Immupharma Share Discussion Threads

[ernestsyngen] 06/4/2018 14:07

That Bullet Ant really gets on my " jack and jills". Looking fwd to the late publication trades this evening.

"I wouldn't want to be out of this over the weekedend"

[mr donkeykong] 06/4/2018 14:07

I am watching with trepidation here, I am rooting for all the longs here. I sold at higher price today.

[l0ngterm] 06/4/2018 14:06

Gis: he just wants in lower is all.. or has a short.. usually doomsayers.. if it's not a gazillion pounds next week, it's the extreme opposite.

[mr donkeykong] 06/4/2018 14:05

Bloody hell, professional players are really dumping on that buyer, can they absorb all those hitting them on bid side.

[l0ngterm] 06/4/2018 14:03

The traders back then with great words of wisdom and doom mongering.. trying to get in lower again boys..

[jace86] 06/4/2018 14:02

Being very specific quoting on Monday... No one knows when results are out. We may not even get confirmation that the database is locked. I seen people asking what SOC is, I believe its just treatment/care you'd ordinarily get as a sufferer of Lupus. Whether this includes a steroid injection or not Im not sure.

[glennrcharles] 06/4/2018 13:58

Johnny and Jane have loans they will never pay off mate..

[deadly heisenberg] 06/4/2018 13:55

Run for your lives Brothers and sistas

Monday morning -80% open is possible.

Yes it could be 50%+ too, but are you going to take the risks of losing Johnny and Jane tuition fees money on a wildcard

[deadly heisenberg] 06/4/2018 13:54

Can you show us your L2 thanks in advance

[ernestsyngen] 06/4/2018 13:53

Looking lively now with L2, Fluid as hell

Game on!

[deadly heisenberg] 06/4/2018 13:52

To all Bros and sistas

careful of ur sacks and titties. Losing those assets could mean , there will be no honey.

[drsmessguide] 06/4/2018 13:43

If the patient is using antimalarials, methotrexate, leflunomide, mycophenolate mofetil (MMF), or azathioprine, the start date must be at least 3 months prior to the 1st dose of study drug, and the daily dose must be stable over the 4 weeks preceding the 1st dose of study drug.
If the patient is not currently using corticosteroids, antimalarials, methotrexate, MMF, or azathioprine, the last dose (in case of previous use) must be at least 4 weeks prior to the 1st dose of study drug. For leflunomide, the stop date must be at least 8 weeks before the 1st dose of study drug unless an adequate cholestryamine washout has been performed. If cholestyramine washout is performed, the last use of leflunomide must be at least 4 weeks before the 1st dose of study drug.

Exclusion Criteria:

The patient has been treated with intramuscular or intravenous (iv) pulse steroids (ie, 250 to 1000 mg iv total daily dose of methylprednisolone) within 4 weeks of the 1st dose of study drug. The use of intra-articular steroids may be allowed after consultation with the medical expert.
The patient has received tacrolimus, cyclosporin A, or iv immunoglobulins (IVIG) within 3 months of the 1st dose of study drug.
The patient has received cyclophosphamide within 6 months prior to the 1st dose of study drug.
The patient has been treated for SLE with agents such as fusion proteins, therapeutic proteins, or monoclonal antibodies or antibody fragments, within 6 months of the 1st dose of study drug.
The patient has received B-cell depleting agents such as rituximab, belimumab or epratuzumab within one year of the 1st dose and has not yet normalized the B-cell count (ie, CD20+ B-cell count is less than normal range and the absolute lymphocyte count [ALC] is less than normal range).

[ernestsyngen] 06/4/2018 13:41

I am still hopeful of an RNS at 2-30

Should cause a stir

[drsmessguide] 06/4/2018 13:41

Yes Homebrewruss placed a link with the inclusion and exclusion criteria which deals with the drugs that cannot be taken during the trial or in the preceding months leading up to the trial

[113mike] 06/4/2018 13:36

not long now :)

[herschel k] 06/4/2018 13:36

Seems my point has been answered above anyway with that link.

Makes sense.

[ny boy] 06/4/2018 13:35

Surprised the derampers aren’t out using the excuse no data locked rns yet lol

[herschel k] 06/4/2018 13:33

Drsmessguide 6 Apr '18 - 13:19 - 23554 of 23555

As you point out, it's a difficult thing to set out explicitly because Lupus affects the immune system, so most palliative care is aimed at treating the symptoms of Lupus, rather than the disease itself.

However, I can't see how they would prescribe the placebo to someone that is already taking Benlysta, and allow them to continue on Benlysta, otherwise the patient would be under the impression that they could be taking an immunosuppressant and an immunoregulator at the same time, and would surely then know they were actually taking the placebo?

Just my view, but it's probably not as straightforward as that.

[aimingupward2] 06/4/2018 13:32

Thanks for replying to my query, Drsmessguide, but telling me the 'standard care' includes 'best practice', doesn't answer my basic question as to whether this can go beyond palliative care and include maedication/active drug such as benlysta.

[homebrewruss] 06/4/2018 13:28

aimingupwards, to follow on from Drmessguide's post, also bear in mind that the trial had strict eligibility criteria which excluded patients with various conditions and on various drugs (including benlysta/belimumab) from taking part:

[drsmessguide] 06/4/2018 13:25

hxxps://www.statista.com/statistics/318206/revenue-of-humira/

anyone in doubt as to the potential market, here is a chart of humira revenues for Abbvie, $18bn in revenue just last year alone. If this drug works for lupus, an autoimmune condition, and is then found to work in rha and there is good reason to believe it might, then the potential is similar. Except, of course, Humira has very significant side effect issues