N4 Pharma Share Discussion Threads

[dplewis1] 19/2/2024 10:44

Meanwhile the share price sinks into the abyss

[nobbygnome] 19/2/2024 10:44

None as blind as those who can’t see….

[nobbygnome] 19/2/2024 08:37

What a strange comment. I have a scientific interest and hopefully I am helping fellow investors to understand the issues….

[nobbygnome] 19/2/2024 08:08

>> featherby

But understanding the science is critical to knowing whether N4P is a good investment or not!!

And although as always I will judge the evidence as it appears, I doubt very much I will ever be buying N4P. I have severe doubts the technology will work in humans…

[featherby81] 19/2/2024 07:44

You’ve spend 24 years posting nearly 32,000 times Nobby, you know how trading works better than you know how Nuvec works. You once thought it was loaded internally until I corrected you!
You’re here waiting for some glimmer of hope, a collab or trial news. You’ll add and begin to ramp the hell out of it as you have in many other stocks.

Once again, ADVFN is a no go area for investors to discuss the science.

[nobbygnome] 19/2/2024 07:24

>> Fydo

Using my PhD in immunology and 28 years of experience in the Pharma industry, I comment on the many issues with Nuvec and N4P more generally. If you want to have a debate about the science please go ahead!

I remember about 5 years ago after Nigel had a trip to Japan Dave was getting excited about the imminent commercialisation of Nuvec. Here we are in 2024 and it hasn’t even been put in a human yet!

[dplewis1] 19/2/2024 07:12

The share price is heading towards half a penny .. absolutely nothing to do with "derampers" and everything to do with N4 failing at every stage. It shouldn't be a listed company, completely pointless waste of investors time and money

[fydo] 18/2/2024 20:44

One deramper backing up another.
Well known tactic used by share bashers.

[nobbygnome] 18/2/2024 18:22

Dave Farrier has been a clueless ramper here for many years as the price has sunk from above 30p. He does deserve to be called out….

[johno1977] 18/2/2024 13:54

Change the record DPL, you're obsessed with D Farrier! Regardless of whoever'Dave' may be, I don't remember him directing any malice towards you.

[dplewis1] 16/2/2024 09:38

Hello Dave .. when the next placing. Not long to wait I'd say

[atmysignal] 16/2/2024 09:28

lipid nanoparticle (LNP) mRNA vaccines were developed and have been instrumental in preventing the disease

[bloomberg2] 15/2/2024 19:15

Does nuvec delivery system work like the COVID virus ? Spikes attaches to cells with there sticky spikes ?

[nobbygnome] 15/2/2024 07:29

Very unimpressive results for an in vitro experiment. So say we have a culture of 100 cells. The single treatment kills 67 cells but adding the second one only kills another 14 cells.

From that result it’s essentially a waste of time combining them and it’s very unlikely to be effective in vivo….

[jakleeds] 15/2/2024 07:20

15 February 2024
N4 Pharma plc
("N4 Pharma" or the "Company")

in-vitro siRNA update

N4 Pharma Plc (AIM: N4P), the specialist pharmaceutical company developing Nuvec®, a novel delivery system for cancer treatments, gene therapy and vaccines, is pleased to provide a further encouraging update on its ongoing in vitro siRNA research work.

The Company has now completed its in-vitro experiments combining EGFR (epidermal growth factor receptor) and PLK1 (Polo Like Kinase 1) siRNA molecules onto the same Nuvec® nanoparticle and testing it in PC9 lung cancer cells.

The work clearly shows that there is a strong beneficial effect at 48 hours on cellular inhibition compared to single dose siRNA, by combining both EGFR and PLK1 onto the same particle.

Specifically, when cells were treated with the highest dose of 75nanomolars (nm) of single loaded EGFR siRNA, cell viability after 48 hours dropped to 38%. When cells were treated with 75nm of single loaded PLK1 siRNA cell viability dropped to 33%, yet when 75nm of EGFR and PLK1 were combined together cell viability dropped to 19%.

The cellular inhibition effect increases over time up to 48 hours and increases with the amount of siRNA applied. The experiments were carried out a number of times showing a consistent effect.

The Company will now expand this work by testing knockdown of EGFR alongside BRD4 (Bromodomain-containing-protein 4) and extend the EGFR/PLK1 data in a different cell line.

Nigel Theobald, Chief Executive Officer of the Company, commented:

"The work we are doing on multiple loading of siRNA onto one nanoparticle is extremely encouraging and is showcasing the versatility of our Nuvec® delivery system.

"This ability to be able to knockdown two independent pathways leading to a positive added impact is an innovative approach in developing novel cancer treatments aimed at reducing the ability for tumour escape. We will continue to present this data to potential licensing partners as all this work strengthens the potential for collaboration opportunities."

[vaston] 07/2/2024 14:49

SYME IS NOW READY TO FLY

[dplewis1] 07/2/2024 11:37

Large sells.. looks like Farrier throwing in the towel finally

[dplewis1] 06/2/2024 11:11

What's happening Dave

[blackhorse23] 26/1/2024 08:11

Money moving to APH

[pwal] 25/1/2024 13:20

From X:An independent appraisal by @EpiVax , concludes Nuvec® has the potential to address crucial shortcomings in cancer therapy to safely and efficiently deliver multiple siRNAs to tumours.