Immupharma Share Discussion Threads

[nobbygnome] 19/4/2022 09:44

The peptide has to be exactly the same however it’s manufactured. That is most definitely not the reason for the PK study request

[pwhite73] 19/4/2022 09:29

The FDA requested information on the PK study because the company had changed the drug since the FDA initially approved the PK study. You can't gain approval from a regulatory authority on a drug then change the drug midstream on the same approval. Its either back to square one or prove the drug is still safe and meets all its endpoints.

RNS 12/08/2021 - "ImmuPharma PLC (LSE:IMM) (Euronext Growth Brussels: ALIMM), the specialist drug discovery and development company, is delighted to announce that the US Food & Drug Administration ("FDA") has approved the commencement of the pharmacokinetic ("PK") study, as part of the new optimised international Phase 3 trial of Lupuzor™."

RNS 07/02/2022 - "As part of the regulatory process, the Investigational Medicinal Product Dossier ("IMPD") required significant revision, due to the inclusion of a new proprietary synthesis of P140, which consequently affords greater IP protection and lower cost of goods."

RNS 13/04/2022 - "Data successfully demonstrates the PK study has met the key endpoints requested by the FDA"

[nobbygnome] 19/4/2022 09:10

And I’m surprised at the certainty of that positive post. We still don’t know why the FDA wanted the PK study done so it’s still entirely possible that they will be far from impressed by the results.

[guy gibson] 19/4/2022 09:06

Blimey, never seen a positive PWhite post.

[pwhite73] 19/4/2022 09:04

They raised £3.55 million in December since then another Pharma and two institutions have taken stakes. The US partner Avion is running the trials and on 13/04/2022 they announced the P140 PK had met all FDA endpoints. The company and the share price appear to be going places at least for now. There is bound to be a pull back after the sharp rise but it won't last for long. The drug is heading for Phase 3 trials in the US which will generate even greater interest.

[guy gibson] 19/4/2022 08:12

Based on the fact he missed the boat....

[thordon] 16/4/2022 11:13

Based on what Evidence NY Boy

[ny boy] 15/4/2022 23:39

Cash call coming up

[letmepass] 15/4/2022 23:13

nope they do it because they have a shed load of shares to sell

[bobdown2] 14/4/2022 16:22

Mms like to keep dropping the bid when buys are taking the offer higher. Do the mms do this so they can keep the price in a range where they can consolidate the sharp rise.

[tomboyb] 14/4/2022 15:27

Would pick up more if it went to 6p -

We may be going blue -

[lse2020] 14/4/2022 15:26

Back to 6p then?

[tomboyb] 14/4/2022 15:03

offer 7.44 but MMs giving 30k at 7.59p -

[firestorm911] 14/4/2022 14:12

I did. My hands are up. Mea Culpa.

[firestorm911] 14/4/2022 11:59

Looks like incineration my friends. That's why always take your money and run very fast.

This was a very good trade yesterday. MMS were kind, but careful what they give in one hand they tend to take double.

I have said it many times, trial not going to happen till next year.

Big big seller, was dumping at 9.00p.

[thordon] 13/4/2022 22:33

In phase 111 trails the drug worked on lower doses then higher dose , from memory 66%.
So maybe the question from FDA was why a higher dose did not work more effectively.
Hence the PK study to understand why in healthy humans does this stay within the body and not rejected as we now know.
In the PK study was positive , so now its a case of finding the right dose in a human that has the disease without dissipating through the liver and using a healthy patient as a set point in understanding what is happening.
Do agree management sometime treats us as non understanding of medical understanding , then you read the forum and its balanced in views.

I suspect Nobbygnome has a small holding in this company as myself and it's a interest only and high speculative that could 10 bag plus in the future.

As with all company's , made good and bad

The Good made 3.5 x on Totally still hold ; ITX made 3 x on ITX still hold


The Bad end Minus 6 x on Loopup was up 5 x ; mayor mistake never sold but invested less then IMM

[nobbygnome] 13/4/2022 21:24

And I don’t quite understand why the data from the PK study has any relevance for the outcome of the phase III because they are using the same dose as failed before. The important question is why did the FDA ask for that study; a question the company has never answered. That is the key to what the outcome here will be and why it’s not cut and dried the phase III will proceed

[nobbygnome] 13/4/2022 21:12

Thanks for the back handed compliment!

Yes I should have said the drug won’t work at the dose they are using…

[lerichman] 13/4/2022 20:54

Alas there is hope. Despite Nobby's snobbish demeaning tone to other posters, it cannot be said that he hasn't been at least mostly correct about Lupuzor thus far.
I absolutely agree with him in regards to the dodgy management, however more than dodgy, they are incompetent. The scientific side of the company has always been quite competent and innovative. They are now partnered with a competent experienced company well versed in setting up clinical trials, and will almost certainly design a high probability for success compared to the comically poor phase three trial Immupharma performed.
For Nobby to say that the drug doesn't work is premature. I do recall him saying in the past that the issue was more of dosage rather than the underlying drug efficacy.
Until we dig into the data from the latest trial with greater detail, it is impossible to accurately determine the probability of a phase three success, however based upon the initial results it appears highly probable to me that they would have successfully passed the previous trial had that trial been performed by competent administrators.

[thordon] 13/4/2022 20:06

Do remember that this is not there only drug in testing phase.

[arcadian] 13/4/2022 18:06

They or somebody here had a lot of mine at one point when Phase 2 reported- something like 150p and down to bottomless perdition.

[ny boy] 13/4/2022 16:26

With this Company it wouldn’t surprise me if they take advantage off this rise and get a cash raise underway, they always seem to like raising more money with lots of promises of gold ahead!

[tomboyb] 13/4/2022 16:24

Probably clearing -