The Children's Hospital Receives $50,000 Donation Through The CRESTOR(R) Charity Challenge at PGA TOUR's The INTERNATIONAL

- Brandt Jobe Wins for Charity - 


CASTLE ROCK, Colo., Aug. 7  /PRNewswire/ -- Brandt Jobe was named this week's CRESTOR(R) (rosuvastatin calcium) Charity Challenge winner for his first-place standing entering the final round of The INTERNATIONAL.  The CRESTOR(R) Charity Challenge is a season-long competition that recognizes and rewards the tournament leader entering the final round at 35 PGA TOUR events. Through the program, now in its second year, AstraZeneca will donate $3.5 million a year to designated health and PGA TOUR charities.  At each of the selected tournaments, a $100,000 contribution will be made, supporting the PGA TOUR's "Drive to a Billion" campaign which celebrates the spirit of giving that has helped the TOUR and its tournaments approach the milestone of $1 billion dollars in charitable giving.

For Jobe's performance, CRESTOR, an AstraZeneca pharmaceutical product, and The INTERNATIONAL will donate $50,000 to The Children's Hospital in Denver.  In addition, $50,000 will be donated to the health care charity of Jobe's choice.  CRESTOR(R) Charity Challenge winners and the tournament's designated charity will be recognized during the network or cable telecast of each tournament.

Last year, Chris DiMarco and Rod Pampling were in the lead entering the final round of The INTERNATIONAL.  For their performance, AstraZeneca donated $50,000 to the University of Colorado Hospital.  DiMarco donated $15,000 to the American Cancer Society and $10,000 to the Cystic Fibrosis Center, and Pampling donated $15,000 to the Cystic Fibrosis Center and $10,000 to the University of Colorado Hospital.

"All of us at The Children's Hospital are excited, pleased, and grateful that this year's CRESTOR(R) Charity Challenge donation is going to help us in our mission to improve the health of children through excellent, coordinated programs of patient care, research, education and advocacy," said Don Elliman, Chair of The Children's Hospital Board of Directors.

The CRESTOR(R) (rosuvastatin calcium) Charity Challenge is the centerpiece of a multi-year PGA TOUR partnership with AstraZeneca (NYSE:AZN). Last year, AstraZeneca donated $2.7 million through the program.  Highlights from the CRESTOR(R) Charity Challenge include

    -- Vijay Singh won last week's CRESTOR(R) Charity Challenge at the Buick
       Open in Flint and now has eight CRESTOR(R) Charity Challenge triumphs
       overall since 2004

    -- Phil Mickelson leads all players in 2005 with three (3) CCC
       victories. (Buick Invitational, AT&T Pebble Beach and Ford
       Championship at Doral)

    -- The other multiple CRESTOR(R) Charity Challenge winners in 2005 are
       Luke Donald and Vijay Singh, who have each won twice

    -- Singh has now won eight (8) CRESTOR(R) Charity Challenges since the
       program's inception in 2004 resulting in $350,000 to the charities of
       his choice -- $150,000 of which was donated to the American Red Cross
       Hurricane Relief Fund (Singh tied for the lead entering the final
       round at two tournaments)



"After just one year, the CRESTOR(R) Charity Challenge has become a visible extension of the PGA TOUR's mission of giving back in local communities throughout America," said Tony Zook, senior vice president, commercial operations, AstraZeneca.  "Through the support of AstraZeneca, the CRESTOR(R) Charity Challenge will play a major role in the PGA TOUR's 'Drive to a Billion' charitable program."

Fans can log on to http://www.crestor.pgatour.com/ to read about past CRESTOR(R) Charity Challenge winners and learn more about CRESTOR. CRESTOR is the presenting sponsor of TOUR Fantasy Golf at http://www.pgatour.com/fantasy and the PGA TOUR's year-end charity special that will air in December.

