Bioventix Share Discussion Threads

[johnsmith321] 28/3/2019 13:41

Siemens also have gained approval for the atellica and advia plateforms using hs-troponin test in July.

hxxps://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm?ID=K171566
hxxps://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm?ID=K171274

[gsbmba99] 27/3/2019 16:49

Looks like Siemens received US FDA approval for the hs-troponin test on the Dimension Vista platform at the beginning of March:

[tadders2] 26/3/2019 17:44

Results on Monday

[diviincomesearch] 26/3/2019 17:20

Half year results normally out about now...any ideas on whether they give a heads up?

[johnsmith321] 21/3/2019 12:44

Thanks for the link gsbmba99 it is very helpful.

[gsbmba99] 21/3/2019 12:20

A recent, very brief presentation from CardiNor CEO (BVXP partner for secretoneurin). There's a milestone chart at 4:30 but we are dealing with an experimental biomarker. There may be significant amounts of research required to establish a scientific use case (as opposed to eg troponin which is replacing an existing test with 40+ years of research).

[steptoes yard] 15/3/2019 19:52

Thanks JS for the measured response and for the interesting attachment. All to play for here.

[steptoes yard] 15/3/2019 13:01

959 John S, Great to see you are back. Are you able to answer my question from post 953 in response to your post 952 please?

[gsbmba99] 14/3/2019 20:01

It's already been addressed but: Dr. Chapman does cardiology research including troponin studies.

[rzbrdbe] 14/3/2019 16:29

The assay used in this publication is the older less sensitive one for Troponin:

"The Beckman Coulter Access AccuTnI+3 assay (Brea, CA, USA) is used in routine clinical practice at our hospital. We applied this assay to measure hs-cTnI concentrations in the study population. The manufacturer’s recommended 99th centile (ULN) is 40 ng/L, which is the level we use in routine clinical practice. The coefficient of variation of the assay is less than 10% at 40 ng/L; the limit of quantification (10% of the coefficient of variation) is 20 ng/L; the limit of detection is 8 ng/L; and the limit of blank is 5 ng/L. For patients in whom troponin had not been requested for clinical reasons, we measured the hs-cTnI level using serum that was surplus to clinical need."

Hence you can't measure hourly changes in Troponin that the newer more sensitive assays (like BVXP's)can provide.
But the real point is that any troponin blood test will always a confirmatory test which should be used on a patient showing clinical symptoms and ECG changes. Doctors should not use it as the lone diagnostic test in anyone presenting with chest pain.

[johnsmith321] 14/3/2019 11:30

It is currently the most sensitive marker of heart damage. With enough evidence for the FDA to approve it. The paper shows some other factors can affect the baseline level in older patients. However, the authors also suggests that it may indicate "a increased risk of vascular events and all cause mortality" for those patients.

Overall, I do not think it is a issue for the test. Only that it should be followed up by a ECG.

[igbertsponk] 14/3/2019 10:54

is this bad news???

[melton john] 07/3/2019 17:34

Two large delayed sales at 3800 printed at the close, one 5000 and one 6000

[dasv] 06/3/2019 13:24

Steptoes, I've held for years and years. Easiest hold I've ever had.

[steptoes yard] 06/3/2019 13:02

JS
I haven't heard Peter indicate it will be substantial. Im not saying he didn't indicate that either but can you advise when he did indicate that please?

SY

[johnsmith321] 06/3/2019 12:52

Hi diviincomesearch,
Abcam is currently at p/e 38 (despite a substantial decline in earnings growth (est. ~5%)). Bioventix at p/e 35 could still go a little higher. All depends on how much of the revenue from the anti-troponin antibody will be logged this coming quarter.

[diviincomesearch] 06/3/2019 12:25

Only bought in, in August last year. Stock at nosebleed levels even if it is a fantastic company! Without some greater news flow in the update about Troponin etc. I’m not sure how much further this can push, despite the institutional buys.

There’s a large spread- i’m Holding out for a bid on half what I have today.

[s_a_b] 06/3/2019 11:03

Hi stepone, for what it's worth I trimmed 1/3 BVXP recently and bought some HUR too. Hope that doesn't jinx you! Been a great investment and planning to let the rest run for the long term.

[stepone68] 06/3/2019 10:33

Good advice Steptoe, and pretty much is how I try to do things. I still have 2/3rds of my BVXP and not planning on getting rid of them any time soon. Both Bioventix and Hurricane are up 6% since I tinkered, so I'm breaking even at the moment, so not a disaster, yet!

[steptoes yard] 06/3/2019 09:30

Find good companies, buy good companies, retain good companies, occasional top slice if you have to, sell your losers, walk the dog, meet some nice people then retire. But never sell companies like these

[stepone68] 06/3/2019 07:30

You are probably right steptoe. Occasionally I try these moves and they never work out.