Eden Research Share Discussion Threads

[supersonico] 11/3/2018 13:33

SO SUPRISINGLY .. Eden have patented a hollow micro-particle which allows encapsulation of a high potency agent and within that patent they have named a multitude of agents each of which offer highly commercial opportunities in addition to the opportunities all ready stated..

I'm struggling to work out why a discovery of this magnitude would not deserve a RNS as it seems to suggest that the company can derive/generate more income from these applications which offer wider commerciality than previously stated..

.. so it would be appropriate to inform the market..would it not??
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supersonico - 10 Mar 2018 - 08:32:40 - 3486 of 3493
Eden Research - EDEN
'Surprising' ..US patent application 4/1/18 .



01/04/18 - Encapsulation of high potency active agents

0007)
It has now been surprisingly found that high potency active agents can be encapsulated in a micro-particle with the use of a hollow micro-particle.

0008)
Therefore according to the first aspect of the present invention there is provided a composition comprising a micro-particle component and a highly potent active agent encapsulated in the micro-particle.

[supersonico] 10/3/2018 19:59

If Prof Alice Roberts is our presenter then Eden have made a good choice IMO

[supersonico] 10/3/2018 18:38

Nematicidal compositions and methods of using them
There is disclosed method of killing nematodes comprising the step of applying an effective amount of a nematicidal composition comprising a terpene component and compositions suitable for use in the method. The terpene component is preferably in association with water, either as a solution or a suspension. An excipient may also be included, which is suitably hollow glucan particles which encapsulate the terpene

[supersonico] 10/3/2018 13:36

Following the Eden Twitter Follows speculative journey Jigsaw.



Is Alice Roberts our Video presenter?

[supersonico] 10/3/2018 11:45

Thanks AttyG.

I'm no chemist so I'm in the dark here but this feels like a very significant Patent which potentially opens up many more opportunities. I'm assuming the 'surprising' part means the find is ground breaking. The other point much repeated is the 'high potency' which I assume means this means the micro-particle can hold considerably more of the load ingredient than the previous technology.

Some interesting new words/ Terms to plough thru;

For starters there is many references to Sulfony Urea applications;



11. A composition according to claims 8 to 10 wherein the sulphonyl urea is metsulfuron-methyl.



Metsulfuron-methyl is an organic compound classified as a sulfonylurea herbicide, which kills broadleaf weeds and some annual grasses.[1] It is a systemic compound with foliar and soil activity, that inhibits cell division in shoots and roots. It has residual activity in soils, allowing it to be used infrequently but requiring up to 22 months before planting certain crops (sunflowers, flax, corn, or safflower). It has very low toxicity to mammals, birds, fish, and insects but is a moderate eye irritant.[2]

12. A composition according to claims 8 to 10 wherein the sulphonyl urea is tribenuron-methyl.



Tribenuron-methyl
Tribenuron-methyl is a selective systemic herbicide used to control annual and perennial dicots in cereals and fallow land.

Tribenuron-methyl is a selective systemic herbicide used to control annual and perennial dicots in cereals and fallow land. Tribenuron-methyl is applied as a foliar spray and directly to the soil as it is rapidly absorbed by the foliage and the roots, and is translocated throughout the plant to the growing points. Tribeneuron-methyl acts by inhibiting the synthesis of amino acids, specifically valine and isoleucine, which prevents cell division and cell growth. Selectivity occurs due to the differences in the metabolism of sulfonylureas between crops and weeds. Growth ceases almost immediately after treatment and death results within 7 – 21 days. Weeds specifically susecptable to treatment with tribenuron-methyl include thistle, dock, curl sorrel, yarrow, milk thistle, plantain, dandelion, horsetail, buttercup and coltsfoot. Crops suitable to be treated with tribenuron-methyl include barley, durum wheat, green cover on land not being used for crop production, oats, rye (winter), triticale, wheat.
Tribenuron-methyl can be used as 50% or 75%, and in numerous formulations, such as water dispersible granules. It can also be used in combination with thiensulfuron-methyl specifically for barley and wheat. If you require tribenuron –methyl please contact Agchem Access directly.

