Evgen Pharma Share Discussion Threads

[amaretto1] 09/12/2020 17:37

I'd say the base was 8 pence.

[kingalf] 09/12/2020 13:20

I appreciate the volumes are low, but there seems to be a solid base at 8.50p.
Expect a move back up within the next week.
The 200 dma is now at 9.99p, break of that will turn all the signals positive.
IMHO, could well be a good time to dip your toes again

[peanut100] 09/12/2020 13:20

Someone takes Cantor out in say 25k shares they go higher. Buyer of 300k earlier after the uncross has cleared some of the market book stock out.

[mesquida] 09/12/2020 09:46

Unusually large uncrossing trade this morning, since when nothing has traded. Not quite sure what to make of that.

[moneymunch] 09/12/2020 07:14

News on SFX-01's breast cancer status could be close. Gla ;-)


Current and planned work programme

All preclinical breast data published in high impact journal in June 2020

Extensive review of clinical pathway to approval close to completion

Supplementary preclinical work required to confirm CDK4/6i “resistance-breaking” hypothesis

New “commercial ready” solid tablet formulation to be completed in H3 2020

Non-dilutive capital e.g. partnering to fund the next trial(s)

Targeting CTA/IND in H1 2021 with first patient first dose in Q2/Q3 2021




...............................

Market opportunity in ER+ metastatic breast cancer

Incidence of ER+ metastatic breast cancer is approximately 130,0001 in US and Europe

CDK4/6 inhibitors are now first line treatment, in combination with hormone therapy

Pfizer (Ibrance®/palbociclib), Novartis (Kisqali®/ribociclib) and Eli Lilly (Versenio®/abemaciclib ) are the key players with billion plus sales - sales forecast to reach c.$9bn by 2021/2

All patients become resistant to CDK4/6 inhibitors

Treatment options post CDK4/6 inhibitors are generally poorly tolerated – treatments which improve quality of life are needed in this terminal population

Potential of SFX-01 to be treatment of choice post CDK4/6 inhibitor failure, extending progression free survival with favourable side-effect profile.

[moneymunch] 09/12/2020 06:37

Rob Clarke Retweeted
Casey
@casey_broadbent
·
9h
Great talk today by @RobClarkeLab
at @SABCSSanAntonio

presenting some of the exciting research going on in the lab focused on ER+ breast cancer and therapeutic resistance #SABCS20

[moneymunch] 08/12/2020 22:32

Aguirre-Ghiso Lab
@JAguirreGhiso

We study how micro-environmental and epigenetic mechanisms drive cancer cells into dormancy. We seek to control this biology to prevent metastasis.





..........................

Piotr Okupski
@PiotrOkupski

Cancer Researcher focused on breast cancer. Following mostly CDK4/6 drugs, STAT3 and Immunotherapy.



...........................

svastiharicharan
@svastiharichar1

Svasti Haricharan's Research Focus
Related Diseases

Dr. Haricharan's lab focuses on the role of DNA damage repair in inducing resistance to endocrine therapy in breast cancer, particularly the role of HER2/4 in mismatch repair deficiency, and in identifying early driver mutations in breast cancer formation.



Sanford Burnham Prebys is uncovering the origins of disease

[moneymunch] 08/12/2020 22:13

ps.

3,3′-Diindolylmethane is a compound derived from the digestion of indole-3-carbinol, found in cruciferous vegetables such as broccoli, Brussels sprouts, cabbage and kale. The reputation of Brassica vegetables as healthy foods rests in part on the activities of diindolylmethane.

[moneymunch] 08/12/2020 22:01

No rumours, just facts....Gla ;-)


Rob Clarke
@RobClarkeLab

Going out live now in the Educational Session at #SABCS2020 @SABCSSanAntonio
Mechanisms of resistance in ER+ breast cancer @MCRCnews
@UoM_DCS

@DrRachelEyre
@MCRBreastCentre
@BreastCancerNow

..................

Aguirre-Ghiso Lab
@JAguirreGhiso
·
3h
Replying to
@RobClarkeLab

@SABCSSanAntonio
and 5 others

I think I like where that slide is going

svastiharicharan
@svastiharichar1
·
2h
Replying to
@RobClarkeLab

@SABCSSanAntonio
and 5 others

Amazing talks all around. Any thoughts on how specific SFX-01 is in terms of the STAT3 node? We're seeing similar effects with di-indolyl methane, but seems more cell cycle checkpoint related.

