Sareum Share Discussion Threads

[criticalthinker1] 06/12/2024 21:11

Finally re points made years ago...you may recall my point about research from Bartholomeus Lakeland.
I got ridiculed.
Not a problem for me. I KNOW WHY IM INVESTED HERE!!!! AND IMO WHY WE HAVE HAD DEBACLES AND FUD ON BOTH LSE AND ADVFN ...ESPECIALLY ON THIS SITE! ITS BEEN FUBAR!!!!
I urge you to go to youtube and watch the post at approx 1700 hrs today (GMT) titled 'Concerns' by Dr John Campbell.
I'm not a conspiracy theorist. He has 3m + subscribers
You should also look at the size and reaction of the audience.
Take note of all but noteably from 5.35minutes in to about 10 minutes....
If anyone reading this wants to know what I'm spouting on about...well its to do with the cytokine storms and cytotoxicity...and the very fact we are addressing the interleukins that imo are the answer! 1801 AND 2802 AND 737!
Go look at the presentation Tim did and check out the UKRI studies ...that got mothballed...go figure.

Sincerely all best to the genuine investors and supporters of our scientists.

Steadydanny

[criticalthinker1] 06/12/2024 20:32

And I'd like to add that we should remember some of the previous posters on lse that made points that have been proven correct...such as WIP

RE: Combo therapy31 Jul 2022 14:51
Afternoon Ahfam3 - flying visit for me as out on site 7 days a week at the mo. I know for a fact GSK Oncology are focusing primarily on combo therapy and have listed Jemperli and Zejula as being key to this. Pls take my word for this, I will show you proof at the £14/£20/£40 party. Stuff I can’t share publicly for obvious reasons.
And recently bought SRA737 under the fanfare that is momy.

The timing is significant. The debacles noteable...but Jemperli and Zejula...now called Niraparib were definitely in progression as WIP stated...the latter getting a MHRA yellow card scheme event....

Sierra Oncology tried Niraparib with 737 ....lots of forwards and backwards with so many of these trials...but fwiw WIP seemed to know what he was discussing albeit without disclosure of sensitive information.

[criticalthinker1] 06/12/2024 18:52

Thank you to desamax for the link!
Excellent imo.

I thought Tim was perfect. I'd rather a genuine scientist delivered a speech re our ipr and progress. And he didn't hold back about its significant advantages over very significant market competition. Very ballsy. And I don't see him as the type to exaggerate.
You can leave the smooth talking snake oil salesman pitch to the gutter pharmas if you want my opinion.

Extraordinary Position.

Who wants it?

I note he said 'Pipeline In A Product'!

1. A Competitor to protect their cash cow drug/s from other competitors and then see 1801 through to PH3 and dovetail it in to realise the increasing market value year on year?

2. The Competitions competitors wanting to get a slice of the action?
I mean we have a novel small molecule, once a day capsule (I note he mentioned tweaking that...interesting...higher dose level?...)with a significantly better half life and to date imo very promising toxicity results.

Also timely was Stephens interview. Very professional and succinct. We know he can hold his own and has the assistance of some seasoned board members re pharma negotiations.

Seems like a all the ducks are lining up.

I'm of the opinion we are in multiple discussions.

My prediction for fair value...

£400M upfront for 1801 then milestones of £1.2B

Added caveat that the licensee requests 1802 is progressed inhouse by the Sareum scientists and board with the licensees requests on direction...and 'if/when' that also gets to PH2a then a further fee of £400m (I'm seeing this as a tie up) and then a renewed discussion on milestones (assuming 1801 progresses well, which I think given how novel we are that a sareum scientist might be requested to work part time overseeing development..isnt Tim part time now....?) and x amount royalties on product/s release.

All best Steadydanny

[criticalthinker1] 03/12/2024 21:20

Hi yzf.

Last point first. If SRA737 has no positive indications given the plethora of its competitors..which are limited in their advancement re dose type and level of dose and its continuatio
in mono amd which will further it in combo imo for certain pharmas.. ..well I follow lots of advancement and bids for clinical advancement and yet to see anything that has the ability to express the advantageous ipr of 1801/2 also..
Re Tim in charge...I assume you mean at Sareum obviously.
Well put yourself in their shoes...imo....if a top guy decided that they would take on a more developmental position of Sareums ipr well irrespective of timings..I think its a good thing.
Pound to a penny if they don't report about the UKRI funding then I'm missing something.

[yzf750] 03/12/2024 20:18

Hi Danny Why would Tim have had to step down for that and it was a few months back . Surely if that is what they are going for Tim would still be in charge.I had always hoped he stepped down because they were in discussions to either license or sell and Stephen will get a better deal. What do you think will happen in Jan with 737

[horridhenry] 29/11/2024 16:00

cubanpete

you forget you are a disgusting pig of a person that has posted some of the most disgusting stuff on here, or anywhere.