13. A composition according to claims 8 to 10 wherein the sulphonyl urea is thifensulfuron-methyl.



A post-emergence herbicide for the control of grass and broad-leaved weeds

14. A composition according to claims 8 to 10 wherein the sulphonyl urea is iodosulfuron.



A post-emergence herbicide used to control weeds in cereals and other crops.

15. A composition according to claims 8 to 10 wherein the sulphonyl urea is amidosulfuron.



Amidosulfuron is a broad spectrum herbicide that has approval for use in the EU. It is volatile, highly soluble in water and, based on its chemical properties, has a high potential for leaching to groundwater. It is not persistent in soil systems but may be persistent in water under certain conditions. It has a low mammalian toxicity and would not be expected to bioaccumulate. Amidosulfuron is moderately toxic to most terrestrial and aquatic species.



16. A composition according to claims 8 to 10 wherein the sulphonyl urea is rimsulfuron.



A herbicide for annual grass and annual broad-leaved weed control in maize and other crops

17. A composition according to claims 8 to 10 wherein the sulphonyl urea is triflusulfuron-methyl.



A post-emergence herbicide for the control many annual and perennial broad-leaved weeds.

18. A composition according to claims 8 to 10 wherein the sulphonyl urea is nicosulfuron.



A post-emergence herbicide used to control annual grass weeds in maize crops

19. A composition according to claims 8 to 10 wherein the sulphonyl urea is mesosulfuron-methyl.



A systemic herbicide used for post-emergence control of grasses and other weeds in cereals

[attyg] 10/3/2018 11:02

Cracking find super

[supersonico] 10/3/2018 08:32

'Surprising' ..US patent application 4/1/18 .



01/04/18 - Encapsulation of high potency active agents

0007)
It has now been surprisingly found that high potency active agents can be encapsulated in a micro-particle with the use of a hollow micro-particle.

0008)
Therefore according to the first aspect of the present invention there is provided a composition comprising a micro-particle component and a highly potent active agent encapsulated in the micro-particle.

[supersonico] 09/3/2018 16:09

Investing.

1) Research papers for all to view. Much the same as Edison so why choose Hardman if they have.

Powerscourt and Hardman have Agricultural specialisms where Edison are not as strong.
This together with Life science specialism make them more suitable..maybe


Dr Gregoire Pave early work and I assume passion is aligned with Eden so could have been important when choosing Hardman (if they have). I feel they do like to work with people who are on the same wavelength.



Dr Gregoire Pave is an analyst in the Life Sciences team at Hardman & Co and has considerable experience in the field of drug discovery and development.

In 2003, he enrolled in a team leader post-doctoral position at Imperial College London working on natural product synthesis....

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The researchers focused on glyphosate-based herbicides, the most used pesticide worldwide. They point out that this weed killer has so many different adjuvant formulations that a safety test of one weed killer does not test the safety of another.

[investingisatrickygame] 09/3/2018 15:46

supersonico,

You are a detective!

So Powerscourt have the PR and it is unlikely to me that Hardman will as Powerscourt has only just been appointed. It would not be good if Eden was contemplating changing PR company again and so soon.

So three things that stand out to me with Hardman are

1) Research papers for all to view. Much the same as Edison so why choose Hardman if they have.

2) Due diligence. What DD might Eden require a company such as Hardman to do and on who?

3) Private valuations. Well the share price is shocking and neither Eden not their PR firm, present and past, appears to have the ability to influence positive movement. So would a valuation seek to explain value. I wonder what the 'private' element of that means?

[investingisatrickygame] 09/3/2018 09:21

AttyG

"Not long to go for a comprehensive (?) update."

I think we're all hoping for a positive price changing update. If not, it could be another 6 months of nothing!

Given what Hardman says about Retail Investors and their impact on the share price (something I have said to Eden for a long while now), I wonder if they may engage in some investor relations with all investors and leave Powerscourt to the 'PR'

Supersonico,

I wonder when they started following Hardman as this could indicate the start of their relationship. Any ideas?

[attyg] 09/3/2018 08:29

Supersonico,
Looks like you could have come across something - as you say could be well off the mark, but could be bang on.

All terribly quiet from the company. Was expecting / hoping for some further developments that could have formed an RNS by now.
I'm hoping the prelims will be announced on 26 March. They said march in the trading update, so surely that won't be Thursday the 29th before Good Friday.
Not long to go for a comprehensive (?) update.

