Optibiotix Health Share Discussion Threads

[kreature] 12/6/2021 17:40

I thought AIM companies need to be able to fold instantly without a trace of complicated assets.....Worthless intangible assets are probably fine though

[sentiment riles] 12/6/2021 17:32

Will opti buy an office soon or is a real asset a bit of a no no ?

[sentiment riles] 12/6/2021 17:30

I think opti are just in the transfer game at the moment.

[kreature] 12/6/2021 17:06

football talk, ironically just as Opti is at the top of its game. Or is that slimfast?

[sentiment riles] 12/6/2021 17:00

Local cups

Even hull got one of those this year

[manc10] 12/6/2021 16:32

which ones the serial winners or man u

[sentiment riles] 12/6/2021 15:28

Watching them choke outside of own back yard is not a pretty sight

[sentiment riles] 12/6/2021 15:27

Hope England don’t look like Manchester if they get to the qtr final

[manc10] 12/6/2021 15:20

england only for me wales its like watching hull looool

[sentiment riles] 12/6/2021 15:13

Wales playing Manc, ironically

[manc10] 12/6/2021 15:04

From butterflies in the stomach to going with your ‘gut instinct’, the gut microbiome and its links with the human brain has been a popular research topic in scientific circles. Growing evidence in this area has shown that the gut microbiome and brain communicate in a ‘bidirectional manner’, influencing each other’s functions.

As a result, we now know that several systems work synergistically to ensure the human body continues to function correctly. This comprises of the central nervous system (CNS), the enteric nervous system (ENS), the endocrine, immune and autonomic nervous system (ANS). When the ENS and CNS systems communicate, it’s called the ‘gut-brain axis’, where complex pathways between cognitive and emotional areas of the brain link with the endocrine and immune systems, alongside the ANS. So, when we feel ‘butterflies in our stomach’, stress and anxiety, the communication between the ENS, CNS and ANS gets disrupted and these feelings become amplified, shifting the overall state of balance of the gut-brain axis.

Evolving science and the gut-brain axis

Scientists have also discovered that one of the most important connections in the human body is the vagus nerve, which is an essential part of the gut-brain axis. It consists of two bundles of neurons that run down each side of the body, from the brain to the abdomen and intestinal tract. As a result, it’s now understood that the stimulation of the vagus nerve can be triggered by signals from specialized cells and bacteria in the gut microbiome.

Recent studies, for example, have demonstrated that when mice lack a microbiome they experience anxiety- and depression-like behaviours. Moreover, researchers have discovered that patients with neurodegenerative diseases such as Parkinson’s and Alzheimer’s Disease are more likely to have an altered microbiome. Evidence like this suggests that the gut microbiome and the bacterial species it is made up from, including Firmicutes, Bacteroides and more, not only influence human behaviour but may affect the pathophysiology of mental illness and neurodegenerative diseases.

The role of prebiotics and probiotics

When it comes to matters of the gut-brain axis, both prebiotics and probiotics have been found to play a significant role. The latest research suggests that probiotics, for example, may have the ability to reduce the production of inflammatory chemicals like cytokines in inflammatory bowel disease. In addition, they may also help direct the action of tryptophan – a chemical that’s noted for its importance in the gut-brain axis in relation to psychiatric disorders.

In a 2018 study, the probiotic strain Lactobacillus plantarum 299v was found to decrease kynurenine concentration – a metabolite of tryptophan that is made in response to immune activation – and improved cognitive function in patients with major depression. While in a randomised, double-blind and placebo-controlled trial, petrochemical workers who consumed a probiotic yoghurt or a multi-species probiotic capsule for six weeks also demonstrated improved mental health, when measured through a depression, anxiety and stress scale.

Interestingly when probiotics are taken in combination with prebiotics, they may help to ease mood disorders. As prebiotics help to feed the good bacteria inside the gut, researchers have found that they could improve sleep and boost stress resilience. For instance, in a new study by the North American Menopause Society, scientists found that a higher dietary fibre intake is linked to a lower risk of depression in pre-menopausal women.

