk/medicinal-forms/remdesivir.html

We have documented an intense binding of both ivermectin B1a and B1b isomer to the main protease with subsequent energy (ETot-) values of -384.56 and -408.6.

PF-07321332 is designed to block the activity of the SARS-CoV-2-3CL protease,
hxxps://www.pfizer.com/news/press-release/press-release-detail/pfizers-novel-covid-19-oral-antiviral-treatment-candidate


Risk of virus developing resistance to PF-07321332


Molecular Docking Reveals Ivermectin and Remdesivir as Potential Repurposed Drugs Against SARS-CoV-2
hxxps://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full


With SARS-CoV-2 S Spike protein
Ivermectin showed high binding affinity to the viral S protein as well as the human cell surface receptors ACE-2 and TMPRSS2.

In agreement to our findings, ivermectin was found to be docked between the viral spike and the ACE2 receptor

Binding Interactions of Selected Drugs With Human TMPRSS2 Protein (ACE2 protein)

The docking results revealed that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −174.971) and protein–ligand interactions

Binding Interactions of Selected Drugs With Human ACE-2 Protein that ivermectin showed the highest binding affinity to the active site of the protein (MolDock score −159.754) and protein–ligand interactions

With SARS-CoV-2 S Glycoprotein
Ivermectin showed the highest binding affinity to the predicted active site of the protein

With SARS-CoV-2 Nsp14 Protein
ivermectin showed the highest binding affinity (MolDock score −212.265) and protein–ligand interactions

Binding Interactions of Selected Drugs With SARS-CoV-2 PLpro
Ivermectin showed the highest binding affinity to the predicted active site of the protein (MolDock score −180.765) and protein–ligand interactions

A brief message to world leaders

[gazza] 28/12/2021 10:12

P7, Invermectin? Can you point me to a single clinical trial where invermectin has been proven effective against COVID-19?

[wigwammer] 28/12/2021 09:40

Dexamethasone too. An off patent drug earning no profit for anyone, widely recommended by freedom sucking, profit lusting, corporate controlled governments everywhere.

[supernumerary] 28/12/2021 09:19

sc - I've been told homeopathy works wonders too!

[wanderer1210_0] 28/12/2021 06:18

https://principia-scientific.com/ivermectin-has-new-application-fighting-cancer-cell-growth/

[panama7] 28/12/2021 01:35

Gazza. may I suggest you treat yourself to a copy of RFK Jr's No.1 Bestseller : The Real Anthony Fauci : Bill Gates, Big Pharma and the Global War on Democracy and Public Health.

[panama7] 28/12/2021 01:08

I V E R M E C T I N

[gazza] 28/12/2021 00:01

P7, Sorry, just remind us what the cheap effective treatment that has been overlooked by governments and their scientific advisers is.

[panama7] 27/12/2021 23:36

Logman, this is most definitely the board for it, what do you think will happen to Covidity when the people of the World wake up , realise they have been lied to and there was already a cheap off the shelf treatment.

[geckotheglorious] 27/12/2021 21:58

EE

Trades for YEAR.

£££ in ITV, pile it ALL into SCLP and at 60p PILE that all into Phar.

This time next year rodders, we'll be multi millionaires :)

[wanderer1210_0] 27/12/2021 20:46

Too much paint fumes, bless him.

[dominiccummings] 27/12/2021 20:42

Anybody replying to the boor 'thelogman' only does so to humour him. He is the idiot that every village needs.

[wanderer1210_0] 27/12/2021 20:24

Been here longer than you think my boy lol

[thelogman] 27/12/2021 17:56

Shout it out loud
THIS IS A BOARD FOR SCLP HOLDERS TO DEBATE NOT FOR YOU NUTTERS TO PRACTISE. yes some good points made, but really this is not the place.

[dominiccummings] 27/12/2021 17:50

Shout it out loud

The FDA lie