[supersonico] 08/3/2018 21:30

Investing,

I'm totally speculating as Eden follow Hardman on Twitter..so could easily be way off the mark. Interestingly Hardman offer services and have expertise in areas such as Agriculture and Life sciences a cross over that they share with Eden tech applications . Hardman life science team also working with TRX who work with Wound care which grabbed my attention.





Dr Gregoire Pave is an analyst in the Life Sciences team at Hardman & Co and has considerable experience in the field of drug discovery and development.

In 2003, he enrolled in a team leader post-doctoral position at Imperial College London working on natural product synthesis....




Wound care.. Hardman working with this company TRX (also Investis)







and recent Eden presentation; Wound care gets a mention..



Pipeline
Head-lice
Fragrances
Wound-care
Food flavourings

[investingisatrickygame] 08/3/2018 21:14

Supersonico,

Thank you for finding and sharing this

@ 1:33, Retail Investors are most important and often determine the share price day to day. Bang on the money and exactly what I bang on about here and to Eden direct, but nobody wants to listen.

@ 3:00 Private valuations!!

Are Eden using Hardman for the latter? Why do you think Eden could be using Hardman? Are Eden getting a Company valuation from Hardman to illustrate that true value is (hopefully) way beyond current share price?

[supersonico] 08/3/2018 18:47

Investing.
This may be of interest.. if Eden are using Hardman they appear to offer services Eden could benefit from and that you have been talking about for a while.

'High quality sector and company research with investor engagement allows company management to get their story heard and their investment case made'



Looking briefly at the other Hardman Videos one thing that was mentioned was Mifid II regulation which may explain why Our Nomad Shorecap has not put any decent research out and why companies like Hardman are getting involved.

[supersonico] 08/3/2018 17:32

Lack of information on the effects of all pesticide ingredients makes them appear safer than they are—potentially causing serious harm to people and the environment.

New regulations are needed to protect people and the environment from toxic pesticide ingredients that are not currently subject to safety assessments. This is the conclusion of the first comprehensive review of gaps in risk assessments for "adjuvants" – ingredients added to pesticide formulations to enhance the function or application of the active ingredient. Ignoring the potential dangers of other ingredients in commonly used commercial pesticides leads to inaccuracies in the safety profile of the pesticide solution, as well as confusion in scientific literature on pesticide effects, finds the review published in Frontiers in Public Health.
"Exposure to environmental levels of some of these adjuvant mixtures can affect non-target organisms—and even can cause chronic human disease," says Dr Robin Mesnage from King's College London, who co-wrote the review with Dr Michael Antoniou. "Despite this, adjuvants are not currently subject to an acceptable daily intake and are not included in the health risk assessment of dietary exposures to pesticide residues."

Pesticides are a mixture of chemicals made up of an active ingredient – the substance that kills or repels a pest – along with a mixture of other ingredients that help with the application or function of the active ingredient. These other ingredients are known as adjuvants, and include dyes, anti-foaming agents and surfactants.
Regulatory tests for pesticide safety are currently only done on the active ingredient, which assumes the other ingredients have no effects. This means the full toxicity of a pesticide formulation—including those used in both agriculture and domestic gardens—is not shown.
"Currently, the health risk assessment of pesticides in the European Union and in the United States focuses almost exclusively on the active ingredient," explains Dr Mesnage. "Despite the known toxicity of adjuvants, they are regulated differently from active principles, with their toxic effects being generally ignored."
Based on a review of current pesticide literature, the authors describe how unregulated chemicals present in commercial formulations of pesticides could provide a missing link between pesticide exposure and observed negative outcomes.
The researchers focused on glyphosate-based herbicides, the most used pesticide worldwide. They point out that this weed killer has so many different adjuvant formulations that a safety test of one weed killer does not test the safety of another.
"Studies comparing the toxicity of commercial weed-killer formulations to that of glyphosate alone have shown that several formulations are up to 1,000 times more toxic than glyphosate on human cells. We believe that the adjuvants are responsible for this additional toxic effect," says Dr Mesnage.