The latest OptiBiotix research

At OptiBiotix, we are fascinated with the latest scientific studies into how microbiome modulation technology can influence mood and mental health. In our latest study conducted by the University of Roehampton, we demonstrated that our patented weight management ingredient, SlimBiome®, greatly improved mood and gut microbiome composition. When participants ingested 9g per day of our multi-award-winning ingredient, it resulted in a statistically significant improvement in mood after four weeks (p = 0.0026).

Our patented probiotic strain, Lactobacillus plantarum LPLDL® has also achieved anecdotal evidence from users that it can improve mood. In fact, we are currently funding new research into how our probiotic strain, alongside SlimBiome, can improve sleep, stress and anxiety.

For pharmaceutical, food and drink and supplement brands and manufacturers that are looking to expand their commercial portfolio with mood-boosting prebiotic and probiotic ingredients, OptiBiotix could have the solution. While scientific evidence is pivotal to the next steps we take as market leaders in microbiome modulation, it is also just as important to seek new understanding on the connection between the gut microbiome and the brain.

[manc10] 12/6/2021 15:01

The human body is inhabited by hundreds of species of microorganisms, mainly bacteria that live in the gut, which are collectively known as the microbiome. In fact, the number of bacterial cells matches that of human cells, with approximately 1013 each for an average adult . However, the importance of the microbiome comes not only from its numbers, but mainly from its activity. Scientists now see the microbiome as the forgotten organ, with metabolic activity often parallel to that of the liver .

The human gut microbiome co-evolves with the host in a symbiotic relationship. Through our diet we deliver nutrients that help gut microbes to grow, while they in turn produce essential nutrients, such as vitamins and short chain fatty acids, which are essential for our wellbeing.

Over the last decade, research has shown that the microbiome performs an active role in cardiovascular wellbeing and that many metabolic activities are jointly carried out through the cross-talk between our body and the gut microbiome. It is also now known that these microbes can produce certain chemicals to communicate with different parts of our body such as the liver, a network known as the gut microbiome-liver axis, and even the brain, the gut microbiome-brain axis.

Altered microbiomes have been linked to very different health issues, ranging from digestive problems, autoimmune conditions and metabolic diseases to obesity to autism. The discovery that the microbiome is crucial for human wellbeing has changed how scientists understand and manage disease, creating huge interest in finding ways to modulate microbiomes and restore them to normality. Probiotics and prebiotics are the two main dietary strategies in this field.

The first approach provides the gut microbial community with live microbes known as probiotics, whose activity can mediate health benefits. Probiotics have been used for millennia in fermented foods and, at present, most strains have been developed to support general digestive wellness and immunity. Advances in our understanding of the gut microbiome composition and function now enable us to develop probiotic strains with activities that bring specific health advantages, such as Lactobacillus plantarum LPLDL® – a next-generation probiotic capable of modulating the microbiome-liver axis, which is heavily involved in cardiovascular health.

The second strategy centres around providing dietary ingredients selectively utilized by the host microorganisms which confer health benefits, known as prebiotics. Gut microbes are adapted to make use of food ingredients that the human organism cannot, such as fibre, the breakdown of which can have a direct or indirect impact on a large number of intestinal microbiome members. The key feature of prebiotics, however, is specificity – stimulating the growth and activity of only those microbes that can help the human host. Achieving true selectivity in an ecosystem as complex as the human gut is difficult, which is evident in the common occurrence of gastrointestinal side effects upon prebiotic ingestion, and the reason why prebiotic precision is key in ensuring only targeted microbes are enhanced. LPGOS® from OptiBiotix is an example of selective microbiome focus, a galactooligosaccharide (GOS) specifically targeting L. plantarum LPLDL® with the capacity to enhance its metabolic activity and growth within the gut microbiome.

