Rule 8 - Profile Therapeutics plc

The Alliance Trust PLC

Disclosure under Rules 8.1(a), 8.1(b)(I) and 8.3 of The City Code on Takeovers
and Mergers

Date of Disclosure                  24 March 2004
                                    
Date of Dealing                     23 March 2004
                                    
Dealing in                          Profile Therapeutics plc
                                    
1.  Class of Securities             Ordinary Shares
                                    
2.  Amount Bought        37,500
    Price per Unit                  48.0p
                                    
3.  Resultant total of the same     750,000    (1.53%)
    class owned or controlled
                                    
4.  Party making disclosure       The Alliance Trust PLC
                                    
5.  Name of Purchaser               Allsec Nominees Limited on
                                    behalf of The Alliance Trust
                                    PLC and The Second Alliance
                                    Trust PLC
                                    
6.  Reason for disclosure           The Alliance Trust PLC and The
                                    Second Alliance Trust PLC
                                    together own 1.53% of the
                                    equity and are deemed to be a
                                    single person for the purpose
                                    of Rule 8.
                                    
               Rule 8.3 (disclosure because
                                    of ownership or conrol of 1%
                                    or more of the class of
                                    relevant securities dealt in).