The authors also highlight neonicotinoid insecticides—strongly suspected to be involved in the collapsing of bee colonies—as another example of adjuvant toxicity affecting non-target organisms. An adjuvant used in these insecticides to increase the penetration of the active ingredient has been shown to cause varying toxic effects in bees. On top of this, residues of the toxin have also been found in honey, pollen and beeswax produced by contaminated bees.
The authors hope their review will stimulate discussion on the toxicity of commonly used pesticides and encourage more thorough regulations.

"Testing of whole pesticide formulations instead of just active ingredients alone would create a precautionary approach, ensuring that the guidance value for the pesticide is valid for the worst-case exposure scenario," says Dr Mesnage.
Their findings have already had a considerable impact. The European Food Safety Authority is now reassessing the validity of pesticide risk assessment in the EU, and authors hope that this reassessment can extend to entire commercial formulations of pesticides and their other ingredients.

[supersonico] 08/3/2018 12:36

Corporate-media WP reporting health risks of Wine but avoiding the Toxic Elephant in the room despite much reporting in the French media.



In France, is wine still a national treasure? Or is it a health risk?

PARIS — In France, wine is not a drink; wine is a way of life.
A crisp sauvignon blanc. A light pinot noir. A mature Bordeaux, deep and dark and wise with age. These are all pillars of national identity at least as much as they are beverages. With the tannins comes a trace of the terroir, and with the terroir comes the taste of tradition.
But wine also poses a significant health risk — or so say the country’s health minister, Agnès Buzyn, and a host of doctors who have rallied behind her. They have launched a bitter debate that has shocked a multibillion-dollar industry and divided ranks even within the French government.
For Buzyn and her allies, the point is not to attack wine but to share the veritas about the vino, so to speak. Her goal is to raise public consciousness about a type of alcohol that can have, in excessive quantities, the same deleterious effects as any other.
“The wine industry today claims wine is different from other types of alcohol,” she said on French television last month. “In terms of public health, it is exactly the same thing to drink wine, beer, vodka, whiskey. There is zero difference.”

[supersonico] 08/3/2018 11:34

Interview 'There is much more, much faster in biological control than is generally known'



Insect mortality and other environmental concerns play a major role in public opinion. They are attributed to the use of chemical pesticides in conventional agriculture. It is therefore logical that the call for more sustainable forms of agriculture and horticulture sounds emphatically. The very first Annual Congress 'Agriculture without chemistry - how?' aims to make the Dutch food chain more opt for green pesticides because of both ecological and commercial potential. Peter Maes and Evert Hamblok of Koppert Biological explain why they are initiating this congress.

Koppert Biological from Berkel en Rodenrijs is the Dutch market leader in green pesticides and experiences that there is less progress than would be possible. In answer to the question of whether fewer chemicals could be used, Peter Maes, Director of Corporate Marketing and Evert Hamblok, Corporate Manager Regulatory Affairs, prefer to refer to independent studies. "Many studies have been conducted by the Center for Agriculture and the Environment (CLM) in which alternatives for neonicotinoids, for example, have been studied. Forty percent of these bee-and insect-unfriendly products could be perfectly replaced by biological means in specific crops. Yet this does not happen because the alternatives are not embraced or remain in the admission pipeline. In both cases the environment loses. "

What is standing in the way of replacing chemicals by biological means? Natural alternatives already exist for many chemical substances. You can find about 110 herbicides in the European pesticide database. There may be many alternatives for Glyphosate between them. In the media and the market, however, it is called that biological alternatives are not available. "That's nonsense," says Maes and Hamblok, "but illustrating the image." Some 1,000 chemical active ingredients were used in the early 1990s. Around 2000 that number dropped to 250. Now it has grown back to 500. "The number of chemical active substances is increasing again, while we want to get off", Maes observes.

Crop health
At European level there is a contradiction in the field of environment and food safety. According to the Sustainable Use Directive (SUD), which promotes the sustainable use of pesticides in member states, countries must have a positive action plan. Only six countries, including the Netherlands, participate. Meanwhile, all countries say they would like new green resources. However, they are not given priority in the admission policy. The testing framework counteracts this. "There is too little knowledge. Governments and authorities do not have enough experts to assess green resources, "says Maes. "In agricultural and horticultural education, ecological control is insufficiently taught and insufficiently recognized as important."