Harnessing the microbiome is the next frontier in human health, the full potential of which we are only starting to discover. Probiotics and prebiotics are amongst the most promising dietary approaches for gut microbiome modulation, with specificity in their mode of action and wellbeing benefits key to pushing the boundaries of disease management.

[manc10] 12/6/2021 14:59

How does our gut respond and adapt to changing conditions? Where does this fundamental and critical flexibility come from? Technion scientists are unraveling the genius of the gut's microbiome, through microbiota, all the way to genetic inversion.


Assistant Professor Naama Geva-Zatorsky and doctoral student Nadav Ben-Assa of the Rappaport Faculty of Medicine, in collaboration with scientists from Harvard University, have decoded a reversible genetic inversion mechanism that helps a bacterial species of the gut microbiota deal with changes in its habitat. Their findings are published in Nucleic Acids Research, a peer-reviewed scientific journal of Oxford University Press.

The human microbiota refers to the collection of microbes (bacteria, viruses, etc.) that colonize the inner and outer surfaces of the human body. The human intestine contains the most abundant and diverse microbiota population.

Gut microbiota provide a fundamental coping mechanism within the dynamic environment of the gut, in which structural, mechanical, and chemical change occurs incessantly. One mechanism that helps the gut microbiota perform involves rapid, reversible changes in genomes in response to external stimuli.

The article published in Nucleic Acids Research discusses this mechanism in one of the most abundant bacterial species in the human gut, Bacteroides fragilis. This bacterium is capable of inverting a large number of defined regions throughout its genome sequence. The researchers focused on the relationship between this capability and the organism's gene expression.

The research team examined the gene expressions of these changes (recombination) and found extensive alterations in the bacterial genome.

"Among other things, we discovered changes in the sugars surrounding the bacterium," said Prof. Geva-Zatorsky. "These sugars serve as a kind of 'identity card' that helps the bacterium communicate with the environment. With these sugars, they also help our bodies, or more precisely, our immune system, to identify the type of bacterium present, and to respond to it. This is why we assume that changes in the gut alter that 'identity card,' which enables our cells to respond to the bacterium in different ways."

The researchers emphasized that these are reversible genetic inversions, based on recombination of regions in the genome in a major system in the B. fragilis organism. Consequently, this recombination has an extensive effect on the organism's gene expression, including various vital molecules.

Genetic analysis was performed using SMRT (single molecule real-time) sequencing—an innovative technology from Pacific Biosciences (PacBio) developed in the past decade. The technology enables the long-range sequencing and mapping of DNA molecules, as well as the detection of epigenetic DNA modifications. In the system that was researched, genetic recombination affected genetic modifications and consequently the gene expression of B. fragilis in its entirety. The system can also detect hostile elements such as bacteriophages, and this is the subject of a new research study that is now underway in the laboratory.

[sentiment riles] 12/6/2021 14:55

They have a point maybe. Every stock I ever turned up on, always ended up investigated . Midas touch

[sentiment riles] 12/6/2021 14:45

They don’t agree On the whole here . Metro bank fraud investigation and Syme etc

But at least I certify two as authentic anyway, they will agree

[sentiment riles] 12/6/2021 14:43

I’m renowned for sniffing around all credible stocks only

So needless to say I sort of certify them

[kreature] 12/6/2021 14:40

Well, you know, add a bedroom and name your price as there’s no comparables out there. Only works in a sellers market though

[kreature] 12/6/2021 14:31

Not many good honest companies left like these. Always adds credibility when you can say you have a doctor Sue

[sentiment riles] 12/6/2021 14:27

It’s the only reason I like these two stocks. Don’t have to read the 98.5/1.5

[kreature] 12/6/2021 14:00

Glee built in with disappointment on AIM but obviously the main ingredients are 98.5% stupidity and 1.5% evil. When was the last fish pandemic, out of interest?