Futura Medical Share Discussion Threads

[mdi] 01/3/2024 14:17

‘Moreover, when assessed against internationally accepted criteria for clinical effectiveness (Rosen and Araujo) the efficacy of Eroxon exceeded the minimal clinically important differences (MCID)’

Also been proven by others that the MCID criteria are actually not ‘internationally accepted’ for use in non regular unblinded non oral drug studies ie ‘non pharmacologic’ medical device studies known to have higher placebo effects



‘MCIDs were estimated using data from 17 randomized, double-blind, placebo-controlled, parallel-group clinical trials of the phosphodiesterase type 5 inhibitor’

‘limitations’

‘Current analyses were based on 17 clinical trials of tadalafil’

‘Results need to be replicated in studies using other PDE5-Is or in nonpharmacologic intervention studies’

[broomrigg] 01/3/2024 14:05

Well done petroc for reporting him and good work here takeiteasy thanks. MDI is looking like a right nutter talking to himself all day on the other thread 🤣🤡

[takeiteasy] 01/3/2024 12:36

hxxps://www.livescience.com/43571-permanent-erection-in-woman-case-report.html

Crikey the things you can learn as an investor in FUM - opened my eyes to a totally new world of how certain body parts work. ...

Want to hear more from the firm at the next general meeting about developments for women...

[takeiteasy] 01/3/2024 12:28

Company website...anyone who spouts on and on without reference to the below is acting in the capacity of a real placebo i.e. makes no difference and waste of time :)

Why are there no placebo controlled studies?
Eroxon, was the “placebo”; used in FM57 and gave surprising results having efficacy approximately double that normally achieved in ED studies with regular placebos. Moreover, when assessed against internationally accepted criteria for clinical effectiveness (Rosen and Araujo) the efficacy of Eroxon exceeded the minimal clinically important differences (MCID).

Why hasn't a double blind study been conducted?
FM57 was a double-blind study. It was not possible to double-blind FM71 as the two treatment arms were not matched; a topical gel and a tablet. US FDA accepted the “open-label221; design proposed by Futura Medical.

[mdi] 01/3/2024 11:18

Haleon on the importance of ‘scientific substantiation’ ‘relative to placebo’

[takeiteasy] 01/3/2024 11:10

I wonder if we can raise this with the firm itself and they raise the matter with the relevant authorities - can but try. This can be plan B if your plan does not work....

[takeiteasy] 01/3/2024 10:18

I wondering to do the same now...the bears have thrown the kitchen sink at us and come up woefully short. We are down to the same old you tube videos relying on amazon scores as primary research - then you know it is a busted flush...

[wheeze] 01/3/2024 10:11

Not sure but have topped up all the same. Given the product, this can only rise, lol

[mdi] 01/3/2024 10:11

With the introduction of EROXON, many wonder if this ED cream is the answer to their prayers. However, a closer look reveals limited clinical evidence of its effectiveness.

[takeiteasy] 01/3/2024 10:06

Question: is the most recent price action looking like a flag - wdik of course.

dyor and no advice...

[mdi] 01/3/2024 09:34

Eroxon was ‘clinically proven’ to be less effective then the lowest dose of Tadalafil.

‘tadalafil showed a greater improvement in erectile function than MED3000’

And now it can be claimed ‘Aerobic activity may work as well as medication for helping erectile dysfunction’

So based on the fact that the placebo Eroxon gel was proven less effective then Tadalafil medication. Therefore free ‘aerobic activity’ is a much more cost effective solution for men with ED then just using an expensive placebo Eroxon gel.



‘If you are concerned about the potential side effects of erectile dysfunction (ED) drugs and you're looking for an alternative treatment, try doing more aerobic exercise’



Dr. Roach: Eroxon cream is safe for ED, but is a placebo

Two trials have been completed, but only one was published. In the published trial, the results showed that the results for the active drug were only marginally better than a placebo, with about 37% of placebo recipients being satisfied with their experience versus 48% in those who received the active drug.

This means that about one man out of nine who used the active drug found it more helpful than a placebo. It also means that most people who were satisfied with the results were having a placebo response

The company then decided to market the placebo compound itself as Eroxon, which does not contain nitroglycerine or any compound that is expected to have a pharmacologic effect, although the company suggests that the “evaporative effect” of the cream may stimulate nerve endings, without any data to support this.

When I looked online to see how much it cost, I was surprised to see that a 1.75-ounce tube costs $99 — and it was temporarily out of stock.

I know that many men are willing to do almost anything to treat erectile dysfunction. I am also supportive of the placebo response when it is used ethically. However, I have a hard time recommending paying $100 for a compound that was designed and tested as a placebo, even if 37% of men will find some benefit from it.

[2 solaris] 29/2/2024 09:07

Why do you keep encouraging him to post by aiming your comments at him haroldthegreat? Please start a MIDI thread and leave this one to FUM.

[mdi] 29/2/2024 08:55

Does ATD 'meet criteria for same intended use'. Yes as proven in Libigel studies. Has 'slightly different technology but produces similar end results'. Yes made of similar solvents and also causes evaporative cooling. And is 'safe and effective'. Yes. Its already on the market in gels delivering drugshTtps://www.pall.com/en/medical/blog/the-importance-of-fda-510k-cleared-product.html a company must compare their product to one already cleared by the FDA and provide evidence that their product is substantially equivalent to the previously cleared (legally marketed) device. To be substantially equivalent, the product must meet criteria for the same intended use, have the same technology or (slightly) different technology but produces similar end results, and be safe and effective. Once pre-market clearance is received from the FDA the device can be distributed commercially immediatelyâ

[mdi] 29/2/2024 08:22

There is no evidence from any direct blind study that the non medicated ‘Dermasys’ hydroalcoholic gel would work any better then any other non medicated hydroalcoholic gel like ATD. And others have already shown other non medicated placebo hydroalcoholic gels can have similar effects on improving Erectile function.



Men were first treated with tadalafil 10 mg once a day (OAD) for 4 weeks; if not successful, they were randomized in a double-blind, placebo-controlled design to receive placebo or a 1% hydroalcoholic T gel (50 mg/5 g gel)

Erectile function progressively improved over a period of at least 12 weeks in both the placebo and T treatment groups