Reneuron Share Discussion Threads

[small crow] 17/6/2020 12:39

sn, perhaps badly expressed but, afaik, the Imperial mRNA needs to be delivered to human muscle cells for translation, so an exosome binding to the virus spike wouldn't be particularly useful. It needs to bind to the spike-receptor on the muscle cell, then merge contents so that the mRNA can be translated into a viral antigen and secreted from the muscle into body fluids. Crossing BBB may be useful but I'm not sure is relevant - the loss of smell could be peripheral.

[bonzo] 17/6/2020 12:32

It would be worth it for in house use, but I think it would need some validation before people would pay for it.

[supernumerary] 17/6/2020 12:27

sc - or perhaps it's just badly expressed, and they mean the exosome can deliver something that binds to spike, while carrying a killer payload such as the Imperial vaccine? That's what I would have expected, and which could provide a very useful vaccine carrier - crossing the blood-brain barrier for instance would obviously be of benefit.

[supernumerary] 17/6/2020 12:20

Bonzo - thought of that, but for in vitro and animal studies it surely wouldn't be worth the bother?

In humans, you would presumably have already proven your vaccine was safe by trialling it in Ph1 in uninfected patients, and by the time you were up for a real Ph2 or 3, I doubt whether simply proving that you can bind to spike would be of great value.

[small crow] 17/6/2020 12:17

Bonzo, you may well be correct but that doesn't sound like 'delivery' to me. My first thought was it might simply be to use the exosome itself as a vaccine, because the spike would sensitize the macrophages but the rest of the infection machinery isn't present? I can't see why that might not work except perhaps cost? But that doesn't really sound like 'delivery' either! Perhaps it might be something like packaging the mRNA vaccine that Imperial are developing and delivering it to the (human) target cells that they hope will translate the stuff into viral proteins? The wording is a bit mysterious, perhaps on purpose.

[bonzo] 17/6/2020 11:38

The spike is the part of the virus whatcha a vaccine would need to recognise and interact with. The RNS means that people could use the exosome to develop and test vaccines, rather than using the virus itself. The virus is (obviously) dangerous but the exosome is harmless. Its value depends whether RENE can exploit this commercially.

[dickbush] 17/6/2020 10:08

Recognition that they can't finance both the RP and CTX trials, they've opted for RP which makes sense based on the results so far. Fosun carrying the CTX line for stroke into Phase IIb testing, presumably restricting the tests to only patients with residual upper limb movement at baseline. The initial results looked promising for that sub-group. Further commercial collaborations expected wrt exosomes. Still trying to ride the covid-19 gravy train.

Looks, as ever, like jam manjana.

[philh75] 17/6/2020 08:47

There is no partnership in US, so it is on hold for foreseeable future. How many people got dosed? Is it sufficiently powered to show a meaningful outcome?

[martinfrench] 17/6/2020 08:46

stroke program will continue through regional partnerships, one of which looks like fosun ?

not sure entirely how this will pan out

[philh75] 17/6/2020 08:20

So the stroke programme is on hold indefinitely???

[bonzo] 17/6/2020 07:39

For example, implicit in this announcement is that in house work cannot continue at the current rate as previously or they will run out of money!

[bonzo] 17/6/2020 07:38

One of the arts of generating a good RNS is to sweeten the bitter - wait til you have some good news to deliver the bad! Just checking this out!

[martinfrench] 17/6/2020 07:29

Mostly good, can't see any negative

[bonzo] 17/6/2020 07:14

Major RNS here. Not immediately clear if this is good or bad news. The RP news clearly good, but not clear what in-house activities have been dropped. The exosomes crossing the BBB would be good for Covid treatment. Covid clearly has central activity as the loss of smell is a central effect...

[supernumerary] 07/5/2020 16:17

I think the history's a bit chequered which doesn't help - everybody's moved on to the latest glamour stock, particularly now with all the C-19 excitement. I was lamenting over on the Maxcyte board this morning that investors weren't showing much enthusiasm despite great progress in the business. Prefer to play musical chairs with hot Covid stocks I expect...

So it goes. Value will out in the end. I hope :)

[rayrac] 07/5/2020 16:06

:))

Some taking profits off the table? Surprisingly rene doesn’t seem to get a large following. Well not yet anyway.

[supernumerary] 07/5/2020 15:48

PS sorry to hear about your affliction Rayrac. Have you tried self-isolating?

[supernumerary] 07/5/2020 15:47

Thought there'd be a bit more excitement when the US woke up, but apparently not. RENE should get in touch with the BBC and get a Panorama/Horizon special on stem cells - this is ground-breaking stuff which is still off the radar for many.

[rayrac] 07/5/2020 13:18

Thank the lord for that volsung!

I’m still suffering.

[small crow] 07/5/2020 13:05

James Brown said it.

[prambigear] 07/5/2020 13:02

Even better with older women volsung. More appreciative.

[volsung] 07/5/2020 13:01

I'm over it now rayrac!

[rayrac] 07/5/2020 13:01

Just a man’s world then!

[rayrac] 07/5/2020 13:00

That’s good news volsung! But don’t overdo it!