We have all of your posts

[silvergreyhead1] 29/11/2024 15:35

I hope your right Critical. Seems we have been at this for way too long.

[criticalthinker1] 29/11/2024 13:57

Literally so much to come good here. Others will see why we were hamstringed....and imo the mc being 'managed'!!!!
Not long now.
All best

[criticalthinker1] 28/11/2024 07:43

If SOG glances over here I wonder if he could share his thoughts on the recent news on Benralizumab.

I could be wrong but it does seem to shine a light on our ipr.....more specifically the coronavirus tests and ARDS results.

Many thanks in advance

[cubanpete] 27/11/2024 16:13

My sister recently had a roll of netting stolen from her allotment. I have urged her to report the matter to the police so they can use their unlimited resources to cordon off the area and send in their best forensic team to "walk the grid" and check all 4 acres for fingerprints and DNA samples.
No doubt they will swiftly apprehend this menace to society and we can all sleep safely again.
The police are happy to throw everything at this case as they have no other pressing matters.

[criticalthinker1] 27/11/2024 11:22

I hope the trials are done in Australia because there are some very different/interesting policies with public health that would see our ipr add more value on the global arena/market.

[horridhenry] 25/11/2024 08:59

Well said Norma. I know of 2 other reports that have gone to Police. 1 of which is pretty damming and very detailed.

You wonder just what he is up to elsewhere (the Police i understand know he is)

[norma_stitts] 24/11/2024 17:53

Good afternoon Danny.

Thank you for continuing to post. I suspect the net is closing in our our resident troll as it’s not bothered posting since I pointed out on the ‘other’ site (that it loves to quote), how it had surpassed the threshold for harassment and recommended that SOG report it to the Police. People should report the piece of 💩.

I opted to log the harassment it has subjected me to but decided to have them close it. It can be reopened at any time.

On a serious note Danny; I acknowledge that we have had our disagreements due to you selfishly engaging with the trolls but I find your thought process extremely difficult to understand.

You spent ages saying COVID was some fictitious thing and it was just Flu.

Now you’re quoting about drug efficacy against COVID?

I find it difficult to understand what point you’re making as you seem to be contradicting yourself.

So is COVID real or are the drug trials based on your purported Jackanory conspiracy theory?

[criticalthinker1] 23/11/2024 21:07

Also CHK1 in hhe news...

Delivering drugs to gut tumors can be tricky. Researchers at Washington University in St. Louis have engineered an oral probiotic yeast to do the work for them, with the fungal cells able to release immune checkpoint inhibitors that shrank intestinal tumors in mice with colorectal cancer.

The results were published in Cell Chemical Biology on Nov. 20.

All best

And Science Direct June 2024.....note discusses 737 more useful as a combo....but I still stipulate that others will require it as a mono in order to pursue it on their drug platform in order to progress THEIR combos...

Review Article
Functions and inhibitors of CHK1 in cancer therapy
Author links open overlay panel
Kailong Jiang a 1
,
Minjie Deng b 1
,
Wenjing Du b
,
Tao Liu b c d
,
Jia Li a e f g
,
Yubo Zhou a

[criticalthinker1] 23/11/2024 20:26

1801 research furthers 1802 progression with data that assists ipr and development.

EP3864009
US2021387981

These patents pending/ moving further forward include Hydroxybenzoic acid and Amfebutabone. The foundations of these drugs are not uncommon but the novel way they are entwined with other elements and processes are very relevant. You can read further re Readers/Sareums patent applications.

In a nutshell as I mentioned (yonks ago )we got positive indications re coronavirus...however...then silence...why...well its imo because of similarities albeit novel ipr.

RFKjr has effectively got carte blanche to completely overhaul the CDC and FDA who for one thing will include the way its funded!!! This will ripple to MHRA and UKRI etc.

Just look up at the effectiveness of certain drugs re coronavirus that then got completely stalled and then the mRNA vaccines got a free reign.

I'm not a conspiracy theorist but I am an individual who researches not only drugs but regulatory bodies. Aka a critical thinker.

Check out SAHPRA foot on full reverse which is extraordinary given its glowing reports initially on fenbendazole and ivermectin...and please before ridicule check out John Campbell yesterday's podcast 'Fen Ben'.

Sareum are literally imo poised for significant progression and interest given the arena is being allowed a reset to MAHA...and tbe world.

It all adds up if you follow the money and the 'debacles' that have been apparent. The huge rise back along was thwarted the same time the big boys got free reign (and are losing billions now as I predicted) ...its all going to do a volte face in our favour.