About The Children's Hospital

Founded in 1908, The Children's Hospital is a private, not-for-profit pediatric health-care network dedicated 100 percent to caring for kids. It has been ranked one of the best children's hospitals in America by U.S. News & World Report and Child Magazine.  With more than 600 experienced experts representing pediatric specialties, and more than 2,900 full-time employees, Children's is home to a number of nationally and internationally recognized medical programs. From medical breakthroughs to late-night fevers, Children's provides complete pediatric care at its main campus and through a network that includes eleven Children's Care Centers and more than 400 outreach clinics held in three states each year. For more information, visit the web site at http://www.thechildrenshospital.org/

About CRESTOR

CRESTOR (rosuvastatin calcium) is a once-daily prescription medication for use as an adjunct to diet in the treatment of various lipid disorders including primary hypercholesterolemia, mixed dyslipidemia and isolated hypertriglyceridemia.  It is a member of the statin (HMG-CoA reductase inhibitors) class of drug therapy.  CRESTOR has not been determined to prevent heart disease, heart attacks, or strokes. For patients with hypercholesterolemia and mixed dyslipidemia, the usual recommended starting dose of CRESTOR is 10 mg.  However, initiation of therapy with 5 mg once daily should be considered for patients requiring less aggressive LDL-C reductions or who have predisposing factors for myopathy, and for special populations such as patients taking cyclosporine, Asian patients, and patients with severe renal insufficiency.  For patients with marked hypercholesterolemia (LDL-C >190 mg/dL) and aggressive lipid targets, a 20-mg starting dose may be considered.  AstraZeneca licensed worldwide rights to CRESTOR from the Japanese pharmaceutical company Shionogi & Co., Ltd.

Important Safety Information

CRESTOR is contraindicated in patients with active liver disease or unexplained persistent elevations of serum transaminases, in women who are pregnant or may become pregnant, and in nursing mothers.  It is recommended that liver function tests be performed before and at 12 weeks following both the initiation of therapy and any elevation of dose, and periodically (e.g., semiannually) thereafter.  Rare cases of rhabdomyolysis with acute renal failure secondary to myoglobinuria have been reported with CRESTOR and with other drugs in this class.  The 40-mg dose of CRESTOR is reserved only for those patients who have not achieved their LDL-C goal utilizing the 20 mg dose of CRESTOR once daily. When initiating statin therapy or switching from another statin therapy, the appropriate CRESTOR starting dose should first be utilized, and only then titrated according to the patient's individualized goal of therapy.  The benefit of further alterations in lipid levels by the combined use of rosuvastatin with fibrates or niacin should be carefully weighed against the potential risks of this combination.  Combination therapy with rosuvastatin and gemfibrozil should generally be avoided. CRESTOR should be prescribed with caution in patients with predisposing factors for myopathy, such as renal impairment, advanced age, and inadequately treated hypothyroidism.  Patients should be advised to promptly report unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever.  CRESTOR is generally well-tolerated.  Adverse reactions have usually been mild and transient.  The most frequent adverse events thought to be related to CRESTOR were myalgia (3.3%), constipation (1.4%), asthenia (1.3%), abdominal pain (1.3%) and nausea (1.3%).

A full copy of the prescribing information for CRESTOR is available at http:/www.astrazeneca-us.com/pi/crestor.pdf or by calling 1-877-420-7249.

About AstraZeneca

AstraZeneca is a major international health care business engaged in the research, development, manufacture, and marketing of prescription pharmaceuticals and the supply of health care services. It is one of the world's leading pharmaceutical companies with health care sales of over $21.4 billion and leading positions in sales of gastrointestinal, cardiovascular, respiratory, oncology, and neuroscience products.  In the United States, AstraZeneca is a $9.6 billion health care business with more than 12,000 employees.  AstraZeneca is listed in the Dow Jones Sustainability Index (Global) as well as the FTSE4Good Index.  For more information about AstraZeneca, please visit: http://www.astrazeneca-us.com/ 

DATASOURCE: AstraZeneca



CONTACT:  Chris Smith, PGA TOUR, [phone], ;

or Kellie Caldwell, AstraZeneca, [phone]



Web site:  http://www.crestor.pgatour.com/

http://www.astrazeneca-us.com/ 

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