Motif Bio Share Discussion Threads

[buywell3] 16/8/2019 16:03

Look at the USA market bullet it's down circa 5%

Those guys know more than here

IMHO no way is the FDA going to green light this

If it does buywell will stop posting

PROMISE

[fillipe] 15/8/2019 13:45

A decent rise today....for whatever reason, I know not.

f

[fillipe] 12/8/2019 10:44

Pretty poor L2 totals at the bid/ ask - 385k v 1141k.

Bests on show are 2.3 p v 2.41p.

All fwiw.

f

[zen12] 12/8/2019 09:15

19th Sept, worrying thing is they're monies will run out by then.

[best1467] 11/8/2019 15:49

Is the date of the FDA meeting known yet anyone

[ivyspivey] 26/7/2019 15:33

All indications are it was only the liver toxicity concerns raised by FDA in the CRL.
As small crow says the trial may reinforce the FDA concerns or alleviate them.
However,I believe a lot of this is about quantifying the risk of Drug Induced Liver Injury(DILI) and the lack of specific biomarkers may mean that the required trial is about generating a sufficient robust body of data.
The fact no patients suffered from Hys law or specific concerns over Bilurubin levels is evidential of that outcome.

[buywell2] 26/7/2019 15:09

Now 3% lower in the USA

More clued up there IMO

[small crow] 26/7/2019 14:19

That's the risk!

[nick rubens] 26/7/2019 13:00

cheers small crow.

What concerns me is that the results/data might confirm the FDA's concerns, rather than be simply a clinical trial prior to gaining approval.

[small crow] 26/7/2019 11:14

The purpose, presumably, is to focus on measuring more reliably any liver toxicity. Not possible to say more as we don't really know exactly what he FDA's objections were.

[nick rubens] 26/7/2019 09:37

From todays RNS

"which indicated that an additional clinical trial will be required prior to granting marketing approval for iclaprim."

What's the point/purpose of this clinical trial?

Shouldn't it read 'clinical trial required prior to considering approval?'

[ultra capital] 23/7/2019 14:04

Buying now

[buywell2] 19/7/2019 08:41

The way I see this latest RNS is that the only way MTFB can stay listed on NASDAQ is to do a share consolidation so as to get the US listed share price up to around $3

Will the company do that ?

Might be better to just let the NASDAQ listing go

[hashertu] 18/7/2019 08:44

Extract from a SUMMIT RNS issued today.

Ignoring the numbers, which are both worrying and mind boggling, it makes we think how difficult it must be to balance potential risk of an antibiotic against "known" benefit.

"Infections caused by the bacteria Neisseria gonorrhoeae are a growing global healthcare problem, with an estimated 78 million new cases globally per year. Infection rates continue to rise sharply as highlighted by the Centers for Disease Control and Prevention (‘CDC’), which reported a 19% increase in US gonorrhoea cases in 2017, and Public Health England, which reported a 26% increase in the UK in 2018. Of great concern is the increase in resistance towards the current standard of care treatment for gonorrhoea, a combination of the broad-spectrum antibiotics, azithromycin and ceftriaxone. N. gonorrhoeae resistance rates to azithromycin are 4.4% and rising, and there is an emergence of resistance to ceftriaxone in these same strains, which are referred to as cases of ‘super gonorrhoea.’"

[zen12] 17/7/2019 09:01

Read AP's post yesterday sums this up nicely, the ones in now are being played with the orchestrated rise yesterday.

[amrishbhim] 16/7/2019 15:50

I have read it

[zen12] 16/7/2019 14:49

You must be living in cloud kookoo land lol It's based on the rns..read yesterday's rns!

[amrishbhim] 16/7/2019 14:35

People please stop writing comments that are based on nothing, the FDA approval will arrive before close of business of month July, they are no funding raising today or next month, speak directly to there broker house, not even considered

[zen12] 16/7/2019 14:22

Agree with you it's a open secret they don't have enough cash for until FDA meeting, so now will need a placing soon at how much discount?

[apfindley] 16/7/2019 12:41

Yes they're quietly buying the price up. They will then sell as they start pumping it.Once sold and the price has risen they will short it heavily.And why, because a large placing is coming and they've been told and will be taking part in it.Know the game of the game players.....

[sbb1x] 16/7/2019 12:21

Nice mover and not a single post

[aladin1033] 13/7/2019 23:43

has returned over £40k so far plus your money back...

A few of us called it at 1.2p for months...

The next picks to get researched on are #ETX and #N4P...grab a coffee for 15mins this weekend and get up to speed on the stories

[small crow] 11/7/2019 11:18

AMP finished selling this week perhaps.