Optibiotix Health Share Discussion Threads

[riskybusiness1] 05/2/2019 16:21

Why would Opti want the NHS to prescribe LPLDL when they can sell it to people at higher prices? NHS would want lots of it but very cheaply cutting out the higher valued higher margin deals Opti are creating. Phase 1&2 are to prove safety and give an indication of efficacy. This has already been achieved. LPLDL is also GRAS rated by the FDA reinforcing Opti own data for phase1&2 allowing to bypass straight to phase 3 which I believe is already underway or about to start. LPLDL will likely become the first probiotic to achieve FDA approval due to its safety, efficacy and known mechanism of action. Likely to get FDA approval this year and biopharmaveutical drug on the market within three years. Multiple 6 figure payments adding to a 7 figure payment and another 7 figure payment if this company wants exclusivity to the product it's paying to bring to market.

[rayrac] 05/2/2019 16:04

It’s no use Parob, statins work, and with hardly any side effects!

LPLDL will have to be put into some medium that will make its cost prohibitive, very much like slimbiome in go figure products. If it were sold at a comparable price and worked to the same level of efficacy as statins! Then you might find the NHS getting interested. It’s strange that Opti never mentions any ties with the NHS.

[m4rtinu] 05/2/2019 16:02

Parob - I have to admire your conscientious researching of all articles relevant to the problems OPTI are trying to solve.

[parob] 05/2/2019 15:44

hTTps://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013What are statin side effects?Muscle pain and damageOne of the most common complaints of people taking statins is muscle pain. You may feel this pain as a soreness, tiredness or weakness in your muscles. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult.Oddly enough, most randomized controlled studies of statins indicate that people taking statins develop muscle pain at the same rate as people taking placebo. But up to 29 percent of the people who start taking statins report muscle pain and many discontinue statins because of it. Many of these people do well when they are switched to a different variety of statin.Very rarely, statins can cause life-threatening muscle damage called rhabdomyolysis (rab-doe-my-OL-ih-sis). Rhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per million of patients taking statins. Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins.Liver damageOccasionally, statin use could cause an increase in the level of enzymes that signal liver inflammation. If the increase is only mild, you can continue to take the drug. Rarely, if the increase is severe, you may need to try a different statin.Although liver problems are rare, your doctor may order a liver enzyme test before or shortly after you begin to take a statin. You shouldn't need any additional liver enzyme tests unless you begin to have signs or symptoms of trouble with your liver.Contact your doctor immediately if you have unusual fatigue or weakness, loss of appetite, pain in your upper abdomen, dark-colored urine, or yellowing of your skin or eyes.Increased blood sugar or type 2 diabetesIt's possible your blood sugar (blood glucose) level may increase when you take a statin, which may lead to developing type 2 diabetes. The risk is small but important enough that the Food and Drug Administration (FDA) has issued a warning on statin labels regarding blood glucose levels and diabetes.Statins prevent heart attacks in patients with diabetes, so the relevance of the mild increase in sugar values with statins observed in some patients is unclear. The benefit of taking statins likely outweighs the small risk to have the blood sugar level go up. Talk to your doctor if you have concerns.Neurological side effectsThe FDA warns on statin labels that some people have developed memory loss or confusion while taking statins. These side effects reverse once you stop taking the medication. There is limited evidence to prove a cause-effect, but talk to your doctor if you experience memory loss or confusion while taking statins. There has also been evidence that statins may help with brain function - in patients with dementia, for example. This is still being studied. Don't stop taking your statin medication before talking to your doctor.

[rayrac] 05/2/2019 15:39

This study was conducted in 49 normal to mildly hypercholesterolaemic adults during a 12-week period. Participants ingested an encapsulated form of LP-LDL twice a day before breakfast and dinner.

12 weeks! Run it through phase 1/2/3 studies, it’ll take far far longer, probably 10years or longer and in the many 100s participants.

In the meantime, Drs will carry on prescribing statins at a far lower price.

[parob] 05/2/2019 15:26

Study shows novel probiotic reduces cholesterol more effectively than plant sterols/stanolshTTps://www.nutraceuticalbusinessreview.com/news/article_page/Study_shows_novel_probiotic_reduces_cholesterol_more_effectively_than_plant_sterolsstanols/143274The results of a research study show that a new bacterial strain, called Lactobacillus plantarum LP-LDL, significantly reduces both cholesterol and blood pressure with no observable side-effectsPlant sterols and stanols are often recommended as natural aids to lowering cholesterol. However, figures suggest that they only lower cholesterol by up to 10%, and must be taken in optimal doses and as part of a diet low in saturated diet to be effective.

[rayrac] 05/2/2019 15:26

FDA approval taking it through phases 1/2/3? That’s at least 10 years away!

