Intelligent Ultrasound Share Discussion Threads

[40 fathoms] 18/10/2023 22:14

Gestational age estimation is interesting and has the potential to be very useful. Below is an abstract from a paper from Prof Noble and Prof Papageorghiou published earlier this year.

“ Accurate estimation of gestational age is an essential component of good obstetric care and informs clinical decision-making throughout pregnancy. As the date of the last menstrual period is often unknown or uncertain, ultrasound measurement of fetal size is currently the best method for estimating gestational age. The calculation assumes an average fetal size at each gestational age. The method is accurate in the first trimester, but less so in the second and third trimesters as growth deviates from the average and variation in fetal size increases. Consequently, fetal ultrasound late in pregnancy has a wide margin of error of at least ±2 weeks' gestation. Here, we utilise state-of-the-art machine learning methods to estimate gestational age using only image analysis of standard ultrasound planes, without any measurement information. The machine learning model is based on ultrasound images from two independent datasets: one for training and internal validation, and another for external validation. During validation, the model was blinded to the ground truth of gestational age (based on a reliable last menstrual period date and confirmatory first-trimester fetal crown rump length). We show that this approach compensates for increases in size variation and is even accurate in cases of intrauterine growth restriction. Our best machine-learning based model estimates gestational age with a mean absolute error of 3.0 (95% CI, 2.9-3.2) and 4.3 (95% CI, 4.1-4.5) days in the second and third trimesters, respectively, which outperforms current ultrasound-based clinical biometry at these gestational ages. Our method for dating the pregnancy in the second and third trimesters is, therefore, more accurate than published methods.”

[gsbmba99] 18/10/2023 20:01

IUG letting us know that SonoLystlive is officially launched. I guess no RNS then.


Looks like Prof. Papageorghiou also presented on using AI to estimate gestational age using ultrasound images. At least one attendee was very impressed. If I recall correctly, 40F brought to our attention that IUG had filed a patent application for a similar sounding invention ( Hopefully this can be incorporated sooner rather than later.

It's a shame the company doesn't have the ability to make the videos of these events (or at least clips) available to shareholders/investors.

[40 fathoms] 15/10/2023 10:47

Yes, lots of things happening with AI and ultrasound at GE. I note on Friday that they have picked up a US$44 million grant from BARDA to develop AI Ultrasound for use in mass casualty trauma situations. While no immediately obvious read across for us it would not be a massive surprise to see as end up with a work package or two.

We may also get an RNS relating to the formal launch of SonolystLive in the first half of the week. Maybe also details of whether it will be included as standard on the Expert series or not. The formal product launch is at the ISUOG Congress being held in Korea Monday to Wednesday of this comming week.

[bamboo2] 12/10/2023 00:10

40F, all, GEHC just updated their website [since the last time I looked just after the acquisition], to include all the Caption Health AI based ideas.




Imo, they'll be ready to add IUG to the stable soon!

GEHC Q3 update in the next two weeks.

[bamboo2] 10/10/2023 16:07

Added a few more.
Got room for another 50k if it goes down a bit more...

Must admit, I didn't expect it get back to 10.2 again.

[w t tutte] 07/10/2023 14:32

This is from a couple of days ago on the IUG twitter feed.

"The Global Grand Challenges Meeting starts next week (8-11 October) in Dakar, Senegal, where our COO @Nicholas Sleep will be speaking on a panel about AI and Medical Devices.

The meeting, supported by the @Bill & Melinda Gates Foundation and its Grand Challenges Partners, convenes a dynamic community of researchers and practitioners and provides a platform to learn about cutting-edge scientific advances, build new local regional and global collaborations and explore how to build a more effective, inclusive and equitable ecosystem for global health R&D"

Confirms links to Gates Foundation

[bamboo2] 07/10/2023 10:34

40F, thanks that all reads really well. I look forward to your next instalment.

It sometimes takes me a bit of time to comprehend your posts, then the penny drops!

The dates co-incide nicely with the apex based turn dates on my chart in post 233.

[40 fathoms] 07/10/2023 06:20

Bamboo, all most there on the battlefield medical research, will update soon.

In the meantime



This is an abstract form a Poster that will be presented at the ISUOG World Congress in Seoul, South Korea from the 16-19 October. You will note it concludes that SonoLyst achieves expert level performance when categorising images for adherence to ISUOG mid-trimester screening guidelines.

"Conclusions: SonoLyst is indistinguishable from an expert when categorising views of routine mid-trimester scans against ISUOG guidelines. Such software can support sonographers during routine scans to ensure completeness and quality of scanning by ‘‘real-time peer review’’ of captured images."

It is also worth noting that full launch of SonolystLive will take place at the same conference and we should find out if it is to be included as standard on the Voluson Expert Series machines. This would result in IUG receiving a royalty on every machine sold rather than when the software is selected as an optional extra.