The board haven't been diligently adding to their patents and geographical zones for no reason.

I love the science but I hate the machine behind the way companies are traded. I know many have been scratching their head at the market capital and progression.....our time is coming.

All best Steadydanny 👌

NB we are pursuing AUTOIMMUNE and CANCER!!!!!!

[criticalthinker1] 20/11/2024 21:33

Celtic it's 1802 that was proven to be a worthwhile ipr re lupus...as in differentcategoryof treatments...but indirectly you are correct because the toxicology trials purports to both 1801 snd 1802...and the change in corporate objectives re toxicology criteria means the fact we never met our critical point in its arena amongst global 'leaders' ...and we have a once a day pill formulation given its credence with attributes with criteria of phosphorylation with certain lipids that have crossed membranes they were not supposed to...

I came to this company for a reason. I'm convinced of that. Multiple individuals have stood strong.

Its not about the money. Its about realising the novel expertise here. It is quite extraordinary.

All best Steadydanny 👌

[criticalthinker1] 20/11/2024 20:59

And anyone....anyone ...want to talk about b cell lymphoma and lupus....

Well here you go

Lupus and lymphoma
It is believed that the elevated risk of lymphoma results from the disease process of lupus—specifically the overstimulation of B-cells coupled with defects in the immune system's surveillance system—and not just from medications or other associated risk factors.

Penny will drop soon.

SOG makes great posts on lse as does Krone and Citizen...but oh my if they did their research beyond certain papers that are backed by the pharma companies then the world would wake up with the platform they have.

Off for a few days. Best to all.
Hope people just looking in look at everything.
All best Steadydanny 👌

[criticalthinker1] 20/11/2024 20:50

Has the handbrake been put on Sareum...you tell me...

7 Oct 2021 10:42

RNS Number : 3573O
Sareum Holdings PLC
07 October 2021

SAREUM HOLDINGS PLC

("Sareum" or "the Company")

US Patent Granted for Sareum's SDC-1802 TYK2/JAK1 Inhibitor

Cambridge, UK, 7 October 2021 - Sareum Holdings plc (AIM: SAR), the specialist drug development company delivering targeted small molecule therapeutics to improve the treatment of cancer and autoimmune diseases, announces that, further to its announcement of 30 July 2021, the United States Patent and Trademark Office has now formally approved its patent in respect of an invention associated with Sareum's proprietary SDC-1802 TYK2/JAK1 Kinase Inhibitor Programme (the "SDC-1802 Programme").

The patent (US 11,154,539) will grant on 26 October 2021 and will protect the SDC-1802 molecule and pharmaceutical preparations thereof as a therapeutic to treat cancer selected from pancreatic, colorectal and kidney cancers, melanoma, and B-cell lymphoma by inhibiting TYK2 kinase. This programme is in preclinical development.

Sareum's CSO, Dr John Reader, commented:

"We are pleased to confirm the grant of this US patent for SDC-1802, adding another layer of protection around this promising candidate in key territories. Our SDC-1802 programme is in preclinical development currently and we are designing the translational studies needed to define the optimal cancer application prior to completing toxicology and manufacturing studies. We look forward to providing further updates on progress as we achieve key milestones."

[criticalthinker1] 20/11/2024 20:29

Appreciate HBDs post but this was known nearly 4 years ago...check out what Thoth was saying...I spoke privately with him albeit our public disagreements on lse but he agreed about the points I made. This was part of a converse on lse Jan 2021
albei Ahfam who got ousted as well from lse...but on the same hymn sheet...hence the recent patent approvals

RE: Il-610 Jan 2021 14:55
I'll second that Thoth- This is from the research update in July in regards Lupus US Army studies-

'Specifically, it was reported that treatment with TYK2/JAK1 inhibitor SAR-20351 (now known as SDC-1802) reduces autoantibodies (biological markers of lupus severity) in a spontaneous mouse model of SLE. The data also provided evidence that SAR-20351 inhibits cytokines that play a critical role in lupus, including interferon-alpha, IL-6 and IL-23. The inhibition of IL-23 signalling by SAR-20351 may play a role in the decrease of autoantibodies in the lupus mouse model, as IL-23 signalling drives the differentiation of Th17 cells, which leads to autoantibody production and are pathogenic in lupus'.

Big pharmas hold the gold and push it back with trolls ...noteabley on ADVFN...but thankfully they have gone...made a point to the domain owner...and they respected my point.

I think the board are getting payback from the big pharma who screwed them.
Large lady is warming her tonsils.
The facts (imo) is the lies die and the real treatments come to fruition.
All best Steadydanny