[rayrac] 05/2/2019 15:22

LPLDL? It doesn’t work to a satisfactory level! How the heck is it going to compete with a little bottle of Benecol at a fraction of the price for lowering cholesterol.
Then there’s bp at just 5.1%. Which means if your bp is at 160/90, it just reduces the top figure to 151. Which is of no use whatever

[riskybusiness1] 05/2/2019 14:40

For example if LPLDL gets FDA approval that vastly increases value of that IP significantly without revenues though we know revenues are building nicely already in the supplements space. Revenues from higher valued dairy/food and pharmaceuticals will make sure of exponential growth. A product like LPLDL and the probiotix division will ultimately get bought out at a later stage at far higher valuations if everything continues on current momentum. If FDA approval is granted that will be guaranteed.

[riskybusiness1] 05/2/2019 14:29

Rathean the valuation is based on having wholly owned interested in 3 core companies and a 41.9% interest in areas that are the fastest growing anywhere in the world. I think SBTX listing and now at £20m mkt cap highlights the individual valuations the market puts on this technology. When you contrast this with the core platforms within Opti; Slimbiome has a medical device claim, LPLDL is now entering the much higher valued bopharmaceutical market with partners taking on the costs AKA the drug market when companies have £100m+ valuations for a single product offering. Sweetbiotix and it's novelty is a technology that holds significant industry value before its even commercialised - Narbel has been brought in to commercialise this now. Not to mention Optibiotics.If you look at the listing of SBTX in terms of whole value it would prove that your theory of overvalued on revenues is way off. Do not get me wrong the current mkt cap is up partially based on potential of revenues but this is only one means to valuing and even then it goes much further in terms of the costs to serve those revenues and profit potential in enormous markets etc. You've got three core platforms at s cost base of around £1.7m building a supply chain of agreements that are mostly license arrangements and therefore go straight to the bottom line. Asset value alone of the IP is significant too.You'll be lucky to see 60s again but then again I thought that when it went to £1.30 after the Opti team delivered all the main price catalysts.

[dire cons] 05/2/2019 14:18

Could materialise any time though, could be tomorrow or next week.
Good luck.

[rathean] 05/2/2019 13:31

Lol voting my post down, the danger of course is optimism becomes fanatical, seen it on other boards where contrary views are blocked... UKOG, Tern are both good examples of controlling the message.I still believe OPTI will be a winner but the valuation suggests exponential growth in revenue and that's yet to materialise. All imo ofc.

[slartybartfaster] 05/2/2019 12:00

Filtered both village idiots.

[rathean] 05/2/2019 11:54

Still looking for this to retest circa 65 floor of longer term rising trend. Will be back in then but for now the valuation just looks silly imo dyor ofc.

[cyberbub] 05/2/2019 10:27

Dazah filtered

[rayrac] 05/2/2019 10:08

Your reading of the situation beggars belief slarty. Better get a new crystal ball!

[slartybartfaster] 05/2/2019 10:00

I see the pi's that have have paid for xmas on the cc now need to cash in. Idiots. I am grateful though. I see the MMs are playing a blinder on poor volume. Suits me fine for another week.

[rayrac] 05/2/2019 09:55

Who was the fool who bought 7.5k?...oh, sorry nobbygnome, it must have been you!

Should have kept stum about that nobby?

[parob] 05/2/2019 09:43

Gregor Reid (Seed Chief Scientist) interview:hTTp://www.digitaljournal.com/tech-and-science/science/can-probiotics-help-stop-honeybee-colony-collapse/article/542447Reid: In the coming years, microbiome science will impact almost every aspect of our lives and the choices we make for our health. As research continues, we're committed to stewarding how that research is both advanced and translated (through both products and education) to set a new standard in consumer health.DJ: What benefits can probiotics deliver for human health? Reid: 78 percent of Americans live with gastrointestinal issues. 68 million suffer from chronic constipation. And with 66% of consumers associating probiotics with digestive health, it's unsurprising that probiotics are the fastest growing category of consumer health.However, the idea that probiotics are exclusively relegated to supporting digestive health is a common misconception. Many of these organisms can provide benefits beyond digestive issues. Your body is complex and interconnected, and the gastrointestinal system sits at the core of it all. It's connected to and influences everything from immunity and metabolic function to cardiovascular, skin, and urogenital health. So, while improvements in gut health are often the most immediate, localized, and evident (with digestion often improved in as little as 24-48 hours), our Daily Synbiotic can actually have powerful effects across the entire body. Both our female and male formulations address cardiovascular, metabolic, and immune health and the female formulation offers additional benefits in dermatological health and the production of folate in the body.As our mindset shifts from sick care to self care, we've become more intentional about our diet, nutrition, exercise, and lifestyle. But we now also know that probiotics and prebiotics are powerful new tools to preventively and proactively care for our whole selves

[dazah] 05/2/2019 09:42

Back down to 60p?

[judijudi] 05/2/2019 09:28

Scotty,
Bang on the money mate

[judijudi] 05/2/2019 09:09

Ey up its the stock market genius aka The Opti Troll up and about early today
Slimfast is losing money
A genius of your standing should know that
How much money are your holdings at UKOT Nowt, Bahamas and Angus making?
Funny
:)

[nobbygnome] 05/2/2019 08:44

I know it was a buy as it was me! It won't necessarily fall, if a few buyers come in at what I consider to be a bargain price. But for me i can wait and it is of no consequence if the pice does drift off some more. Patience is a virtue....