This linkedin post
Suggests to me it is. -" #AI a still secret AI feature reducing scanning time by 40% 🤫"

[bamboo2] 05/10/2023 15:23

40F, thanks for posting info on Needletrainer.

How is your research going where you looking into combat use of ultrasound. Any further developments?

[bmcollins] 05/10/2023 07:00

40 Fathoms
Seriously impressive imho
Thanks for posting this

[40 fathoms] 05/10/2023 02:33

The above links to a practical review of Needle Trainer. The page times out after a certain period of time, however if you refresh the page the timer resets.

[bamboo2] 04/10/2023 16:26

Bought 37702 for 11.35

[bmcollins] 03/10/2023 14:45

bamboo
Much appreciated for this link, how on earth the stock is where it is currently languishing is to me, a mystery, even more so after reading the Sonogram

[bamboo2] 03/10/2023 13:54

Welcome to The SonoGram your quarterly newsletter from Intelligent Ultrasound (IU).
In this edition, we bring you the latest updates on BodyWorks and the new ScanNav
Anatomy PNB probe placement video tutorials, let you know where you can meet the IU
team and join us for our upcoming webinars and events, and share the latest industry
news.

Nine events in the next nine weeks!

[40 fathoms] 29/9/2023 02:40

@Bamboo - very sensible too and ONT is at a cracking price as will be proven in time.

[bamboo2] 28/9/2023 18:57

Hi 40F, I am running a large holding, sometimes up to 500,000

I tend to average in and out, as price dictates.

I was taking some cash from here to average down my holding in ONT, as the opportunity there seemed too good to miss.

If this drops a bit more, I will buy them back.

[40 fathoms] 28/9/2023 09:42

Surprised to see you trimming down !

[bamboo2] 27/9/2023 14:13

Still after 100k

100k 12.505p or 12.65 for 25k

Sold another 25k

[bamboo2] 26/9/2023 08:48

Strong demand apparent from dummy sells.

Quite happy to auto-quote for 100k

[bamboo2] 25/9/2023 16:31

Looks like a breakout this week, fingers xx'd

[bamboo2] 25/9/2023 14:36

Maddox, thanks for the Gates vid.
Really interesting about AI.
Gates suggesting it's becoming bigger than the Personal Computer boom that started in the 1980's

[40 fathoms] 23/9/2023 01:57

@ Maddox, well spotted. The Gates Foundation has been supporting Ultrasound with grants for years this includes lowering the cost of hardware and increasing the automation in the software.

I am not sure anything in his show and tell actually gives us a signal either way ... he does say.

"Another amazing thing is that because the software here is doing the work, to look at the placenta, to look at the cord, to look at the amniotic sac, understanding because we have trained in AI on lots of data about good outcome pregnancies and tough outcome pregnancies the actual work does not require as much training. It guides you to scan properly and then gives you the information as to what they should do"

My suspicion still, is that as a minimum we will be providing some pared down form of Sonolyst for protocol based scans and we will also be providing our new gestational age product that has recently been patented.



I have posted something similar before but it is sets it out more clearly on a single webpage the existing links between IUG and the Gates Foundation in the area of AI driven neonatal imaging in the developing world. It is worth noting the following.

- Prof Papageorghiou was the co founder of Intelligent Ultrasound
- Over a signficant number of years he has received funding from the Gates Foundation
- His clinical special interests include all aspects of fetal medicine and ultrasound, fetal growth and pre-eclampsia, non-invasive and invasive prenatal diagnosis, and fetal therapy.

I think and this is probably the basis of our GA product - from the Prof Papageorghiou and team.



and a video of it in action



Here is a link to an academic paper about Machine Learning for Accurate Estimation of Fatal age based on Ultrasound Images



I would draw your attention to the bottom of the article firstly the acknowledgments

"This Biometry Automation in OBstetric And Beyond (BAOBAB) study was supported by generous grants from the Bill & Melinda Gates Foundation to the University of Oxford (INV-000368)"

I would then draw your attention to the ethics declaration

"Competing interests
J.A.N. (Alison Noble) and A.T.P. (Aris Papageorgiou ) are Senior Scientific Advisors of Intelligent Ultrasound Ltd. All other authors declare that they have no competing interests or other interests that might be perceived to influence the results and/or discussion reported in this paper."

[maddox] 23/9/2023 00:06

Hi Guys,

Bill Gates talking about his ultrasound donation - doesn't look like it's relevant to IUG: www.youtube.com/watch?v=Ng5mYx4rDso

[bmcollins] 22/9/2023 11:28

@40 Fathoms
Excellent info, your research is way better than those talking heads on youtube/vox etc, thanks for putting us in the bigger picture like this, much appreciated.