And the way of thinking has to be reversed. "First of all, it must be thought from prevention, such as crop health. That is the basis for the prevention of diseases and pests. Then monitoring of any diseases that still arise. And only then to combat and intervention. But then you are already in the top of the pyramid. You have to start at the basis. "Even so, training is thought very quickly from intervention, while in ecological thinking the basic - prevention - is crucial. "It is easy to think immediately from combat", says Maes. "Compare it to taking a paracetamol in headache instead of a daily relaxing walk to prevent. You have to tackle the underlying problem. We feel that it should be different, but we do not. "

Admission authorities
So you have to get started so that you do not get a headache. But that means a lot. To few understand that. Hamblok: "It is often said that biological solutions are not always that safe. We have an answer to that: a good registration process with admission overcomes that fear. In the research phase, substances that could be harmful (pathogenic) are immediately selected. When the biological crop protection system is applied, the system returns to balance very quickly. Bacteria and fungi are fighting each other, while chemistry is the system.

Why does it take so long to get green medicines? Hamblok: "The process is not necessarily longer than that of chemical means. All means go almost mathematically through the same funnel. Ecological resources also go through that funnel. At a certain moment this is faltered and additional safety questions emerge that, from a scientific point of view, are sometimes irrelevant to microbiological substances. They lead to additional questions and sometimes endless tests. Nevertheless, many of these questions can be answered faster and better from an understanding of the functioning of ecosystems and microbiology. It is not sufficiently present at the admission authorities. This is also recognized by the Dutch approval authority, the Ctgb. We therefore advocate investing in this. Especially because the Dutch government wants to be a green pioneer, but has insufficient knowledge of the effect of green resources. Incidentally, no admission regime requires more time than the European one. In non-European countries like the US and Brazil, an average admission costs 3 years. In Europe it costs on average 8 years. "

Koppert thinks that in the EU the development of biological means is at risk if that speed does not come
Not more expensive
Koppert Biological advocates a new approval framework based on the properties of microbiological agents and evaluated by experts in the field with the right background and knowledge. The active agent must determine whether a biological or chemical assessment framework applies. "If we want to lead the way in Europe," says Maes, "we will have to be able to go faster than the 8 years that now apply to chemicals in the EU

In the US chemical and biological authorizations cost on average the same - short - time.

Koppert thinks that in the EU the development of biological means is at risk if that speed does not come. Different incentives must be introduced to achieve more biological resources. Large and smaller companies must always be able to continue to develop resources and bring them to the market. Maes: "I would not want to say immediately that the development of green resources ends completely. I do think that other routes will arise. Europe and the Netherlands can lose their leading position if authorizations in other countries are easier. That would be a shame for Europe. "

What will the use of 'green' resources mean for consumers? Are fruits and vegetables, for example, more expensive? Maes: "The product does not have to be expensive at all. On the contrary, every link in the chain, and there are quickly four or five of them, takes residual samples to check whether the predecessor has said it is correct. With bio that can all be done. That saves a lot in the cost price. We want to show processors and retailers that they can put the voice of the consumer and promise him and her that their wish 'I do not want to eat poison' is affordable. "

[supersonico] 08/3/2018 11:26

Off Topic SEE



About to POP.... I hope

BMW leak from credible source here not RNS yet.

[supersonico] 08/3/2018 10:54

Not sure if I'm doing a 2=2=5 here but this company are followed by Eden on Twitter and mention wound care and have life sciences and Agriculture specialist research in the blurb. I'm going to have to do a bit of scratching around as I recall wound care applications being mentioned by Eden previously.







TBC

[supersonico] 08/3/2018 09:30

Post Harvest treatment on my Easy Peelers.

Noticed that my Tesco Finest Easy peelers from Spain (which were much poorer quality than my M&S Easy peelers) listed ILAZALIL / FLUDIOXONIL/ E904 /E914 as a post harvest treatment.



tbc

[supersonico] 07/3/2018 14:14

#WithOrWithout campaign points to 20% reduction of apple production! This gap can be plugged by #lowrisk #biocontrol products both existing today and with accelerated access for these products as asked for by the EU parliament! #biopesticides #sustainableagriculture #ECPAreg2018
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His twin is a late riser ..

[northwick] 07/3/2018 13:19

Wait to see if he has twin