Angle Share Discussion Threads

[5oletrader] 26/1/2024 13:24

@DaveMac - I stick to my original thesis - NOT competition - WHY?-• The news articles are irrelevant - go to the source which is DATAR CANCER GENETICS. Their news release here:• https://datarpgx.com/wp-content/uploads/2022/12/TriNetra-Glio-PPT-India-1.pdf-• PAGE 12 indicates the TriNetra Glio Principal - This looks to be an Affinity-Based System? (Happy to be corrected)• Affinity-based systems are based on binding antibody-coated magnetic beads to the CTCs. These systems FAIL to capture the clinically SIGNIFICANT EMT'ing and mesenchymal CTCs as they DO NOT express the CELL surface MARKERs targeted by the antibodies. In addition, the antibody capture process KILLS the CELLS NEGATING the ABILITY to CULTURE the CTCs and potentially CHANGING the RNA and protein expression of the cells.-• TriNetra is NOT FDA approved - it ONLY qualified for the FDA Breakthrough Program - intended to speed up development, assessment, and review for premarket approval, 510(k) clearance, and De Novo marketing authorization.• https://www.fda.gov/medical-devices/how-study-and-market-your-device/breakthrough-devices-program#:~:text=The%20Breakthrough%20Devices%20Program%20is%20intended%20to%20provide%20patients%20and,and%20De%20Novo%20marketing%20authorization.• Years of data to collect ahead of them - it took AGL six (6)!-• TriNetra is NOT even marketed.• https://trinetra360.com-• ABOVE is all a SIDE BAR TOPIC (granted). As @jelenko pointed out - screening is not the immediate goal.• HOWEVER - I feel it be relevant. As AN stated by year end is aiming to provide tests FOR patients, not ABOUT but FOR. (Makes me curious).-WHY AGL TRUMPs IT?• Parsortix can capture and harvest live, intact CTCs + CTC Clusters for downstream analysis.• Key ADVANTAGEs of the Parsortix system compared to alternative CTC approaches are that it is epitope-independent (does not rely on antibodies to capture CTCs) and captures ALL TYPES of CTCs INCLUDING those that are mesenchymal. It also allows EASY HARVEST of the CTCs (recovery from the system) for analysis unlike filtration systems, which have the added problems of clogging up and lack of purity in addition to problems of harvesting the cells for analysis.-• I think I've exhausted this side bar discussion?! Have a good day.-ATB

[dave4545] 26/1/2024 13:23

Nice £20k buy there at 17.22p

Now if that was a sale there would have been a instant mark down to fuel the shake to get more people to panic sell.

[boris cobaka] 26/1/2024 13:03

Volume just a trickle. Needs another catalyst to underpin the bounce. In the meantime more drift likely and a capitulation still required imo.

[atmysignal] 26/1/2024 12:56

Above 20p then we on for 40, 50p

[cocorico2009] 26/1/2024 12:54

lets fill the gap first

[bones698] 26/1/2024 12:52

Maybe ,40p tbh most or say on big losses here 20p isn't any bug help really

[atmysignal] 26/1/2024 12:49

The moaning will stop above 20pPatience

[bones698] 26/1/2024 11:42

Agree with the summary . Similar pattern to before the jump and why the UK is an awful place to invest . Mms don't want anyone else making money but themselves and so mark things down and drag them back all the time .get the government wonder why people don't like investing in the UK . America companies get huge valuations on hopes and dreams ,here they are punished
Golden cross lols to be here next week or week after see if that provides some.positivity

[dave4545] 26/1/2024 11:34

Offer limits way too small to have a seller, they only offer a little size after flushing out the weak.

I mean if there was a seller earlier it would and should be easy to buy 50k at all times yet it was NT.

Lets see what happens on the next run of buys, if there is a seller they will not budge the online price will they !

[john henry] 26/1/2024 11:15

Which makes me think Dave is there still an institutional seller

[dave4545] 26/1/2024 11:11

It was, utterly frustrating

16.75p or less for anybody wanting a dip now mm's have won again

[broom23] 26/1/2024 11:11

Jelenko, I think you may be missing the point here. Angle succeeded in getting FDA clearance using the De Novo process because there was no other cleared CTC harvesting device already on the market - potential predicate devices. I agree that it is for use with diagnosed breast cancer patients. However, the information that can now be generated downstream using DNA sequencing techniques on Parsortix PC1 class II device samples is invaluable and provides clinicians with very specific information, laterally unavailable. This is just the start.

[john henry] 26/1/2024 10:52

If you think about it, Dave, this is the same price action that was going on before the spike. It's been going on for months.

[dave4545] 26/1/2024 10:26

here we go 67k sale way lower than online and bang mm drops

All the buys no movement, this is just manipulation and you watch the jittery brigade all panic sell,

I'll be adding on the dip, did buy more earlier over 17.5p

[john henry] 26/1/2024 09:38

No No buying

[dave4545] 26/1/2024 09:04

Oh JH I thought you were unusually positive last few days, sold out :-))

Yeah the mm's are short and they are not getting their usual feed of the weak sheep
so for once instead of drifting perhaps we can push on.

[atmysignal] 26/1/2024 08:54

This can bag in a day from any levelQuietly accumulated before your eyes

[john henry] 26/1/2024 08:42

Imho for whatever reason the MMs ( Maybe still short) want this lower.

[dave4545] 26/1/2024 08:34

Morning

mm's trying a shake dropping to 16.5p yet 17.333p bid online.

Online is 17.33-17.48p which is miles better than the 16.5-18p showing on the monitor.