Piotr Okupski
@PiotrOkupski
·
2h
Replying to
@RobClarkeLab

@SABCSSanAntonio
and 5 others

Lets wait for other slides ;) after live event.

[moneymunch] 08/12/2020 09:14

Prof Clarke's presentation is scheduled between 11am - 1pm, and the UK is 6 hours ahead of Texas, and so maybe news tomorrow if he was reporting on any new developments ( if SFX-01 related ) ...Gla ;-)

[moneymunch] 08/12/2020 07:59

Speculate on the rumour!!! ;-)

[amaretto1] 08/12/2020 07:12

Or maybe false !

[kingalf] 07/12/2020 20:34

Interim results should be announced next week.
Will have some clarity around its cash position and updates on ongoing trials.

[hodhasharon] 07/12/2020 20:20

So much positivity from MM...this thread thrives on it.

[moneymunch] 07/12/2020 19:34

Lol...yes I'm sure...:-)

Ps Prof Rob Clarke from Manchester University has a pre-recorded lecture presentation on  ER+ breast cancer: mechanisms of therapeutic resistance, for the San Antonio breast cancer symposium tomorrow, and so hoping it might be SFX-01 related along with news of further progress, fingers crossed. Gla ;-)

[hodhasharon] 07/12/2020 19:05

In MoneyMunch we Trust!

[moneymunch] 07/12/2020 18:58

Anyways, good luck at SNG and any news on EVG will be well received...C'mon Dr Jones, pull your finger out!!! :-)

[moneymunch] 07/12/2020 18:55

Lol...or maybe my positive post yesterday on news of their phase 3 trial coming soon...Gl :-)

[amaretto1] 07/12/2020 17:29

The rumour must be true .... what ever it is ...

[nobbygnome] 07/12/2020 17:11

I'm saying nothing...except that if you were in the Guild you would have known yesterday about the rumour which may well have driven the rise today!

[moneymunch] 07/12/2020 07:16

We need Covid-19 treatments as well as vaccines – and they have to work for everyone

Effective treatments, that are accessible to everyone who needs them, have to be part of the solution to the coronavirus pandemic – here's why.



"Treatments are not just a contingency for when the vaccine comes along."

Nick Cammack, Wellcome’s COVID-19 Therapeutics Accelerator Lead

Even when effective vaccines are found, the process of manufacturing and distributing them around the world will be complex. Nick Cammack, Wellcome’s COVID-19 Therapeutics Accelerator Lead, says: "Imagine we find a successful vaccine – one that develops the appropriate immunity – by the end of this year. It will still take a number of years to roll that vaccine out around the world." Effective treatments will help us save lives while this is happening.

Nor are treatments just a temporary solution – they're an integral part of how we tackle Covid-19. Even when we have a vaccine, people will continue to be infected. We also don’t know how much immunity it will give us, or for how long. For as long as people continue to get sick with Covid-19, we need effective treatments to help them. "Treatments are not just a contingency for when the vaccine comes along," says Nick.

[moneymunch] 07/12/2020 06:55

We still need Covid-19 treatments as well as vaccines

Intensive care physician and researcher Charlotte Summers has spent the pandemic advising on treatments – and the work isn't over

Monday 7 December 2020

Before the pandemic hit, her research focused on understanding acute respiratory distress syndrome (ARDS), a life-threatening condition that causes lung failure in around 10 per cent of intensive care patients and 25 per cent of all people who are put on ventilators. The hospital mortality rate is 35 per cent to 50 per cent – “incredibly serious and yet most people have never heard of it.” Her group will continue this work over the coming months, using data samples from previous viral outbreaks such as H1N1 (“swine flu”) to identify subgroups within some of the causes of ARDS – Covid-19 being one. Understanding the different clinical outcomes of different groups of people will allow scientists to develop treatments and target therapies more effectively.

[moneymunch] 06/12/2020 15:28

Lol Nobby, if there's one thing we need for our home team games is a decent referee, he's been part of the club for years, but is rarely anywhere near the action on the field and has at least a one minute delay in blowing his whistle and so blatant fouls, offsides and penalties are not given to either side, which can generally lead to a bit of dissent from both teams from time to time, especially from the opposition that aren't familiar with the Refs way of playing.....but great fun nevertheless in what's normally very competitive games, win or lose...;-)

[nobbygnome] 06/12/2020 13:56

Oh and a supporter of AFC Bournemouth for the last 45 years as well....